BRPI0513287A - derivados de pirido-pirimidina, sua preparação, sua aplicação em terapêutica - Google Patents

derivados de pirido-pirimidina, sua preparação, sua aplicação em terapêutica

Info

Publication number
BRPI0513287A
BRPI0513287A BRPI0513287-8A BRPI0513287A BRPI0513287A BR PI0513287 A BRPI0513287 A BR PI0513287A BR PI0513287 A BRPI0513287 A BR PI0513287A BR PI0513287 A BRPI0513287 A BR PI0513287A
Authority
BR
Brazil
Prior art keywords
preparation
therapeutic
application
pyrimidine derivatives
formula
Prior art date
Application number
BRPI0513287-8A
Other languages
English (en)
Inventor
Bernard Bourrie
Samir Jegham
Pierre Perreaut
Pierre Casellas
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0513287A publication Critical patent/BRPI0513287A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

DERIVADOS DE PIRIDO-PIRIMIDINA, SUA PREPARAçãO, SUA APLICAçãO EM TERAPêUTICA. A presente invenção refere-se a derivados de pirido¢2,3-d!pirimidina, sua preparação e sua aplicação em terapêutica, da fórmula geral (1) a seguir: fórmula (1) na forma de base ou de adição de ácido farmaceuticamente aceitável, na forma de hidratos ou solvatos, bem como na forma de enantiómeros, diastereoisómeros e sua mistura. A invenção também refere-se ao processo de preparação, composições farmacêuticas contendo um composto de fórmula geral (1), e seu uso no tratamento de câncer.
BRPI0513287-8A 2004-07-15 2005-07-13 derivados de pirido-pirimidina, sua preparação, sua aplicação em terapêutica BRPI0513287A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0407898A FR2873118B1 (fr) 2004-07-15 2004-07-15 Derives de pyrido-pyrimidine, leur application en therapeutique
PCT/FR2005/001809 WO2006016067A2 (fr) 2004-07-15 2005-07-13 Derives de pyrido-pyrimidine, leur preparation, leur application dans le traitement du cancer

Publications (1)

Publication Number Publication Date
BRPI0513287A true BRPI0513287A (pt) 2008-05-06

Family

ID=34947008

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513287-8A BRPI0513287A (pt) 2004-07-15 2005-07-13 derivados de pirido-pirimidina, sua preparação, sua aplicação em terapêutica

Country Status (28)

Country Link
US (2) US7544682B2 (pt)
EP (1) EP1773835B1 (pt)
JP (1) JP5161568B2 (pt)
KR (1) KR101236676B1 (pt)
CN (1) CN101124223A (pt)
AR (1) AR049845A1 (pt)
AU (1) AU2005271071B2 (pt)
BR (1) BRPI0513287A (pt)
CA (1) CA2572614A1 (pt)
CR (1) CR8842A (pt)
EA (1) EA011406B1 (pt)
EC (1) ECSP067111A (pt)
FR (1) FR2873118B1 (pt)
GT (1) GT200500191A (pt)
HN (1) HN2005000370A (pt)
IL (1) IL180256A (pt)
MA (1) MA28742B1 (pt)
MX (1) MX2007000508A (pt)
NO (1) NO20070837L (pt)
PA (1) PA8639301A1 (pt)
PE (1) PE20060380A1 (pt)
SV (1) SV2006002170A (pt)
TN (1) TNSN06440A1 (pt)
TW (1) TWI391390B (pt)
UA (1) UA95223C2 (pt)
UY (1) UY29015A1 (pt)
WO (1) WO2006016067A2 (pt)
ZA (1) ZA200700992B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
BRPI0610133A2 (pt) * 2005-05-17 2010-06-01 Schering Corp heterociclos como agonistas de receptor de ácido nicotìnico para o tratamento de dislipidemia
US7737155B2 (en) * 2005-05-17 2010-06-15 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
US7750015B2 (en) * 2005-05-17 2010-07-06 Schering Corporation Nitrogen-containing heterocyclic compounds and methods of use thereof
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
AU2007208478A1 (en) * 2006-01-20 2007-08-02 Schering Corpooration Heterocycles as nicotinic acid receptor agonists for the treatment of dyyslipidemia
FR2910813B1 (fr) * 2006-12-28 2009-02-06 Sanofi Aventis Sa Nouvelle utilisation therapeutique pour le traitement des leucemies
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
TW200835497A (en) * 2007-01-11 2008-09-01 Astrazeneca Ab Chemical compounds 636
PL2168966T3 (pl) * 2007-06-15 2017-06-30 Msd K.K. Pochodna bicykloaniliny
FR2933701A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Derives anticancereux, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1171218A (en) 1967-11-09 1969-11-19 Parke Davis & Co New Heterocyclic Amine Compounds and Methods for their Production
FI971953A7 (fi) * 1994-11-14 1997-05-12 Warner Lambert Co Proteiinityrosiinikinaasin välittämää soluproliferaatiota inhiboivat 6 -aryyli-pyrido(2,3-d)pyrimidiinit ja naftyridiinit
IL115256A0 (en) 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US5620981A (en) 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
US7115750B1 (en) 1999-09-20 2006-10-03 Takeda Pharmaceutical Company Limited Melanin concentrating hormone antagonist
US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
WO2001055147A1 (en) 2000-01-25 2001-08-02 Warner-Lambert Company PYRIDO[2,3-d]PYRIMIDINE-2,7-DIAMINE KINASE INHIBITORS
AP2002002643A0 (en) 2000-03-06 2002-12-31 Warner Lambert Co 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors
JP2004519422A (ja) 2000-08-04 2004-07-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ２−（４−ピリジル）アミノ−６−ジアルコキシフェニルピリド〔２，３−ｄ〕ピリミジン−７−オン
AU2002324450A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyridopyrimidines and uses thereof
WO2003026665A1 (en) * 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4-(5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, src kinase inhibitors
WO2003055866A1 (en) * 2001-12-21 2003-07-10 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
RU2310657C2 (ru) * 2002-04-03 2007-11-20 Ф.Хоффманн-Ля Рош Аг Имидазоконденсированные соединения и фармацевтическая композиция, содержащая их
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
TW200413381A (en) * 2002-11-04 2004-08-01 Hoffmann La Roche Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
WO2004063195A1 (en) 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Pyridopyrimidine kinase inhibitors
TW200502236A (en) * 2003-03-28 2005-01-16 Hoffmann La Roche Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
WO2005034869A2 (en) * 2003-10-08 2005-04-21 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2005105097A2 (en) 2004-04-28 2005-11-10 Gpc Biotech Ag Pyridopyrimidines for treating inflammatory and other diseases
FR2873118B1 (fr) * 2004-07-15 2007-11-23 Sanofi Synthelabo Derives de pyrido-pyrimidine, leur application en therapeutique
FR2887882B1 (fr) 2005-07-01 2007-09-07 Sanofi Aventis Sa Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
FR2896246B1 (fr) 2006-01-13 2008-08-15 Sanofi Aventis Sa Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.

Also Published As

Publication number Publication date
CR8842A (es) 2007-08-28
US7544682B2 (en) 2009-06-09
WO2006016067A3 (fr) 2006-06-01
FR2873118A1 (fr) 2006-01-20
AU2005271071A1 (en) 2006-02-16
US20070167469A1 (en) 2007-07-19
PE20060380A1 (es) 2006-06-06
TWI391390B (zh) 2013-04-01
JP5161568B2 (ja) 2013-03-13
EA011406B1 (ru) 2009-02-27
NO20070837L (no) 2007-04-16
US20090233923A1 (en) 2009-09-17
IL180256A0 (en) 2007-07-04
EA200700144A1 (ru) 2007-08-31
HN2005000370A (es) 2009-06-01
ECSP067111A (es) 2007-01-26
ZA200700992B (en) 2008-05-28
CN101124223A (zh) 2008-02-13
MA28742B1 (fr) 2007-07-02
US7893259B2 (en) 2011-02-22
IL180256A (en) 2014-04-30
UY29015A1 (es) 2006-02-24
GT200500191A (es) 2006-03-07
TNSN06440A1 (fr) 2008-02-22
UA95223C2 (ru) 2011-07-25
JP2008506673A (ja) 2008-03-06
EP1773835A2 (fr) 2007-04-18
PA8639301A1 (es) 2006-11-09
WO2006016067A2 (fr) 2006-02-16
TW200607808A (en) 2006-03-01
KR101236676B1 (ko) 2013-02-22
KR20070037489A (ko) 2007-04-04
AU2005271071B2 (en) 2011-09-15
SV2006002170A (es) 2006-01-13
FR2873118B1 (fr) 2007-11-23
CA2572614A1 (fr) 2006-02-16
AR049845A1 (es) 2006-09-06
EP1773835B1 (fr) 2014-09-24
MX2007000508A (es) 2007-03-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.