BR9713253A - Derivados de 3-carboxamida de 5h-pirrol [2,1-c][1,4]-benzodiazepinas - Google Patents
Derivados de 3-carboxamida de 5h-pirrol [2,1-c][1,4]-benzodiazepinasInfo
- Publication number
- BR9713253A BR9713253A BR9713253-5A BR9713253A BR9713253A BR 9713253 A BR9713253 A BR 9713253A BR 9713253 A BR9713253 A BR 9713253A BR 9713253 A BR9713253 A BR 9713253A
- Authority
- BR
- Brazil
- Prior art keywords
- benzodiazepines
- conditions
- carboxamide derivatives
- pyrrole
- vasopressin
- Prior art date
Links
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 title abstract 2
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical class N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- JZIBVTUXIVIFGC-UHFFFAOYSA-N 2H-pyrrole Chemical class C1C=CC=N1 JZIBVTUXIVIFGC-UHFFFAOYSA-N 0.000 title 1
- GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 abstract 2
- 108010004977 Vasopressins Proteins 0.000 abstract 2
- 102000002852 Vasopressins Human genes 0.000 abstract 2
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 abstract 2
- 229960003726 vasopressin Drugs 0.000 abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010047139 Vasoconstriction Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000008060 renal absorption Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
- 230000025033 vasoconstriction Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Patente de Invenção:<B>"DERIVADOS DE 3-CARBOXAMIDA DE 5H-PIRROL[2,1-c][1,4]-BENZODIAZEPINAS"<D>. A presente invenção se refere a antagonistas não peptídeos tricíclicos da vasopressina, os quais são úteis no tratamento de condições onde níveis diminuídos de vasopressina são desejados, tais como em insuficiência cardíaca congestiva, em condições de doença com absorção renal em excesso de água e em condições com resistência vascular aumentada a vasocontrição coronariana, os compostos tendo a estrutura geral (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74344396A | 1996-11-01 | 1996-11-01 | |
| PCT/US1997/018918 WO1998020011A1 (en) | 1996-11-01 | 1997-10-22 | 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9713253A true BR9713253A (pt) | 1999-11-03 |
Family
ID=24988792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9713253-5A BR9713253A (pt) | 1996-11-01 | 1997-10-22 | Derivados de 3-carboxamida de 5h-pirrol [2,1-c][1,4]-benzodiazepinas |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1021444B1 (pt) |
| JP (1) | JP2001503759A (pt) |
| KR (1) | KR20000052978A (pt) |
| CN (1) | CN1330653C (pt) |
| AR (1) | AR013329A1 (pt) |
| AT (1) | ATE250607T1 (pt) |
| AU (1) | AU737689B2 (pt) |
| BR (1) | BR9713253A (pt) |
| CA (1) | CA2268327C (pt) |
| DE (1) | DE69725182T2 (pt) |
| DK (1) | DK1021444T3 (pt) |
| ES (1) | ES2206693T3 (pt) |
| HU (1) | HUP9904514A3 (pt) |
| IL (1) | IL129150A0 (pt) |
| NZ (1) | NZ335483A (pt) |
| PT (1) | PT1021444E (pt) |
| TW (1) | TW496869B (pt) |
| WO (1) | WO1998020011A1 (pt) |
| ZA (1) | ZA979782B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001014336A1 (en) * | 1999-08-20 | 2001-03-01 | Nippon Kayaku Kabushiki Kaisha | Benzene derivatives substituted by aromatic ring and process for producing the same |
| US6271418B1 (en) | 2000-02-22 | 2001-08-07 | Nippon Kayaku Co., Ltd. | Process for preparing (hetero) aromatic substituted benzene derivatives |
| US7202239B2 (en) | 2001-04-12 | 2007-04-10 | Wyeth | Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists |
| US6903087B2 (en) | 2001-04-12 | 2005-06-07 | Wyeth | Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
| US7326700B2 (en) | 2001-04-12 | 2008-02-05 | Wyeth | Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
| US6977254B2 (en) | 2001-04-12 | 2005-12-20 | Wyeth | Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists |
| US7109193B2 (en) | 2001-04-12 | 2006-09-19 | Wyeth | Tricyclic diazepines tocolytic oxytocin receptor antagonists |
| US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
| US7064120B2 (en) | 2001-04-12 | 2006-06-20 | Wyeth | Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
| US6900200B2 (en) | 2001-04-12 | 2005-05-31 | Wyeth | Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists |
| GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| US7119088B2 (en) | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
| AP2005003376A0 (en) * | 2003-02-19 | 2005-09-30 | Pfizer | Triazole compounds useful in therapy. |
| WO2009130232A1 (en) * | 2008-04-24 | 2009-10-29 | Glaxo Group Limited | Pyrazolo [1, 5 -a] pyrazine derivatives as antagonists of v1b receptors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
-
1997
- 1997-10-22 CN CNB971991294A patent/CN1330653C/zh not_active Expired - Fee Related
- 1997-10-22 DE DE69725182T patent/DE69725182T2/de not_active Expired - Fee Related
- 1997-10-22 IL IL12915097A patent/IL129150A0/xx unknown
- 1997-10-22 HU HU9904514A patent/HUP9904514A3/hu unknown
- 1997-10-22 DK DK97911809T patent/DK1021444T3/da active
- 1997-10-22 PT PT97911809T patent/PT1021444E/pt unknown
- 1997-10-22 BR BR9713253-5A patent/BR9713253A/pt not_active Application Discontinuation
- 1997-10-22 ES ES97911809T patent/ES2206693T3/es not_active Expired - Lifetime
- 1997-10-22 NZ NZ335483A patent/NZ335483A/en unknown
- 1997-10-22 CA CA002268327A patent/CA2268327C/en not_active Expired - Fee Related
- 1997-10-22 WO PCT/US1997/018918 patent/WO1998020011A1/en not_active Ceased
- 1997-10-22 AT AT97911809T patent/ATE250607T1/de not_active IP Right Cessation
- 1997-10-22 AU AU49097/97A patent/AU737689B2/en not_active Ceased
- 1997-10-22 EP EP97911809A patent/EP1021444B1/en not_active Expired - Lifetime
- 1997-10-22 JP JP52143198A patent/JP2001503759A/ja active Pending
- 1997-10-22 KR KR1019990703855A patent/KR20000052978A/ko not_active Ceased
- 1997-10-28 TW TW086115936A patent/TW496869B/zh active
- 1997-10-30 ZA ZA979782A patent/ZA979782B/xx unknown
- 1997-10-30 AR ARP970105056A patent/AR013329A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL129150A0 (en) | 2000-02-17 |
| WO1998020011A1 (en) | 1998-05-14 |
| AU737689B2 (en) | 2001-08-30 |
| DK1021444T3 (da) | 2004-01-19 |
| AR013329A1 (es) | 2000-12-27 |
| PT1021444E (pt) | 2004-02-27 |
| NZ335483A (en) | 2001-09-28 |
| EP1021444B1 (en) | 2003-09-24 |
| CA2268327A1 (en) | 1998-05-14 |
| HUP9904514A2 (hu) | 2000-05-28 |
| CA2268327C (en) | 2002-05-21 |
| ATE250607T1 (de) | 2003-10-15 |
| KR20000052978A (ko) | 2000-08-25 |
| DE69725182D1 (de) | 2003-10-30 |
| CN1330653C (zh) | 2007-08-08 |
| HUP9904514A3 (en) | 2000-10-30 |
| ZA979782B (en) | 1999-04-30 |
| CN1234801A (zh) | 1999-11-10 |
| TW496869B (en) | 2002-08-01 |
| JP2001503759A (ja) | 2001-03-21 |
| ES2206693T3 (es) | 2004-05-16 |
| EP1021444A1 (en) | 2000-07-26 |
| DE69725182T2 (de) | 2004-06-24 |
| AU4909797A (en) | 1998-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25D | Requested change of name of applicant approved | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL: A61K 31/551, C07D 487/00, C07D 243/14, A61P 5/12 Ipc: C07D 487/04 (2008.04), A61K 31/55 (2008.04) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM O ART. 8O DA LPI. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |