BR0210537A - Anticolinérgico cristalino, processo para a sua preparação e sua aplicação para a preparação de um medicamento - Google Patents

Anticolinérgico cristalino, processo para a sua preparação e sua aplicação para a preparação de um medicamento

Info

Publication number
BR0210537A
BR0210537A BR0210537-3A BR0210537A BR0210537A BR 0210537 A BR0210537 A BR 0210537A BR 0210537 A BR0210537 A BR 0210537A BR 0210537 A BR0210537 A BR 0210537A
Authority
BR
Brazil
Prior art keywords
preparation
application
medicine
crystalline
anticholinergic
Prior art date
Application number
BR0210537-3A
Other languages
English (en)
Inventor
Peter Sieger
Ulrike Werthmann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR0210537A publication Critical patent/BR0210537A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

"ANTICOLINéRGICO CRISTALINO, PROCESSO PARA A SUA PREPARAçãO E SUA APLICAçãO PARA A PREPARAçãO DE UM MEDICAMENTO". A invenção refere-se a um brometo de (1<244>,2<225>,4<225>,5<244>,7<225>)-7-[(hidroxidi-2-tienilacetil) óxi]-9,9-dimetil-3-oxa-9-azoniatriciclo[3.3.1.0^ 2.4^] nonano anidro, cristalino, a processos para a sua preparação, bem como sua aplicação para a preparação de um medicamento, especialmente para a preparação de um medicamento com efeito anticolinérgico.
BR0210537-3A 2001-06-22 2002-06-08 Anticolinérgico cristalino, processo para a sua preparação e sua aplicação para a preparação de um medicamento BR0210537A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08
PCT/EP2002/006291 WO2003000265A1 (de) 2001-06-22 2002-06-08 Kristallines anticholinergikum, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (1)

Publication Number Publication Date
BR0210537A true BR0210537A (pt) 2004-06-22

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0210537-3A BR0210537A (pt) 2001-06-22 2002-06-08 Anticolinérgico cristalino, processo para a sua preparação e sua aplicação para a preparação de um medicamento

Country Status (37)

Country Link
EP (1) EP1401445B1 (pt)
JP (1) JP2005504015A (pt)
KR (2) KR100971616B1 (pt)
CN (1) CN100586948C (pt)
AR (1) AR037491A1 (pt)
AT (1) ATE337006T1 (pt)
AU (1) AU2002345016B2 (pt)
BG (1) BG66303B1 (pt)
BR (1) BR0210537A (pt)
CA (1) CA2450961C (pt)
CO (1) CO5550423A2 (pt)
CY (1) CY1105223T1 (pt)
CZ (1) CZ302786B6 (pt)
DE (1) DE50207943D1 (pt)
DK (1) DK1401445T3 (pt)
EA (1) EA005813B1 (pt)
EE (1) EE05316B1 (pt)
EG (1) EG24851A (pt)
ES (1) ES2271280T3 (pt)
HR (1) HRP20031066B1 (pt)
HU (1) HUP0400333A3 (pt)
IL (2) IL159238A0 (pt)
ME (1) ME00412B (pt)
MX (1) MXPA03011718A (pt)
MY (1) MY122779A (pt)
NO (1) NO334301B1 (pt)
NZ (1) NZ530690A (pt)
PE (2) PE20081305A1 (pt)
PL (1) PL208137B1 (pt)
PT (1) PT1401445E (pt)
RS (1) RS50441B (pt)
SA (1) SA02230255B1 (pt)
SI (1) SI1401445T1 (pt)
SK (1) SK287262B6 (pt)
TW (2) TWI261589B (pt)
UY (1) UY27342A1 (pt)
WO (1) WO2003000265A1 (pt)

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DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
CN101163706A (zh) 2005-04-21 2008-04-16 贝林格尔·英格海姆国际有限公司 用于治疗炎性疾病的二氢噻吩并嘧啶
NZ563448A (en) 2005-04-28 2011-01-28 Boehringer Ingelheim Int Benzofuranone derivatives for treating inflammatory diseases
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CN102822172A (zh) 2010-01-29 2012-12-12 贝林格尔.英格海姆国际有限公司 取代的二氮杂萘及其作为syk 激酶抑制剂的用途
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
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US9018212B2 (en) 2010-05-25 2015-04-28 Boehringer Ingelheim International Gmbh Pyridazine carboxamides as CCR2 receptor antagonists
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TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
JP5959537B2 (ja) 2011-01-28 2016-08-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピリジニル−ピリミジン及び医薬としてのその使用
TR201101897A2 (tr) 2011-02-28 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal madde
TR201111589A2 (tr) * 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür susuz kristal formu.
TR201102068A2 (tr) 2011-03-03 2012-09-21 Bi̇lgi̇ç Mahmut Tiotropyum bromür içeren kristal maddeler
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JP5786258B2 (ja) 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬
CA2843022C (en) 2011-07-26 2019-09-24 Boehringer Ingelheim International Gmbh Substituted quinolines and their use as medicaments
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
UA120278C2 (uk) 2011-11-25 2019-11-11 Адверіо Фарма Гмбх Заміщені 5-фтор-1н-піразолопіридини в кристалічній формі
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GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
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WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
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CN104341412A (zh) * 2013-07-29 2015-02-11 天津金耀集团有限公司 一种无水噻托溴铵结晶的制备方法
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KR102331856B1 (ko) 2014-10-21 2021-11-29 다케다 야쿠힌 고교 가부시키가이샤 결정 형태의 5-클로로-n4-[2-(디메틸포스포릴)페닐]-n2-｛2-메톡시-4-[4-(4-메틸피페라진-1-일)피페리딘-1-일]피리미딘-2,4-디아민
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Also Published As

Publication number Publication date
PL208137B1 (pl) 2011-03-31
HRP20031066A2 (en) 2004-04-30
ES2271280T3 (es) 2007-04-16
PE20030130A1 (es) 2003-04-02
CZ302786B6 (cs) 2011-11-09
WO2003000265A1 (de) 2003-01-03
CN100586948C (zh) 2010-02-03
PE20081305A1 (es) 2008-10-01
IL159238A0 (en) 2004-06-01
DE50207943D1 (de) 2006-10-05
YU99703A (sh) 2006-05-25
MXPA03011718A (es) 2004-12-06
TWI261589B (en) 2006-09-11
EE05316B1 (et) 2010-08-16
NO334301B1 (no) 2014-02-03
EA005813B1 (ru) 2005-06-30
RS50441B (sr) 2010-03-02
EA200301293A1 (ru) 2004-08-26
HUP0400333A3 (en) 2012-10-29
HK1068540A1 (zh) 2005-04-29
KR100971616B1 (ko) 2010-07-22
CA2450961A1 (en) 2003-01-03
EE200400029A (et) 2004-04-15
ME00412B (me) 2011-10-10
DK1401445T3 (da) 2006-11-27
BG108440A (bg) 2004-08-31
NO20035696D0 (no) 2003-12-19
UY27342A1 (es) 2003-02-28
ATE337006T1 (de) 2006-09-15
SK287262B6 (sk) 2010-04-07
EP1401445B1 (de) 2006-08-23
CY1105223T1 (el) 2010-03-03
KR20090031638A (ko) 2009-03-26
HRP20031066B1 (en) 2011-10-31
AU2002345016B2 (en) 2008-04-17
EG24851A (en) 2010-10-27
JP2005504015A (ja) 2005-02-10
KR20040018285A (ko) 2004-03-02
SI1401445T1 (sl) 2007-02-28
SA02230255B1 (ar) 2006-10-31
EP1401445A1 (de) 2004-03-31
NZ530690A (en) 2005-05-27
CO5550423A2 (es) 2005-08-31
HUP0400333A2 (hu) 2004-12-28
AR037491A1 (es) 2004-11-17
CN1520294A (zh) 2004-08-11
KR101011353B1 (ko) 2011-01-28
MEP62008A (en) 2011-05-10
CA2450961C (en) 2010-03-30
PT1401445E (pt) 2006-10-31
PL364489A1 (en) 2004-12-13
IL159238A (en) 2010-04-15
BG66303B1 (bg) 2013-03-29
MY122779A (en) 2006-05-31
SK522004A3 (en) 2004-06-08
CZ2004120A3 (cs) 2004-05-12
TW200617007A (en) 2006-06-01

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