BR0308748A - Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida - Google Patents

Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida

Info

Publication number
BR0308748A
BR0308748A BR0308748-4A BR0308748A BR0308748A BR 0308748 A BR0308748 A BR 0308748A BR 0308748 A BR0308748 A BR 0308748A BR 0308748 A BR0308748 A BR 0308748A
Authority
BR
Brazil
Prior art keywords
thiazolidine carboxamide
prostaglandin
preparing
thiazolidine
receptor modulators
Prior art date
Application number
BR0308748-4A
Other languages
English (en)
Inventor
Patrick Page
Catherine Jorand-Lebrun
Anna Quattropani
Vincent Pomel
Matthias Schwarz
Russell J Thomas
Estelle Hamelin
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BR0308748A publication Critical patent/BR0308748A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"DERIVADOS DE TIAZOLIDINA CARBOXAMIDA COMO MODULADORES DO RECEPTOR F DE PROSTAGLANDINA E MéTODO DE PREPARAçãO DE UM DERIVADO DE TIAZOLIDINA CARBOXAMIDA". A presente invenção está relacionada a derivados de tiazolidina carboxamida de fórmula (II) para o tratamento e/ou profilaxia de parto prematuro, nascimento prematuro, dismenorréia e para interromper o trabalho de parto antes de cesariana. G é selecionado do grupo consistindo de aril alquila C~ 1~-C~ 6~, heteroaril alquila C~ 1~-C~ 5~, cicloalquil alquila C~ 1~ C~ 6~, heteroaril alquila C~ 1~-C~ 6~, arila, heteroarila, cicloalquila ou heterocicloalquila C~ 3~-C~ 8~, os referidos grupos cicloalquila ou arila ou heteroarila podem ser fundidos com grupos cicloalquila ou arila ou heteroarila. R^ 1^ é selecionado do grupo consistindo de arila, heteroarila, cicloalquila ou heterocicloalquila C~ 3~ - C~ 8~, os referidos grupos (hetero)cicloalquila ou arila ou heteroarila podem ser fundidos com grupos (hetero)cicloalquila ou arila ou heteroarila. R^ 2^ é selecionado do grupo consistindo de H, carboxi, acila, alcoxicarbonila, aminocarbonila, carboxi alquila C~ 1~-C~ 5~, acil alquila C~ 1~-C~ 5~, alcoxicarbonil alquila C~ 1~-C~ 5~, aminocarbonil alquila C~ 1~-C~ 5~, aciloxi alquila C~ 1~C~ 5~, acilamino alquila C~ 1~- C~ 5~, ureído alquila C~ 1~-C~ 5~, amino alquila C~ 1~-C~ 5~, alcoxi alquila C~ 1~C~ 5~, sulfanil alquila C~ 1~-C~ 5~, sulfonil alquila C~ 1~-C~ 5~, sulfonil alquila C~ 1~-C~ 5~, sulfonilamino alquila C~ 1~-C~ 5~, sulfoniloxi alquila C~ 1~-C~ 5~, alquila C~ 1~-C~ 6~, alquenila C~ 2~-C~ 6~, alquinila C~ 2~-C~ 6~, arila, heteroarila, cicloalquila C~ 3~-C~ 8~, heterocicloalquila, aril alquila C~ 1~-C~ 6~, heteroaril alquila C~ 2~-C~ 6~, cicloalquila alquila C~ 1~-C~ 6~, heterocicloalquil alquila C~ 1~-C~ 6~, aril alquenila C~ 2~-C~ 6~, heteroaril alquenila C~ 2~-C~ 6~, aril alquinila C~ 2~-C~ 6~, ou heteroaril alquinila C~ 2~-C~ 6~.
BR0308748-4A 2002-03-28 2003-03-27 Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida BR0308748A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100314 2002-03-28
PCT/EP2003/050083 WO2003082278A1 (en) 2002-03-28 2003-03-27 Thiazolidine carboxamide derivatives as modulators of the prostaglandin f receptor

Publications (1)

Publication Number Publication Date
BR0308748A true BR0308748A (pt) 2005-01-11

Family

ID=28459561

Family Applications (1)

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BR0308748-4A BR0308748A (pt) 2002-03-28 2003-03-27 Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida

Country Status (21)

Country Link
US (2) US20050215605A1 (pt)
EP (1) EP1487442B1 (pt)
JP (1) JP4602672B2 (pt)
KR (1) KR20040095311A (pt)
CN (1) CN100484524C (pt)
AT (1) ATE489951T1 (pt)
AU (2) AU2003240757B2 (pt)
BR (1) BR0308748A (pt)
CA (1) CA2477265A1 (pt)
DE (1) DE60335175D1 (pt)
EA (1) EA007328B1 (pt)
ES (1) ES2360882T3 (pt)
HR (1) HRP20040759A2 (pt)
IL (1) IL164212A0 (pt)
MX (1) MXPA04009374A (pt)
NO (1) NO20044262L (pt)
PL (1) PL372919A1 (pt)
RS (1) RS81604A (pt)
UA (1) UA78021C2 (pt)
WO (1) WO2003082278A1 (pt)
ZA (1) ZA200406763B (pt)

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WO2018113785A1 (zh) * 2016-12-22 2018-06-28 广州华睿光电材料有限公司 含呋喃交联基团的聚合物及其应用
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US20240024294A1 (en) 2020-11-16 2024-01-25 Xoma (Us) Llc Compositions and methods for the treatment or prevention of preterm labor
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Also Published As

Publication number Publication date
US20080255094A1 (en) 2008-10-16
JP4602672B2 (ja) 2010-12-22
ATE489951T1 (de) 2010-12-15
EA200401270A1 (ru) 2005-02-24
US20050215605A1 (en) 2005-09-29
DE60335175D1 (de) 2011-01-13
NO20044262L (no) 2004-10-07
US8415480B2 (en) 2013-04-09
EP1487442B1 (en) 2010-12-01
PL372919A1 (en) 2005-08-08
EP1487442A1 (en) 2004-12-22
ES2360882T3 (es) 2011-06-10
AU2003240757A1 (en) 2003-10-13
RS81604A (sr) 2006-12-15
IL164212A0 (en) 2005-12-18
UA78021C2 (en) 2007-02-15
AU2003240757B2 (en) 2008-07-03
EA007328B1 (ru) 2006-08-25
US20090215749A9 (en) 2009-08-27
ZA200406763B (en) 2005-09-30
WO2003082278A1 (en) 2003-10-09
MXPA04009374A (es) 2005-01-25
CN1655780A (zh) 2005-08-17
CA2477265A1 (en) 2003-10-09
HK1075215A1 (zh) 2005-12-09
KR20040095311A (ko) 2004-11-12
CN100484524C (zh) 2009-05-06
HRP20040759A2 (en) 2004-12-31
JP2005531524A (ja) 2005-10-20
AU2008207407A1 (en) 2008-09-11

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