IS7559A - Spírósýklísk piperidín sem MCH1 mótlyf og notkun á þeim - Google Patents

Spírósýklísk piperidín sem MCH1 mótlyf og notkun á þeim

Info

Publication number: IS7559A
Authority: IS; Iceland
Prior art keywords: subject; compound; provides; pharmaceutically acceptable; pharmaceutical composition
Prior art date: 2002-07-03

Application number

IS7559A

Other languages

English (en)

Inventor

Marzabadi Mohammad

Jiang Yu

Lu Kai

Chen Chien-An

Deleon John

Wetzel John

Andersen Kim

Original Assignee

H. Lundbeck A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-03

Filing date

2004-11-26

Publication date

2004-11-26

2004-11-26 Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S

2004-11-26 Publication of IS7559A publication Critical patent/IS7559A/is

Links

239000005557 antagonist Substances 0.000 title abstract 2
101150104680 MCH1 gene Proteins 0.000 title 1
101100382379 Rattus norvegicus Cap1 gene Proteins 0.000 title 1
150000003053 piperidines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
239000003937 drug carrier Substances 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 3
208000019901 Anxiety disease Diseases 0.000 abstract 2
XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract 2
230000036506 anxiety Effects 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002485 urinary effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
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- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Child & Adolescent Psychology (AREA)
Toxicology (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)

IS7559A 2002-07-03 2004-11-26 Spírósýklísk piperidín sem MCH1 mótlyf og notkun á þeim IS7559A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US18914602A	2002-07-03	2002-07-03
PCT/US2003/021348 WO2004004714A1 (en)	2002-07-03	2003-07-03	Spirocyclic piperidines as mch1 antagonists and uses thereof

Publications (1)

Publication Number	Publication Date
IS7559A true IS7559A (is)	2004-11-26

Family

ID=30114021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS7559A IS7559A (is)	2002-07-03	2004-11-26	Spírósýklísk piperidín sem MCH1 mótlyf og notkun á þeim

Country Status (21)

Country	Link
US (1)	US7335665B2 (is)
EP (1)	EP1531816B1 (is)
JP (1)	JP2006501188A (is)
KR (1)	KR20050047075A (is)
CN (1)	CN1668300A (is)
AT (1)	ATE421504T1 (is)
AU (1)	AU2003261133A1 (is)
BR (1)	BR0312256A (is)
CA (1)	CA2485375A1 (is)
DE (1)	DE60325973D1 (is)
EA (1)	EA007387B1 (is)
ES (1)	ES2318165T3 (is)
IL (1)	IL165906A0 (is)
IS (1)	IS7559A (is)
MX (1)	MXPA04012171A (is)
NO (1)	NO20050145L (is)
NZ (1)	NZ536844A (is)
PL (1)	PL373622A1 (is)
UA (1)	UA77814C2 (is)
WO (1)	WO2004004714A1 (is)
ZA (1)	ZA200409426B (is)

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AU2004209505B2 (en) *	2003-02-10	2009-07-23	Banyu Pharmaceutical Co., Ltd.	Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient
US7786141B2 (en)	2004-08-19	2010-08-31	Vertex Pharmaceuticals Incorporated	Dihydrospiroindene modulators of muscarinic receptors
US7879834B2 (en)	2004-08-19	2011-02-01	Vertex Pharmaceuticals Incorporated	Spiroindoline modulators of muscarinic receptors
JP2008521825A (ja) *	2004-11-29	2008-06-26	バーテックスファーマシューティカルズインコーポレイテッド	ムスカリン受容体のモジュレーター
WO2007028638A1 (en)	2005-09-09	2007-03-15	Euro-Celtique S.A.	Fused and spirocycle compounds and the use thereof
CA2634456A1 (en) *	2005-12-22	2007-07-05	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
EP1991528A2 (en) *	2006-01-18	2008-11-19	Siena Biotech S.p.A.	Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof
US8003660B2 (en)	2006-02-22	2011-08-23	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
RU2008137583A (ru) *	2006-02-22	2010-03-27	Вертекс Фармасьютикалз Инкорпорейшн (Us)	Спиропиперидины в качестве модуляторов мускариновых рецепторов
US7858790B2 (en) *	2006-06-29	2010-12-28	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
CN101553231A (zh) *	2006-08-15	2009-10-07	弗特克斯药品有限公司	毒蕈碱受体调节剂
US7786107B2 (en)	2006-08-18	2010-08-31	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
EP2072519A4 (en) *	2006-09-28	2009-10-21	Banyu Pharma Co Ltd	DIARYLKETIMINDERIVAT
TW200901974A (en)	2007-01-16	2009-01-16	Wyeth Corp	Compounds, compositions, and methods of making and using them
KR100816267B1 (ko) *	2007-07-18	2008-03-25	주식회사 코리아나화장품	천상초 추출물을 유효성분으로 함유하는 화장료 조성물
JP2010540640A (ja) *	2007-10-03	2010-12-24	バーテックスファーマシューティカルズインコーポレイテッド	ムスカリン作用性レセプターのモジュレーター
US20210130285A1 (en)	2008-03-19	2021-05-06	Aurimmed Pharma, Inc.	Novel compounds advantageous in the treatment of central nervous system diseases and disorders
JP5746612B2 (ja) *	2008-03-19	2015-07-08	オーリムメッド・ファルマ・インコーポレーテッド	中枢神経系疾患および障害の治療に有効な新規化合物
US10793515B2 (en)	2008-03-19	2020-10-06	Aurimmed Pharma, Inc.	Compounds advantageous in the treatment of central nervous system diseases and disorders
US8785634B2 (en) *	2010-04-26	2014-07-22	Merck Sharp & Dohme Corp	Spiropiperidine prolylcarboxypeptidase inhibitors

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2003
- 2003-03-07 UA UA20041210497A patent/UA77814C2/uk unknown
- 2003-07-03 WO PCT/US2003/021348 patent/WO2004004714A1/en not_active Ceased
- 2003-07-03 EA EA200500156A patent/EA007387B1/ru not_active IP Right Cessation
- 2003-07-03 NZ NZ536844A patent/NZ536844A/en unknown
- 2003-07-03 AT AT03763351T patent/ATE421504T1/de not_active IP Right Cessation
- 2003-07-03 PL PL03373622A patent/PL373622A1/xx not_active Application Discontinuation
- 2003-07-03 AU AU2003261133A patent/AU2003261133A1/en not_active Abandoned
- 2003-07-03 JP JP2004520024A patent/JP2006501188A/ja not_active Withdrawn
- 2003-07-03 KR KR1020057000069A patent/KR20050047075A/ko not_active Withdrawn
- 2003-07-03 CA CA002485375A patent/CA2485375A1/en not_active Abandoned
- 2003-07-03 ES ES03763351T patent/ES2318165T3/es not_active Expired - Lifetime
- 2003-07-03 BR BR0312256-5A patent/BR0312256A/pt not_active IP Right Cessation
- 2003-07-03 MX MXPA04012171A patent/MXPA04012171A/es not_active Application Discontinuation
- 2003-07-03 EP EP03763351A patent/EP1531816B1/en not_active Expired - Lifetime
- 2003-07-03 CN CNA038158833A patent/CN1668300A/zh active Pending
- 2003-07-03 DE DE60325973T patent/DE60325973D1/de not_active Expired - Fee Related
- 2003-07-03 US US10/518,939 patent/US7335665B2/en not_active Expired - Fee Related
2004
- 2004-11-23 ZA ZA200409426A patent/ZA200409426B/en unknown
- 2004-11-26 IS IS7559A patent/IS7559A/is unknown
- 2004-12-21 IL IL16590604A patent/IL165906A0/xx unknown
2005
- 2005-01-11 NO NO20050145A patent/NO20050145L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ATE421504T1 (de)	2009-02-15
US7335665B2 (en)	2008-02-26
BR0312256A (pt)	2005-04-26
EP1531816B1 (en)	2009-01-21
ZA200409426B (en)	2006-04-26
UA77814C2 (en)	2007-01-15
ES2318165T3 (es)	2009-05-01
NO20050145L (no)	2005-01-11
EP1531816A1 (en)	2005-05-25
EP1531816A4 (en)	2005-12-28
MXPA04012171A (es)	2005-02-25
IL165906A0 (en)	2006-01-15
KR20050047075A (ko)	2005-05-19
EA007387B1 (ru)	2006-10-27
WO2004004714A1 (en)	2004-01-15
EA200500156A1 (ru)	2005-06-30
PL373622A1 (en)	2005-09-05
NZ536844A (en)	2007-02-23
AU2003261133A1 (en)	2004-01-23
CN1668300A (zh)	2005-09-14
US20060173027A1 (en)	2006-08-03
DE60325973D1 (de)	2009-03-12
JP2006501188A (ja)	2006-01-12
CA2485375A1 (en)	2004-07-15

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