ES2158269T3 - Un metodo de rastreo para identificar ligandos para proteinas diana. - Google Patents

Un metodo de rastreo para identificar ligandos para proteinas diana.

Info

Publication number
ES2158269T3
ES2158269T3 ES96610042T ES96610042T ES2158269T3 ES 2158269 T3 ES2158269 T3 ES 2158269T3 ES 96610042 T ES96610042 T ES 96610042T ES 96610042 T ES96610042 T ES 96610042T ES 2158269 T3 ES2158269 T3 ES 2158269T3
Authority
ES
Spain
Prior art keywords
proteins
target protein
diana
tracking
ligands
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96610042T
Other languages
English (en)
Inventor
Andrew Pakula
James Bowie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anadys Pharmaceuticals Inc
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2158269T3 publication Critical patent/ES2158269T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PROPORCIONA UN METODO NOVEDOSO PARA VISUALIZAR LOS COMPUESTOS QUIMICOS (LIGANTES DE PRUEBA) CON EFECTIVIDAD FARMACEUTICA POTENCIAL. EL METODO PRESENTADO IDENTIFICA LOS LIGANTES DE PRUEBA TERAPEUTICAS POSIBLES MEDIANTE COLOCARLAS EN PRESENCIA DE PROTEINAS SELECCIONADAS Y DETERMINAR SU HABILIDAD PARA AUMENTAR O DESCENDER LA RAZON DE LA PROTEINA META DOBLADA PARA DESDOBLAR LA PROTEINA SELECCIONADA. EL PRESENTE METODO NO REQUIERE QUE SE CONOZCA LA FUNCION BIOQUIMICA DE LA PROTEINA SELECCIONADA NI QUE SE IDENTIFIQUE PREVIAMENTE CUALQUIER OTRO LIGANTE.
ES96610042T 1995-10-25 1996-10-17 Un metodo de rastreo para identificar ligandos para proteinas diana. Expired - Lifetime ES2158269T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54788995A 1995-10-25 1995-10-25

Publications (1)

Publication Number Publication Date
ES2158269T3 true ES2158269T3 (es) 2001-09-01

Family

ID=24186560

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96610042T Expired - Lifetime ES2158269T3 (es) 1995-10-25 1996-10-17 Un metodo de rastreo para identificar ligandos para proteinas diana.

Country Status (14)

Country Link
EP (1) EP0770876B1 (es)
JP (1) JP2952848B2 (es)
KR (1) KR0161256B1 (es)
AT (1) ATE200579T1 (es)
AU (1) AU698862B2 (es)
BR (1) BR9604352A (es)
CA (1) CA2184195C (es)
DE (2) DE69612457T2 (es)
DK (1) DK0770876T3 (es)
ES (1) ES2158269T3 (es)
GR (1) GR3036138T3 (es)
IL (1) IL119149A (es)
MX (1) MX9604183A (es)
PT (1) PT770876E (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036920A (en) 1996-05-09 2000-03-14 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
AU722989B2 (en) 1996-11-04 2000-08-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for the visualization and interactive processing and analysis of chemical data
US6571227B1 (en) 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
WO1999024050A1 (en) 1997-11-12 1999-05-20 3-Dimensional Pharmaceuticals, Inc. High throughput method for functionally classifying proteins identified using a genomics approach
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
GB9904395D0 (en) * 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
US6972198B2 (en) * 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
JP4493125B2 (ja) * 1999-05-07 2010-06-30 独立行政法人理化学研究所 相互作用するタンパク質の検出方法
US6376180B1 (en) 1999-12-09 2002-04-23 Pharmacia & Upjohn Company Methods of identifying compounds that bind to target species under isothermal denaturing conditions
US6582907B1 (en) * 1999-12-09 2003-06-24 Pharmacia & Upjohn Company Use of fluorescence correlation spectroscopy to identify compounds that bind to target species under isothermal denaturing conditions
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
WO2001065462A2 (en) 2000-02-29 2001-09-07 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
US7039621B2 (en) 2000-03-22 2006-05-02 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method, and computer program product for representing object relationships in a multidimensional space
WO2001075790A2 (en) 2000-04-03 2001-10-11 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
KR20010112840A (ko) * 2000-06-15 2001-12-22 김유삼 기능성 단백질의 패턴분석을 이용한 진단 시스템
US7054757B2 (en) 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
DE60216487T2 (de) * 2001-09-03 2007-09-13 Kyowa Hakko Kogyo Co., Ltd. Verfahren zur bestimmung eines zielproteins eines arzneistoffs
EP1451348B1 (en) 2001-09-10 2015-08-12 Meso Scale Technologies, LLC Methods, reagents, kits and apparatus for protein function analysis
ES2336605T3 (es) 2005-08-12 2010-04-14 Astellas Pharma Inc. Metodo para identificar la proteina diana de un agente y metodo para explorar un agente terapeutico para diabetes usando la proteina diana.
DE102006027259A1 (de) * 2006-06-09 2007-12-13 Protagen Ag Protein-Biochip zum differentiellen Screenen von Protein-Protein-Wechselwirkungen
WO2018152329A1 (en) 2017-02-15 2018-08-23 Ohio State Innovation Foundation Heteroaromatic electrophiles and methods of using thereof
CN114076826A (zh) * 2020-08-20 2022-02-22 中国科学院大连化学物理研究所 一种微球辅助的基于蛋白加热沉淀的药物靶蛋白筛选方法
GB202118173D0 (en) * 2021-12-15 2022-01-26 Medicines Discovery Catpult Ltd Protein stability assay

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5231755B2 (es) * 1973-01-08 1977-08-17
US4859609A (en) * 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
HUT69771A (en) * 1990-08-17 1995-09-28 Univ Boston Proteases causing abnormal degradation of amyloid beta-proteine precursors
US5506097A (en) * 1990-08-24 1996-04-09 President And Fellows Of Harvard College Method for inhibiting β-protein enzymatic activity
WO1993014781A1 (en) * 1992-01-24 1993-08-05 The Regents Of The University Of California Novel peptides and method for altering the activity of allosteric proteins
CA2115900A1 (en) * 1993-02-22 1994-08-23 Gerald W. Becker Pharmaceutical screens and antibodies
US5585277A (en) * 1993-06-21 1996-12-17 Scriptgen Pharmaceuticals, Inc. Screening method for identifying ligands for target proteins
WO1997020952A1 (en) 1995-12-07 1997-06-12 Scriptgen Pharmaceuticals, Inc. A fluorescence-based screening method for identifying ligands
WO1997020925A1 (en) * 1995-12-08 1997-06-12 Hybridon, Inc. Modified vegf antisense oligonucleotides for treatment of skin disorders
US6036920A (en) * 1996-05-09 2000-03-14 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay apparatus for ligand development and multi-variable protein chemistry optimization
US8082993B2 (en) 2009-03-12 2011-12-27 Halliburton Energy Services, Inc. One trip gravel pack assembly

Also Published As

Publication number Publication date
JP2952848B2 (ja) 1999-09-27
KR0161256B1 (ko) 1999-03-30
EP0770876A1 (en) 1997-05-02
IL119149A (en) 2002-03-10
CA2184195C (en) 2002-04-16
DE69612457T2 (de) 2001-11-08
DE770876T1 (de) 1999-07-22
MX9604183A (es) 1998-04-30
DE69612457D1 (de) 2001-05-17
JPH09178746A (ja) 1997-07-11
BR9604352A (pt) 1998-06-16
CA2184195A1 (en) 1997-04-26
IL119149A0 (en) 1996-11-14
GR3036138T3 (en) 2001-09-28
DK0770876T3 (da) 2001-08-06
KR970022315A (ko) 1997-05-28
AU698862B2 (en) 1998-11-12
PT770876E (pt) 2001-09-28
EP0770876B1 (en) 2001-04-11
ATE200579T1 (de) 2001-04-15
AU6429896A (en) 1997-05-01

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