BR112012017346A2 - "método para a produção enzimática de isoprenol usando mevalonato como um substrato" - Google Patents
"método para a produção enzimática de isoprenol usando mevalonato como um substrato"Info
- Publication number
- BR112012017346A2 BR112012017346A2 BR112012017346A BR112012017346A BR112012017346A2 BR 112012017346 A2 BR112012017346 A2 BR 112012017346A2 BR 112012017346 A BR112012017346 A BR 112012017346A BR 112012017346 A BR112012017346 A BR 112012017346A BR 112012017346 A2 BR112012017346 A2 BR 112012017346A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoprenol
- mevalonate
- substrate
- production
- converting
- Prior art date
Links
- CPJRRXSHAYUTGL-UHFFFAOYSA-N isopentenyl alcohol Chemical compound CC(=C)CCO CPJRRXSHAYUTGL-UHFFFAOYSA-N 0.000 title abstract 13
- 238000004519 manufacturing process Methods 0.000 title abstract 9
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 title abstract 7
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 5
- 239000000758 substrate Substances 0.000 title abstract 5
- 230000002255 enzymatic effect Effects 0.000 title abstract 3
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 abstract 4
- 238000006114 decarboxylation reaction Methods 0.000 abstract 4
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
patente de invenção: "método para a produção enzimática de isoprenol usando mevalonato como um substrato". a presente invenção refere-se a um método para a produção enzimática de isoprenol usando mevalonato como um substrato e convertendo-o enzimaticamente, através de uma etapa de descarboxilação, em isoprenol como também o uso de uma enzima que é capaz de catalisar a descarboxilação de mevalonato para a produção de isoprenol de mevalanato. além disso, é descrito o uso de mevalonato como um material de partida para a produção de isoprenol em uma reação enzimaticamente catalisada. é também descrito um método para a produção de isopreno compreendendo o método para a produção de isoprenol usando mevalonato como um substrato e enzimaticamente convertendo-o através de uma etapa de descarboxilação em isoprenol, e ainda compreendendo uma etapa de converter o isoprenol produzido em isopreno, como também um método para a produção de álcool isoamílico compreendendo o método paraa produção de isoprenol usando mevalonato como um substrato e enzimaticamente convertendo-o, através de uma etapa de descarboxilação, em isoprenol e ainda compreendendo uma etapa de converter o isoprenol produzido em álcool isoamílico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2009/067784 WO2011076261A1 (en) | 2009-12-22 | 2009-12-22 | Process for the production of isoprenol from mevalonate employing a diphosphomevalonate decarboxylase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012017346A2 true BR112012017346A2 (pt) | 2015-09-15 |
| BR112012017346A8 BR112012017346A8 (pt) | 2018-06-26 |
Family
ID=42830006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012017346A BR112012017346A8 (pt) | 2009-12-22 | 2009-12-22 | método para a produção enzimática de isoprenol usando mevalonato como um substrato |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9102952B2 (pt) |
| EP (1) | EP2516656B1 (pt) |
| CN (1) | CN102686734A (pt) |
| AU (1) | AU2009357243B2 (pt) |
| BR (1) | BR112012017346A8 (pt) |
| CA (1) | CA2785101C (pt) |
| DK (1) | DK2516656T3 (pt) |
| ES (1) | ES2478844T3 (pt) |
| IL (1) | IL220145A (pt) |
| PL (1) | PL2516656T3 (pt) |
| WO (1) | WO2011076261A1 (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009357243B2 (en) * | 2009-12-22 | 2014-07-03 | Global Bioenergies | Process for the production of isoprenol from mevalonate employing a diphosphomevalonate decarboxylase |
| US9422578B2 (en) | 2011-06-17 | 2016-08-23 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| WO2012174439A2 (en) | 2011-06-17 | 2012-12-20 | Invista Technologies S.A R.L. | Methods of producing four carbon molecules |
| JP6231011B2 (ja) * | 2011-12-20 | 2017-11-15 | サイエンティスト・オブ・フォーチュン・ソシエテ・アノニム | ３−ヒドロキシアルク−４−エノエートおよび／または３−ホスホノキシアルク−４−エノエートの酵素変換による１，３−ジエンの産生 |
| CA2867980A1 (en) * | 2012-04-05 | 2013-10-10 | Global Bioenergies | Method for the enzymatic production of isoprenol using mevalonate as a substrate |
| US20130323820A1 (en) | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
| BR112015009078A2 (pt) * | 2012-10-25 | 2017-07-04 | Global Bioenergies | produção de alcenos a partir de ácidos 3-hidroxi-1- carboxilícos via ácidos 3-sulfoniloxi - 1 - carboxílicos. |
| EP2925871A1 (en) | 2012-11-28 | 2015-10-07 | Invista Technologies S.A R.L. | Methods for biosynthesis of isobutene |
| US20150329877A1 (en) | 2012-12-07 | 2015-11-19 | Global Bioenergies | Fermentation method |
| DK3019604T3 (da) | 2013-07-09 | 2020-10-26 | Global Bioenergies | Mevalonat-diphosphat-dicarboxylase-varianter |
| US10294496B2 (en) | 2013-07-19 | 2019-05-21 | Invista North America S.A.R.L. | Methods for biosynthesizing 1,3 butadiene |
| WO2015021045A2 (en) | 2013-08-05 | 2015-02-12 | INVISTA North America S.á r.l. | Methods for biosynthesis of isoprene |
| BR112016002626A2 (pt) | 2013-08-05 | 2017-09-12 | Invista Tech Sarl | método para sintetizar isobuteno e hospedeiro recombinante |
| US9938543B2 (en) | 2014-06-16 | 2018-04-10 | Invista North America S.A.R.L. | Methods, reagents and cells for biosynthesizing glutarate methyl ester |
| US10941423B2 (en) | 2015-06-26 | 2021-03-09 | Global Bioenergies | Method for the production of isoamyl alcohol |
| CN109715815B (zh) * | 2016-09-28 | 2022-11-29 | 国立研究开发法人理化学研究所 | 二磷酸甲羟戊酸脱羧酶变异体、和利用了该变异体的烯烃化合物的制造方法 |
| US11162115B2 (en) | 2017-06-30 | 2021-11-02 | Inv Nylon Chemicals Americas, Llc | Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons |
| US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
| US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
| WO2021211862A1 (en) * | 2020-04-15 | 2021-10-21 | University of Alaska Anchorage | Methods and compositions for the production of isobutene |
| AU2022334334A1 (en) * | 2021-08-24 | 2024-02-22 | Lanzatech, Inc. | Microbial fermentation for the production of isoprenoid alcohols and derivatives |
| WO2023151894A1 (en) | 2022-02-11 | 2023-08-17 | Henkel Ag & Co. Kgaa | Process for the synthesis of alpha-methylene-gamma-butyrolactone |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1354955A4 (en) * | 2000-12-28 | 2005-01-05 | Toyota Motor Co Ltd | PROCESS FOR PREPARING PRENYL ALCOHOL |
| EP1392824B1 (en) * | 2001-06-06 | 2008-08-20 | DSM IP Assets B.V. | Improved isoprenoid production |
| US7854774B2 (en) | 2006-05-26 | 2010-12-21 | Amyris Biotechnologies, Inc. | Fuel components, fuel compositions and methods of making and using same |
| DK2235190T3 (en) | 2007-12-13 | 2018-07-23 | Danisco Us Inc | COMPOSITIONS AND PROCEDURES FOR PRODUCING ISOPRENE |
| AU2009357243B2 (en) * | 2009-12-22 | 2014-07-03 | Global Bioenergies | Process for the production of isoprenol from mevalonate employing a diphosphomevalonate decarboxylase |
-
2009
- 2009-12-22 AU AU2009357243A patent/AU2009357243B2/en not_active Ceased
- 2009-12-22 WO PCT/EP2009/067784 patent/WO2011076261A1/en not_active Ceased
- 2009-12-22 US US13/518,146 patent/US9102952B2/en not_active Expired - Fee Related
- 2009-12-22 ES ES09799636.7T patent/ES2478844T3/es active Active
- 2009-12-22 EP EP09799636.7A patent/EP2516656B1/en active Active
- 2009-12-22 CN CN2009801631111A patent/CN102686734A/zh active Pending
- 2009-12-22 DK DK09799636.7T patent/DK2516656T3/da active
- 2009-12-22 BR BR112012017346A patent/BR112012017346A8/pt not_active IP Right Cessation
- 2009-12-22 PL PL09799636T patent/PL2516656T3/pl unknown
- 2009-12-22 CA CA2785101A patent/CA2785101C/en not_active Expired - Fee Related
-
2012
- 2012-06-04 IL IL220145A patent/IL220145A/en active IP Right Grant
-
2015
- 2015-07-07 US US14/792,669 patent/US9752163B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK2516656T3 (da) | 2014-07-21 |
| US20150376653A1 (en) | 2015-12-31 |
| IL220145A (en) | 2015-06-30 |
| US20130052706A1 (en) | 2013-02-28 |
| HK1175815A1 (en) | 2013-07-12 |
| CA2785101C (en) | 2017-06-20 |
| EP2516656B1 (en) | 2014-06-04 |
| PL2516656T3 (pl) | 2014-10-31 |
| ES2478844T3 (es) | 2014-07-23 |
| CN102686734A (zh) | 2012-09-19 |
| US9752163B2 (en) | 2017-09-05 |
| AU2009357243A1 (en) | 2012-06-21 |
| CA2785101A1 (en) | 2011-06-30 |
| WO2011076261A1 (en) | 2011-06-30 |
| EP2516656A1 (en) | 2012-10-31 |
| IL220145A0 (en) | 2012-07-31 |
| BR112012017346A8 (pt) | 2018-06-26 |
| AU2009357243B2 (en) | 2014-07-03 |
| US9102952B2 (en) | 2015-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2545 DE 15-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |