BR9408435A - Gene para dessaturase de ácido graxo vetor contendo o dito gene planta transformada com o dito gene e processo para criar a dita planta - Google Patents
Gene para dessaturase de ácido graxo vetor contendo o dito gene planta transformada com o dito gene e processo para criar a dita plantaInfo
- Publication number
- BR9408435A BR9408435A BR9408435A BR9408435A BR9408435A BR 9408435 A BR9408435 A BR 9408435A BR 9408435 A BR9408435 A BR 9408435A BR 9408435 A BR9408435 A BR 9408435A BR 9408435 A BR9408435 A BR 9408435A
- Authority
- BR
- Brazil
- Prior art keywords
- gene
- plant
- fatty acid
- creating
- vector
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19002—Acyl-[acyl-carrier-protein] desaturase (1.14.19.2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP35285893 | 1993-12-28 | ||
| PCT/JP1994/002288 WO1995018222A1 (en) | 1993-12-28 | 1994-12-28 | Gene for fatty acid desaturase, vector containing said gene, plant containing said gene transferred thereinto, and process for creating said plant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9408435A true BR9408435A (pt) | 1997-08-05 |
Family
ID=18426926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9408435A BR9408435A (pt) | 1993-12-28 | 1994-12-28 | Gene para dessaturase de ácido graxo vetor contendo o dito gene planta transformada com o dito gene e processo para criar a dita planta |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6043411A (pt) |
| EP (1) | EP0736598B1 (pt) |
| JP (1) | JP3313724B2 (pt) |
| KR (1) | KR100224120B1 (pt) |
| CN (2) | CN1108382C (pt) |
| AT (1) | ATE273395T1 (pt) |
| AU (1) | AU688834B2 (pt) |
| BR (1) | BR9408435A (pt) |
| CA (1) | CA2180154C (pt) |
| DE (1) | DE69433941T2 (pt) |
| ES (1) | ES2222462T3 (pt) |
| FI (1) | FI962664A7 (pt) |
| NO (1) | NO962727L (pt) |
| NZ (1) | NZ277562A (pt) |
| WO (1) | WO1995018222A1 (pt) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998018948A1 (en) * | 1996-10-31 | 1998-05-07 | National Research Council Of Canada | Flax promoters for manipulating gene expression |
| EP0969014B1 (en) | 1997-01-24 | 2008-10-08 | Kirin Holdings Kabushiki Kaisha | Beta-ketoacyl-acp-synthetase ii enzyme and gene encoding the same |
| US6051754A (en) * | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US7745694B1 (en) | 1997-04-11 | 2010-06-29 | Monsanto Technology Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
| US6075183A (en) * | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| AU9126198A (en) * | 1997-09-04 | 1999-03-22 | Rutgers, The State University Of New Jersey | Pathogen-resistant transgenic plants and methods of making |
| JP2002529049A (ja) * | 1998-03-30 | 2002-09-10 | ダウ・アグロサイエンス・エル・エル・シー | アスペルギルス・ニドゥランス(Aspergillusnidulans)デルタ−9CoAデサチュラーゼの発現による植物の脂肪酸組成の改変 |
| DK1086236T3 (da) | 1998-06-12 | 2007-12-03 | Calgene Llc | Polyumættede fedtsyrer i planter |
| IL146782A0 (en) | 1999-06-07 | 2002-07-25 | Basf Plant Science Gmbh | 6-acetylenase and 6-desaturase from ceratodon purpureus |
| DE10030976A1 (de) | 2000-06-30 | 2002-01-10 | Basf Ag | DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren |
| PL207026B1 (pl) | 2000-02-09 | 2010-10-29 | Basf Ag | Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA) |
| DE10102337A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte |
| GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
| DE10134660A1 (de) * | 2001-07-20 | 2003-02-06 | Basf Plant Science Gmbh | Fettsäure-Desaturase-Gene aus Granatapfel und Verfahren zur Herstellung von ungesättigten Fettsäuren |
| AU2003206714B2 (en) | 2002-01-30 | 2007-09-06 | Basf Plant Science Gmbh | Elongase gene and method for producing polyunsaturated fatty acids |
| GB2385852A (en) | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
| DE10219203A1 (de) | 2002-04-29 | 2003-11-13 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen |
| EP2216405A1 (en) | 2002-05-03 | 2010-08-11 | Monsanto Technology LLC | Speed specific USP promoters for expressing genes in plants |
| US7078234B2 (en) | 2002-12-18 | 2006-07-18 | Monsanto Technology Llc | Maize embryo-specific promoter compositions and methods for use thereof |
| AU2003296638B2 (en) * | 2002-12-19 | 2009-06-11 | University Of Bristol | Method for the production of polyunsaturated fatty acids |
| GB0229578D0 (en) * | 2002-12-19 | 2003-01-22 | Univ Bristol | Novel method for the production of polyunsaturated fatty acids |
| ATE517984T1 (de) | 2003-02-27 | 2011-08-15 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren |
| BRPI0408896A (pt) | 2003-03-28 | 2006-04-25 | Monsanto Technology Llc | promotores de planta para uso no desenvolvimento precoce de sementes |
| US7855321B2 (en) | 2003-03-31 | 2010-12-21 | University Of Bristol | Plant acyltransferases specific for long-chained, multiply unsaturated fatty acids |
| WO2004090123A2 (de) | 2003-04-08 | 2004-10-21 | Basf Plant Science Gmbh | Δ-4-desaturasen aus euglena gracilis, exprimierende pflanzen und pufa enthaltende öle |
| EP2166067B1 (de) | 2003-08-01 | 2015-07-01 | BASF Plant Science GmbH | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen |
| ATE430802T1 (de) | 2003-08-21 | 2009-05-15 | Monsanto Technology Llc | Fettsäuredesaturasen aus primula |
| CA2450000A1 (en) * | 2003-12-18 | 2005-06-18 | Alberta Research Council Inc. | Method of creating plants with reduced level of saturated fatty acid in seed oil |
| MY140210A (en) * | 2003-12-22 | 2009-11-30 | Suntory Holdings Ltd | Marchantiales-derived unsaturated fatty acid synthetase genes and use of the same |
| EP1720988B1 (de) | 2004-02-27 | 2011-10-12 | BASF Plant Science GmbH | Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen |
| US9458436B2 (en) | 2004-02-27 | 2016-10-04 | Basf Plant Science Gmbh | Method for producing polyunsaturated fatty acids in transgenic plants |
| CN1968688A (zh) | 2004-04-16 | 2007-05-23 | 孟山都技术有限公司 | 脂肪酸去饱和酶在玉米中的表达 |
| US7364883B2 (en) | 2004-05-07 | 2008-04-29 | Yeastern Biotech Co., Ltd. | Process for producing poly-unsaturated fatty acids by oleaginous yeasts |
| HUE034217T2 (en) | 2004-10-08 | 2018-01-29 | Dow Agrosciences Llc | Certain plants with no saturated fatty acid in the core or a reduced level of saturated fatty acids and seed oil |
| US7901063B2 (en) * | 2004-12-17 | 2011-03-08 | Agfa Graphics Nv | Ink rejuvenation system for inkjet printing |
| DE102004063326A1 (de) * | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen |
| US20090031440A1 (en) | 2005-02-26 | 2009-01-29 | Basf Plant Science Gmbh | Expression Cassettes for Seed-Preferential Expression in Plants |
| WO2006092449A2 (en) * | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| DE102005013779A1 (de) | 2005-03-22 | 2006-09-28 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen |
| US8034994B2 (en) | 2005-04-19 | 2011-10-11 | Basf Plant Science Gmbh | Starchy-endosperm and/or germinating embryo-specific expression in mono-cotyledonous plants |
| CA2605393A1 (en) | 2005-04-20 | 2006-10-26 | Basf Plant Science Gmbh | Expression cassettes for seed-preferential expression in plants |
| EP1882037A2 (en) | 2005-05-10 | 2008-01-30 | BASF Plant Science GmbH | Expression cassettes for seed-preferential expression in plants |
| CN1302110C (zh) * | 2005-06-23 | 2007-02-28 | 复旦大学 | 水稻Osfad8编码序列及其应用 |
| DE102005038036A1 (de) * | 2005-08-09 | 2007-02-15 | Basf Plant Science Gmbh | Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen |
| GB2431158A (en) | 2005-10-13 | 2007-04-18 | Rothamsted Res Ltd | Process for the production of arachidonic and/or eicosapentaenoic acid |
| DE102005052551A1 (de) | 2005-11-02 | 2007-05-16 | Rothamsted Res Harpenden | Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae |
| GB0603160D0 (en) | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| US8629195B2 (en) | 2006-04-08 | 2014-01-14 | Bayer Materialscience Ag | Production of polyurethane foams |
| MX2009000757A (es) | 2006-07-19 | 2009-03-09 | Monsanto Technology Llc | Acido graso desaturasas de tetraselmis suecica. |
| EP2500420B1 (en) | 2006-08-24 | 2016-06-22 | BASF Plant Science GmbH | Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
| PL2177605T3 (pl) | 2006-10-06 | 2015-05-29 | Basf Plant Science Gmbh | Delta-5 desaturazy i sposób wytwarzania wielokrotnie nienasyconych kwasów tłuszczowych w organizmach transgenicznych innych niż człowiek |
| CA2675926A1 (en) | 2007-02-16 | 2008-08-21 | Basf Plant Science Gmbh | Nucleic acid sequences for regulation of embryo-specific expression in monocotyledonous plants |
| US8318914B2 (en) | 2007-07-31 | 2012-11-27 | Bioriginal Food & Science Corp. | Elongases and methods for producing polyunsaturated fatty acids in transgenic organisms |
| AU2008337600A1 (en) | 2007-12-14 | 2009-06-25 | Basf Plant Science Gmbh | Promoters from brassica napus for seed specific gene expression |
| BRPI0911892A8 (pt) * | 2008-04-30 | 2018-06-26 | Rothamsted Res Ltd | polinucleotídeo, vetor, célula hospedeira, polipeptídeo e organismo não humano, transgênico, e uso dos mesmos, processo de geração de um polipeptídio com atividade de desaturase ou elongase, anticorpo e processo para a produção de uma composição de óleo, lipídio ou ácido graxo |
| AU2009265795B2 (en) | 2008-07-01 | 2014-12-11 | Basf Plant Science Gmbh | Promoters from Brassica napus for seed specific gene expression |
| JP5757870B2 (ja) | 2008-08-26 | 2015-08-05 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | デサチュラーゼをコードする核酸および改変植物油 |
| EP2669380B1 (en) | 2008-12-12 | 2017-09-27 | BASF Plant Science GmbH | Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms |
| CA3020943A1 (en) | 2009-04-22 | 2010-10-28 | Basf Plant Science Company Gmbh | Whole seed specific promoter |
| US9212371B2 (en) | 2009-05-13 | 2015-12-15 | Basf Plant Science Company Gmbh | Acyltransferases and uses thereof in fatty acid production |
| AU2010270309A1 (en) | 2009-07-10 | 2012-02-02 | Basf Plant Science Company Gmbh | Expression cassettes for endosperm-specific expression in plants |
| EP2507375A4 (en) | 2009-12-03 | 2013-04-24 | Basf Plant Science Co Gmbh | EXPRESSION CASSETTES FOR EMBRYOSPECIFIC EXPRESSION IN PLANTS |
| AU2011269059B2 (en) | 2010-06-25 | 2016-01-28 | Basf Plant Science Company Gmbh | Acyltransferases and uses therof in fatty acid production |
| CN104195169A (zh) * | 2014-08-29 | 2014-12-10 | 兰州理工大学 | 一种基于脂肪酸去饱和酶基因的抗寒转基因烟草的构建方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE241007T1 (de) * | 1990-03-16 | 2003-06-15 | Calgene Llc | Dnas, die für pflanzliche desaturasen kodieren und deren anwendungen |
| NL9002130A (nl) * | 1990-09-28 | 1992-04-16 | Stichting Tech Wetenschapp | Dna-sequentie die ten minste een deel van een gen coderend voor stearoyl-acp-desaturase omvat, alsmede toepassing van de dna-sequentie in een werkwijze voor het wijzigen van de vetzuurbiosynthese van een plant. |
| CA2084348A1 (en) * | 1991-12-31 | 1993-07-01 | David F. Hildebrand | Fatty acid alteration by a d9 desaturase in transgenic plant tissue |
| JPH0614667A (ja) * | 1992-03-13 | 1994-01-25 | Lubrizol Corp:The | デサチュラーゼを使用しての植物油の改変 |
| US5639645A (en) * | 1993-09-22 | 1997-06-17 | Mitsubishi Corporation | Recombinant Δ9 desaturase and a gene encoding the same |
-
1994
- 1994-12-28 JP JP51792895A patent/JP3313724B2/ja not_active Expired - Fee Related
- 1994-12-28 US US08/663,082 patent/US6043411A/en not_active Expired - Fee Related
- 1994-12-28 CA CA002180154A patent/CA2180154C/en not_active Expired - Fee Related
- 1994-12-28 WO PCT/JP1994/002288 patent/WO1995018222A1/ja not_active Ceased
- 1994-12-28 KR KR1019960703438A patent/KR100224120B1/ko not_active Expired - Fee Related
- 1994-12-28 AU AU12837/95A patent/AU688834B2/en not_active Ceased
- 1994-12-28 EP EP95904020A patent/EP0736598B1/en not_active Expired - Lifetime
- 1994-12-28 ES ES95904020T patent/ES2222462T3/es not_active Expired - Lifetime
- 1994-12-28 AT AT95904020T patent/ATE273395T1/de not_active IP Right Cessation
- 1994-12-28 CN CN94195032A patent/CN1108382C/zh not_active Expired - Fee Related
- 1994-12-28 NZ NZ277562A patent/NZ277562A/en unknown
- 1994-12-28 BR BR9408435A patent/BR9408435A/pt not_active IP Right Cessation
- 1994-12-28 DE DE69433941T patent/DE69433941T2/de not_active Expired - Lifetime
- 1994-12-28 FI FI962664A patent/FI962664A7/fi not_active Application Discontinuation
-
1996
- 1996-06-27 NO NO962727A patent/NO962727L/no not_active Application Discontinuation
-
2001
- 2001-07-24 CN CN01123093.2A patent/CN1334340A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI962664L (fi) | 1996-08-26 |
| NZ277562A (en) | 1997-12-19 |
| DE69433941D1 (de) | 2004-09-16 |
| CA2180154A1 (en) | 1995-07-06 |
| NO962727L (no) | 1996-08-27 |
| FI962664A0 (fi) | 1996-06-27 |
| NO962727D0 (no) | 1996-06-27 |
| EP0736598A1 (en) | 1996-10-09 |
| ES2222462T3 (es) | 2005-02-01 |
| EP0736598A4 (en) | 1998-05-06 |
| EP0736598B1 (en) | 2004-08-11 |
| FI962664A7 (fi) | 1996-08-26 |
| CN1108382C (zh) | 2003-05-14 |
| WO1995018222A1 (en) | 1995-07-06 |
| AU688834B2 (en) | 1998-03-19 |
| CA2180154C (en) | 2000-02-15 |
| KR100224120B1 (ko) | 1999-10-15 |
| US6043411A (en) | 2000-03-28 |
| JP3313724B2 (ja) | 2002-08-12 |
| ATE273395T1 (de) | 2004-08-15 |
| CN1142853A (zh) | 1997-02-12 |
| CN1334340A (zh) | 2002-02-06 |
| DE69433941T2 (de) | 2005-07-28 |
| AU1283795A (en) | 1995-07-17 |
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