BR0308748A - Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida - Google Patents

Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida

Info

Publication number
BR0308748A
BR0308748A BR0308748-4A BR0308748A BR0308748A BR 0308748 A BR0308748 A BR 0308748A BR 0308748 A BR0308748 A BR 0308748A BR 0308748 A BR0308748 A BR 0308748A
Authority
BR
Brazil
Prior art keywords
thiazolidine carboxamide
prostaglandin
preparing
thiazolidine
receptor modulators
Prior art date
Application number
BR0308748-4A
Other languages
English (en)
Inventor
Patrick Page
Catherine Jorand-Lebrun
Anna Quattropani
Vincent Pomel
Matthias Schwarz
Russell J Thomas
Estelle Hamelin
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BR0308748A publication Critical patent/BR0308748A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"DERIVADOS DE TIAZOLIDINA CARBOXAMIDA COMO MODULADORES DO RECEPTOR F DE PROSTAGLANDINA E MéTODO DE PREPARAçãO DE UM DERIVADO DE TIAZOLIDINA CARBOXAMIDA". A presente invenção está relacionada a derivados de tiazolidina carboxamida de fórmula (II) para o tratamento e/ou profilaxia de parto prematuro, nascimento prematuro, dismenorréia e para interromper o trabalho de parto antes de cesariana. G é selecionado do grupo consistindo de aril alquila C~ 1~-C~ 6~, heteroaril alquila C~ 1~-C~ 5~, cicloalquil alquila C~ 1~ C~ 6~, heteroaril alquila C~ 1~-C~ 6~, arila, heteroarila, cicloalquila ou heterocicloalquila C~ 3~-C~ 8~, os referidos grupos cicloalquila ou arila ou heteroarila podem ser fundidos com grupos cicloalquila ou arila ou heteroarila. R^ 1^ é selecionado do grupo consistindo de arila, heteroarila, cicloalquila ou heterocicloalquila C~ 3~ - C~ 8~, os referidos grupos (hetero)cicloalquila ou arila ou heteroarila podem ser fundidos com grupos (hetero)cicloalquila ou arila ou heteroarila. R^ 2^ é selecionado do grupo consistindo de H, carboxi, acila, alcoxicarbonila, aminocarbonila, carboxi alquila C~ 1~-C~ 5~, acil alquila C~ 1~-C~ 5~, alcoxicarbonil alquila C~ 1~-C~ 5~, aminocarbonil alquila C~ 1~-C~ 5~, aciloxi alquila C~ 1~C~ 5~, acilamino alquila C~ 1~- C~ 5~, ureído alquila C~ 1~-C~ 5~, amino alquila C~ 1~-C~ 5~, alcoxi alquila C~ 1~C~ 5~, sulfanil alquila C~ 1~-C~ 5~, sulfonil alquila C~ 1~-C~ 5~, sulfonil alquila C~ 1~-C~ 5~, sulfonilamino alquila C~ 1~-C~ 5~, sulfoniloxi alquila C~ 1~-C~ 5~, alquila C~ 1~-C~ 6~, alquenila C~ 2~-C~ 6~, alquinila C~ 2~-C~ 6~, arila, heteroarila, cicloalquila C~ 3~-C~ 8~, heterocicloalquila, aril alquila C~ 1~-C~ 6~, heteroaril alquila C~ 2~-C~ 6~, cicloalquila alquila C~ 1~-C~ 6~, heterocicloalquil alquila C~ 1~-C~ 6~, aril alquenila C~ 2~-C~ 6~, heteroaril alquenila C~ 2~-C~ 6~, aril alquinila C~ 2~-C~ 6~, ou heteroaril alquinila C~ 2~-C~ 6~.
BR0308748-4A 2002-03-28 2003-03-27 Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida BR0308748A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100314 2002-03-28
PCT/EP2003/050083 WO2003082278A1 (en) 2002-03-28 2003-03-27 Thiazolidine carboxamide derivatives as modulators of the prostaglandin f receptor

Publications (1)

Publication Number Publication Date
BR0308748A true BR0308748A (pt) 2005-01-11

Family

ID=28459561

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308748-4A BR0308748A (pt) 2002-03-28 2003-03-27 Derivados de tiazolidina carboxamida como moduladores do receptor f de prostaglandina e método de preparação de um derivado de tiazolidina carboxamida

Country Status (21)

Country Link
US (2) US20050215605A1 (pt)
EP (1) EP1487442B1 (pt)
JP (1) JP4602672B2 (pt)
KR (1) KR20040095311A (pt)
CN (1) CN100484524C (pt)
AT (1) ATE489951T1 (pt)
AU (2) AU2003240757B2 (pt)
BR (1) BR0308748A (pt)
CA (1) CA2477265A1 (pt)
DE (1) DE60335175D1 (pt)
EA (1) EA007328B1 (pt)
ES (1) ES2360882T3 (pt)
HR (1) HRP20040759A2 (pt)
IL (1) IL164212A0 (pt)
MX (1) MXPA04009374A (pt)
NO (1) NO20044262L (pt)
PL (1) PL372919A1 (pt)
RS (1) RS81604A (pt)
UA (1) UA78021C2 (pt)
WO (1) WO2003082278A1 (pt)
ZA (1) ZA200406763B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2360882T3 (es) * 2002-03-28 2011-06-10 Merck Serono Sa Derivados de tiazolidina carboxamida como moduladores del receptor de prostaglandina f.
CA2511970C (en) 2003-01-14 2012-06-26 Cytokinetics, Inc. Urea derivatives useful in the treatment of heart failure
MY150129A (en) 2004-04-09 2013-11-29 Archer Daniels Midland Co Method of preparing fatty acid alkyl esters from waste or recycled fatty acid stock
BRPI0512193B8 (pt) 2004-06-17 2021-05-25 Cytokinetics Inc composto ou sal farmaceuticamente aceitável, composição farmacêutica, e, uso do composto ou sal
US7176222B2 (en) 2004-07-27 2007-02-13 Cytokinetics, Inc. Syntheses of ureas
ES2419007T3 (es) 2005-12-15 2013-08-19 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y procedimientos
US7825120B2 (en) 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
US7718657B2 (en) 2005-12-16 2010-05-18 Cytokinetics, Inc. Certain indanyl urea modulators of the cardiac sarcomere
EP1962852B1 (en) 2005-12-19 2017-01-25 Cytokinetics, Inc. Compounds, compositions and methods
CN103804338A (zh) * 2006-02-07 2014-05-21 株式会社·R-技术上野 用于制备前列腺素衍生物的方法
US20090163586A1 (en) 2007-12-20 2009-06-25 Astrazeneca Ab Bis-(Sulfonylamino) Derivatives in Therapy 205
WO2011014649A1 (en) * 2009-07-29 2011-02-03 Duke University Compositions and methods for inhibiting hair growth
MY157429A (en) 2011-06-24 2016-06-15 Amgen Inc Trpm8 antagonists and their use in treatments
JP2014517074A (ja) 2011-06-24 2014-07-17 アムジエン・インコーポレーテツド Ｔｒｐｍ８アンタゴニストおよび治療におけるそれらの使用
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
US20160264536A1 (en) 2013-10-23 2016-09-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
ES2915948T3 (es) * 2016-01-04 2022-06-27 ObsEva SA Administración conjunta de alfa-aminoéster de derivado de hidroxipropiltiazolidin-carboxamida y un agente tocolítico
US9447055B1 (en) 2016-01-04 2016-09-20 Merck Serono S.A. α-amino esters of hydroxypropylthiazolidine carboxamide derivative and salt form, crystal polymorph thereof
BR112018013597A2 (pt) * 2016-01-04 2019-01-08 ObsEva S.A. composição farmacêutica, método para tratar ou impedir o trabalho de parto prematuro, método para impedir o trabalho de parto antes do parto cesariana, método para tratar ou impedir a dismenorreia e kit
EA202092538A1 (ru) * 2016-10-13 2021-05-31 Мерк Сероно С.А. Альфа-сложные аминоэфиры производного гидроксипропилтиазолидин карбоксамида и его солевая форма, кристаллический полиморф
CN109790136B (zh) * 2016-12-22 2024-01-12 广州华睿光电材料有限公司 含呋喃交联基团的聚合物及其应用
US11534428B1 (en) 2018-05-16 2022-12-27 Xoma (Us) Llc Compositions and methods for delaying the incidence of labor
CA3198802A1 (en) 2020-11-16 2022-05-19 Jean-Pierre Gotteland Compositions and methods for the treatment or prevention of preterm labor
US20240024295A1 (en) * 2020-12-11 2024-01-25 Elise A. Olsen Compositions and methods for inhibiting hair growth
WO2025124698A1 (en) 2023-12-12 2025-06-19 Idorsia Pharmaceuticals Ltd Aryl sulfone and sulfanone derivatives as orexin receptor modulators
WO2025132542A1 (en) 2023-12-19 2025-06-26 Idorsia Pharmaceuticals Ltd Macrocyclic orexin agonists

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016270A (en) * 1975-10-31 1977-04-05 Alza Corporation Method for treating dysmenorrhea with a uterine therapeutic system
JPH0662529B2 (ja) * 1984-07-13 1994-08-17 三共株式会社 アミノ酸誘導体
JPS6450818A (en) * 1987-08-20 1989-02-27 Tsumura & Co Prostaglandin f2alpha-inhibitor
US5338755A (en) * 1990-07-31 1994-08-16 Elf Sanofi N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present
US6271201B1 (en) 1993-07-15 2001-08-07 Board Of Regents, The University Of Texas System Methods for the selective regulation of placental prostanoids and inhibition of labor using IGF-I
IL128661A (en) * 1996-08-28 2001-10-31 Procter & Gamble Teleprotease inhibitors 1, 3 - diethocycles and pharmaceutical preparations containing them
HUP0002680A3 (en) * 1997-07-31 2001-12-28 American Home Prod Benzyl compounds which inhibit leukocyte adhesion mediated by vla-4
AR016133A1 (es) * 1997-07-31 2001-06-20 Wyeth Corp Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria
US6645939B1 (en) * 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
ES2360882T3 (es) * 2002-03-28 2011-06-10 Merck Serono Sa Derivados de tiazolidina carboxamida como moduladores del receptor de prostaglandina f.

Also Published As

Publication number Publication date
DE60335175D1 (de) 2011-01-13
JP2005531524A (ja) 2005-10-20
EP1487442A1 (en) 2004-12-22
US8415480B2 (en) 2013-04-09
US20050215605A1 (en) 2005-09-29
US20080255094A1 (en) 2008-10-16
HK1075215A1 (zh) 2005-12-09
JP4602672B2 (ja) 2010-12-22
WO2003082278A1 (en) 2003-10-09
EA200401270A1 (ru) 2005-02-24
AU2008207407A1 (en) 2008-09-11
PL372919A1 (en) 2005-08-08
CN1655780A (zh) 2005-08-17
KR20040095311A (ko) 2004-11-12
EP1487442B1 (en) 2010-12-01
EA007328B1 (ru) 2006-08-25
US20090215749A9 (en) 2009-08-27
HRP20040759A2 (en) 2004-12-31
UA78021C2 (en) 2007-02-15
ES2360882T3 (es) 2011-06-10
CA2477265A1 (en) 2003-10-09
ATE489951T1 (de) 2010-12-15
MXPA04009374A (es) 2005-01-25
IL164212A0 (en) 2005-12-18
NO20044262L (no) 2004-10-07
ZA200406763B (en) 2005-09-30
RS81604A (sr) 2006-12-15
AU2003240757B2 (en) 2008-07-03
AU2003240757A1 (en) 2003-10-13
CN100484524C (zh) 2009-05-06

Similar Documents

Publication Publication Date Title
EA200401270A1 (ru) Тиазолидинкарбоксамидные производные как модуляторы рецептора простагландина f
NO20073465L (no) Benzotiazol-derivater
EA200900779A1 (ru) Производные дигидропиридина, полезные как ингибиторы протеинкиназы
NO20072747L (no) Fremgangsmate for fremstilling av indazolforbindelser
NO20083214L (no) Pyrimidinylarylurea-derivater som omdannes til FGF-inhibitorer
NO20053748L (no) Pyrrolopyridazinderivater.
NO20082136L (no) 1,5-substituerte indol-2-yl-amidderivater
DE602004015810D1 (de) Substituierte isochinolinderivate und anwendungsverfahren
DE602006017694D1 (de) C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden
NO20050014L (no) 1-Heterosyklylalkyl-3-sulfonylindol eller -indazolderivater som 5-hydroksytryptamin-6 ligander
PA8523001A1 (es) Derivados de la 3-indolil-4-fenil-1h-pirrol-2,5-diona como inhibidores de glicogeno sintasa quinasa-3b
NO20082939L (no) Sykloheksyl piperasinyl metanon derivater og anvendelse av disse som histamin H3 reseptor modulatorer
AU2004212335A8 (en) Piperazine-2-carboxamide derivatives
CY1107747T1 (el) Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
TW200637827A (en) Processes for preparing substituted phenylpyrazole ureas
NO20063132L (no) Naftyridinderivater og deres anvendelse som modulatorer av muskarinreceptorer
NO20082214L (no) 1,1-Diokso-tiomorfolinyl-indolyl-metanonderivater for anvendelse som H3-modulatorer
NO20065678L (no) 3-(4-heteroarylcykloheksylamino) cyklopentankarboksamider som modulatorer for kjemokinreseptorer.
CY1109076T1 (el) Παραγωγα της 4- phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline ως φαρμακα για θεραπεια της στειροτητας
DK1926729T3 (da) Benzothiazolcyclobutylaminderivater og deres anvendelse som histamin-3-receptorligander
ATE372114T1 (de) Verfahren zur erhöhung des testosteronspiegels
NO20072060L (no) 2-acylaminotiazolderivater
ATE483679T1 (de) Substituierte cyclohexylessigsäure-derivate
MX2024002173A (es) Compuestos de arilsulfonilo como inhibidores de ccr6.
ATE438617T1 (de) Substituierte cyclohexyl-1,4-diamin-derivate

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: LABORATOIRES SERONO S.A. (CH)

Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012.