BR112014032017A2 - dispersão sólida, dispersão sólida extrudada e processo para produzir uma dispersão sólida - Google Patents

dispersão sólida, dispersão sólida extrudada e processo para produzir uma dispersão sólida

Info

Publication number
BR112014032017A2
BR112014032017A2 BR112014032017A BR112014032017A BR112014032017A2 BR 112014032017 A2 BR112014032017 A2 BR 112014032017A2 BR 112014032017 A BR112014032017 A BR 112014032017A BR 112014032017 A BR112014032017 A BR 112014032017A BR 112014032017 A2 BR112014032017 A2 BR 112014032017A2
Authority
BR
Brazil
Prior art keywords
solid dispersion
producing
extruded
substitution
dispersion
Prior art date
Application number
BR112014032017A
Other languages
English (en)
Inventor
P O'donnell Kevin
j hall Mark
L Rose Maureen
S Grasman Nicholas
J Guillaudeu Steven
L Rogers True
Shrestha Uma
J Spaulding Wesley
W Porter William
Original Assignee
Dow Global Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Global Technologies Llc filed Critical Dow Global Technologies Llc
Publication of BR112014032017A2 publication Critical patent/BR112014032017A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo “dispersão sólida, dispersão sólida extrudada e processo para produzir uma dispersão sólida” uma dispersão sólida compreendendo pelo menos um ingrediente ativo em pelo menos uma hidroxialquil metil celulose tendo um ds de 1,0 a 2,7 e uma ms de 0,40 a 1,30, sendo que ds é o grau de substituição de grupos metoxila e ms é a substituição molar de grupos hidroxialcoxila, pode ser produzida por extrusão ou por secagem por aspersão. 1/1
BR112014032017A 2012-07-17 2013-07-12 dispersão sólida, dispersão sólida extrudada e processo para produzir uma dispersão sólida BR112014032017A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672409P 2012-07-17 2012-07-17
PCT/US2013/050213 WO2014014752A1 (en) 2012-07-17 2013-07-12 Solid dispersion comprising a highly substituted hydroxyalkyl methylcellulose

Publications (1)

Publication Number Publication Date
BR112014032017A2 true BR112014032017A2 (pt) 2017-06-27

Family

ID=48857004

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014032017A BR112014032017A2 (pt) 2012-07-17 2013-07-12 dispersão sólida, dispersão sólida extrudada e processo para produzir uma dispersão sólida

Country Status (8)

Country Link
US (1) US9962446B2 (pt)
EP (1) EP2874607B1 (pt)
JP (1) JP6235584B2 (pt)
KR (1) KR102160903B1 (pt)
CN (1) CN104602673B (pt)
BR (1) BR112014032017A2 (pt)
PT (1) PT2874607T (pt)
WO (1) WO2014014752A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3021835B1 (en) * 2013-07-17 2017-05-10 Dow Global Technologies LLC Composition for application to a mucosa comprising a hydroxyalkyl methylcellulose
CN105873954B (zh) 2014-01-16 2019-03-29 陶氏环球技术有限责任公司 用于3d打印的支撑材料
CN107690458B (zh) * 2015-06-09 2020-07-24 陶氏环球技术有限责任公司 用于三维印刷的支撑材料
WO2017019393A1 (en) * 2015-07-27 2017-02-02 Dow Global Technologies Llc Method to additive manufacture biocompatible material and articles made by the method
CN106556567A (zh) * 2016-10-01 2017-04-05 德州学院 一种羟丙基甲基纤维素羟丙基取代度的测试方法
JP7377782B2 (ja) * 2019-09-04 2023-11-10 信越化学工業株式会社 フィルム成形用組成物及びフィルム
EP4073167A1 (en) * 2019-12-09 2022-10-19 Nutrition & Biosciences USA 1, LLC Composition comprising a highly substituted hydroxypropyl methylcellulose and a sugar alcohol
CN114867800A (zh) * 2019-12-30 2022-08-05 陶氏环球技术有限责任公司 水性组合物及其制备方法
WO2023006424A1 (en) 2021-07-28 2023-02-02 Nutrition & Biosciences Usa 1, Llc Hpmc composition for providing a heat-sealable coating on paper and board

Family Cites Families (22)

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DE2917104A1 (de) 1979-04-27 1980-11-06 Hoechst Ag Verfahren zur viskositaetserniedrigung von celluloseethern durch ozon und seine verwendung
US4678516A (en) * 1984-10-09 1987-07-07 The Dow Chemical Company Sustained release dosage form based on highly plasticized cellulose ether gels
US4614545A (en) 1985-08-15 1986-09-30 The Dow Chemical Company Hydroxypropyl methyl cellulose thickening agents for organic liquids
JPS6225101A (ja) 1985-07-24 1987-02-03 Shin Etsu Chem Co Ltd 低重合度セルロ−スエ−テルの製造方法
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
US5721221A (en) 1991-03-08 1998-02-24 Regents Of The University Of Minnesota Lowering blood cholesterol levels using water soluble cellulose ethers
JPH06239764A (ja) * 1993-02-17 1994-08-30 Yoshiaki Kawashima 錠剤用基剤組成物およびその製造方法
DK0904060T3 (da) * 1996-05-20 2004-04-13 Janssen Pharmaceutica Nv Antifungale præparater med forbedret biotilgængelighed
EP0872233A1 (en) 1997-04-14 1998-10-21 Janssen Pharmaceutica N.V. Antiretroviral compositions with improved bioavailability
DK0901786T3 (da) * 1997-08-11 2007-10-08 Pfizer Prod Inc Faste farmaceutiske dispersioner med foröget biotilgængelighed
US6261218B1 (en) 1998-12-01 2001-07-17 The Dow Chemical Company Process and apparatus for making low molecular weight cellulose ethers
KR20010097244A (ko) 2000-04-21 2001-11-08 유충식 위산도 비의존성 고용해도를 갖는 이트라코나졸 함유약학적 조성물 및 그 제조방법
DE10141680B4 (de) 2001-08-25 2004-02-26 Clariant Gmbh Verfahren zur Herstellung niederviskoser Celluloseether durch sauer-oxidativen Abbau von gemahlenen und getrockneten Celluloseethern
WO2003020247A1 (en) * 2001-09-04 2003-03-13 Dow Global Technologies Inc. Process for coating solid particles
HUP0402325A2 (hu) * 2001-12-07 2005-02-28 Janssen Pharmaceutica N.V. Eljárás cisz-fuzionált 3,3a,8,12b-tetrahidro-2H-dibenzo [3,4:6,7] ciklohepta [1,2-b]furán-származékok előállítására
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
MXPA06013891A (es) 2004-05-28 2007-01-26 Pfizer Prod Inc Composiciones farmaceuticas con comportamiento potenciado.
JP4887727B2 (ja) * 2005-10-20 2012-02-29 ソニー株式会社 画像信号処理装置、カメラシステム、および画像信号処理方法
AU2007212197B2 (en) * 2006-02-09 2012-12-13 Merck Sharp & Dohme Corp. Polymer formulations of CETP inhibitors
ATE476966T1 (de) 2006-10-17 2010-08-15 Bend Res Inc Feste dispersion mit schwer wasserlöslichem wirkstoff
KR101498639B1 (ko) * 2008-06-26 2015-03-11 에스에스 세야쿠 가부시키 가이샤 필름 코팅용 조성물
EP2836559B1 (en) * 2012-04-11 2016-05-25 Dow Global Technologies LLC Composition comprising an organic diluent and a cellulose ether

Also Published As

Publication number Publication date
KR102160903B1 (ko) 2020-10-05
CN104602673B (zh) 2017-11-24
KR20150031299A (ko) 2015-03-23
EP2874607A1 (en) 2015-05-27
WO2014014752A1 (en) 2014-01-23
US9962446B2 (en) 2018-05-08
PT2874607T (pt) 2017-08-14
CN104602673A (zh) 2015-05-06
JP2015522613A (ja) 2015-08-06
JP6235584B2 (ja) 2017-11-22
EP2874607B1 (en) 2017-05-31
US20150140091A1 (en) 2015-05-21

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: THE DOW CHEMICAL COMPANY (US)

B25A Requested transfer of rights approved

Owner name: DDP SPECIALTY ELECTRONIC MATERIALS US, INC. (US)

B25D Requested change of name of applicant approved

Owner name: DDP SPECIALTY ELECTRONIC MATERIALS US, LLC (US)

B25A Requested transfer of rights approved

Owner name: NUTRITION AND BIOSCIENCES USA 1, LLC (US)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time