BR9405892A - Compostos de amino insaturados para uso como agente anti-câncer e anti-protozoários - Google Patents
Compostos de amino insaturados para uso como agente anti-câncer e anti-protozoáriosInfo
- Publication number
- BR9405892A BR9405892A BR9405892A BR9405892A BR9405892A BR 9405892 A BR9405892 A BR 9405892A BR 9405892 A BR9405892 A BR 9405892A BR 9405892 A BR9405892 A BR 9405892A BR 9405892 A BR9405892 A BR 9405892A
- Authority
- BR
- Brazil
- Prior art keywords
- pct
- carbon atom
- bonding
- nitrogen
- cancer
- Prior art date
Links
- 230000001093 anti-cancer Effects 0.000 title 1
- 230000000884 anti-protozoa Effects 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/23—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton containing carbon-to-carbon triple bonds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH387693 | 1993-12-27 | ||
| EP9404320 | 1994-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9405892A true BR9405892A (pt) | 1995-12-12 |
Family
ID=4265390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9405892A BR9405892A (pt) | 1993-12-27 | 1994-12-14 | Compostos de amino insaturados para uso como agente anti-câncer e anti-protozoários |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5627215A (pt) |
| EP (1) | EP0686143B1 (pt) |
| JP (1) | JPH08507548A (pt) |
| CN (1) | CN1121707A (pt) |
| AT (1) | ATE169614T1 (pt) |
| AU (1) | AU690618B2 (pt) |
| BR (1) | BR9405892A (pt) |
| CA (1) | CA2155095A1 (pt) |
| DE (1) | DE69412467T2 (pt) |
| DK (1) | DK0686143T3 (pt) |
| ES (1) | ES2119371T3 (pt) |
| NZ (1) | NZ277503A (pt) |
| WO (1) | WO1995018091A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6184232B1 (en) * | 1986-12-02 | 2001-02-06 | University Of Florida | Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment |
| EP0934249B1 (en) * | 1996-10-18 | 2002-03-27 | Wisconsin Alumni Research Foundation | Conformationally restricted polyamines and their use as antineoplastic agents |
| US5889061A (en) * | 1997-10-15 | 1999-03-30 | Wisconsin Alumni Research Foundation | Conformationally restricted polyamines |
| DE60029944T2 (de) * | 1999-04-30 | 2007-04-05 | Cellgate, Inc., Redwood City | Polyamine und ihre therapeutische verwendung |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| IL146126A0 (en) * | 1999-04-30 | 2002-07-25 | Slil Biomedical Corp | Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| US7312244B2 (en) * | 1999-04-30 | 2007-12-25 | Cellgate, Inc. | Polyamine analog-amino acid conjugates useful as anticancer agents |
| US20030130356A1 (en) * | 2001-10-16 | 2003-07-10 | Slil Biomedical Corporation | Oligoamine compounds and derivatives thereof for cancer therapy |
| CA2469354A1 (en) | 2001-12-07 | 2003-06-19 | Slil Biomedical Corporation | Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor |
| WO2003066572A1 (en) * | 2002-02-07 | 2003-08-14 | Wisconsin Alumni Research Foundation | Polyamine compounds and compositions for use in conjunction with cancer therapy |
| US7314959B2 (en) * | 2003-08-07 | 2008-01-01 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
| KR101050328B1 (ko) | 2004-08-31 | 2011-07-19 | 엘지디스플레이 주식회사 | 램프 및 이를 구비한 백라이트 구동장치 |
| WO2007021839A2 (en) * | 2005-08-10 | 2007-02-22 | Johns Hopkins University | Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors |
| US20130102556A1 (en) * | 2010-02-02 | 2013-04-25 | The Johns Hopkins University | Use of N1,N4-bis[3-(Ethylamino)Propyl]-2-Butene-1,4-Diamine Compounds in Combination with Epigenetic-Acting Pharmaceuticals for Enhanced Cancer Therapy |
| CN102212013A (zh) * | 2011-03-30 | 2011-10-12 | 广东中科药物研究有限公司 | 一种多胺化合物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2991290A (en) * | 1957-03-20 | 1961-07-04 | Us Vitamin Corp | Nu-alkylamino-alpha-hydroxy-alkanoic acid amides |
| US4278605A (en) * | 1980-06-30 | 1981-07-14 | American Cyanamid Company | Heteroalkylenebisanthraquinones |
| CA1305425C (en) * | 1986-12-02 | 1992-07-21 | Raymond J. Bergeron | Anti-neoplastic spermine derivative |
| US5091576A (en) * | 1986-12-02 | 1992-02-25 | University Of Florida | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| AU602186B2 (en) * | 1987-02-03 | 1990-10-04 | Merrell Dow Pharmaceuticals Inc. | Novel polyamine derivatives |
| US4935449A (en) * | 1988-08-04 | 1990-06-19 | Merrell Dow Pharmaceuticals Inc. | N-2,3-butadienyl tri- and tetraaminoalkane derivatives |
| JPH02118405A (ja) * | 1988-10-27 | 1990-05-02 | Nec Yamagata Ltd | 微小寸法測定装置 |
| GB9115375D0 (en) * | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
-
1994
- 1994-12-14 ES ES95903819T patent/ES2119371T3/es not_active Expired - Lifetime
- 1994-12-14 DK DK95903819T patent/DK0686143T3/da active
- 1994-12-14 CA CA002155095A patent/CA2155095A1/en not_active Abandoned
- 1994-12-14 WO PCT/EP1994/004230 patent/WO1995018091A1/en not_active Ceased
- 1994-12-14 EP EP95903819A patent/EP0686143B1/en not_active Expired - Lifetime
- 1994-12-14 BR BR9405892A patent/BR9405892A/pt not_active Application Discontinuation
- 1994-12-14 NZ NZ277503A patent/NZ277503A/en unknown
- 1994-12-14 US US08/505,329 patent/US5627215A/en not_active Expired - Fee Related
- 1994-12-14 AT AT95903819T patent/ATE169614T1/de not_active IP Right Cessation
- 1994-12-14 DE DE69412467T patent/DE69412467T2/de not_active Expired - Fee Related
- 1994-12-14 CN CN94191922A patent/CN1121707A/zh active Pending
- 1994-12-14 JP JP7517762A patent/JPH08507548A/ja active Pending
- 1994-12-14 AU AU12744/95A patent/AU690618B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0686143A1 (en) | 1995-12-13 |
| US5627215A (en) | 1997-05-06 |
| AU1274495A (en) | 1995-07-17 |
| CN1121707A (zh) | 1996-05-01 |
| NZ277503A (en) | 1997-07-27 |
| EP0686143B1 (en) | 1998-08-12 |
| AU690618B2 (en) | 1998-04-30 |
| ES2119371T3 (es) | 1998-10-01 |
| CA2155095A1 (en) | 1995-07-06 |
| DE69412467D1 (de) | 1998-09-17 |
| DK0686143T3 (da) | 1999-05-17 |
| DE69412467T2 (de) | 1999-01-28 |
| JPH08507548A (ja) | 1996-08-13 |
| WO1995018091A1 (en) | 1995-07-06 |
| ATE169614T1 (de) | 1998-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer |
Free format text: NOVARTIS AG (NOVARTIS SA) (NOVARTIS INC.) (CH) |
|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal |