BR0316583A - Derivados de ácido acético 3-alquil e 3-arilalquil 1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1) - Google Patents

Derivados de ácido acético 3-alquil e 3-arilalquil 1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1)

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Publication number
BR0316583A
BR0316583A BR0316583-3A BR0316583A BR0316583A BR 0316583 A BR0316583 A BR 0316583A BR 0316583 A BR0316583 A BR 0316583A BR 0316583 A BR0316583 A BR 0316583A
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BR
Brazil
Prior art keywords
sub
indol
arylalkyl
inhibitors
alkyl
Prior art date
Application number
BR0316583-3A
Other languages
English (en)
Inventor
Lee Dalton Jennings
Scott Lee Kincaid
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0316583A publication Critical patent/BR0316583A/pt

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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring

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Abstract

"DERIVADOS DE áCIDO ACéTICO 3-ALQUIL E 3-ARILALQUIL 1HINDOL-1-IL-SUBSTITUìDO COMO INIBIDORES DO INIBIDOR-1 DO ATIVADOR DO PLASMINOGêNIO (PAI-1)". A fórmula da invenção (1) derivados de ácido acético 3-alquil e 3-arialquil 1Hindol-1-il que são úteis como inibidores do inibidor-1 do ativador do plasminogênio (PAI-1) úteis para o tratamento de desordens fibrinolíticas, os compostos apresentando a estrutura em que: R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~ e R~ 7~ São Como definidos aqui ou seu sal ou éster aceitável farmaceuticamente.
BR0316583-3A 2002-12-10 2003-12-09 Derivados de ácido acético 3-alquil e 3-arilalquil 1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1) BR0316583A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43233002P 2002-12-10 2002-12-10
PCT/US2003/038930 WO2004052853A2 (en) 2002-12-10 2003-12-09 Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)

Publications (1)

Publication Number Publication Date
BR0316583A true BR0316583A (pt) 2005-10-04

Family

ID=32507902

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316583-3A BR0316583A (pt) 2002-12-10 2003-12-09 Derivados de ácido acético 3-alquil e 3-arilalquil 1h-indol-1-il substituìdo como inibidores do inibidor-1 do ativador do plasminogênio (pai-1)

Country Status (13)

Country Link
US (1) US7348351B2 (pt)
EP (1) EP1569899B1 (pt)
JP (1) JP2006514640A (pt)
CN (1) CN1723197A (pt)
AT (1) ATE331708T1 (pt)
AU (1) AU2003297727A1 (pt)
BR (1) BR0316583A (pt)
CA (1) CA2509170A1 (pt)
DE (1) DE60306547T2 (pt)
DK (1) DK1569899T3 (pt)
ES (1) ES2268480T3 (pt)
MX (1) MXPA05006282A (pt)
WO (1) WO2004052853A2 (pt)

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CA2509170A1 (en) 2004-06-24
EP1569899B1 (en) 2006-06-28
CN1723197A (zh) 2006-01-18
MXPA05006282A (es) 2005-08-19
DE60306547D1 (de) 2006-08-10
WO2004052853A2 (en) 2004-06-24
DE60306547T2 (de) 2007-06-28
US7348351B2 (en) 2008-03-25
US20040116488A1 (en) 2004-06-17
ATE331708T1 (de) 2006-07-15
AU2003297727A1 (en) 2004-06-30
WO2004052853A3 (en) 2004-09-16
ES2268480T3 (es) 2007-03-16

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