ES2119371T3 - Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico. - Google Patents

Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico.

Info

Publication number
ES2119371T3
ES2119371T3 ES95903819T ES95903819T ES2119371T3 ES 2119371 T3 ES2119371 T3 ES 2119371T3 ES 95903819 T ES95903819 T ES 95903819T ES 95903819 T ES95903819 T ES 95903819T ES 2119371 T3 ES2119371 T3 ES 2119371T3
Authority
ES
Spain
Prior art keywords
pct
carbon atom
bonding
nitrogen
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95903819T
Other languages
English (en)
Inventor
Jorg Frei
Jaroslav Stanek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2119371T3 publication Critical patent/ES2119371T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/23—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton containing carbon-to-carbon triple bonds

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE R{SUB, 1} Y R{SUB, 2}, CADA UNO INDEPENDIENTEMENTE DEL OTRO, SE SELECCIONAN DE ALKILO BAJO QUE ESTA NO SUSTITUIDO O SUSTITUIDO POR UNO O MAS ATOMOS DE FLUOR QUE NO ESTAN UNIDOS AL ATOMO DE CARBONO DE R{SUB, 1} O R{SUB, 2} QUE UNE EL NITROGENO; DE ALQUENILO BAJO EN DONDE LA UNION DOBLE NO SE ORIGINA DESDE EL ATOMO DE CARBONO QUE ESTA UNIDO A UNA UNION DE NITROGENO R{SUB, 1} O R{SUB, 2}; DE ALKINILO BAJO EN DONDE LA UNION TRIPLE NO SE ORIGINA DESDE EL ATOMO DE CARBONO QUE ESTA UNIDO A UNA UNION DE NITROGENO R{SUB, 1} O R{SUB, 2}; Y DE ALKILO DE CICLOALKILO BAJO; CON LA CONDICION DE QUE NO MAS DE UNO DE LOS DOS RADICALES R{SUB, 1} Y R{SUB, 2} SEA METILO; O SALES DEL MISMO. LOS COMPUESTOS MENCIONADOS SON ACTIVOS FARMACOLOGICAMENTE FRENTE A DESORDENES QUE SON RESPONSABLES DE UNA REDUCCION EN POLIAMINAS INTRACELULARES, COMO ENFERMEDADES TUMOROSAS O PROTOZOALES.
ES95903819T 1993-12-27 1994-12-14 Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico. Expired - Lifetime ES2119371T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH387693 1993-12-27

Publications (1)

Publication Number Publication Date
ES2119371T3 true ES2119371T3 (es) 1998-10-01

Family

ID=4265390

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95903819T Expired - Lifetime ES2119371T3 (es) 1993-12-27 1994-12-14 Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico.

Country Status (13)

Country Link
US (1) US5627215A (es)
EP (1) EP0686143B1 (es)
JP (1) JPH08507548A (es)
CN (1) CN1121707A (es)
AT (1) ATE169614T1 (es)
AU (1) AU690618B2 (es)
BR (1) BR9405892A (es)
CA (1) CA2155095A1 (es)
DE (1) DE69412467T2 (es)
DK (1) DK0686143T3 (es)
ES (1) ES2119371T3 (es)
NZ (1) NZ277503A (es)
WO (1) WO1995018091A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184232B1 (en) * 1986-12-02 2001-02-06 University Of Florida Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
EP0934249B1 (en) * 1996-10-18 2002-03-27 Wisconsin Alumni Research Foundation Conformationally restricted polyamines and their use as antineoplastic agents
US5889061A (en) * 1997-10-15 1999-03-30 Wisconsin Alumni Research Foundation Conformationally restricted polyamines
DE60029944T2 (de) * 1999-04-30 2007-04-05 Cellgate, Inc., Redwood City Polyamine und ihre therapeutische verwendung
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
IL146126A0 (en) * 1999-04-30 2002-07-25 Slil Biomedical Corp Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US7312244B2 (en) * 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
US20030130356A1 (en) * 2001-10-16 2003-07-10 Slil Biomedical Corporation Oligoamine compounds and derivatives thereof for cancer therapy
CA2469354A1 (en) 2001-12-07 2003-06-19 Slil Biomedical Corporation Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor
WO2003066572A1 (en) * 2002-02-07 2003-08-14 Wisconsin Alumni Research Foundation Polyamine compounds and compositions for use in conjunction with cancer therapy
US7314959B2 (en) * 2003-08-07 2008-01-01 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
KR101050328B1 (ko) 2004-08-31 2011-07-19 엘지디스플레이 주식회사 램프 및 이를 구비한 백라이트 구동장치
WO2007021839A2 (en) * 2005-08-10 2007-02-22 Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
US20130102556A1 (en) * 2010-02-02 2013-04-25 The Johns Hopkins University Use of N1,N4-bis[3-(Ethylamino)Propyl]-2-Butene-1,4-Diamine Compounds in Combination with Epigenetic-Acting Pharmaceuticals for Enhanced Cancer Therapy
CN102212013A (zh) * 2011-03-30 2011-10-12 广东中科药物研究有限公司 一种多胺化合物及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2991290A (en) * 1957-03-20 1961-07-04 Us Vitamin Corp Nu-alkylamino-alpha-hydroxy-alkanoic acid amides
US4278605A (en) * 1980-06-30 1981-07-14 American Cyanamid Company Heteroalkylenebisanthraquinones
CA1305425C (en) * 1986-12-02 1992-07-21 Raymond J. Bergeron Anti-neoplastic spermine derivative
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
AU602186B2 (en) * 1987-02-03 1990-10-04 Merrell Dow Pharmaceuticals Inc. Novel polyamine derivatives
US4935449A (en) * 1988-08-04 1990-06-19 Merrell Dow Pharmaceuticals Inc. N-2,3-butadienyl tri- and tetraaminoalkane derivatives
JPH02118405A (ja) * 1988-10-27 1990-05-02 Nec Yamagata Ltd 微小寸法測定装置
GB9115375D0 (en) * 1991-07-17 1991-09-04 Salutar Inc Compounds

Also Published As

Publication number Publication date
EP0686143A1 (en) 1995-12-13
US5627215A (en) 1997-05-06
AU1274495A (en) 1995-07-17
BR9405892A (pt) 1995-12-12
CN1121707A (zh) 1996-05-01
NZ277503A (en) 1997-07-27
EP0686143B1 (en) 1998-08-12
AU690618B2 (en) 1998-04-30
CA2155095A1 (en) 1995-07-06
DE69412467D1 (de) 1998-09-17
DK0686143T3 (da) 1999-05-17
DE69412467T2 (de) 1999-01-28
JPH08507548A (ja) 1996-08-13
WO1995018091A1 (en) 1995-07-06
ATE169614T1 (de) 1998-08-15

Similar Documents

Publication Publication Date Title
ES2119371T3 (es) Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico.
UY28374A1 (es) Agentes terapéuticos
BRPI0407329A (pt) Derivados de pirimidina para a prevenção de infecção de hiv
AR038045A1 (es) Agentes terapeuticos
MX2007007220A (es) Compuestos de pirazolona como agonistas de receptor de glutamato metabotropico para el tratamiento de trastornos neurologicos y psiquiatricos.
TWI265928B (en) A61k 31/4025 200601 a i htw a61p 25/00 200601 a n htw
MY139357A (en) Novel benzoimidazole derivatives useful as antiproliferative agents
UY28376A1 (es) Agentes terapéuticos
CA2304713A1 (en) Biphenyl-5-alkanoic acid derivatives and use thereof
UY28144A1 (es) Agentes terapéuticos
AR050261A2 (es) Aminoacidos con afinidad por la proteina alfa-2-delta y composiciones farmaceuticas que los contienen y su uso para preparar un medicamento
UY28377A1 (es) Agentes terapeuticos
NO944287L (no) Anvendelse av terfenadinderivater som antihistaminmidler i en hepatisk svekket pasient
ES2138092T3 (es) Utilizacion de los derivados de carbostirilo para la obtencion de un medicamento destinado para inhibir la produccion de la interleucina-8.
KR950703941A (ko) 일산화질소 합성 억제제(nitrogen monoxide synthesis inhibitor)
UY28839A1 (es) Agentes terapeuticos
AR042444A1 (es) Metodo para el tratamiento de desordenes del movimiento mediante la utilizacion de acido barbiturico
AR057461A1 (es) Derivados de pirazol, proceso de preparacion, composiciones farmaceuticas y usos
MA26485A1 (fr) Analogues de vitamine d3 a chaines laterales bis en c-20.
AR037140A1 (es) Un compuesto de aminopirrol, su utilizacion, un procedimiento para producirlo y una composicion que lo comprende
ATE172959T1 (de) Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten
HN2001000119A (es) S-metil-dihidro -ziprasidona para el tratamiento de trastornos psiquiatricos y oculares.
PL368208A1 (en) Tetrahydropyran derivatives and their use as therapeutic agents
MX25359A (es) 4-/3-4(oxotiazollidinil/butilnilaminas un procedimiento para su preparacion y su uso como medicamentos.
ATE169021T1 (de) Cephalostatin-analoga und ihre verwendung als antitumormittel

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 686143

Country of ref document: ES