BR0312256A - Composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, e, método de tratamento de um indivìduo sofrendo de um distúrbio mediado pelo receptor de mch1 e de tratamento de um indivìduo sofrendo de depressão, ansiedade, incontinência de urgência ou obesidade - Google Patents

Composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, e, método de tratamento de um indivìduo sofrendo de um distúrbio mediado pelo receptor de mch1 e de tratamento de um indivìduo sofrendo de depressão, ansiedade, incontinência de urgência ou obesidade

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Publication number
BR0312256A
BR0312256A BR0312256-5A BR0312256A BR0312256A BR 0312256 A BR0312256 A BR 0312256A BR 0312256 A BR0312256 A BR 0312256A BR 0312256 A BR0312256 A BR 0312256A
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Brazil
Prior art keywords
pharmaceutical composition
treating
compound
individual suffering
subject
Prior art date
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BR0312256-5A
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English (en)
Inventor
Mohammad Marzabadi
Yu Jiang
Kai Lu
Chien-An Chen
John Deleon
John Wetzel
Kim Andersen
Original Assignee
Lundbeck & Co As H
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Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0312256A publication Critical patent/BR0312256A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, PROCESSO PARA A PREPARAçãO DE UMA COMPOSIçãO FARMACêUTICA, E, MéTODOS DE TRATAMENTO DE UM INDIVìDUO SOFRENDO DE UM DISTúRBIO MEDIADO PELO RECEPTOR DE MCH1 E DE TRATAMENTO DE UM INDIVìDUO SOFRENDO DE DEPRESSãO, ANSIEDADE, INCONTINêNCIA DE URGêNCIA OU OBESIDADE". Esta invenção refere-se aos compostos que são antagonistas seletivos para receptores de hormónio-1 concentrador de melanina (MCH1). A invenção proporciona uma composição farmacêutica compreendendo uma quantidade terapeuticamente efetiva do composto da invenção e um veículo farmaceuticamente aceitável. Esta invenção proporciona uma composição farmacêutica preparada pela combinação de uma quantidade terapeuticamente efetiva de composto desta invenção e um veículo farmaceuticamente aceitável. Esta invenção proporciona adicionalmente um processo para a preparação de uma composição farmacêutica compreendendo a combinação de uma quantidade terapeuticamente efetiva de composto da invenção e um veículo farmaceuticamente aceitável. Esta invenção também proporciona um método de redução da massa corporal de um indivíduo que compreende a administração ao indivíduo de uma quantidade de um composto da invenção efetiva para reduzir a massa corporal do individuo. Esta invenção proporciona adicionalmente um método de tratamento de um indivíduo sofrendo de depressão e/ou de ansiedade que compreende a administração ao indivíduo de uma quantidade de um composto da invenção efetiva para tratar a depressão e/ou a ansiedade do indivíduo. Esta invenção proporciona adicionalmente um método de tratamento de um indivíduo sofrendo de distúrbio urinário.
BR0312256-5A 2002-07-03 2003-07-03 Composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, e, método de tratamento de um indivìduo sofrendo de um distúrbio mediado pelo receptor de mch1 e de tratamento de um indivìduo sofrendo de depressão, ansiedade, incontinência de urgência ou obesidade BR0312256A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18914602A 2002-07-03 2002-07-03
PCT/US2003/021348 WO2004004714A1 (en) 2002-07-03 2003-07-03 Spirocyclic piperidines as mch1 antagonists and uses thereof

Publications (1)

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BR0312256A true BR0312256A (pt) 2005-04-26

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BR0312256-5A BR0312256A (pt) 2002-07-03 2003-07-03 Composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, e, método de tratamento de um indivìduo sofrendo de um distúrbio mediado pelo receptor de mch1 e de tratamento de um indivìduo sofrendo de depressão, ansiedade, incontinência de urgência ou obesidade

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US (1) US7335665B2 (pt)
EP (1) EP1531816B1 (pt)
JP (1) JP2006501188A (pt)
KR (1) KR20050047075A (pt)
CN (1) CN1668300A (pt)
AT (1) ATE421504T1 (pt)
AU (1) AU2003261133A1 (pt)
BR (1) BR0312256A (pt)
CA (1) CA2485375A1 (pt)
DE (1) DE60325973D1 (pt)
EA (1) EA007387B1 (pt)
ES (1) ES2318165T3 (pt)
IL (1) IL165906A0 (pt)
IS (1) IS7559A (pt)
MX (1) MXPA04012171A (pt)
NO (1) NO20050145L (pt)
NZ (1) NZ536844A (pt)
PL (1) PL373622A1 (pt)
UA (1) UA77814C2 (pt)
WO (1) WO2004004714A1 (pt)
ZA (1) ZA200409426B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
US7105544B2 (en) 2001-07-05 2006-09-12 Synaptic Pharmaceutical Corporation Substituted alkyl amido piperidines
US7199135B2 (en) 2001-07-05 2007-04-03 H. Lundbeck A/S Substituted alkyl amido piperidines
AU2003284984B2 (en) * 2002-10-30 2008-10-23 Merck Sharp & Dohme Corp. Gamma-aminoamide modulators of chemokine receptor activity
CA2515717A1 (en) * 2003-02-10 2004-08-19 Banyu Pharmaceutical Co., Ltd. Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient
KR20070046929A (ko) 2004-08-19 2007-05-03 버텍스 파마슈티칼스 인코포레이티드 무스카린 수용체 조절제
US7786141B2 (en) 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
RU2007124373A (ru) 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
US8193208B2 (en) 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
JP2009521483A (ja) * 2005-12-22 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
AU2007219509A1 (en) * 2006-01-18 2007-09-07 Siena Biotech S.P.A Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
AU2007221214A1 (en) * 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP1987034B1 (en) * 2006-02-22 2011-07-20 Vertex Pharmceuticals Incorporated Spiro condensed piperidines as modulators of muscarinic receptors
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
AU2007284548A1 (en) * 2006-08-15 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP2051715A2 (en) 2006-08-18 2009-04-29 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
WO2008047544A1 (en) * 2006-09-28 2008-04-24 Banyu Pharmaceutical Co., Ltd. Diaryl ketimine derivative
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
KR100816267B1 (ko) * 2007-07-18 2008-03-25 주식회사 코리아나화장품 천상초 추출물을 유효성분으로 함유하는 화장료 조성물
US7973162B2 (en) * 2007-10-03 2011-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US20210130285A1 (en) 2008-03-19 2021-05-06 Aurimmed Pharma, Inc. Novel compounds advantageous in the treatment of central nervous system diseases and disorders
US10793515B2 (en) 2008-03-19 2020-10-06 Aurimmed Pharma, Inc. Compounds advantageous in the treatment of central nervous system diseases and disorders
JP5746612B2 (ja) * 2008-03-19 2015-07-08 オーリムメッド・ファルマ・インコーポレーテッド 中枢神経系疾患および障害の治療に有効な新規化合物
US8785634B2 (en) * 2010-04-26 2014-07-22 Merck Sharp & Dohme Corp Spiropiperidine prolylcarboxypeptidase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2006A (en) * 1841-03-16 Clamp for crimping leather
US5382583A (en) * 1989-04-22 1995-01-17 John Wyeth & Brother, Limited Piperazine derivatives
WO1997045415A1 (en) * 1996-05-28 1997-12-04 Rotta Research Laboratorium S.P.A. Polyamide derivatives or ornithine, lysine and analogous substances with cck-b and gastrin-antagonistic activity
AU5604998A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
WO2002002744A2 (en) 2000-07-05 2002-01-10 Synaptic Pharmaceutical Corporation Dna encoding a human melanin concentrating hormone receptor (mch1) and uses thereof
CA2384041A1 (en) 2000-07-05 2002-01-24 Synaptic Pharmaceuticals Corporation Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof
WO2002088089A1 (en) * 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Spiropiperidine derivatives, nociceptin receptor antagonists containing the same as the active ingredient and medicinal compositions
IL159697A0 (en) 2001-07-05 2004-06-20 Synaptic Pharma Corp Substituted anilinic piperidines as mch selective antagonists
CA2515717A1 (en) 2003-02-10 2004-08-19 Banyu Pharmaceutical Co., Ltd. Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient

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