BR0308472A - Processo para preparar a forma i cristalina de cabergolina - Google Patents

Processo para preparar a forma i cristalina de cabergolina

Info

Publication number: BR0308472A
Authority: BR; Brazil
Prior art keywords: cabergoline; toluene; preparing crystalline; cabergoline form; mixture
Prior art date: 2002-03-15

Application number

BR0308472-8A

Other languages

English (en)

Portuguese (pt)

Inventor

Ahmad Y Sheikh

Original Assignee

Pharmacia Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-15

Filing date

2003-03-10

Publication date

2005-01-11

2003-03-10 Application filed by Pharmacia Corp filed Critical Pharmacia Corp

2005-01-11 Publication of BR0308472A publication Critical patent/BR0308472A/pt

Links

KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical group C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 title abstract 5
238000004519 manufacturing process Methods 0.000 title abstract 2
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 9
229960004596 cabergoline Drugs 0.000 abstract 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000012453 solvate Substances 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BR0308472-8A 2002-03-15 2003-03-10 Processo para preparar a forma i cristalina de cabergolina BR0308472A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US36456702P	2002-03-15	2002-03-15
US41025302P	2002-09-12	2002-09-12
PCT/US2003/007138 WO2003078392A2 (en)	2002-03-15	2003-03-10	Process for preparing crystalline form i of cabergoline

Publications (1)

Publication Number	Publication Date
BR0308472A true BR0308472A (pt)	2005-01-11

Family

ID=28045415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR0308472-8A BR0308472A (pt)	2002-03-15	2003-03-10	Processo para preparar a forma i cristalina de cabergolina

Country Status (14)

Country	Link
EP (1)	EP1507777A4 (sr)
JP (1)	JP2005520831A (sr)
KR (1)	KR100605794B1 (sr)
CN (1)	CN1642953A (sr)
AU (1)	AU2003224665A1 (sr)
BR (1)	BR0308472A (sr)
CA (1)	CA2478149A1 (sr)
IL (1)	IL163779A0 (sr)
MX (1)	MXPA04008935A (sr)
PL (1)	PL372371A1 (sr)
RS (1)	RS77704A (sr)
RU (1)	RU2277536C2 (sr)
TW (1)	TW200306312A (sr)
WO (1)	WO2003078392A2 (sr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL155545A (en)	2003-04-21	2009-12-24	Finetech Pharmaceutical Ltd	Solvate form of cabergoline
AU2004238833A1 (en) *	2003-05-08	2004-11-25	Ivax Pharmaceuticals S.R.O.	Polymorphs of cabergoline
GB0409785D0 (en) *	2004-04-30	2004-06-09	Resolution Chemicals Ltd	Preparation of cabergoline
US7339060B2 (en)	2005-03-23	2008-03-04	Resolution Chemicals, Ltd.	Preparation of cabergoline
GB0505965D0 (en)	2005-03-23	2005-04-27	Resolution Chemicals Ltd	Preparation of cabergoline
GB0515430D0 (en) *	2005-07-27	2005-08-31	Resolution Chemicals Ltd	Preparation of cabergoline
EP1953157A1 (en) *	2007-01-31	2008-08-06	LEK Pharmaceuticals D.D.	New crystal form of cabergoline

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4526892A (en) *	1981-03-03	1985-07-02	Farmitalia Carlo Erba, S.P.A.	Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas
GB0007308D0 (en) *	2000-03-24	2000-05-17	Pharmacia & Upjohn Spa	Process for preparing crystalline form \| of cabergoline
RS81804A (sr) *	2002-03-15	2006-10-27	Pharmacia Corporation	Postupak za dobijanje kristalnog oblika kabergolina

2003
- 2003-03-10 PL PL03372371A patent/PL372371A1/xx not_active Application Discontinuation
- 2003-03-10 KR KR1020047014429A patent/KR100605794B1/ko not_active Expired - Fee Related
- 2003-03-10 IL IL16377903A patent/IL163779A0/xx unknown
- 2003-03-10 MX MXPA04008935A patent/MXPA04008935A/es not_active Application Discontinuation
- 2003-03-10 RS YU77704A patent/RS77704A/sr unknown
- 2003-03-10 CN CNA038061309A patent/CN1642953A/zh active Pending
- 2003-03-10 AU AU2003224665A patent/AU2003224665A1/en not_active Abandoned
- 2003-03-10 RU RU2004127582/04A patent/RU2277536C2/ru not_active IP Right Cessation
- 2003-03-10 CA CA002478149A patent/CA2478149A1/en not_active Abandoned
- 2003-03-10 JP JP2003576398A patent/JP2005520831A/ja active Pending
- 2003-03-10 WO PCT/US2003/007138 patent/WO2003078392A2/en not_active Ceased
- 2003-03-10 EP EP03721346A patent/EP1507777A4/en not_active Withdrawn
- 2003-03-10 BR BR0308472-8A patent/BR0308472A/pt not_active IP Right Cessation
- 2003-03-13 TW TW092105467A patent/TW200306312A/zh unknown

Also Published As

Publication number	Publication date
IL163779A0 (en)	2005-12-18
EP1507777A2 (en)	2005-02-23
KR100605794B1 (ko)	2006-08-01
WO2003078392A3 (en)	2003-12-11
EP1507777A4 (en)	2007-03-07
CN1642953A (zh)	2005-07-20
RU2277536C2 (ru)	2006-06-10
PL372371A1 (en)	2005-07-25
TW200306312A (en)	2003-11-16
AU2003224665A1 (en)	2003-09-29
KR20050002858A (ko)	2005-01-10
CA2478149A1 (en)	2003-09-25
WO2003078392A2 (en)	2003-09-25
RS77704A (sr)	2006-10-27
RU2004127582A (ru)	2006-01-27
MXPA04008935A (es)	2004-11-26
JP2005520831A (ja)	2005-07-14

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Legal Events

Date	Code	Title	Description
2010-04-27	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 5A, 6A E 7A ANUIDADE(S).
2011-05-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.