BR112012021202A2 - aparelho e metodos para preparacao, reacao e deteccao integradas de amostras - Google Patents

aparelho e metodos para preparacao, reacao e deteccao integradas de amostras

Info

Publication number
BR112012021202A2
BR112012021202A2 BR112012021202A BR112012021202A BR112012021202A2 BR 112012021202 A2 BR112012021202 A2 BR 112012021202A2 BR 112012021202 A BR112012021202 A BR 112012021202A BR 112012021202 A BR112012021202 A BR 112012021202A BR 112012021202 A2 BR112012021202 A2 BR 112012021202A2
Authority
BR
Brazil
Prior art keywords
sample
reaction
detection
methods
nucleic acid
Prior art date
Application number
BR112012021202A
Other languages
English (en)
Other versions
BR112012021202B1 (pt
Inventor
Bruce A Johnson
Bruce Richardson
Dylan Hilmer Bird
Jesus Ching
Keith E Moravick
Original Assignee
Genturadx Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genturadx Usa Inc filed Critical Genturadx Usa Inc
Publication of BR112012021202A2 publication Critical patent/BR112012021202A2/pt
Publication of BR112012021202B1 publication Critical patent/BR112012021202B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/24—Apparatus for enzymology or microbiology tube or bottle type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
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    • B01F25/60—Pump mixers, i.e. mixing within a pump
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
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    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
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    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
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Abstract

aparelho e métodos para preparação, reação e detecção integradas de amostras. trata-se de cartuchos para o isolamento de uma amostra biológica e ensaios biológicos a jusante na amostra. em uma modalidade, uma amostra de ácido nucléico é isolada de uma amostra biológica e a amostra de ácido nucléico é amplificada, por exemplo, através da reação em cadeia da polimerase. os cartuchos aqui proprocionados também podem ser usados para isolar amostras de não-ácido nucléico, por exemplo, proteínas, ensaios de ligação. proporcionam-se, também, instrumentos para realiza ensaios biológicos a jusante e detectar os resultados dos ensaios.
BR112012021202A 2010-02-23 2011-02-23 aparelho e métodos para preparação, reação e detecção integradas de amostras BR112012021202B1 (pt)

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