ATE200579T1 - Screening-verfahren zur ligand-identifizierung von zielproteinen - Google Patents

Screening-verfahren zur ligand-identifizierung von zielproteinen

Info

Publication number
ATE200579T1
ATE200579T1 AT96610042T AT96610042T ATE200579T1 AT E200579 T1 ATE200579 T1 AT E200579T1 AT 96610042 T AT96610042 T AT 96610042T AT 96610042 T AT96610042 T AT 96610042T AT E200579 T1 ATE200579 T1 AT E200579T1
Authority
AT
Austria
Prior art keywords
target proteins
target protein
screening method
ligands
ligand identification
Prior art date
Application number
AT96610042T
Other languages
English (en)
Inventor
Andrew Pakula
James Bowie
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE200579T1 publication Critical patent/ATE200579T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96610042T 1995-10-25 1996-10-17 Screening-verfahren zur ligand-identifizierung von zielproteinen ATE200579T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54788995A 1995-10-24 1995-10-24

Publications (1)

Publication Number Publication Date
ATE200579T1 true ATE200579T1 (de) 2001-04-15

Family

ID=24186560

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96610042T ATE200579T1 (de) 1995-10-25 1996-10-17 Screening-verfahren zur ligand-identifizierung von zielproteinen

Country Status (14)

Country Link
EP (1) EP0770876B1 (de)
JP (1) JP2952848B2 (de)
KR (1) KR0161256B1 (de)
AT (1) ATE200579T1 (de)
AU (1) AU698862B2 (de)
BR (1) BR9604352A (de)
CA (1) CA2184195C (de)
DE (2) DE69612457T2 (de)
DK (1) DK0770876T3 (de)
ES (1) ES2158269T3 (de)
GR (1) GR3036138T3 (de)
IL (1) IL119149A (de)
MX (1) MX9604183A (de)
PT (1) PT770876E (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9902418A3 (en) 1996-05-09 2001-10-29 Dimensional Pharm Inc Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US6571227B1 (en) 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
JP2001503546A (ja) 1996-11-04 2001-03-13 ３―ディメンショナル ファーマシューティカルズ インコーポレイテッド 化学データの可視化、並びに対話式に処理および分析するためのシステム、方法、およびコンピュータプログラム製品
IL136046A0 (en) 1997-11-12 2001-05-20 Dimensional Pharm Inc Methods for classifying proteins
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
GB9904395D0 (en) * 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
US6972198B2 (en) * 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
JP4493125B2 (ja) 1999-05-07 2010-06-30 独立行政法人理化学研究所 相互作用するタンパク質の検出方法
US6376180B1 (en) 1999-12-09 2002-04-23 Pharmacia & Upjohn Company Methods of identifying compounds that bind to target species under isothermal denaturing conditions
US6582907B1 (en) * 1999-12-09 2003-06-24 Pharmacia & Upjohn Company Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
AU2001241800A1 (en) 2000-02-29 2001-09-12 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
WO2001071624A1 (en) 2000-03-22 2001-09-27 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing object relationships in a multidimensional space
AU2001249805A1 (en) 2000-04-03 2001-10-15 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
KR20010112840A (ko) * 2000-06-15 2001-12-22 김유삼 기능성 단백질의 패턴분석을 이용한 진단 시스템
US7054757B2 (en) 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
AU2002328413B2 (en) * 2001-09-03 2007-03-15 Kyowa Hakko Kogyo Co., Ltd. Method for Determining Target Protein of Medicament
AU2002333526B2 (en) 2001-09-10 2008-01-17 Meso Scale Technologies, Llc. Methods and apparatus for conducting multiple measurements on a sample
CA2601869A1 (en) 2005-08-12 2007-02-22 Astellas Pharma Inc. Method for identifying target protein of agent and method for screening therapeutic agent for diabetes using target protein
DE102006027259A1 (de) * 2006-06-09 2007-12-13 Protagen Ag Protein-Biochip zum differentiellen Screenen von Protein-Protein-Wechselwirkungen
US11492340B2 (en) 2017-02-15 2022-11-08 Ohio State Innovation Foundation Heteroaromatic electrophiles and methods of using thereof
CN114076826A (zh) * 2020-08-20 2022-02-22 中国科学院大连化学物理研究所 一种微球辅助的基于蛋白加热沉淀的药物靶蛋白筛选方法
GB202118173D0 (en) * 2021-12-15 2022-01-26 Medicines Discovery Catpult Ltd Protein stability assay

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231755B2 (de) * 1973-01-08 1977-08-17
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
HUT69771A (en) * 1990-08-17 1995-09-28 Univ Boston Proteases causing abnormal degradation of amyloid beta-proteine precursors
US5506097A (en) * 1990-08-24 1996-04-09 President And Fellows Of Harvard College Method for inhibiting β-protein enzymatic activity
WO1993014781A1 (en) * 1992-01-24 1993-08-05 The Regents Of The University Of California Novel peptides and method for altering the activity of allosteric proteins
CA2115900A1 (en) * 1993-02-22 1994-08-23 Gerald W. Becker Pharmaceutical screens and antibodies
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
JP2000502440A (ja) 1995-12-07 2000-02-29 スクリプトジェン・ファーマスーティカルズ，インコーポレイテッド リガンドを識別するための蛍光に基づくスクリーニング方法
AU1686997A (en) * 1995-12-08 1997-06-27 Hybridon, Inc. Modified vegf antisense oligonucleotides for treatment of skin disorders
HUP9902418A3 (en) * 1996-05-09 2001-10-29 Dimensional Pharm Inc Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization
US8082993B2 (en) 2009-03-12 2011-12-27 Halliburton Energy Services, Inc. One trip gravel pack assembly

Also Published As

Publication number Publication date
CA2184195C (en) 2002-04-16
PT770876E (pt) 2001-09-28
DK0770876T3 (da) 2001-08-06
IL119149A (en) 2002-03-10
KR0161256B1 (ko) 1999-03-30
EP0770876A1 (de) 1997-05-02
MX9604183A (es) 1998-04-30
AU698862B2 (en) 1998-11-12
BR9604352A (pt) 1998-06-16
GR3036138T3 (en) 2001-09-28
CA2184195A1 (en) 1997-04-26
AU6429896A (en) 1997-05-01
DE69612457T2 (de) 2001-11-08
ES2158269T3 (es) 2001-09-01
KR970022315A (ko) 1997-05-28
EP0770876B1 (de) 2001-04-11
IL119149A0 (en) 1996-11-14
DE69612457D1 (de) 2001-05-17
JP2952848B2 (ja) 1999-09-27
JPH09178746A (ja) 1997-07-11
DE770876T1 (de) 1999-07-22

Similar Documents

Publication Publication Date Title
ATE200579T1 (de) Screening-verfahren zur ligand-identifizierung von zielproteinen
DE68907407D1 (de) Verfahren zur sequenzanalyse von dna.
DE3887168D1 (de) Verfahren zur quantitativen analyse von mineralien.
DE69122494D1 (de) Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
DE69829606D1 (de) Reagenz und Verfahren zur Klassifizierung und Zählung von Leukozyten
DE68909962D1 (de) Verfahren und Vorrichtung zur quantitativen Bestimmung von Trihalomethanen.
DE59007613D1 (de) Verfahren zum Nachweis und zur Bestimmung von Humanserumalbumin in biologischen Flüssigkeiten mit Hilfe fluorogener Cyanin-Farbstoffe.
DE3678489D1 (de) Verfahren zur quantitativen bestimmung von protein c und aktivatorpraeparat zur durchfuehrung des verfahrens.
DE3850512D1 (de) Verfahren und Vorrichtung zur Feststellung von bitteren oder riechenden Stoffen.
DE69022819D1 (de) Verbindungen und Reagenzien zur Bestimmung von Retikulozyten.
DE59208032D1 (de) Funktioneller Test und Reagenz zur Bestimmung von Fibrinogen
DE3863285D1 (de) Verfahren und reagenz zur bestimmung von persaeuren.
DE69029556D1 (de) Trockenes analytisches Element zur quantitativen Analyse von in Vollblut enthaltenen Analyten
ATA43187A (de) Verfahren zur quantitativen bestimmung von nucleinsaeure-molekuelen und reagenziensatz hierfuer
DE69312185D1 (de) Chromatographischer Sandwichtest zur Bestimmung von spezifischen Antikörpern und Vorrichtung hierfür
DE3889279D1 (de) Diagnostisches Mittel und Verfahren zur Bestimmung von Apolipoprotein B.
DE68909995D1 (de) Reagenz zur Bestimmung von Kreatinkinase und Messverfahren dafür.
ATE284034T1 (de) Verfahren zum nachweis von protein s
DE69019810D1 (de) Verfahren zur optischen Bestimmung von Bilirubin und Reagenz dafür.
DE69007155D1 (de) Automatisierte Schnittentwicklungsanalyse von mehrfachen Proben.
DK0445626T3 (da) Funktionel test til bestemmelse af protein S-aktivitet.
ATE182215T1 (de) Verfahren zur bestimmung von rheumafaktoren und mittel zur durchführung des verfahrens
DE59008687D1 (de) Verfahren zur selektiven komplexometrischen quantitativen Bestimmung von N-(Phosphonomethyl)-glycin-(glifosat(R)) und Derivat davon.
DE3783840D1 (de) Verfahren zur bestimmung von plasma-protein und testsatz dafuer.
DE58907208D1 (de) Verfahren zur Bestimmung von Antikörpern.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee