BR9604352A - Métodos para identificar um ligando que se ligue a uma proteína-alvo e à elastase de neutrófilo humano método para identificar um ligando de uma proteína-alvo e métodos de seleção de elevada produção para identificar um ligando que se ligue a hemoglobina s humana e á elastase de neutrófilo humano - Google Patents

Métodos para identificar um ligando que se ligue a uma proteína-alvo e à elastase de neutrófilo humano método para identificar um ligando de uma proteína-alvo e métodos de seleção de elevada produção para identificar um ligando que se ligue a hemoglobina s humana e á elastase de neutrófilo humano

Info

Publication number: BR9604352A
Authority: BR; Brazil
Prior art keywords: ligand; identifying; target protein; binds; elastase
Prior art date: 1995-10-25

Application number

BR9604352A

Other languages

English (en)

Inventor

James Bowie

Andrew Pakula

Original Assignee

Scriptgen Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-25

Filing date

1996-10-04

Publication date

1998-06-16

1996-10-04 Application filed by Scriptgen Pharm Inc filed Critical Scriptgen Pharm Inc

1998-06-16 Publication of BR9604352A publication Critical patent/BR9604352A/pt

Links

239000003446 ligand Substances 0.000 title abstract 6
102000004169 proteins and genes Human genes 0.000 title abstract 6
108090000623 proteins and genes Proteins 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 5
102000001554 Hemoglobins Human genes 0.000 title 1
108010054147 Hemoglobins Proteins 0.000 title 1
101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 title 1
102000016387 Pancreatic elastase Human genes 0.000 title 1
108010067372 Pancreatic elastase Proteins 0.000 title 1
102000052502 human ELANE Human genes 0.000 title 1
210000000440 neutrophil Anatomy 0.000 title 1
238000010187 selection method Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BR9604352A 1995-10-25 1996-10-04 Métodos para identificar um ligando que se ligue a uma proteína-alvo e à elastase de neutrófilo humano método para identificar um ligando de uma proteína-alvo e métodos de seleção de elevada produção para identificar um ligando que se ligue a hemoglobina s humana e á elastase de neutrófilo humano BR9604352A (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US54788995A	1995-10-25	1995-10-25

Publications (1)

Publication Number	Publication Date
BR9604352A true BR9604352A (pt)	1998-06-16

Family

ID=24186560

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9604352A BR9604352A (pt)	1995-10-25	1996-10-04	Métodos para identificar um ligando que se ligue a uma proteína-alvo e à elastase de neutrófilo humano método para identificar um ligando de uma proteína-alvo e métodos de seleção de elevada produção para identificar um ligando que se ligue a hemoglobina s humana e á elastase de neutrófilo humano

Country Status (14)

Country	Link
EP (1)	EP0770876B1 (pt)
JP (1)	JP2952848B2 (pt)
KR (1)	KR0161256B1 (pt)
AT (1)	ATE200579T1 (pt)
AU (1)	AU698862B2 (pt)
BR (1)	BR9604352A (pt)
CA (1)	CA2184195C (pt)
DE (2)	DE69612457T2 (pt)
DK (1)	DK0770876T3 (pt)
ES (1)	ES2158269T3 (pt)
GR (1)	GR3036138T3 (pt)
IL (1)	IL119149A (pt)
MX (1)	MX9604183A (pt)
PT (1)	PT770876E (pt)

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* Cited by examiner, † Cited by third party
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AU741049B2 (en) *	1996-05-09	2001-11-22	Life Technologies Corporation	Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US6453246B1 (en)	1996-11-04	2002-09-17	3-Dimensional Pharmaceuticals, Inc.	System, method, and computer program product for representing proximity data in a multi-dimensional space
US6571227B1 (en)	1996-11-04	2003-05-27	3-Dimensional Pharmaceuticals, Inc.	Method, system and computer program product for non-linear mapping of multi-dimensional data
CA2269669A1 (en)	1996-11-04	1998-05-14	3-Dimensional Pharmaceuticals, Inc.	System, method and computer program product for identifying chemical compounds having desired properties
PL194483B1 (pl)	1997-11-12	2007-06-29	Dimensional Pharmaceuticals 3	Sposób wyznaczania funkcji biologicznej docelowego białka
US6569631B1 (en)	1998-11-12	2003-05-27	3-Dimensional Pharmaceuticals, Inc.	Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
GB9904395D0 (en) *	1999-02-25	1999-04-21	Fluorescience Ltd	Protein assay
US6972198B2 (en) *	1999-02-26	2005-12-06	Cyclacel, Ltd.	Methods and compositions using protein binding partners
JP4493125B2 (ja)	1999-05-07	2010-06-30	独立行政法人理化学研究所	相互作用するタンパク質の検出方法
US6582907B1 (en) *	1999-12-09	2003-06-24	Pharmacia & Upjohn Company	Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
US6376180B1 (en)	1999-12-09	2002-04-23	Pharmacia & Upjohn Company	Methods of identifying compounds that bind to target species under isothermal denaturing conditions
US7416524B1 (en)	2000-02-18	2008-08-26	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	System, method and computer program product for fast and efficient searching of large chemical libraries
AU2001241800A1 (en)	2000-02-29	2001-09-12	3-Dimensional Pharmaceuticals, Inc.	Method and computer program product for designing combinatorial arrays
AU2001247627A1 (en)	2000-03-22	2001-10-03	3-Dimensional Pharmaceuticals, Inc.	System, method, and computer program product for representing object relationships in a multidimensional space
WO2001075790A2 (en)	2000-04-03	2001-10-11	3-Dimensional Pharmaceuticals, Inc.	Method, system, and computer program product for representing object relationships in a multidimensional space
KR20010112840A (ko) *	2000-06-15	2001-12-22	김유삼	기능성 단백질의 패턴분석을 이용한 진단 시스템
US7054757B2 (en)	2001-01-29	2006-05-30	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Method, system, and computer program product for analyzing combinatorial libraries
JPWO2003020960A1 (ja) *	2001-09-03	2004-12-16	協和醗酵工業株式会社	薬物の標的蛋白質を決定する方法
WO2003023360A2 (en)	2001-09-10	2003-03-20	Meso Scale Technologies, Llc	Methods and apparatus for conducting multiple measurements on a sample
CA2601869A1 (en)	2005-08-12	2007-02-22	Astellas Pharma Inc.	Method for identifying target protein of agent and method for screening therapeutic agent for diabetes using target protein
DE102006027259A1 (de) *	2006-06-09	2007-12-13	Protagen Ag	Protein-Biochip zum differentiellen Screenen von Protein-Protein-Wechselwirkungen
US11492340B2 (en)	2017-02-15	2022-11-08	Ohio State Innovation Foundation	Heteroaromatic electrophiles and methods of using thereof
CN114076826A (zh) *	2020-08-20	2022-02-22	中国科学院大连化学物理研究所	一种微球辅助的基于蛋白加热沉淀的药物靶蛋白筛选方法
GB202118173D0 (en) *	2021-12-15	2022-01-26	Medicines Discovery Catpult Ltd	Protein stability assay

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Publication number	Priority date	Publication date	Assignee	Title
JPS5231755B2 (pt) *	1973-01-08	1977-08-17
US4859609A (en) *	1986-04-30	1989-08-22	Genentech, Inc.	Novel receptors for efficient determination of ligands and their antagonists or agonists
WO1992003542A1 (en) *	1990-08-17	1992-03-05	Boston University	PROTEASES CAUSING ABNORMAL DEGRADATION OF AMYLOID β-PROTEIN PRECURSOR
US5506097A (en) *	1990-08-24	1996-04-09	President And Fellows Of Harvard College	Method for inhibiting β-protein enzymatic activity
WO1993014781A1 (en) *	1992-01-24	1993-08-05	The Regents Of The University Of California	Novel peptides and method for altering the activity of allosteric proteins
CA2115900A1 (en) *	1993-02-22	1994-08-23	Gerald W. Becker	Pharmaceutical screens and antibodies
US5585277A (en) *	1993-06-21	1996-12-17	Scriptgen Pharmaceuticals, Inc.	Screening method for identifying ligands for target proteins
JP2000502440A (ja)	1995-12-07	2000-02-29	スクリプトジェン・ファーマスーティカルズ，インコーポレイテッド	リガンドを識別するための蛍光に基づくスクリーニング方法
WO1997020925A1 (en) *	1995-12-08	1997-06-12	Hybridon, Inc.	Modified vegf antisense oligonucleotides for treatment of skin disorders
AU741049B2 (en) *	1996-05-09	2001-11-22	Life Technologies Corporation	Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US8082993B2 (en)	2009-03-12	2011-12-27	Halliburton Energy Services, Inc.	One trip gravel pack assembly

1996
- 1996-08-26 CA CA002184195A patent/CA2184195C/en not_active Expired - Fee Related
- 1996-08-28 AU AU64298/96A patent/AU698862B2/en not_active Ceased
- 1996-08-28 IL IL11914996A patent/IL119149A/en not_active IP Right Cessation
- 1996-09-10 JP JP8239252A patent/JP2952848B2/ja not_active Expired - Fee Related
- 1996-09-17 KR KR1019960040360A patent/KR0161256B1/ko not_active Expired - Fee Related
- 1996-09-19 MX MX9604183A patent/MX9604183A/es unknown
- 1996-10-04 BR BR9604352A patent/BR9604352A/pt not_active Application Discontinuation
- 1996-10-17 EP EP96610042A patent/EP0770876B1/en not_active Expired - Lifetime
- 1996-10-17 PT PT96610042T patent/PT770876E/pt unknown
- 1996-10-17 AT AT96610042T patent/ATE200579T1/de not_active IP Right Cessation
- 1996-10-17 DK DK96610042T patent/DK0770876T3/da active
- 1996-10-17 DE DE69612457T patent/DE69612457T2/de not_active Expired - Fee Related
- 1996-10-17 ES ES96610042T patent/ES2158269T3/es not_active Expired - Lifetime
- 1996-10-17 DE DE0770876T patent/DE770876T1/de active Pending
2001
- 2001-06-27 GR GR20010400992T patent/GR3036138T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0770876A1 (en)	1997-05-02
DE69612457D1 (de)	2001-05-17
EP0770876B1 (en)	2001-04-11
IL119149A (en)	2002-03-10
ES2158269T3 (es)	2001-09-01
AU6429896A (en)	1997-05-01
KR0161256B1 (ko)	1999-03-30
JP2952848B2 (ja)	1999-09-27
DK0770876T3 (da)	2001-08-06
GR3036138T3 (en)	2001-09-28
AU698862B2 (en)	1998-11-12
DE69612457T2 (de)	2001-11-08
MX9604183A (es)	1998-04-30
JPH09178746A (ja)	1997-07-11
IL119149A0 (en)	1996-11-14
DE770876T1 (de)	1999-07-22
PT770876E (pt)	2001-09-28
CA2184195C (en)	2002-04-16
ATE200579T1 (de)	2001-04-15
CA2184195A1 (en)	1997-04-26
KR970022315A (ko)	1997-05-28

Legal Events

Date	Code	Title	Description
2001-04-24	TCP	Change of proprietor's name pending
2002-05-14	TCR	Change of proprietor's name refused
2005-08-30	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2006-02-21	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO - DE ACORDO COM O ART. 8O DA LPI.

Publication	Publication Date	Title
BR9604352A (pt)	1998-06-16	Métodos para identificar um ligando que se ligue a uma proteína-alvo e à elastase de neutrófilo humano método para identificar um ligando de uma proteína-alvo e métodos de seleção de elevada produção para identificar um ligando que se ligue a hemoglobina s humana e á elastase de neutrófilo humano
FI915150A7 (fi)	1991-10-31	Menetelmät, reagenssit ja testikäyttöpakkaukset biologisten yksiköiden alapopulaatioiden määrittämiseksi
Ferranti et al.	1997	Characterisation of S‐nitrosohaemoglobin by mass spectrometry
DE69929185D1 (de)	2006-02-02	Tumormarker
DE69834719D1 (de)	2006-07-06	Methode zur diagnose von abnormalem knochenstoffwechsel
DE69029556D1 (de)	1997-02-13	Trockenes analytisches Element zur quantitativen Analyse von in Vollblut enthaltenen Analyten
DE69108554T2 (de)	1995-08-31	Analyse der varianten von analyten.
ATE90791T1 (de)	1993-07-15	Mittel zum nachweis von gehirnkrankheiten in zusammenhang mit nervenscheidenmarkzerstoerung, insbesondere sklerosis multiplex.
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IT8719998A0 (it)	1987-04-06	Procedimento di analisi immunologica o chimica per la determinazione di proteine in fluidi biologici e relativo completo (kit) di mezzi analitici.
DE69032489D1 (de)	1998-08-20	Ligand/antiligandteste für anklebende proteine
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DE3889279D1 (de)	1994-06-01	Diagnostisches Mittel und Verfahren zur Bestimmung von Apolipoprotein B.
FI854627A7 (fi)	1986-05-24	Menetelmä ja reagenssi plasmassa, seerumissa tai kokoveressä olevan vapaan tyroksiinin kvantitatiiviseksi määrittämiseksi.
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Henry et al.	1975	Drug displacement of warfarin from human serum albumin: A fluorometric analysis
DE69007155D1 (de)	1994-04-14	Automatisierte Schnittentwicklungsanalyse von mehrfachen Proben.
DK173884A (da)	1984-10-01	Fremgangsmaade til kvantitativ bestemmelse af haemoglobinkoncentrationen i en biologisk proeve
EP0839068A1 (en)	1998-05-06	On line detection of a desired solute in an effluent stream using fluorescence spectroscopy
ES2097158T3 (es)	1997-04-01	Ensayo funcional para la determinacion de la actividad de proteina s.
Wiederkehr et al.	1986	Two‐dimensional gel electrophoresis of cerebrospinal fluid immunoglobulins
ATE217087T1 (de)	2002-05-15	Chemilumineszierende derivate mit langer emissionswellenlänge und ihre verwendung in assays
RU94021664A (ru)	1996-04-10	Способ идентификации и количественного определения вредных побочных продуктов сульфирования методом ионной хроматографии