BR0214775A - Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos - Google Patents

Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos

Info

Publication number
BR0214775A
BR0214775A BR0214775-0A BR0214775A BR0214775A BR 0214775 A BR0214775 A BR 0214775A BR 0214775 A BR0214775 A BR 0214775A BR 0214775 A BR0214775 A BR 0214775A
Authority
BR
Brazil
Prior art keywords
cis
fused
dibenzo
tetrahydro
preparation
Prior art date
Application number
BR0214775-0A
Other languages
English (en)
Inventor
Hua Mao
Tomasz Kozlecki
Frans Josef Cornel Compernolle
Georges Joseph Corne Hoornaert
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR0214775A publication Critical patent/BR0214775A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

"PREPARAçãO DE DERIVADOS DE 3,3a,8,12b-TETRAIDRO-2H-DIBENZO[3,4:6,7]CICLOHEPTA[1,2- b]FURANO CIS-FUNDIDOS". A presente invenção refere-se a um processo para preparação de cada dos 4 diastereómeros individuais de fórmula (I) em forma estereoquimicamente pura de um precursor enantiomericamente puro simples. O sistema de anel tetracíclico tendo anéis de sete membros e cinco cis-fundidos é formado em uma reação de ciclização de base catalisada. A invenção ainda refere-se aos intermediários de álcool tetracíclicos cis-fundidos desse modo obtidos e produtos finais de metanamina, e os produtos finais de metanamina para uso como um medicamento, em particular como medicamentos ativos de CNS.
BR0214775-0A 2001-12-07 2002-12-02 Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos BR0214775A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01204962 2001-12-07
PCT/EP2002/013561 WO2003048147A2 (en) 2001-12-07 2002-12-02 PREPARATION OF CIS-FUSED 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES

Publications (1)

Publication Number Publication Date
BR0214775A true BR0214775A (pt) 2004-11-09

Family

ID=8181461

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214775-0A BR0214775A (pt) 2001-12-07 2002-12-02 Preparação de derivados de 3,3a,8,12b-tetraidro-2h-dibenzo[3,4:6,7]ciclohepta[1,2- b]furano cis-fundidos

Country Status (16)

Country Link
US (1) US7205335B2 (pt)
EP (1) EP1463722A2 (pt)
JP (1) JP2005511692A (pt)
KR (1) KR20050044334A (pt)
CN (1) CN1697833A (pt)
AU (1) AU2002352205A1 (pt)
BR (1) BR0214775A (pt)
CA (1) CA2468040A1 (pt)
HR (1) HRP20040489A2 (pt)
HU (1) HUP0402325A2 (pt)
IL (1) IL162350A0 (pt)
MX (1) MXPA04005399A (pt)
NO (1) NO20042883L (pt)
PL (1) PL370440A1 (pt)
WO (1) WO2003048147A2 (pt)
ZA (1) ZA200404392B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050044329A (ko) * 2001-12-07 2005-05-12 얀센 파마슈티카 엔.브이. 트랜스-융합된3,3ａ,8,12ｂ-테트라히드로-2Ｈ-디벤조[3,4:6,7]시클로헵타[1,2-ｂ]푸란 유도체의 제조
CA2577305C (en) 2004-08-31 2013-12-17 Janssen Pharmaceutica N.V. Process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid
JP4912320B2 (ja) 2004-12-07 2012-04-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 置換された四環式テトラヒドロピラン、ピロリジンおよびテトラヒドロチオフェン誘導体
NZ564181A (en) 2005-06-17 2010-02-26 Janssen Pharmaceutica Nv Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain
US9962446B2 (en) 2012-07-17 2018-05-08 Dow Global Technologies Llc Solid dispersion comprising a highly substituted hydroxyalkyl methylcellulose
BR112014031471B1 (pt) * 2012-07-17 2020-12-01 Dow Global Technologies Llc composição líquida, uso da composição líquida, dispersão sólida, processo para produzir a dispersão sólida e processo para revestir uma forma de dosagem

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2196328T3 (es) * 1996-04-12 2003-12-16 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos sustituidos.
UA52778C2 (uk) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі

Also Published As

Publication number Publication date
IL162350A0 (en) 2005-11-20
MXPA04005399A (es) 2004-10-11
WO2003048147A3 (en) 2004-04-01
US20050033067A1 (en) 2005-02-10
HRP20040489A2 (en) 2005-04-30
HUP0402325A2 (hu) 2005-02-28
AU2002352205A1 (en) 2003-06-17
CA2468040A1 (en) 2003-06-12
US7205335B2 (en) 2007-04-17
JP2005511692A (ja) 2005-04-28
CN1697833A (zh) 2005-11-16
NO20042883L (no) 2004-07-07
KR20050044334A (ko) 2005-05-12
WO2003048147A2 (en) 2003-06-12
PL370440A1 (en) 2005-05-30
ZA200404392B (en) 2005-09-27
EP1463722A2 (en) 2004-10-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010.