BR112012000320A2 - derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêutica - Google Patents

derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêutica

Info

Publication number: BR112012000320A2
Authority: BR; Brazil
Prior art keywords: sphingosine; hydrate; phosphate; pharmaceutically acceptable; pharmaceutical composition
Prior art date: 2009-07-09

Application number

BR112012000320A

Other languages

English (en)

Inventor

Keita Miyoshi

Kiyoshi Fujii

Momoko Taru

Yasushi Kohno

Original Assignee

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-09

Filing date

2010-07-08

Publication date

2016-03-22

2010-07-08 Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk

2016-03-22 Publication of BR112012000320A2 publication Critical patent/BR112012000320A2/pt

Links

230000003042 antagnostic effect Effects 0.000 title 1
LTYMSROWYAPPGB-UHFFFAOYSA-N diphenyl sulfide Chemical class C=1C=CC=CC=1SC1=CC=CC=C1 LTYMSROWYAPPGB-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Pulmonology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Diabetes (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BR112012000320A 2009-07-09 2010-07-08 derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêutica BR112012000320A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2009162289		2009-07-09
JP2010112138		2010-05-14
PCT/JP2010/004453 WO2011004604A1 (ja)	2009-07-09	2010-07-08	ジフェニルスルフィド誘導体及びそれらを有効成分とする医薬

Publications (1)

Publication Number	Publication Date
BR112012000320A2 true BR112012000320A2 (pt)	2016-03-22

Family

ID=43429031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR112012000320A BR112012000320A2 (pt)	2009-07-09	2010-07-08	derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêutica

Country Status (19)

Country	Link
US (1)	US8569270B2 (pt)
EP (1)	EP2452944B1 (pt)
JP (1)	JP5616342B2 (pt)
KR (1)	KR20120089234A (pt)
CN (1)	CN102471355B (pt)
AU (1)	AU2010269668B2 (pt)
BR (1)	BR112012000320A2 (pt)
CA (1)	CA2764126A1 (pt)
DK (1)	DK2452944T3 (pt)
ES (1)	ES2514665T3 (pt)
HR (1)	HRP20141065T1 (pt)
MX (1)	MX2011013182A (pt)
NZ (1)	NZ596605A (pt)
PL (1)	PL2452944T3 (pt)
PT (1)	PT2452944E (pt)
SG (1)	SG176573A1 (pt)
SI (1)	SI2452944T1 (pt)
WO (1)	WO2011004604A1 (pt)
ZA (1)	ZA201108459B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI519539B (zh) *	2010-12-21	2016-02-01	Kyorin Seiyaku Kk	Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof
CN102863345A (zh) *	2011-07-06	2013-01-09	中国医学科学院药物研究所	胺基丙二醇类衍生物、其制备方法和其药物组合物与用途
JPWO2015194157A1 (ja) *	2014-06-16	2017-04-20	杏林製薬株式会社	ジフェニルスルフィド誘導体の製造方法及び製造中間体
CN110357773A (zh) *	2019-07-08	2019-10-22	南通嘉禾化工有限公司	3-氯-4-羟基苯甲酸的合成
CN113754613B (zh) *	2021-09-27	2023-06-30	北京工商大学	一种4-烯醇的苯硫基环醚化方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1424078A4 (en)	2001-09-04	2009-03-25	Ono Pharmaceutical Co	RESPIRATORY DISEASE MEDICINES COMPRISING A SPHINGOSINE-1-PHOSPHATE RECEPTOR REGULATING AGENT
DE60235900D1 (de)	2001-09-27	2010-05-20	Kyorin Seiyaku Kk	Osuppressivum
CA2461212C (en)	2001-09-27	2010-08-17	Kyorin Pharmaceutical Co., Ltd.	Diaryl sulfide derivatives, salts thereof and immunosuppressive agents using the same
JP4571497B2 (ja)	2002-09-19	2010-10-27	杏林製薬株式会社	アミノアルコール誘導体とその付加塩及び免疫抑制剤
BRPI0407658A (pt) *	2003-02-18	2006-02-21	Kyorin Seiyaku Kk	derivados de ácido aminofosfÈnico, seus sais e hidratos que atuam como moduladores de receptor de s1p e agente farmacêutico
SA04250253B1 (ar)	2003-08-21	2009-11-10	استرازينيكا ايه بي	احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
WO2005044780A1 (ja)	2003-11-10	2005-05-19	Kyorin Pharmaceutical Co., Ltd.	アミノカルボン酸誘導体とその付加塩及びｓ１ｐ受容体調節剤
JP2005247691A (ja)	2004-03-01	2005-09-15	Toa Eiyo Ltd	Ｓ１ｐ３受容体拮抗薬
WO2006063033A2 (en)	2004-12-06	2006-06-15	University Of Virginia Patent Foundation	Aryl amide sphingosine 1-phosphate analogs
US8546452B2 (en)	2005-10-12	2013-10-01	Toa Eiyo Ltd.	S1P3 receptor antagonist
JP2009545630A (ja) *	2006-08-04	2009-12-24	プリーシス・ファーマシューティカルズ・インコーポレイテッド	化合物
CA2659598A1 (en)	2006-08-08	2008-02-14	Kyorin Pharmaceutical Co., Ltd.	Amino phosphate derivative and s1p receptor modulator having same as an active ingredient
JP2008239546A (ja) *	2007-03-27	2008-10-09	Kyorin Pharmaceut Co Ltd	アミノアルコール誘導体及びそれらを有効成分とする免疫抑制剤
JP2010013407A (ja) *	2008-07-04	2010-01-21	Kyorin Pharmaceut Co Ltd	アミノアルコール誘導体
JP2010077053A (ja) *	2008-09-25	2010-04-08	Kyorin Pharmaceut Co Ltd	フェノール誘導体及びそれらを有効成分とする医薬

2010
- 2010-07-08 HR HRP20141065AT patent/HRP20141065T1/hr unknown
- 2010-07-08 WO PCT/JP2010/004453 patent/WO2011004604A1/ja not_active Ceased
- 2010-07-08 BR BR112012000320A patent/BR112012000320A2/pt not_active IP Right Cessation
- 2010-07-08 NZ NZ596605A patent/NZ596605A/xx not_active IP Right Cessation
- 2010-07-08 AU AU2010269668A patent/AU2010269668B2/en not_active Ceased
- 2010-07-08 JP JP2011521823A patent/JP5616342B2/ja not_active Expired - Fee Related
- 2010-07-08 CN CN201080030630.3A patent/CN102471355B/zh not_active Expired - Fee Related
- 2010-07-08 KR KR1020127003551A patent/KR20120089234A/ko not_active Abandoned
- 2010-07-08 SI SI201030811T patent/SI2452944T1/sl unknown
- 2010-07-08 ES ES10796915.6T patent/ES2514665T3/es active Active
- 2010-07-08 MX MX2011013182A patent/MX2011013182A/es active IP Right Grant
- 2010-07-08 US US13/382,011 patent/US8569270B2/en not_active Expired - Fee Related
- 2010-07-08 CA CA2764126A patent/CA2764126A1/en not_active Abandoned
- 2010-07-08 PT PT107969156T patent/PT2452944E/pt unknown
- 2010-07-08 PL PL10796915T patent/PL2452944T3/pl unknown
- 2010-07-08 DK DK10796915.6T patent/DK2452944T3/da active
- 2010-07-08 EP EP10796915.6A patent/EP2452944B1/en active Active
- 2010-07-08 SG SG2011085511A patent/SG176573A1/en unknown
2011
- 2011-11-17 ZA ZA2011/08459A patent/ZA201108459B/en unknown

Also Published As

Publication number	Publication date
PT2452944E (pt)	2014-10-13
AU2010269668B2 (en)	2013-12-19
ZA201108459B (en)	2012-07-25
AU2010269668A1 (en)	2011-12-15
SI2452944T1 (sl)	2015-01-30
CN102471355B (zh)	2015-10-07
ES2514665T3 (es)	2014-10-28
US20120101068A1 (en)	2012-04-26
JPWO2011004604A1 (ja)	2012-12-20
HRP20141065T1 (hr)	2015-02-13
CA2764126A1 (en)	2011-01-13
WO2011004604A1 (ja)	2011-01-13
CN102471355A (zh)	2012-05-23
KR20120089234A (ko)	2012-08-09
JP5616342B2 (ja)	2014-10-29
EP2452944A1 (en)	2012-05-16
SG176573A1 (en)	2012-01-30
HK1171234A1 (zh)	2013-03-22
US8569270B2 (en)	2013-10-29
DK2452944T3 (da)	2014-10-27
MX2011013182A (es)	2012-01-31
PL2452944T3 (pl)	2015-03-31
NZ596605A (en)	2013-09-27
EP2452944B1 (en)	2014-09-10
EP2452944A4 (en)	2013-04-03

Legal Events

Date	Code	Title	Description
2017-12-12	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.
2018-05-02	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2018-08-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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EP1980271A4 (en)	2012-04-25	MEDICINE FOR TRANSNASAL ADMINISTRATION
BRPI0808293A2 (pt)	2019-09-24	"composições para administração nasal"
IL223783B (en)	2018-06-28	Compound 1-converted indole for use in the treatment of a disease or condition, a pharmaceutical preparation containing the compound and use of the compound to prepare a medicine
BRPI0917540A2 (pt)	2015-11-17	composto, sal farmacologicamente aceitavél, composição farmacêutica, e, uso de um composto ou sal farmacologicamente aceitável
BRPI1011220A2 (pt)	2016-03-15	composição farmacêutica, métodos para tratar uma doença ou distúrbio, para administração respiratória de dois ou mais agentes ativos, para administração respiratória de uma combinação de agentes ativos, e, para preparar uma composição adequada.
BRPI0711985A2 (pt)	2014-06-10	Dispositivo inalador para a inalação de um medicamento a partir de uma cápsula perfurável
MX2016006053A (es)	2016-08-17	Compuestos selectivos de peptido yy (pyy) y usos de los mismos.
IL228017A0 (en)	2013-09-30	Quinazolinone derivatives donated at position 5 as anti-cancer agents
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BRPI0807285A2 (pt)	2014-05-06	"composição, método para preparar composição farmacêutica, forma unitária de dosagem, método para admnistrar um agente biologicamente ativo a um animal necessitando o agente, método para aumentar a biodisponibilidade de um agente biologicamente ativo, método para preparar uma composição e composto"
EP2339973A4 (en)	2015-06-17	ACTIVE RELEASE IMPLANTS
BRPI1011815A2 (pt)	2016-03-29	"composição farmacêutica para a contracepção de emergência"
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BR112012022211A2 (pt)	2017-07-18	composto. composição farmacêutica, método de tratamento de uma doença meidada por h4r, método de inibição de h4h, método de tratamento da dor ou inflamação resultante de cirurgia de catarata, método para atingir um efeito em um paciente e uso de uma composto
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PL2066179T3 (pl)	2017-02-28	Formulacje zawierające indoksakarb do miejscowego podawania na skórę
EP2219725A4 (en)	2011-05-18	CUFFS FOR ACTIVE INJECTION
BRPI1014865A2 (pt)	2016-05-03	"composição e formulação farmacêutica comreendendo derivados de nitrocatecol, e, método para fabricar uma composição ou formulação farmacêutica"
BRPI1013763A2 (pt)	2015-08-25	Composto ou sal do mesmo, prodroga, composição farmacêutica, agente diminuidor da proteína de ligação de retinol 4, agente para a profilaxia ou tratamento de diabetes, e, uso de um composto
BRPI0908124A2 (pt)	2015-08-04	Composto, ativador de glucoquinase, composição farmacêutica, uso de um composto ou sal farmacologicamente aceitavél do mesmo, e, métodos de ativação da glucoquinase, e para tratar e/ou prevenir uma doença
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EP2219553A4 (en)	2013-02-27	SINGLE AMPOULE FORMULATION FOR MEDICAL CYANOACRYLATE
BR112012000320A2 (pt)	2016-03-22	derivado de sulfeto de difenil, hidrato ou um sal farmaceuticamente aceitável do mesmo, medicamento baseado na ação antagônica-receptor da esfingosina-1-fosfato 3 (s1p3) e composição farmacêutica