BR0312092A - Uso de derivados de tio-oxindol no tratamento de distúrbios da pele - Google Patents
Uso de derivados de tio-oxindol no tratamento de distúrbios da peleInfo
- Publication number
- BR0312092A BR0312092A BR0312092-9A BR0312092A BR0312092A BR 0312092 A BR0312092 A BR 0312092A BR 0312092 A BR0312092 A BR 0312092A BR 0312092 A BR0312092 A BR 0312092A
- Authority
- BR
- Brazil
- Prior art keywords
- skin disorders
- derivatives
- treatment
- thiooxyindole
- formula
- Prior art date
Links
- 208000017520 skin disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000002874 Acne Vulgaris Diseases 0.000 abstract 1
- 206010020112 Hirsutism Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010000496 acne Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003750 conditioning effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"USO DE DERIVADOS DE TIO-OXINDOL NO TRATAMENTO DE DISTúRBIOS DA PELE". A presente invenção refere-se a métodos de tratamento de distúrbios da pele inclui a aplicação a um mamífero de uma composição que contém um composto de fórmula I ou tautómeros do mesmo, em um regime, em que a fórmula é apresentada e em que R^ 1^-R^ 5^ e Q^ 1^ são definidos como descrito neste caso. Especificamente, são descritos processos para o tratamento de acne, hirsutismo e uma composição para o condicionamento da pele.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39191302P | 2002-06-25 | 2002-06-25 | |
| PCT/US2003/019791 WO2004000227A2 (en) | 2002-06-25 | 2003-06-23 | Use of thio-oxindole derivatives in treatment of skin disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0312092A true BR0312092A (pt) | 2005-03-22 |
Family
ID=30000776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0312092-9A BR0312092A (pt) | 2002-06-25 | 2003-06-23 | Uso de derivados de tio-oxindol no tratamento de distúrbios da pele |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7115649B2 (pt) |
| EP (1) | EP1515680A4 (pt) |
| JP (1) | JP2005535625A (pt) |
| KR (1) | KR20050012831A (pt) |
| CN (1) | CN1662206A (pt) |
| AR (1) | AR040338A1 (pt) |
| AU (1) | AU2003258952A1 (pt) |
| BR (1) | BR0312092A (pt) |
| CA (1) | CA2489810A1 (pt) |
| EC (1) | ECSP055575A (pt) |
| IL (1) | IL165394A0 (pt) |
| MX (1) | MXPA04012418A (pt) |
| NO (1) | NO20045215L (pt) |
| RU (1) | RU2005101624A (pt) |
| TW (1) | TW200401637A (pt) |
| WO (1) | WO2004000227A2 (pt) |
| ZA (1) | ZA200410401B (pt) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| JP2005535623A (ja) * | 2002-06-25 | 2005-11-24 | ワイス | ホルモン関連症状の治療における、チオ−オキシインドール誘導体の使用 |
| EP1732921B1 (en) * | 2004-04-08 | 2008-11-05 | Wyeth | Thioamide derivatives as progesterone receptor modulators |
| JP4950027B2 (ja) * | 2004-04-08 | 2012-06-13 | ワイス・エルエルシー | チオアミド不純物を最小限に抑えるための方法 |
| BRPI0510260A (pt) * | 2004-04-27 | 2007-10-23 | Wyeth Corp | método para purificar um composto, e, kit farmacêutico |
| GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| MY144968A (en) | 2005-04-11 | 2011-11-30 | Xenon Pharmaceuticals Inc | Spiro-oxindole compounds and their uses as therapeutic agents |
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| EP2073806B1 (en) | 2006-10-12 | 2012-02-15 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| CN101636157A (zh) * | 2007-01-12 | 2010-01-27 | 康乃尔研究基金会有限公司 | 作为抗菌干预的新型靶的腺苷酰环化酶 |
| US9095578B2 (en) * | 2007-01-12 | 2015-08-04 | Cornell Research Foundation, Inc. | Adenylyl cyclases as novel targets for the treatment of infection by eukaryotic pathogens |
| HRP20150882T1 (hr) | 2008-10-17 | 2015-09-25 | Xenon Pharmaceuticals Inc. | Spirooksindolski spojevi i njihova upotreba kao terapijska sredstva |
| WO2010045197A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals, Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| PE20170202A1 (es) | 2009-10-14 | 2017-03-24 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol |
| RU2596488C2 (ru) | 2010-02-26 | 2016-09-10 | Ксенон Фармасьютикалз Инк. | Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов |
| KR101278271B1 (ko) * | 2011-08-02 | 2013-06-25 | 충남대학교산학협력단 | 인돌린-2-티온 유사체를 함유한 미백용 조성물 |
| US9737522B2 (en) | 2012-08-09 | 2017-08-22 | Emory University | NMDA receptor modulators and uses related thereto |
| AR103636A1 (es) | 2015-02-05 | 2017-05-24 | Teva Pharmaceuticals Int Gmbh | Métodos de tratamiento de neuralgia postherpética con una formulación tópica de un compuesto de espiro-oxindol |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US169198A (en) * | 1875-10-26 | Improvement in treating quicksilver-ore | ||
| US92711A (en) * | 1869-07-20 | e d w a r d s | ||
| EP0155934B1 (en) | 1983-07-29 | 1989-12-06 | Duke University | Pharmaceutical compositions for treating androgen-related disorders in humans |
| DE4335876A1 (de) | 1993-10-17 | 1995-04-20 | Schering Ag | Kombination von Progesteronantagonisten und Antiöstrogenen mit partialer agonistischer Wirkung für die Hormonsubstitutions-Therapie für peri- und postmenopausale Frauen |
| ES2258342T3 (es) | 1998-10-23 | 2006-08-16 | Aventis Pharma S.A. | Preparaciones para aplicacion topica de sustancias que tienen efecto antiandrogenico. |
| IL143920A0 (en) | 1998-12-31 | 2002-04-21 | Sugen Inc | 3-heteroarylidenyl-2-indolinone derivatives and pharmaceutical compositions containing the same |
| US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| EP1206761B1 (en) | 1999-08-26 | 2007-10-03 | Automotive Systems Laboratory Inc. | Magnetic sensor |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US7119207B2 (en) | 2000-04-10 | 2006-10-10 | Pfizer Inc | Benzoamide piperidine containing compounds and related compounds |
| HUP0300413A2 (hu) | 2000-04-10 | 2003-06-28 | Pfizer Products Inc. | Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| WO2006006555A1 (ja) * | 2004-07-12 | 2006-01-19 | Rohm Co., Ltd. | 半導体発光素子 |
-
2003
- 2003-06-23 MX MXPA04012418A patent/MXPA04012418A/es unknown
- 2003-06-23 RU RU2005101624/04A patent/RU2005101624A/ru not_active Application Discontinuation
- 2003-06-23 US US10/601,442 patent/US7115649B2/en not_active Expired - Fee Related
- 2003-06-23 AU AU2003258952A patent/AU2003258952A1/en not_active Abandoned
- 2003-06-23 CN CN038147823A patent/CN1662206A/zh active Pending
- 2003-06-23 KR KR10-2004-7021067A patent/KR20050012831A/ko not_active Withdrawn
- 2003-06-23 WO PCT/US2003/019791 patent/WO2004000227A2/en not_active Ceased
- 2003-06-23 EP EP03761271A patent/EP1515680A4/en not_active Withdrawn
- 2003-06-23 CA CA002489810A patent/CA2489810A1/en not_active Abandoned
- 2003-06-23 BR BR0312092-9A patent/BR0312092A/pt not_active IP Right Cessation
- 2003-06-23 JP JP2004516162A patent/JP2005535625A/ja active Pending
- 2003-06-23 TW TW092116985A patent/TW200401637A/zh unknown
- 2003-06-24 AR ARP030102254A patent/AR040338A1/es unknown
-
2004
- 2004-11-25 IL IL16539404A patent/IL165394A0/xx unknown
- 2004-11-29 NO NO20045215A patent/NO20045215L/no not_active Application Discontinuation
- 2004-12-23 ZA ZA200410401A patent/ZA200410401B/xx unknown
-
2005
- 2005-01-25 EC EC2005005575A patent/ECSP055575A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200410401B (en) | 2006-05-31 |
| WO2004000227A2 (en) | 2003-12-31 |
| JP2005535625A (ja) | 2005-11-24 |
| CN1662206A (zh) | 2005-08-31 |
| ECSP055575A (es) | 2005-04-18 |
| RU2005101624A (ru) | 2005-06-27 |
| EP1515680A2 (en) | 2005-03-23 |
| US20040006122A1 (en) | 2004-01-08 |
| AU2003258952A1 (en) | 2004-01-06 |
| WO2004000227A3 (en) | 2004-04-08 |
| IL165394A0 (en) | 2006-01-15 |
| EP1515680A4 (en) | 2005-09-21 |
| TW200401637A (en) | 2004-02-01 |
| AR040338A1 (es) | 2005-03-30 |
| US7115649B2 (en) | 2006-10-03 |
| NO20045215L (no) | 2005-03-17 |
| KR20050012831A (ko) | 2005-02-02 |
| MXPA04012418A (es) | 2005-04-19 |
| CA2489810A1 (en) | 2003-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A,6A E 7A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2064 DE 27/07/2010. |
|
| B15K | Others concerning applications: alteration of classification |
Free format text: PROCEDIMENTO AUTOMATICO DE RECLASSIFICACAO. AS CLASSIFICACOES IPC ANTERIORES ERAM: A61K 6/00; A61K 7/00. Ipc: A61K 31/404 (2006.01), A61K 8/49 (2006.01), A61K 3 Ipc: A61K 31/404 (2006.01), A61K 8/49 (2006.01), A61K 3 |