BR112012018376A2 - "sistema e método para filtração de partículas" - Google Patents

"sistema e método para filtração de partículas"

Info

Publication number
BR112012018376A2
BR112012018376A2 BR112012018376A BR112012018376A BR112012018376A2 BR 112012018376 A2 BR112012018376 A2 BR 112012018376A2 BR 112012018376 A BR112012018376 A BR 112012018376A BR 112012018376 A BR112012018376 A BR 112012018376A BR 112012018376 A2 BR112012018376 A2 BR 112012018376A2
Authority
BR
Brazil
Prior art keywords
filtration
filtration system
particle filtration
particulate
particle
Prior art date
Application number
BR112012018376A
Other languages
English (en)
Inventor
Huang Lotien
Original Assignee
Cytovera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytovera Inc filed Critical Cytovera Inc
Publication of BR112012018376A2 publication Critical patent/BR112012018376A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/50—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D29/00—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor
    • B01D29/01—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements
    • B01D29/03—Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups B01D24/00 - B01D27/00; Filtering elements therefor with flat filtering elements self-supporting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1029—Particle size

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Computer Hardware Design (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Filtering Materials (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • External Artificial Organs (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)

Abstract

sistema e método para filtração de partículas. modalidades da presente divulgação apresentam um sistema de filtração compreendendo um módulo de filtração para filtração de partículas e métodos de usar o dispositivo para o isolamento de partículas (por exemplo, células viáveis). vantajosamente, modalidades do dispositivo fornecem filtração de alta taxa de transferência de grandes volumes de amostra, embora preservando a viabilidade celular e proporcionando altos rendimentos.
BR112012018376A 2009-12-23 2010-12-22 "sistema e método para filtração de partículas" BR112012018376A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28973009P 2009-12-23 2009-12-23
US29461110P 2010-01-13 2010-01-13
PCT/US2010/061866 WO2011079217A1 (en) 2009-12-23 2010-12-22 A system and method for particle filtration

Publications (1)

Publication Number Publication Date
BR112012018376A2 true BR112012018376A2 (pt) 2017-10-10

Family

ID=44196143

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012018376A BR112012018376A2 (pt) 2009-12-23 2010-12-22 "sistema e método para filtração de partículas"

Country Status (16)

Country Link
US (2) US8679751B2 (pt)
EP (1) EP2516320A4 (pt)
JP (2) JP5624629B2 (pt)
KR (1) KR101443133B1 (pt)
CN (1) CN102791616B (pt)
AU (1) AU2010336424B2 (pt)
BR (1) BR112012018376A2 (pt)
CA (1) CA2785390C (pt)
CR (1) CR20120391A (pt)
DO (1) DOP2012000181A (pt)
IL (1) IL220274A (pt)
MX (1) MX344460B (pt)
RU (1) RU2539989C2 (pt)
SG (1) SG181676A1 (pt)
TW (1) TWI566793B (pt)
WO (1) WO2011079217A1 (pt)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2086573B1 (en) 2006-10-09 2020-11-25 Neurofluidics, Inc. Cerebrospinal fluid purification system
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
MX344460B (es) 2009-12-23 2016-12-14 Cytovera Inc * Sistema y método para la filtración de partículas.
ITTO20100068U1 (it) * 2010-04-20 2011-10-21 Eltek Spa Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici
WO2013070899A1 (en) 2011-11-08 2013-05-16 Auxocell Laboratories, Inc. Systems and methods for processing cells
EP2788008A4 (en) 2011-12-07 2015-08-26 Cytovera Inc PROCESS AND DEVICE FOR SAMPLE PROCESSING
JP5963159B2 (ja) * 2012-01-05 2016-08-03 日立化成株式会社 細胞捕捉デバイス
DE102012103256A1 (de) * 2012-04-16 2013-10-17 Karlsruher Institut für Technologie Mikrostrukturapparat mit optischer Oberflächengüte sowie Verfahren zur Herstellung desselben
EP2677024B1 (de) 2012-06-22 2019-11-20 Human Med AG Vorrichtung zum Separieren von adulten Stammzellen
KR101303059B1 (ko) * 2012-06-28 2013-09-03 포항공과대학교 산학협력단 물과 기름을 선택적으로 분리할 수 있는 극친수성 여과 구조물
DE102012220250A1 (de) * 2012-11-07 2014-05-08 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Fluidikmodul für eine zentrifugale filtration und verfahren zum filtern einer probe
US9386948B2 (en) 2012-12-05 2016-07-12 Theranos, Inc. Systems, devices, and methods for bodily fluid sample transport
US10248765B1 (en) 2012-12-05 2019-04-02 Theranos Ip Company, Llc Systems, devices, and methods for bodily fluid sample collection, transport, and handling
WO2014113598A2 (en) * 2013-01-16 2014-07-24 The Regents Of The University Of California Microfluidic devices to extract, concentrate and isolate molecules
US9862987B2 (en) 2013-01-16 2018-01-09 The Regents Of The University Of California Label free molecular detection methods, systems and devices
US10082452B2 (en) 2013-02-05 2018-09-25 Pocared Diagnostics Ltd. Filter arrangement and method for using the same
US11493428B2 (en) 2013-03-15 2022-11-08 Gpb Scientific, Inc. On-chip microfluidic processing of particles
US20150064153A1 (en) * 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
EP3608022A1 (en) 2013-03-15 2020-02-12 The Trustees of Princeton University Methods and devices for high throughput purification
US20150273467A1 (en) * 2013-03-15 2015-10-01 Theranos, Inc. Methods and devices for sample collection and sample separation
US12590955B2 (en) 2013-03-15 2026-03-31 Zeon Corporation Methods and systems for processing particles
US20140342375A1 (en) * 2013-03-15 2014-11-20 University Of Maryland Microfluidic processing of leukocytes for molecular diagnostic testing
EP2972184A4 (en) 2013-03-15 2016-11-30 Theranos Inc Methods and devices for sample collection and sample separation
CN103190245B (zh) * 2013-04-01 2015-01-07 中国水产科学研究院黑龙江水产研究所 冰下着生藻类的采集装置及其方法
KR102243597B1 (ko) * 2013-08-16 2021-04-26 메사추세츠 인스티튜트 오브 테크놀로지 세포로의 선택적 물질 전달
ES2663225T3 (es) * 2013-09-30 2018-04-11 Westfälische Wilhelms-Universität Münster Método de enriquecimiento o aislamiento de una población de células diana
NO342032B1 (no) * 2013-10-25 2018-03-12 Trilobite Innovation As Fluidraffineringsanordning og -sammenstilling
GB201319139D0 (en) * 2013-10-30 2013-12-11 Exmoor Pharma Concepts Ltd Apparatus and method for filtration of a suspension
CA2931609A1 (en) 2013-12-04 2015-06-11 Pocared Diagnostics Ltd. Filter arrangement with slider valve and method for using the same
US20150166956A1 (en) 2013-12-16 2015-06-18 General Electric Company Devices for separation of particulates, associated methods and systems
BR112016016780A2 (pt) * 2014-01-20 2017-08-08 Halcyon Biomedical Incorporated Separação passiva de sangue total
US10518196B2 (en) 2014-01-29 2019-12-31 General Electric Company Devices for separation of particulates, associated methods and systems
ES2754326T3 (es) * 2014-01-31 2020-04-17 Dsm Ip Assets Bv Centrifugadora de tejido adiposo y procedimiento de uso
CN113796860A (zh) * 2014-03-05 2021-12-17 赛拉诺斯知识产权有限责任公司 用于样品收集和样品分离的方法和装置
US9796166B2 (en) 2014-03-24 2017-10-24 Fenwal, Inc. Flexible biological fluid filters
US10159778B2 (en) 2014-03-24 2018-12-25 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US10376627B2 (en) 2014-03-24 2019-08-13 Fenwal, Inc. Flexible biological fluid filters
US9782707B2 (en) 2014-03-24 2017-10-10 Fenwal, Inc. Biological fluid filters having flexible walls and methods for making such filters
US9968738B2 (en) 2014-03-24 2018-05-15 Fenwal, Inc. Biological fluid filters with molded frame and methods for making such filters
CN106536056B (zh) * 2014-06-13 2021-07-16 儿童医学中心公司 分离线粒体的产品和方法
US9993748B2 (en) 2014-08-11 2018-06-12 Auxocell Laboratories, Inc. Centrifuge clip and method
USD748462S1 (en) 2014-08-11 2016-02-02 Auxocell Laboratories, Inc. Centrifuge clip
JP6509330B2 (ja) * 2014-09-05 2019-05-08 イマジン ティーエフ，エルエルシー 微細構造分離フィルタ
US10124275B2 (en) * 2014-09-05 2018-11-13 Imagine Tf, Llc Microstructure separation filters
EP3209766A4 (en) 2014-10-20 2018-08-15 University of Utah Research Foundation Tissue sample processing system and associated methods
KR20170074235A (ko) 2014-10-31 2017-06-29 메사추세츠 인스티튜트 오브 테크놀로지 면역 세포로의 생체분자의 전달
CA2966623C (en) * 2014-11-03 2024-02-20 The General Hospital Corporation Concentrating particles in a microfluidic device
EP3048163B1 (en) 2014-11-20 2020-04-08 UNIST (Ulsan National Institute of Science and Technology) Particle filtering device and particle filtering method
KR101776245B1 (ko) 2014-11-20 2017-09-11 울산과학기술원 입자 여과 장치 및 입자 여과 방법
JP6382699B2 (ja) * 2014-11-28 2018-08-29 株式会社東芝 マイクロ分析チップ
CN107250373A (zh) 2015-01-12 2017-10-13 麻省理工学院 通过微流体递送实现的基因编辑
GB2534182A (en) 2015-01-15 2016-07-20 Univ Dublin City Microfluidic device
CN104549588B (zh) * 2015-01-20 2016-04-06 重庆科技学院 一种多级微球筛选芯片及使用方法
WO2016145198A1 (en) * 2015-03-10 2016-09-15 Viatar LLC Systems, methods, and devices for removing circulating tumor cells from blood
US9868659B2 (en) 2015-04-17 2018-01-16 General Electric Company Subsurface water purification method
CN209221880U (zh) 2015-06-08 2019-08-09 贝克顿·迪金森公司 用于生物样品的过滤单元
US20160367918A1 (en) * 2015-06-22 2016-12-22 Fuji Electric Co., Ltd. Filter system
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
AU2016289530B2 (en) 2015-07-09 2021-05-06 Massachusetts Institute Of Technology Delivery of materials to anucleate cells
US10371606B2 (en) 2015-07-21 2019-08-06 Theraos IP Company, LLC Bodily fluid sample collection and transport
CN108367102B (zh) 2015-08-05 2021-04-30 米奈特朗尼克斯有限公司 用于来自生物流体的物料的过滤的切向流过滤器系统
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
EP3344575B1 (en) 2015-09-04 2020-04-15 SQZ Biotechnologies Company Intracellular delivery of biomolecules to cells comprising a cell wall
WO2017044888A1 (en) 2015-09-09 2017-03-16 Theranos, Inc. Methods and devices for sample collection and sample separation
CN105203375B (zh) * 2015-09-16 2018-05-22 北京大学 一种高通量的血浆分离器件及其制备方法
KR101891890B1 (ko) * 2015-10-23 2018-08-28 울산과학기술원 원심력 기반 나노 입자 분리장치 및 이를 이용한 나노 입자 분리방법
US20180318735A1 (en) * 2015-11-05 2018-11-08 Abi Micro Filters Multi-layered water purifying device for the protection of the washing machine and dish washer
EP3842080B1 (en) 2015-12-04 2023-04-12 Minnetronix Inc. Systems for the conditioning of cerebrospinal fluid
KR101791671B1 (ko) * 2015-12-31 2017-11-20 주식회사 큐리오시스 미세입자 분리 및 정렬 장치, 및 그 방법
WO2017124037A1 (en) 2016-01-15 2017-07-20 The Children's Medical Center Corporation Therapeutic use of mitochondria and combined mitochondrial agents
AU2017227802B2 (en) 2016-03-02 2020-11-12 Becton, Dickinson And Company Biological fluid separation device
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
WO2017182776A1 (en) * 2016-04-18 2017-10-26 Momentum Bioscience Limited Filter arrangement
WO2017188962A1 (en) * 2016-04-28 2017-11-02 Hewlett-Packard Development Company, L.P. Microfluidic filtering
CA3023092A1 (en) 2016-05-03 2017-11-09 Sqz Biotechnologies Company Intracellular delivery of biomolecules to induce tolerance
AU2017259988B2 (en) * 2016-05-03 2023-04-27 Sqz Biotechnologies Company Intracellular delivery of biomolecules to induce tolerance
JP6933212B2 (ja) * 2016-06-20 2021-09-08 凸版印刷株式会社 液体媒体の置換方法及び該方法のための流路デバイス
KR101711792B1 (ko) * 2016-06-27 2017-03-06 한국기계연구원 고속처리 미세유체소자
WO2018003476A1 (ja) * 2016-06-30 2018-01-04 富士フイルム株式会社 細胞懸濁液の膜分離方法及び細胞培養装置
WO2018013135A1 (en) * 2016-07-15 2018-01-18 Hewlett-Packard Development Company, L.P. Microfluidic filtering system
CN109475868B (zh) * 2016-07-21 2021-08-17 新加坡科技研究局 用于高体积分数颗粒微滤的外壁聚焦的设备及其制造方法
EP3301445B1 (en) 2016-09-30 2020-03-18 ARKRAY, Inc. Method for magnetically labeling particles
IT201600104612A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Sistema microfluidico e metodo per l'isolamento di particelle
IT201600104645A1 (it) * 2016-10-18 2018-04-18 Menarini Silicon Biosystems Spa Dispositivo microfluidico e metodo per l'isolamento di particelle
SG11201903247VA (en) * 2016-10-18 2019-05-30 Menarini Silicon Biosystems Spa Microfluidic device, microfluidic system and method for the isolation of particles
US10471425B2 (en) * 2017-02-16 2019-11-12 International Business Machines Corporation Automated machine for sorting of biological fluids
US11857966B1 (en) 2017-03-15 2024-01-02 Labrador Diagnostics Llc Methods and devices for sample collection and sample separation
WO2018183744A1 (en) 2017-03-29 2018-10-04 The Research Foundation For The State University Of New York Microfluidic device and methods
CN110785649A (zh) * 2017-06-26 2020-02-11 埃斯特万·门多萨 样本过滤装置
TWI671397B (zh) * 2017-07-14 2019-09-11 國立中興大學 粒線體萃取裝置
CN107523481B (zh) * 2017-08-17 2020-11-13 北京旌准医疗科技有限公司 一种基于微流控芯片的微纳生物粒子分选设备
CN111065399B (zh) 2017-09-01 2023-11-28 Gpb科学有限公司 使用微流体制备治疗活性细胞的方法
EP3700505A4 (en) 2017-10-26 2021-01-06 Repligen Corporation MICRO-ALTERNATIVE TANGENTIAL FLOW INFUSION FILTER, PROCESSING CONTAINER, AND METHODS OF USE THEREOF
US11524293B2 (en) * 2018-01-17 2022-12-13 Sartorius Stedim North America Inc. Cell separation device, method and system
KR102056938B1 (ko) * 2018-01-26 2019-12-17 (주)메타포어 매트릭스 구조를 가진 멤브레인 구조체 및 이를 이용한 생체분자 필터
US11946029B2 (en) * 2018-02-16 2024-04-02 Astrego Diagnostics Ab Microfluidic device
AU2019234549B2 (en) 2018-03-12 2026-02-12 Sqz Biotechnologies Company Methods for treating HPV-associated diseases
CN108949522B (zh) * 2018-07-19 2022-02-08 重庆医科大学附属第三医院(捷尔医院） 整形美容用自体脂肪活性细胞过滤装置
DE102018212930B3 (de) * 2018-08-02 2019-11-07 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zum Leiten einer Flüssigkeit durch ein poröses Medium
US12172108B2 (en) 2018-08-16 2024-12-24 Emd Millipore Corporation Closed bioprocessing device
CA3126717A1 (en) * 2019-01-25 2020-07-30 Becton, Dickinson And Company Methods and apparatus to selectively extract constituents from biological samples
CA3131701A1 (en) 2019-02-28 2020-09-03 Sqz Biotechnologies Company Delivery of biomolecules to pbmcs to modify an immune response
US11504713B2 (en) 2019-03-11 2022-11-22 Genzyme Corporation Tangential viral filtration
KR20210149791A (ko) 2019-04-08 2021-12-09 에스큐지 바이오테크놀로지스 컴퍼니 페이로드를 세포 내로 전달하기 위한 시스템에서 이용하기 위한 카트리지
GB2580723A (en) * 2019-05-02 2020-07-29 Renishaw Plc Powder handling apparatus
CN114599781B (zh) * 2019-06-17 2025-12-16 佐治亚技术研究公司 用于分离聚团颗粒的过滤基系统和方法
CN110160942B (zh) * 2019-07-01 2022-03-29 重庆交通大学 一种河流水域鱼卵监测装置
WO2021049163A1 (ja) * 2019-09-09 2021-03-18 株式会社村田製作所 濃縮装置及び濃縮方法
CN110608989B (zh) * 2019-10-11 2021-12-21 西安石油大学 一种纳米尺度聚合物微球在中高渗油藏适用性的筛选方法
KR20210053010A (ko) * 2019-11-01 2021-05-11 주식회사라이브셀인스트루먼트 세포 분주 및 배양용 디스크, 실시간 모니터링 시스템 및 세포 분주 및 배양 방법
CN115243713A (zh) * 2020-03-05 2022-10-25 埃克苏马生物技术公司 用于递送修饰的淋巴细胞聚集体的方法和组合物
CN112304827B (zh) * 2020-04-07 2024-02-02 中国石油天然气股份有限公司 油田产出液中聚合物微球含量获取方法及装置
WO2022079494A2 (en) * 2020-10-15 2022-04-21 Sartorius Stedim Biotech Gmbh Channel designs and components
JP7682619B2 (ja) * 2020-10-19 2025-05-26 キヤノンメディカルシステムズ株式会社 誘導多能性幹細胞樹立装置及び方法
RU2757639C1 (ru) * 2021-02-12 2021-10-19 Общество с ограниченной ответственностью «ЭНЕРДЖИН» Способ выделения опухолевых клеток из периферической крови
JP7696441B2 (ja) * 2021-04-01 2025-06-20 エックスキャス， インコーポレイテッド ガイドワイヤ制御装置カセットおよびその使用方法
EP4351972A4 (en) * 2021-06-07 2025-04-30 Plexium, Inc. Transfer dispenser for test devices with bead size exclusion
CN117460670A (zh) * 2021-06-07 2024-01-26 普莱克斯姆公司 具有珠大小排除的用于测定装置的转移分配器
DE102021208831A1 (de) * 2021-08-12 2023-02-16 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung und Verfahren zu ihrem Betrieb
US20230139871A1 (en) * 2021-11-02 2023-05-04 Terumo Bct, Inc. Systems and Methods For Using Microfluidic Devices With Apheresis Systems
US12487229B2 (en) * 2021-12-08 2025-12-02 Western Digital Technologies, Inc. Devices, systems, and methods of using smart fluids to control molecule speeds
US11892445B2 (en) 2021-12-08 2024-02-06 Western Digital Technologies, Inc. Devices, systems, and methods of using smart fluids to control translocation speed through a nanopore
JP2024013994A (ja) * 2022-07-21 2024-02-01 株式会社Ｓｃｒｅｅｎホールディングス 流路チップ
US11821828B1 (en) * 2022-12-20 2023-11-21 Kuwait University System and method for determining physical stability of dispersed particles in flowing liquid suspensions
US12461064B2 (en) 2023-06-23 2025-11-04 Western Digital Technologies, Inc. Magnetic control of molecule translocation speed through a nanopore
WO2025019580A1 (en) * 2023-07-18 2025-01-23 Portal Biotechnologies, Inc. Centrifuge devices and methods for intracellular delivery
EP4574969A1 (en) * 2023-12-22 2025-06-25 Sartorius Stedim Biotech GmbH A method of producing differentiated cells from pluripotent stem cells, cell populations obtained by the method, corresponding pharmaceutical compositions and a system for producing differentiated cells from pluripotent stem cells
WO2025247997A1 (en) * 2024-05-29 2025-12-04 Sartorius Stedim FMT S.A.S. Fluidic modules comprising membranes and associated methods
CN118636420B (zh) * 2024-06-18 2025-02-25 东莞市睿欣环保材料有限公司 一种环保哑光触感膜及其生产方法
CN118914015B (zh) * 2024-07-30 2025-09-09 中国石油大学(北京) 一种分散体系在多孔介质中孔隙尺寸下滞留率的测定方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4422939A (en) 1979-11-07 1983-12-27 Texas Medical Products, Inc. Blood and perfusate filter
DE3546091A1 (de) 1985-12-24 1987-07-02 Kernforschungsz Karlsruhe Querstrom-mikrofilter
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US5601711A (en) 1994-10-31 1997-02-11 Gelman Sciences Inc. Selective separation filter device
US5715946A (en) 1995-06-07 1998-02-10 Reichenbach; Steven H. Method and apparatus for sorting particles suspended in a fluid
US6635430B1 (en) * 1999-07-16 2003-10-21 Dupont Pharmaceuticals Company Filtrate plate device and reversible-well plate device
CN2411833Y (zh) * 2000-03-31 2000-12-27 新汶矿业集团有限责任公司莱芜医院 简易液体过滤器
WO2002050095A1 (en) 2000-12-18 2002-06-27 Trustees Of Princeton University Fractionation of macro-molecules using asymmetric pulsed field electrophoresis
US7597791B2 (en) 2001-10-19 2009-10-06 The Trustees Of Princeton University Method and apparatus for generating electric fields and flow distributions for rapidly separating molecules
JP2004042012A (ja) * 2001-10-26 2004-02-12 Nec Corp 分離装置、分析システム、分離方法および分離装置の製造方法
WO2003066191A1 (en) 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7455770B2 (en) 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
EP2359689B1 (en) * 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
EP1585583B1 (en) 2002-10-23 2010-04-07 The Trustees of Princeton University Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
JP2004228382A (ja) 2003-01-23 2004-08-12 Nikon Corp 露光装置
DE10313201A1 (de) * 2003-03-21 2004-10-07 Steag Microparts Gmbh Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit, die Partikel enthält
US7291450B2 (en) * 2003-03-28 2007-11-06 Smith & Nephew, Inc. Preparation of a cell concentrate from a physiological solution
EP1636564A1 (en) 2003-06-13 2006-03-22 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
JP2005007352A (ja) 2003-06-20 2005-01-13 Sharp Corp 粒子の分離方法及び分離装置並びに検出装置
US20060046305A1 (en) * 2003-10-15 2006-03-02 National University Of Singapore Method and apparatus for detecting analyte with filter
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
JP2005205387A (ja) 2004-01-24 2005-08-04 Minoru Seki 連続粒子分級方法
US7575681B2 (en) * 2004-07-06 2009-08-18 Schlumberger Technology Corporation Microfluidic separator
US20060204400A1 (en) 2004-11-24 2006-09-14 Christoph Blattert Process for separation of dispersions and an apparatus
JP2006263693A (ja) 2005-03-22 2006-10-05 Minoru Seki 微粒子の連続分離機構及び装置
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
JPWO2006123664A1 (ja) 2005-05-17 2008-12-25 旭硝子株式会社 硬化性組成物、および新規なアダマンタン化合物
JP2007021465A (ja) 2005-07-12 2007-02-01 Minoru Seki 粒子を連続的に濃縮・分離するための流路構造および方法
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
JP2007175684A (ja) 2005-12-26 2007-07-12 Minoru Seki 微粒子の濃縮・分級のための流路構造および方法
US7735652B2 (en) 2006-06-01 2010-06-15 The Trustees Of Princeton University Apparatus and method for continuous particle separation
WO2008024070A1 (en) * 2006-08-22 2008-02-28 Agency For Science, Technology And Research Microfluidic filtration unit, device and methods thereof
US7718420B2 (en) 2006-10-10 2010-05-18 Postech Academy-Industry Foundation Microfluidic biochip for blood typing based on agglutination reaction
KR100843339B1 (ko) 2006-12-07 2008-07-03 한국전자통신연구원 혈액 중의 혈장 분리를 위하여 마이크로채널을 이용한혈장분리기 및 이에 의한 혈장분리방법
US20080290037A1 (en) * 2007-05-23 2008-11-27 Applera Corporation Methods and Apparatuses for Separating Biological Particles
FR2931085B1 (fr) * 2008-05-13 2011-05-27 Commissariat Energie Atomique Procede de tri de particules ou d'amas de particules dans un fluide circulant dans un canal
RU87084U1 (ru) * 2009-06-16 2009-09-27 Закрытое акционерное общество Научно-производственный комплекс "КБ ВЗЛЕТ" Фильтр для вакуумируемого кардиотомического резервуара
MX344460B (es) 2009-12-23 2016-12-14 Cytovera Inc * Sistema y método para la filtración de partículas.

Also Published As

Publication number Publication date
WO2011079217A1 (en) 2011-06-30
TWI566793B (zh) 2017-01-21
JP2013515599A (ja) 2013-05-09
JP5624629B2 (ja) 2014-11-12
TW201132371A (en) 2011-10-01
CR20120391A (es) 2012-11-21
US20120258459A1 (en) 2012-10-11
US9174212B2 (en) 2015-11-03
IL220274A (en) 2016-10-31
KR101443133B1 (ko) 2014-11-03
CN102791616A (zh) 2012-11-21
EP2516320A4 (en) 2015-03-04
IL220274A0 (en) 2012-07-31
CA2785390A1 (en) 2011-06-30
CN102791616B (zh) 2015-07-29
MX344460B (es) 2016-12-14
SG181676A1 (en) 2012-07-30
AU2010336424B2 (en) 2013-06-13
AU2010336424A1 (en) 2012-08-02
DOP2012000181A (es) 2012-12-15
EP2516320A1 (en) 2012-10-31
JP2015062414A (ja) 2015-04-09
RU2539989C2 (ru) 2015-01-27
RU2012131424A (ru) 2014-01-27
MX2012007372A (es) 2012-10-05
KR20120117834A (ko) 2012-10-24
US20140190903A1 (en) 2014-07-10
US8679751B2 (en) 2014-03-25
CA2785390C (en) 2016-02-09

Similar Documents

Publication Publication Date Title
BR112012018376A2 (pt) "sistema e método para filtração de partículas"
WO2010104856A3 (en) Devices and methods for contactless dielectrophoresis for cell or particle manipulation
WO2012122314A3 (en) Rapid cell purification systems
WO2011116922A9 (de) Thermoresponsives substrat mit mikrogelen, verfahren zu dessen herstellung und kultivierungsverfahren für biologische zellen
WO2011094572A3 (en) Hanging drop devices, systems and/or methods
WO2014152048A3 (en) Assemblies and methods for reducing optical crosstalk in particle processing systems
DK2499236T3 (da) Dyrkningsmedier, cellekulturer og metoder til dyrkning af pluripotente stamceller i en udifferentieret tilstand
WO2009117611A3 (en) Trapping magnetic cell sorting system
WO2011047103A3 (en) Cell reprogramming with applications for epigenetic and non-epigenetic base induced pluripotent stem cell derivation
WO2011108909A3 (en) Method and kit for isolating target cell
WO2007038478A3 (en) Cassette containing growth medium
WO2010048417A3 (en) Perfusion bioreactors, cell culture systems, and methods for production of cells and cell-derived products
HK1218310A1 (zh) 鉴定细胞群体、特别是间充质干细胞群体的多色流式细胞术方法
WO2014117021A3 (en) Methods, compositions, kits, and systems for selective enrichment of target cells
WO2009086319A3 (en) Specimen mount for microscopy
WO2012065004A3 (en) Methods and systems for predicting whether a subject has a cervical intraepithelial neoplasia (cin) lesion from a suspension sample of cervical cells
ES2479542T1 (es) Métodos y composiciones para su uso en terapias celulares
WO2011088014A3 (en) Systems and methods for counting cells and biomolecules
WO2012009682A3 (en) Elastic substrates and methods of use in cell manipulation and culture
EP2796854A3 (en) Micro-lens systems for particle processing systems
WO2012037061A3 (en) Handheld low pressure mechanical cell lysis device with single cell resolution
WO2009016078A3 (en) Method for culturing mammalian stem cells
WO2011047058A3 (en) Assay for the prediction of therapeutic effectiveness of mesenchymal stromal cells, and methods of using same
ATE526583T1 (de) Immunomagnetische erfassung und abbildung biologischer zielmoleküle
WO2012024546A3 (en) Incorporation of health measurments in analysis and interpretation of functional biological response data

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]