BR122020002986A8 - Método e composições para imunoterapia celular - Google Patents

Método e composições para imunoterapia celular

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Publication number
BR122020002986A8
BR122020002986A8 BR122020002986A BR122020002986A BR122020002986A8 BR 122020002986 A8 BR122020002986 A8 BR 122020002986A8 BR 122020002986 A BR122020002986 A BR 122020002986A BR 122020002986 A BR122020002986 A BR 122020002986A BR 122020002986 A8 BR122020002986 A8 BR 122020002986A8
Authority
BR
Brazil
Prior art keywords
cells
chimeric receptor
polynucleotide
compositions
methods
Prior art date
Application number
BR122020002986A
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English (en)
Other versions
BR122020002986A2 (pt
Inventor
Jensen Michael
R Riddell Stanley
Hudecek Michael
Original Assignee
Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Hutchinson Fred Cancer Res
Fred Hutchinson Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49054932&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR122020002986(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Childrens Hospital Dba Seattle Childrens Res Inst, Hutchinson Fred Cancer Res, Fred Hutchinson Cancer Center filed Critical Seattle Childrens Hospital Dba Seattle Childrens Res Inst
Publication of BR122020002986A2 publication Critical patent/BR122020002986A2/pt
Publication of BR122020002986A8 publication Critical patent/BR122020002986A8/pt

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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Abstract

POLIPEPTÍDIO DE RECEPTOR QUIMÉRICO, ÁCIDO NUCLEICO, VETOR DE EXPRESSÃO, COMPOSIÇÕES, MÉTODOS E USOS DOS MESMOS PARA IMUNOTERAPIA CELULAR. A presente invenção proporciona ácidos nucleicos, vetores, células hospedeiras, métodos e composições para conferir e/ou aumentar as respostas imunes mediadas por imunoterapia celular, tal como por adotivamente transferir as células T CD8+ da memória central ou combinações de células T da memória central com células T CD4+ que são geneticamente modificadas para expressar um receptor quimérico. Nas modalidades a célula hospedeira geneticamente modificada compreende um ácido nucleico compreendendo um polinucleotídeo que codifica para um domínio de ligação ao ligante, um polinucleotídeo compreendendo uma região de espaçamento personalizada, um polinucleotídeo compreendendo um domínio transmembranar, e um polinucleotídeo compreendendo um domínio de sinalização intracelular. Foi surpreendentemente verificado que o comprimento da região de espaçamento pode afetar a capacidade das células T modificadas com receptor quimérico para reconhecer as células-alvo in vitro, e afeta a eficácia in vivo das células T modificadas com receptor quimérico. As formulações farmacêuticas produzidas pelo método, e os métodos de utilização das mesmas, também são descritos.
BR122020002986A 2012-08-20 2013-08-20 Método e composições para imunoterapia celular BR122020002986A8 (pt)

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US201261691117P 2012-08-20 2012-08-20
PCT/US2013/055862 WO2014031687A1 (en) 2012-08-20 2013-08-20 Method and compositions for cellular immunotherapy

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BR122020002986A2 BR122020002986A2 (pt) 2017-11-28
BR122020002986A8 true BR122020002986A8 (pt) 2023-04-18

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