CU20130137A7 - Derivados de ácido 3- fenilpropiónico ramificados y su uso - Google Patents

Derivados de ácido 3- fenilpropiónico ramificados y su uso

Info

Publication number
CU20130137A7
CU20130137A7 CU2013000137A CU20130137A CU20130137A7 CU 20130137 A7 CU20130137 A7 CU 20130137A7 CU 2013000137 A CU2013000137 A CU 2013000137A CU 20130137 A CU20130137 A CU 20130137A CU 20130137 A7 CU20130137 A7 CU 20130137A7
Authority
CU
Cuba
Prior art keywords
phenylpropionics
ramified
acid derivatives
prevention
preparation
Prior art date
Application number
CU2013000137A
Other languages
English (en)
Other versions
CU24183B1 (es
Inventor
Michael G Hahn
Thomas Lampe
Johannes-Peter Stasch
Karl-Heinz Schlemmer
Frank Wunder
Volkhart Min-Jian Li
Eva María Becker-Pelster
Friederike Stoll
Andreas Knorr
Elisabeth Woltering
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45928886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20130137(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CU20130137A7 publication Critical patent/CU20130137A7/es
Publication of CU24183B1 publication Critical patent/CU24183B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud se refiere a nuevos derivados de ácido 3-fenilpropiónico que poseen en la posición 3 un sustituyente de alquilo ramificado o cíclico, a procedimientos para su preparación y a su uso para el tratamiento y/o la prevención de enfermedades, así como a su uso para la preparación de medicamentos para el tratamiento y/o la prevención de afecciones cardiovasculares.
CUP2013000137A 2011-04-13 2012-03-28 Derivados de ácido 3-fenilpropiónico ramificados CU24183B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011007272A DE102011007272A1 (de) 2011-04-13 2011-04-13 Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
PCT/EP2012/055474 WO2012139888A1 (de) 2011-04-13 2012-03-28 Verzweigte 3-phenylpropionsäure-derivate und ihre verwendung

Publications (2)

Publication Number Publication Date
CU20130137A7 true CU20130137A7 (es) 2014-01-29
CU24183B1 CU24183B1 (es) 2016-07-29

Family

ID=45928886

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2013000137A CU24183B1 (es) 2011-04-13 2012-03-28 Derivados de ácido 3-fenilpropiónico ramificados

Country Status (43)

Country Link
US (6) US8796335B2 (es)
EP (1) EP2697191B1 (es)
JP (1) JP5911950B2 (es)
KR (1) KR101944559B1 (es)
CN (1) CN103796989B (es)
AP (1) AP3482A (es)
AR (1) AR085586A1 (es)
AU (1) AU2012242122B2 (es)
BR (1) BR112013026466B1 (es)
CA (1) CA2832970C (es)
CL (1) CL2013002902A1 (es)
CO (1) CO6801742A2 (es)
CR (1) CR20130524A (es)
CU (1) CU24183B1 (es)
CY (1) CY1117183T1 (es)
DE (1) DE102011007272A1 (es)
DK (1) DK2697191T3 (es)
DO (1) DOP2013000239A (es)
EA (1) EA023990B1 (es)
EC (1) ECSP13012966A (es)
ES (1) ES2561753T3 (es)
GT (1) GT201300243A (es)
HR (1) HRP20160100T1 (es)
HU (1) HUE026859T2 (es)
IL (1) IL228677A (es)
JO (1) JO3091B1 (es)
MA (1) MA35039B1 (es)
ME (1) ME02310B (es)
MX (1) MX337712B (es)
MY (1) MY173877A (es)
PE (1) PE20140630A1 (es)
PH (1) PH12013502126A1 (es)
PL (1) PL2697191T3 (es)
PT (1) PT2697191E (es)
RS (1) RS54527B1 (es)
SG (2) SG10201602852WA (es)
SI (1) SI2697191T1 (es)
TN (1) TN2013000411A1 (es)
TW (1) TWI549933B (es)
UA (1) UA110054C2 (es)
UY (1) UY33970A (es)
WO (1) WO2012139888A1 (es)
ZA (1) ZA201308490B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0775033B2 (ja) 1991-12-13 1995-08-09 松下電器産業株式会社 暗証番号照合方法及びその装置
DE102009012314A1 (de) * 2009-03-09 2010-09-16 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung
DE102009046115A1 (de) 2009-10-28 2011-09-08 Bayer Schering Pharma Aktiengesellschaft Substituierte 3-Phenylpropansäuren und ihre Verwendung
KR20130136504A (ko) 2010-12-07 2013-12-12 바이엘 인텔렉쳐 프로퍼티 게엠베하 치환된 1-벤질사이클로알킬카르복실산 및 그의 용도
DE102011007272A1 (de) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
PL2782914T3 (pl) 2011-11-25 2019-01-31 Adverio Pharma Gmbh Sposób wytwarzania podstawionych 5-fluoro-1H-pirazolopirydyn
DE102012208530A1 (de) 2012-05-22 2013-11-28 Bayer Pharma AG Substituierte Piperidinoacetamide und ihre Verwendung
AU2013353117A1 (en) * 2012-11-30 2015-06-04 Astellas Pharma Inc. Imidazopyridine compound
WO2014186704A2 (en) * 2013-05-17 2014-11-20 N30 Pharmaceuticals, Inc. Novel compounds for the treatment of cystic fibrosis
US10265314B2 (en) 2013-07-25 2019-04-23 Bayer Pharma Aktiengesellschaft SGC stimulators in combination with additional treatment for the therapy of cystic fibrosis
TW201625586A (zh) 2014-07-02 2016-07-16 諾華公司 環己烯－１－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
TW201625584A (zh) 2014-07-02 2016-07-16 諾華公司 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
TW201625601A (zh) 2014-07-02 2016-07-16 諾華公司 噻吩－２－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
EA035788B1 (ru) 2014-12-18 2020-08-11 Байер Фарма Акциенгезельшафт Замещенный пиридил-циклоалкил-карбоновые кислоты, содержащие их композиции и их медицинское применение
US20180169095A1 (en) 2015-05-06 2018-06-21 Bayer Pharma Aktiengesellschaft The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of digital ulcers (du) concomitant to systemic sclerosis (ssc)
CN113750102A (zh) 2015-07-23 2021-12-07 拜耳制药股份公司 可溶性鸟苷酸环化酶的刺激剂和/或活化剂及其用途
JP7101688B2 (ja) 2016-10-11 2022-07-15 バイエル・ファルマ・アクティエンゲゼルシャフト ｓＧＣ刺激薬とミネラルコルチコイド受容体拮抗薬とを含む組み合わせ
CN109890379A (zh) * 2016-10-11 2019-06-14 拜耳制药股份公司 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品
WO2018153899A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc)
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
JOP20200073A1 (ar) 2017-10-24 2020-04-29 Bayer Pharma AG مركبات أميد إيميدازوبيريدين تحمل بدائل واستخداماتها
RU2020121714A (ru) * 2017-12-01 2022-01-04 Байер Фарма Акциенгезельшафт Способ получения (3s)-3-(4-хлор-3-{ [(2s,3r)-2-(4-хлорфенил)-4,4,4-трифтор-3-метилбутаноил]амино} фенил)-3-циклопропилпропановой кислоты и её кристаллической формы для применения в качестве фармацевтического активного вещества
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
WO2019211081A1 (en) * 2018-04-30 2019-11-07 Bayer Aktiengesellschaft The use of sgc activators and sgc stimulators for the treatment of cognitive impairment
CA3100096A1 (en) 2018-05-15 2019-11-21 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
US11508483B2 (en) 2018-05-30 2022-11-22 Adverio Pharma Gmbh Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group
WO2020020790A1 (de) 2018-07-24 2020-01-30 Bayer Aktiengesellschaft Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung
US10905667B2 (en) * 2018-07-24 2021-02-02 Bayer Pharma Aktiengesellschaft Orally administrable modified-release pharmaceutical dosage form
EP3826627B1 (de) 2018-07-24 2023-10-18 Bayer Aktiengesellschaft Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung
CA3126778A1 (en) 2019-01-17 2020-07-23 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
WO2020164008A1 (en) 2019-02-13 2020-08-20 Bayer Aktiengesellschaft Process for the preparation of porous microparticles
WO2020216669A1 (de) 2019-04-23 2020-10-29 Bayer Aktiengesellschaft Phenylsubstituierte imidazopyridinamide und ihre verwendung
EP3966226B1 (en) 2019-05-07 2025-12-24 Bayer Aktiengesellschaft Masp inhibitory compounds and uses thereof
WO2020245342A1 (en) 2019-06-07 2020-12-10 Bayer Aktiengesellschaft The use of sgc activators for the treatment of ophthalmologic diseases
EP3822268A1 (en) 2019-11-15 2021-05-19 Bayer Aktiengesellschaft Substituted hydantoinamides as adamts7 antagonists
EP3822265A1 (en) 2019-11-15 2021-05-19 Bayer AG Substituted hydantoinamides as adamts7 antagonists
MX2023006903A (es) 2020-12-10 2023-06-26 Bayer Ag Acidos pirazol piperidin carboxilicos sustituidos.
JP7458683B2 (ja) 2020-12-10 2024-04-01 バイエル・アクチエンゲゼルシヤフト 眼科疾患の治療のためのｓＧＣ活性化剤の使用
CN116829545A (zh) 2020-12-10 2023-09-29 拜耳公司 取代的吡唑基哌啶羧酸
EP4011873A1 (en) 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
EP4011874A1 (en) 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
WO2022237797A1 (zh) * 2021-05-14 2022-11-17 南京明德新药研发有限公司 烷基羧酸化合物及其应用
WO2023275796A1 (en) * 2021-07-01 2023-01-05 Novartis Ag Heterocyclic derivatives as sphingosine-1-phosphate 3 inhibitors
CN117460713A (zh) * 2021-07-15 2024-01-26 江苏恒瑞医药股份有限公司 3-苯基丙酸类化合物、其制备方法及其在医药上的应用
TW202342420A (zh) * 2022-02-18 2023-11-01 大陸商江蘇恆瑞醫藥股份有限公司 羧酸類化合物、其製備方法及其在醫藥上的應用
EP4536205A1 (en) 2022-06-09 2025-04-16 Bayer Aktiengesellschaft Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women
CN120152950A (zh) * 2022-11-08 2025-06-13 康臣药业(内蒙古)有限责任公司 一种烷基羧酸类化合物的晶型及其应用

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
GB1478759A (en) 1974-11-18 1977-07-06 Alza Corp Process for forming outlet passageways in pills using a laser
US4063064A (en) 1976-02-23 1977-12-13 Coherent Radiation Apparatus for tracking moving workpiece by a laser beam
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4765989A (en) 1983-05-11 1988-08-23 Alza Corporation Osmotic device for administering certain drugs
NZ206600A (en) 1983-05-11 1987-01-23 Alza Corp Osmotic drug delivery device
DE3868077D1 (de) 1987-01-14 1992-03-12 Ciba Geigy Ag Therapeutisches system fuer schwerloesliche wirkstoffe.
US5041453A (en) 1990-05-30 1991-08-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
CA2150550A1 (en) 1992-12-01 1994-06-09 Melissa S. Egbertson Fibrinogen receptor antagonists
DE4301900A1 (de) 1993-01-25 1994-07-28 Bayer Ag 2-Oxochinolin-1-yl-methylphenylessigsäurederivate
US5643957A (en) * 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
DE4326344A1 (de) 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2722145B1 (fr) 1994-07-05 1996-09-27 Michelin & Cie Bande de roulement pour pneumatique hivernaux
NL9401707A (nl) 1994-10-17 1996-06-03 Dsm Nv Werkwijze voor de bereiding van 3-fenylpropaanzuur.
DE4443892A1 (de) 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
DE19546918A1 (de) 1995-12-15 1997-06-19 Bayer Ag Bicyclische Heterocyclen
EP0802192A1 (de) 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19747261A1 (de) 1997-10-25 1999-04-29 Bayer Ag Osmotisches Arzneimittelfreisetzungssystem
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
CN1131212C (zh) 1999-02-24 2003-12-17 弗·哈夫曼-拉罗切有限公司 苯基－和吡啶基衍生物
WO2000064876A1 (en) 1999-04-28 2000-11-02 Aventis Pharma Deutschland Gmbh Tri-aryl acid derivatives as ppar receptor ligands
EP1177187B1 (en) 1999-04-28 2007-07-25 Sanofi-Aventis Deutschland GmbH Di-aryl acid derivatives as ppar receptor ligands
DE19929065A1 (de) 1999-06-25 2000-12-28 Bayer Ag Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
WO2001025190A1 (en) 1999-10-01 2001-04-12 Japan Energy Corporation Novel diarylamide derivatives and use thereof as medicines
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
SI1285908T1 (sl) 2000-05-29 2008-12-31 Kyorin Seiyaku Kk Substituirani fenilpropionski kislinski derivati
WO2002016311A1 (en) 2000-08-22 2002-02-28 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives, process for producing the same and drugs containing the same as the active ingredient
AU2001288067A1 (en) 2000-09-21 2002-04-02 Sankyo Company Limited Phenylpropionic acid derivatives
MXPA03003829A (es) 2000-11-04 2003-07-28 Aventis Pharma Ltd Acidos alcanoicos substituidos.
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
EP1348698A4 (en) 2000-12-05 2005-01-19 Kyorin Seiyaku Kk SUBSTITUTED CARBOXYLENE DERIVATIVES
ATE433964T1 (de) 2000-12-28 2009-07-15 Takeda Pharmaceutical Alkansäurederivate, verfahren zu deren herstellung und deren verwendung
WO2002076959A1 (en) 2001-03-23 2002-10-03 Takeda Chemical Industries, Ltd. Five-membered heterocyclic alkanoic acid derivative
US7244861B2 (en) 2001-03-30 2007-07-17 Eisai Co., Ltd. Benzene compound and salt thereof
US20030105097A1 (en) 2001-05-14 2003-06-05 Pfizer Inc. Alkylamide compounds
BR0211810A (pt) 2001-08-09 2004-08-24 Ono Pharmaceutical Co Derivados ácido carboxìlico e agente farmacêutico compreendendo os mesmos como ingrediente ativo
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US20030161882A1 (en) 2002-02-01 2003-08-28 Waterman Kenneth C. Osmotic delivery system
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
WO2004024705A1 (ja) 2002-09-10 2004-03-25 Takeda Pharmaceutical Company Limited ５員複素環化合物
US20050187266A1 (en) 2003-04-15 2005-08-25 Pfizer Inc Alpha substituted carboxylic acids
US20050234066A1 (en) 2004-04-15 2005-10-20 Agouron Pharmaceuticals, Inc. Alpha substituted carboxylic acids
MXPA05011536A (es) 2003-04-30 2006-01-23 Inst For Pharm Discovery Inc Acidos carboxilicos substituidos con fenilo como inhibidores de la proteina tirosina fosfatasa-1b.
EA011010B1 (ru) 2004-02-27 2008-12-30 Эмджен, Инк. Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина
EP1786821B1 (en) 2004-07-19 2009-09-16 Intercasting Corporation Dynamic knowledge-based networking system and method
WO2006030036A1 (es) 2004-08-10 2006-03-23 Microelectronica Española, S.A.U Unidad de procesado y método de gestión de memoria en sistemas de procesado con recursos limitados
MY145712A (en) 2004-09-15 2012-03-30 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
JP2008518926A (ja) 2004-10-28 2008-06-05 ジ インスティチューツ フォー ファーマシューティカル ディスカバリー、エルエルシー 置換フェニルアルカン酸
CA2587566A1 (en) 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Heterocyclylbiphenyl derivates as protein tyrosine phosphatase inhibitors
GT200500375A (es) 2004-12-20 2006-11-28 Derivados de piperidina y su uso como agentes antiinflamatorios
DE102004062475A1 (de) 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
PL372356A1 (pl) 2005-01-20 2006-07-24 ADAMED Sp.z o.o. Nowe związki, pochodne kwasu 3-fenylopropionowego
CA2621164A1 (en) 2005-08-26 2007-03-01 Shionogi & Co., Ltd. Derivative having ppar agonistic activity
DE102005050377A1 (de) 2005-10-21 2007-04-26 Bayer Healthcare Ag Heterocyclische Verbindungen und ihre Verwendung
CN101116660A (zh) * 2006-08-04 2008-02-06 瑟维尔实验室 抗动脉粥样化血栓形成的化合物在获得用于治疗血管疾病的药物中的用途
WO2009067493A2 (en) 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
DE102008018675A1 (de) * 2008-04-14 2009-10-15 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclisch substituierte Carbonsäure-Derivate und ihre Verwendung
MX2010014572A (es) 2008-06-27 2011-03-24 Novartis Ag Compuestos organicos.
EP2179992A1 (de) 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Sulfonsubstituierte Anlinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
EP2179993A1 (de) 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Sulfoxidsubstituierte Anilinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
DE102008059206A1 (de) 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
DE102009012314A1 (de) 2009-03-09 2010-09-16 Bayer Schering Pharma Aktiengesellschaft Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung
DE102009046115A1 (de) * 2009-10-28 2011-09-08 Bayer Schering Pharma Aktiengesellschaft Substituierte 3-Phenylpropansäuren und ihre Verwendung
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
PH12013500055A1 (en) 2010-07-09 2017-08-23 Bayer Ip Gmbh Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
KR20130136504A (ko) 2010-12-07 2013-12-12 바이엘 인텔렉쳐 프로퍼티 게엠베하 치환된 1-벤질사이클로알킬카르복실산 및 그의 용도
DE102011007272A1 (de) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
DE102012208530A1 (de) 2012-05-22 2013-11-28 Bayer Pharma AG Substituierte Piperidinoacetamide und ihre Verwendung
BR112015001211B1 (pt) 2012-07-20 2020-12-15 Bayer Pharma Aktiengesellschaft Ácidos 5-aminotetra-hidroquinolina-2-carboxílicos, processos para a sua preparação, seus usos no tratamento e/ou prevenção de doenças e seus medicamentos
CN109890379A (zh) 2016-10-11 2019-06-14 拜耳制药股份公司 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品
RU2020121714A (ru) 2017-12-01 2022-01-04 Байер Фарма Акциенгезельшафт Способ получения (3s)-3-(4-хлор-3-{ [(2s,3r)-2-(4-хлорфенил)-4,4,4-трифтор-3-метилбутаноил]амино} фенил)-3-циклопропилпропановой кислоты и её кристаллической формы для применения в качестве фармацевтического активного вещества
US20200237648A1 (en) 2018-07-24 2020-07-30 Bayer Pharma Aktiengesellschaft Orally administrable modified-released pharmaceutical dosage form
US10905667B2 (en) 2018-07-24 2021-02-02 Bayer Pharma Aktiengesellschaft Orally administrable modified-release pharmaceutical dosage form
WO2020020790A1 (de) 2018-07-24 2020-01-30 Bayer Aktiengesellschaft Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung
WO2020245342A1 (en) 2019-06-07 2020-12-10 Bayer Aktiengesellschaft The use of sgc activators for the treatment of ophthalmologic diseases

Also Published As

Publication number Publication date
PT2697191E (pt) 2016-03-11
CY1117183T1 (el) 2017-04-05
IL228677A (en) 2017-06-29
KR20140021008A (ko) 2014-02-19
UA110054C2 (uk) 2015-11-10
US20200385335A1 (en) 2020-12-10
NZ616274A (en) 2016-02-26
CN103796989A (zh) 2014-05-14
DOP2013000239A (es) 2014-01-15
TWI549933B (zh) 2016-09-21
TN2013000411A1 (en) 2015-03-30
PE20140630A1 (es) 2014-05-24
US8796335B2 (en) 2014-08-05
EP2697191B1 (de) 2015-11-18
SG10201602852WA (en) 2016-05-30
TW201302674A (zh) 2013-01-16
KR101944559B1 (ko) 2019-01-31
US20160264515A1 (en) 2016-09-15
US10023528B2 (en) 2018-07-17
US20130079412A1 (en) 2013-03-28
ECSP13012966A (es) 2013-11-29
ZA201308490B (en) 2015-08-26
BR112013026466A2 (pt) 2020-09-01
EA201301154A1 (ru) 2014-04-30
CA2832970A1 (en) 2012-10-18
PL2697191T3 (pl) 2016-04-29
MX337712B (es) 2016-03-15
SG193941A1 (en) 2013-11-29
US11377417B2 (en) 2022-07-05
RS54527B1 (sr) 2016-06-30
ES2561753T3 (es) 2016-02-29
CN103796989B (zh) 2017-03-01
GT201300243A (es) 2015-02-23
JP5911950B2 (ja) 2016-04-27
EP2697191A1 (de) 2014-02-19
MX2013011774A (es) 2013-11-01
WO2012139888A1 (de) 2012-10-18
MA35039B1 (fr) 2014-04-03
US20140309307A1 (en) 2014-10-16
ME02310B (me) 2016-06-20
HRP20160100T1 (hr) 2016-02-26
AR085586A1 (es) 2013-10-09
CA2832970C (en) 2019-06-04
US10259776B2 (en) 2019-04-16
EA023990B1 (ru) 2016-08-31
US20180282262A1 (en) 2018-10-04
PH12013502126A1 (en) 2014-01-13
MY173877A (en) 2020-02-26
AP2013007164A0 (en) 2013-10-31
JO3091B1 (ar) 2017-03-15
JP2014522383A (ja) 2014-09-04
CO6801742A2 (es) 2013-11-29
DK2697191T3 (en) 2016-02-15
SI2697191T1 (sl) 2016-03-31
CU24183B1 (es) 2016-07-29
IL228677A0 (en) 2013-12-31
AU2012242122A1 (en) 2013-10-24
AU2012242122B2 (en) 2017-06-01
HUE026859T2 (en) 2016-07-28
UY33970A (es) 2012-11-30
BR112013026466B1 (pt) 2022-05-10
CR20130524A (es) 2014-01-31
AP3482A (en) 2015-12-31
DE102011007272A1 (de) 2012-10-18
US20190185415A1 (en) 2019-06-20
CL2013002902A1 (es) 2014-02-14

Similar Documents

Publication Publication Date Title
CU20130137A7 (es) Derivados de ácido 3- fenilpropiónico ramificados y su uso
ECSP15001882A (es) Ácidos 5-aminotetrahidroquinolin-2-carboxílicos novedosos y su uso
UY33776A (es) Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su uso
UY32970A (es) Acidos 3-fenilpropionicos sustituidos y su uso
GT201200250A (es) Ariltriazolonas ligadas a bisarilo y su uso
CR20150370A (es) Compuestos antivirales
ECSP12012310A (es) 5-fluoro-1h-pirazolopiridinas sustituidas y su uso
CU20140025A7 (es) Pirimidinas anilladas sustituidas
MX2015006039A (es) Derivados de pirimidin-2, 4-diamina para el tratamiento de cancer.
BR112014013661A8 (pt) derivados de nucleosídeos 2’,4’-difluoro-2’-metil substituídos como inibidores de replicação de hcv-rna
GT201400178A (es) Compuestos de oxazolidin-2-ona y usos de los mismos como inhibidores de la pi3ks
UY31228A1 (es) Ariloxazoles sustituidos y su uso
CO7350620A2 (es) Nuevos derivados de piridina
MX2015003021A (es) Derivados de acido glicirretinico y metodos de uso de los mismos.
UY35276A (es) Nuevos compuestos que inhiben la actividad de Lp-PLA2
CR20140435A (es) Nuevos derivados de tienopirimidina, procesos para su preparacion y sus usos terapeuticos
MX2013007436A (es) Uso de estabilizadores de glutamina.
BR112015027164A2 (pt) novos compostos com tripla atividade de trombólise, antitrombótica e neutralização de radical, e sua síntese, nanoestrutura e uso
BR112013018738A2 (pt) novos derivados de tetrahidroquinolina
BR112015009988A2 (pt) melhoramentos em compostos orgânicos ou relativos
BR112014030992A2 (pt) composições compreendendo calcogenetos e métodos relacionados
AR095353A1 (es) Compuesto
CU20130078A7 (es) Ácidos 1-bencicloalquilcarboxílicos sustituidos y su uso
CR20120445A (es) Ariltriazolonas ligadas a bisarilo y su uso
CO6670570A2 (es) Pirimidinadas y tirazinas condensadas y su uso

Legal Events

Date Code Title Description
FG Grant of patent