ATE200579T1 - Screening-verfahren zur ligand-identifizierung von zielproteinen - Google Patents

Screening-verfahren zur ligand-identifizierung von zielproteinen

Info

Publication number
ATE200579T1
ATE200579T1 AT96610042T AT96610042T ATE200579T1 AT E200579 T1 ATE200579 T1 AT E200579T1 AT 96610042 T AT96610042 T AT 96610042T AT 96610042 T AT96610042 T AT 96610042T AT E200579 T1 ATE200579 T1 AT E200579T1
Authority
AT
Austria
Prior art keywords
target proteins
target protein
screening method
ligands
ligand identification
Prior art date
Application number
AT96610042T
Other languages
English (en)
Inventor
Andrew Pakula
James Bowie
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE200579T1 publication Critical patent/ATE200579T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96610042T 1995-10-25 1996-10-17 Screening-verfahren zur ligand-identifizierung von zielproteinen ATE200579T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54788995A 1995-10-25 1995-10-25

Publications (1)

Publication Number Publication Date
ATE200579T1 true ATE200579T1 (de) 2001-04-15

Family

ID=24186560

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96610042T ATE200579T1 (de) 1995-10-25 1996-10-17 Screening-verfahren zur ligand-identifizierung von zielproteinen

Country Status (14)

Country Link
EP (1) EP0770876B1 (de)
JP (1) JP2952848B2 (de)
KR (1) KR0161256B1 (de)
AT (1) ATE200579T1 (de)
AU (1) AU698862B2 (de)
BR (1) BR9604352A (de)
CA (1) CA2184195C (de)
DE (2) DE69612457T2 (de)
DK (1) DK0770876T3 (de)
ES (1) ES2158269T3 (de)
GR (1) GR3036138T3 (de)
IL (1) IL119149A (de)
MX (1) MX9604183A (de)
PT (1) PT770876E (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020141A (en) 1996-05-09 2000-02-01 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development and multi-variable protein chemistry optimization
WO1998020437A2 (en) 1996-11-04 1998-05-14 3-Dimensional Pharmaceuticals, Inc. System, method and computer program product for identifying chemical compounds having desired properties
US6571227B1 (en) 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
PL194483B1 (pl) 1997-11-12 2007-06-29 Dimensional Pharmaceuticals 3 Sposób wyznaczania funkcji biologicznej docelowego białka
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
GB9904395D0 (en) * 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
US6972198B2 (en) * 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
JP4493125B2 (ja) * 1999-05-07 2010-06-30 独立行政法人理化学研究所 相互作用するタンパク質の検出方法
US6376180B1 (en) 1999-12-09 2002-04-23 Pharmacia & Upjohn Company Methods of identifying compounds that bind to target species under isothermal denaturing conditions
US6582907B1 (en) 1999-12-09 2003-06-24 Pharmacia & Upjohn Company Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
WO2001065462A2 (en) 2000-02-29 2001-09-07 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
US7039621B2 (en) 2000-03-22 2006-05-02 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method, and computer program product for representing object relationships in a multidimensional space
WO2001075790A2 (en) 2000-04-03 2001-10-11 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
KR20010112840A (ko) * 2000-06-15 2001-12-22 김유삼 기능성 단백질의 패턴분석을 이용한 진단 시스템
US7054757B2 (en) 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
ATE346952T1 (de) * 2001-09-03 2006-12-15 Kyowa Hakko Kogyo Kk Verfahren zur bestimmung eines zielproteins eines arzneistoffs
US7063946B2 (en) 2001-09-10 2006-06-20 Meso Scale Technologies, Llc. Methods, reagents, kits and apparatus for protein function analysis
JP4992716B2 (ja) 2005-08-12 2012-08-08 アステラス製薬株式会社 薬剤の標的蛋白質を同定する方法及び標的蛋白質を用いた糖尿病治療薬のスクリーニング方法
DE102006027259A1 (de) * 2006-06-09 2007-12-13 Protagen Ag Protein-Biochip zum differentiellen Screenen von Protein-Protein-Wechselwirkungen
WO2018152329A1 (en) 2017-02-15 2018-08-23 Ohio State Innovation Foundation Heteroaromatic electrophiles and methods of using thereof
CN114076826A (zh) * 2020-08-20 2022-02-22 中国科学院大连化学物理研究所 一种微球辅助的基于蛋白加热沉淀的药物靶蛋白筛选方法
GB202118173D0 (en) * 2021-12-15 2022-01-26 Medicines Discovery Catpult Ltd Protein stability assay

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231755B2 (de) * 1973-01-08 1977-08-17
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
WO1992003542A1 (en) * 1990-08-17 1992-03-05 Boston University PROTEASES CAUSING ABNORMAL DEGRADATION OF AMYLOID β-PROTEIN PRECURSOR
US5506097A (en) * 1990-08-24 1996-04-09 President And Fellows Of Harvard College Method for inhibiting β-protein enzymatic activity
WO1993014781A1 (en) * 1992-01-24 1993-08-05 The Regents Of The University Of California Novel peptides and method for altering the activity of allosteric proteins
CA2115900A1 (en) * 1993-02-22 1994-08-23 Gerald W. Becker Pharmaceutical screens and antibodies
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
WO1997020952A1 (en) 1995-12-07 1997-06-12 Scriptgen Pharmaceuticals, Inc. A fluorescence-based screening method for identifying ligands
WO1997020925A1 (en) * 1995-12-08 1997-06-12 Hybridon, Inc. Modified vegf antisense oligonucleotides for treatment of skin disorders
US6020141A (en) * 1996-05-09 2000-02-01 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development and multi-variable protein chemistry optimization
US8082993B2 (en) 2009-03-12 2011-12-27 Halliburton Energy Services, Inc. One trip gravel pack assembly

Also Published As

Publication number Publication date
BR9604352A (pt) 1998-06-16
DE69612457D1 (de) 2001-05-17
JP2952848B2 (ja) 1999-09-27
DE770876T1 (de) 1999-07-22
DK0770876T3 (da) 2001-08-06
CA2184195A1 (en) 1997-04-26
AU698862B2 (en) 1998-11-12
JPH09178746A (ja) 1997-07-11
KR0161256B1 (ko) 1999-03-30
IL119149A (en) 2002-03-10
ES2158269T3 (es) 2001-09-01
PT770876E (pt) 2001-09-28
EP0770876B1 (de) 2001-04-11
EP0770876A1 (de) 1997-05-02
MX9604183A (es) 1998-04-30
CA2184195C (en) 2002-04-16
DE69612457T2 (de) 2001-11-08
IL119149A0 (en) 1996-11-14
GR3036138T3 (en) 2001-09-28
KR970022315A (ko) 1997-05-28
AU6429896A (en) 1997-05-01

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Legal Events

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REN Ceased due to non-payment of the annual fee