BR112012000525A2 - inibidores da bace - Google Patents

inibidores da bace

Info

Publication number
BR112012000525A2
BR112012000525A2 BR112012000525A BR112012000525A BR112012000525A2 BR 112012000525 A2 BR112012000525 A2 BR 112012000525A2 BR 112012000525 A BR112012000525 A BR 112012000525A BR 112012000525 A BR112012000525 A BR 112012000525A BR 112012000525 A2 BR112012000525 A2 BR 112012000525A2
Authority
BR
Brazil
Prior art keywords
bace inhibitors
bace
inhibitors
Prior art date
Application number
BR112012000525A
Other languages
English (en)
Inventor
Brian Morgan Watson
Chongsheng Eric Shi
Dustin James Mergott
Grant Mathews Vaught
James Edmund Audia
Leonard Larry Winneroski Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42985394&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112012000525(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112012000525A2 publication Critical patent/BR112012000525A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
BR112012000525A 2009-07-09 2010-07-06 inibidores da bace BR112012000525A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22424109P 2009-07-09 2009-07-09
PCT/US2010/041034 WO2011005738A1 (en) 2009-07-09 2010-07-06 Bace inhibitors

Publications (1)

Publication Number Publication Date
BR112012000525A2 true BR112012000525A2 (pt) 2015-09-15

Family

ID=42985394

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012000525A BR112012000525A2 (pt) 2009-07-09 2010-07-06 inibidores da bace

Country Status (26)

Country Link
US (2) US8278441B2 (pt)
EP (1) EP2451793B1 (pt)
JP (1) JP5666578B2 (pt)
KR (1) KR101362557B1 (pt)
CN (1) CN102471296B (pt)
AR (1) AR077277A1 (pt)
AU (1) AU2010270691B8 (pt)
BR (1) BR112012000525A2 (pt)
CA (1) CA2764429C (pt)
CL (1) CL2012000033A1 (pt)
CO (1) CO6480979A2 (pt)
CR (1) CR20120011A (pt)
DO (1) DOP2012000004A (pt)
EA (1) EA019892B1 (pt)
EC (1) ECSP12011581A (pt)
HN (1) HN2012000012A (pt)
IL (1) IL216742A0 (pt)
MA (1) MA33492B1 (pt)
MX (1) MX2012000510A (pt)
NZ (1) NZ596579A (pt)
PE (1) PE20120632A1 (pt)
SG (1) SG177594A1 (pt)
TN (1) TN2011000673A1 (pt)
TW (1) TWI405765B (pt)
WO (1) WO2011005738A1 (pt)
ZA (1) ZA201109385B (pt)

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JP5834091B2 (ja) 2010-12-22 2015-12-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ ベータ−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な５，６−ジヒドロ−イミダゾ［１，２−ａ］ピラジン−８−イルアミン誘導体
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JP5853035B2 (ja) 2011-03-09 2016-02-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ β−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な３，４−ジヒドロ−ピロロ［１，２−ａ］ピラジン−１−イルアミン誘導体
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WO2012138734A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
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JP6043355B2 (ja) 2011-08-31 2016-12-14 ファイザー・インク ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
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IL216742A0 (en) 2012-03-01
NZ596579A (en) 2013-12-20
KR101362557B1 (ko) 2014-02-13
WO2011005738A1 (en) 2011-01-13
CN102471296A (zh) 2012-05-23
DOP2012000004A (es) 2012-01-31
ZA201109385B (en) 2013-05-29
JP2012532874A (ja) 2012-12-20
US8278441B2 (en) 2012-10-02
EA019892B1 (ru) 2014-07-30
EP2451793A1 (en) 2012-05-16
CL2012000033A1 (es) 2012-09-14
MX2012000510A (es) 2012-01-27
EA201270149A1 (ru) 2012-06-29
AU2010270691B2 (en) 2013-08-01
TWI405765B (zh) 2013-08-21
AR077277A1 (es) 2011-08-17
KR20120027482A (ko) 2012-03-21
CA2764429C (en) 2014-11-18
SG177594A1 (en) 2012-02-28
PE20120632A1 (es) 2012-05-26
US20120323001A1 (en) 2012-12-20
CA2764429A1 (en) 2011-01-13
AU2010270691B8 (en) 2013-11-28
JP5666578B2 (ja) 2015-02-12
MA33492B1 (fr) 2012-08-01
EP2451793B1 (en) 2016-11-02
TW201113289A (en) 2011-04-16
AU2010270691A1 (en) 2011-12-22
US20110009395A1 (en) 2011-01-13
ECSP12011581A (es) 2012-02-29
CN102471296B (zh) 2014-11-12
TN2011000673A1 (en) 2013-05-24
CR20120011A (es) 2012-02-09

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