BR112012012151A2 - lipossoma de irinotecano ou seu cloridrato e seu método de preparação - Google Patents

lipossoma de irinotecano ou seu cloridrato e seu método de preparação

Info

Publication number
BR112012012151A2
BR112012012151A2 BR112012012151A BR112012012151A BR112012012151A2 BR 112012012151 A2 BR112012012151 A2 BR 112012012151A2 BR 112012012151 A BR112012012151 A BR 112012012151A BR 112012012151 A BR112012012151 A BR 112012012151A BR 112012012151 A2 BR112012012151 A2 BR 112012012151A2
Authority
BR
Brazil
Prior art keywords
hydrochloride
preparation
liposome
irinotecan
irinotecan liposome
Prior art date
Application number
BR112012012151A
Other languages
English (en)
Other versions
BR112012012151B8 (pt
BR112012012151B1 (pt
Inventor
Chengxia Yu
Guofeng Lei
Liang Chen
Xinyong Tong
Original Assignee
Jiangsu Hengrui Medicine Co
Shanghai Hengrui Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co, Shanghai Hengrui Pharm Co Ltd filed Critical Jiangsu Hengrui Medicine Co
Publication of BR112012012151A2 publication Critical patent/BR112012012151A2/pt
Publication of BR112012012151B1 publication Critical patent/BR112012012151B1/pt
Publication of BR112012012151B8 publication Critical patent/BR112012012151B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

lipossoma e irinotecano ou seu cloridrato e seu método de preparação. a presente invenção refere-se a um lipossoma de irinotecano ou seu cloridrato e seu método de preparação. o lipossoma compreende irinotecano ou seu cloridrato, foslolipídio neutro e colesterol, em que a razão em peso de colesterol para fosfolipídio neutro é de 1:3-5. o dito lipossoma é preparado pelo método de gradiente iônico.
BR112012012151A 2009-12-03 2009-12-03 lipossoma de irinotecano ou cloridrato de irinotecano, método de preparação do mesmo, bem como injeção de lipossoma e processo de preparação da mesma BR112012012151B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2009/075298 WO2011066684A1 (zh) 2009-12-03 2009-12-03 伊立替康或盐酸伊立替康脂质体及其制备方法

Publications (3)

Publication Number Publication Date
BR112012012151A2 true BR112012012151A2 (pt) 2016-04-12
BR112012012151B1 BR112012012151B1 (pt) 2021-01-19
BR112012012151B8 BR112012012151B8 (pt) 2021-05-25

Family

ID=44114598

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012012151A BR112012012151B8 (pt) 2009-12-03 2009-12-03 lipossoma de irinotecano ou cloridrato de irinotecano, método de preparação do mesmo, bem como injeção de lipossoma e processo de preparação da mesma

Country Status (21)

Country Link
US (2) US20120282325A1 (pt)
EP (1) EP2508170B1 (pt)
JP (1) JP5645954B2 (pt)
KR (2) KR20120089754A (pt)
CN (1) CN102271659B (pt)
AU (1) AU2009356132B2 (pt)
BR (1) BR112012012151B8 (pt)
CA (1) CA2782911C (pt)
CY (1) CY1116811T1 (pt)
DK (1) DK2508170T3 (pt)
ES (1) ES2547698T3 (pt)
HR (1) HRP20150911T1 (pt)
HU (1) HUE027467T2 (pt)
MX (1) MX2012005775A (pt)
PL (1) PL2508170T3 (pt)
PT (1) PT2508170E (pt)
RU (1) RU2526114C2 (pt)
SI (1) SI2508170T1 (pt)
SM (1) SMT201500245B (pt)
WO (1) WO2011066684A1 (pt)
ZA (1) ZA201203316B (pt)

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CN107456456A (zh) * 2016-06-03 2017-12-12 江苏恒瑞医药股份有限公司 伊立替康或其可药用盐在制备治疗乳腺癌的药物中的用途
AU2017290703B2 (en) * 2016-06-28 2023-03-30 Emergent Biodefense Operations Lansing Llc Formulations of brincidofovir
CN106109415B (zh) * 2016-07-26 2019-01-29 金华市人民医院 一种载喜树碱类抗肿瘤药物脂质体、制备方法及其应用
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Also Published As

Publication number Publication date
PT2508170E (pt) 2015-10-16
AU2009356132A1 (en) 2012-06-21
CA2782911A1 (en) 2011-06-09
KR101780915B1 (ko) 2017-09-21
KR20120089754A (ko) 2012-08-13
CN102271659A (zh) 2011-12-07
RU2012123875A (ru) 2014-01-20
ZA201203316B (en) 2013-11-27
US20120282325A1 (en) 2012-11-08
DK2508170T3 (en) 2015-09-21
AU2009356132B2 (en) 2015-01-22
CN102271659B (zh) 2013-09-18
US10022365B2 (en) 2018-07-17
EP2508170A1 (en) 2012-10-10
EP2508170A4 (en) 2014-01-15
EP2508170B1 (en) 2015-07-29
SMT201500245B (it) 2015-10-30
MX2012005775A (es) 2012-06-13
HUE027467T2 (en) 2016-10-28
SI2508170T1 (sl) 2015-12-31
HK1159482A1 (en) 2012-08-03
KR20160140992A (ko) 2016-12-07
CY1116811T1 (el) 2017-03-15
BR112012012151B8 (pt) 2021-05-25
US20170189392A1 (en) 2017-07-06
BR112012012151B1 (pt) 2021-01-19
HRP20150911T1 (hr) 2015-10-23
WO2011066684A1 (zh) 2011-06-09
ES2547698T3 (es) 2015-10-08
JP5645954B2 (ja) 2014-12-24
PL2508170T3 (pl) 2015-12-31
CA2782911C (en) 2016-08-23
RU2526114C2 (ru) 2014-08-20
JP2013512262A (ja) 2013-04-11

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