BR0312854A - Compostos 1-fenil-2-dimetilaminometilciclohexano para a terapia de sintomas de depressão, dor e incontinência - Google Patents

Compostos 1-fenil-2-dimetilaminometilciclohexano para a terapia de sintomas de depressão, dor e incontinência

Info

Publication number
BR0312854A
BR0312854A BR0312854-7A BR0312854A BR0312854A BR 0312854 A BR0312854 A BR 0312854A BR 0312854 A BR0312854 A BR 0312854A BR 0312854 A BR0312854 A BR 0312854A
Authority
BR
Brazil
Prior art keywords
depression
incontinence
pain
symptoms
therapy
Prior art date
Application number
BR0312854-7A
Other languages
English (en)
Inventor
Elmar Friderichs
Wolfgang Strassburger
Helmut Heinrich Buschmann
Oswald Zimmer
Jorg Holenz
Hagen Heinrich Hennies
Werner Gunter Englberger
Ulrich Jahnel
Derek Saunders
Original Assignee
Gr Nenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gr Nenthal Gmbh filed Critical Gr Nenthal Gmbh
Publication of BR0312854A publication Critical patent/BR0312854A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"COMPOSTOS 1-FENIL-2-DIMETILAMINOMETILCICLOHEXANO PARA A TERAPIA DE SINTOMAS DE DEPRESSãO, DOR E INCONTINêNCIA". A presente invenção refere-se a metabolitos de [2-(3-metoxifenil)-ciclohexilmetil)-dimetilamina como bases livres e/ou em forma de sais fisiologicamente compatíveis, a correspondentes medicamentos, bem como ao uso de [2-(3-metoxifenil)-ciclohexilmetil)-dimetilamina e de seus metabolitos para a produção de um medicamento para o tratamento de depressões e a processos para o tratamento de depressões.
BR0312854-7A 2002-07-19 2003-07-16 Compostos 1-fenil-2-dimetilaminometilciclohexano para a terapia de sintomas de depressão, dor e incontinência BR0312854A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10233048A DE10233048A1 (de) 2002-07-19 2002-07-19 Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken
PCT/EP2003/007720 WO2004009067A1 (de) 2002-07-19 2003-07-16 1-phenyl-2-dimethylaminomethylcyclohexanverbindungen zur therapie von depressiven symptomatiken, schmerz und inkontinenz

Publications (1)

Publication Number Publication Date
BR0312854A true BR0312854A (pt) 2005-04-19

Family

ID=29796483

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312854-7A BR0312854A (pt) 2002-07-19 2003-07-16 Compostos 1-fenil-2-dimetilaminometilciclohexano para a terapia de sintomas de depressão, dor e incontinência

Country Status (25)

Country Link
EP (1) EP1530462B1 (pt)
JP (1) JP4616644B2 (pt)
KR (1) KR101056343B1 (pt)
CN (1) CN1697651B (pt)
AR (1) AR040574A1 (pt)
AT (1) ATE491442T1 (pt)
AU (1) AU2003263179B2 (pt)
BR (1) BR0312854A (pt)
CA (1) CA2492876C (pt)
CO (1) CO5680411A2 (pt)
CY (1) CY1111607T1 (pt)
DE (2) DE10233048A1 (pt)
DK (1) DK1530462T3 (pt)
EC (1) ECSP055583A (pt)
ES (1) ES2357947T3 (pt)
IL (2) IL166363A (pt)
MX (1) MXPA05000791A (pt)
NO (1) NO333812B1 (pt)
PE (1) PE20050126A1 (pt)
PL (1) PL214703B1 (pt)
PT (1) PT1530462E (pt)
RU (1) RU2387446C2 (pt)
SI (1) SI1530462T1 (pt)
WO (1) WO2004009067A1 (pt)
ZA (1) ZA200501428B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1562567T (pt) * 2002-11-22 2017-08-24 Gruenenthal Gmbh Combinação de analgésicos selecionados e inibidores da cox-ii
DE10356362A1 (de) * 2003-11-28 2005-06-23 Grünenthal GmbH Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen
US20080261955A1 (en) * 2004-10-01 2008-10-23 Timothy Dinan Use of Pharmaceutical Compositions of Lofepramine for the Treatment of Adhd, Cfs, Fm and Depression
DE102005034973A1 (de) * 2005-07-22 2007-02-15 Grünenthal GmbH Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen
JP5323480B2 (ja) * 2005-07-22 2013-10-23 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ３−［２−（ジメチルアミノ）メチル−（シクロヘキシ−１−イル）］−フェノールのＨＣｌ多形体
CA2688493C (en) 2007-05-31 2016-04-19 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
EP2085081A1 (de) 2008-02-04 2009-08-05 Grünenthal GmbH 3-(2-Dimethylaminomethyl-cyclohexyl)-phenol gegen polyneuropathischen Schmerz
WO2011147576A1 (en) * 2010-05-28 2011-12-01 Grünenthal GmbH Process for the preparation of substituted 1-aminomethyl-2-phenyl-cyclohexane compounds
WO2012100423A1 (en) * 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
US8853393B2 (en) 2011-07-29 2014-10-07 Anhui New Star Pharmaceutical Development Co., Ltd. Intermediate for preparing tapentadol or analogues thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
JP2001233762A (ja) * 2000-02-21 2001-08-28 Gruenenthal Gmbh Ｏ−デスメチル−ｎ−モノ−デスメチル−トラマドールの使用方法
DE10059411A1 (de) * 2000-11-30 2002-06-13 Gruenenthal Gmbh Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz

Also Published As

Publication number Publication date
IL166363A (en) 2012-05-31
ATE491442T1 (de) 2011-01-15
EP1530462A1 (de) 2005-05-18
CN1697651B (zh) 2011-09-21
IL166363A0 (en) 2006-01-16
CA2492876A1 (en) 2004-01-29
AR040574A1 (es) 2005-04-13
DE50313329D1 (de) 2011-01-27
DE10233048A1 (de) 2004-01-29
IL209789A0 (en) 2011-02-28
HK1075843A1 (en) 2005-12-30
CN1697651A (zh) 2005-11-16
RU2005104821A (ru) 2006-01-20
ECSP055583A (es) 2005-04-18
AU2003263179B2 (en) 2009-10-22
DK1530462T3 (da) 2011-02-14
KR101056343B1 (ko) 2011-08-12
WO2004009067A1 (de) 2004-01-29
PT1530462E (pt) 2011-02-22
PL214703B1 (pl) 2013-09-30
CA2492876C (en) 2011-06-14
PL375629A1 (en) 2005-12-12
ZA200501428B (en) 2006-09-27
NO333812B1 (no) 2013-09-23
JP2006511453A (ja) 2006-04-06
NO20050861L (no) 2005-02-17
JP4616644B2 (ja) 2011-01-19
ES2357947T3 (es) 2011-05-04
AU2003263179A1 (en) 2004-02-09
PE20050126A1 (es) 2005-04-19
CY1111607T1 (el) 2015-10-07
CO5680411A2 (es) 2006-09-29
SI1530462T1 (sl) 2011-03-31
RU2387446C2 (ru) 2010-04-27
EP1530462B1 (de) 2010-12-15
MXPA05000791A (es) 2005-10-19
KR20050019909A (ko) 2005-03-03

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Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority

Free format text: PERDA DA PRIORIDADE REIVINDICADA NO DE 102330484 DE 19/07/2002, POR NAO ESTAR EM CONFORMIDADE COM OS PARAGRAFOS 2O, 3ODO ART. 16 DA LPI.

B12F Other appeals [chapter 12.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2264 DE 27/05/2014.