ES2168384T3 - Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos para el sistema cardiovascular. - Google Patents

Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos para el sistema cardiovascular.

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Publication number
ES2168384T3
ES2168384T3 ES95932708T ES95932708T ES2168384T3 ES 2168384 T3 ES2168384 T3 ES 2168384T3 ES 95932708 T ES95932708 T ES 95932708T ES 95932708 T ES95932708 T ES 95932708T ES 2168384 T3 ES2168384 T3 ES 2168384T3
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Spain
Prior art keywords
derivatives
amino
tetrahidronaftaleno
active
cardiovascular system
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Expired - Lifetime
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ES95932708T
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English (en)
Inventor
Stefania Montanari
Paolo Cavalleri
Cristina Fraire
Gian Carlo Grancini
Mauro Napoletano
Francesco Santangelo
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Zambon Group SpA
Zambon SpA
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Zambon Group SpA
Zambon SpA
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

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  • Pharmacology & Pharmacy (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

DERIVADOS DE 2-AMINO.1,2,3,4-TETRAHIDRO-NAFTALENO CONFORME CON LA FORMULA (I) PARA EL TRATAMIENTO DE LA HIPERTENSION ARTERIAL, EL FALLO CARDIACO CONGESTIVO Y ARTERIOPATIAS PERIFERICAS DE INSUFICIENCIAS CEREBRO VASCULARES.
ES95932708T 1994-09-13 1995-09-11 Derivados de 2-amino-1,2,3,4-tetrahidronaftaleno activos para el sistema cardiovascular. Expired - Lifetime ES2168384T3 (es)

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ITMI941868A IT1271007B (it) 1994-09-13 1994-09-13 Derivati del 2-ammino-1,2,3,4-tetraidronaftalene attivi sul sistema cardiovascolare

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EP (1) EP0781126B1 (es)
JP (1) JPH11501006A (es)
KR (1) KR970705989A (es)
AT (1) ATE210433T1 (es)
AU (1) AU694563B2 (es)
CA (1) CA2199484A1 (es)
CZ (1) CZ76597A3 (es)
DE (1) DE69524610T2 (es)
DK (1) DK0781126T3 (es)
ES (1) ES2168384T3 (es)
FI (1) FI971039L (es)
HU (1) HUT76837A (es)
IT (1) IT1271007B (es)
NO (1) NO971134L (es)
NZ (1) NZ293258A (es)
PT (1) PT781126E (es)
RU (1) RU2149158C1 (es)
WO (1) WO1996008228A2 (es)

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IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare
IT1289980B1 (it) * 1997-02-26 1998-10-19 Zambon Spa Derivati idrossimetilici del 2-ammino-1,2,3,4-tetraidronaftalene attivi in campo cardiovascolare
WO1999062867A1 (fr) * 1998-06-03 1999-12-09 Nissan Chemical Industries, Ltd. Derives d'indane
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
DE10109859A1 (de) * 2001-03-01 2002-09-05 Bayer Ag Neuartige Aminodicarbonsäurederivate
GB2389582A (en) * 2002-06-13 2003-12-17 Bayer Ag Pharmaceutically active carboxamides
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
JP2006523674A (ja) * 2003-04-18 2006-10-19 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 慢性閉塞性肺疾患（ｃｏｐｄ）のための組合せ治療法
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
BRPI0811204A8 (pt) * 2007-05-10 2015-09-22 Bristol Myers Squibb Co Tetra-hidroibenzo-1,4-diazepinas substituídas por arila e heteroarila e uso das mesmas para bloquear a recaptação de norepinefrina, dopamina e serotonina
WO2012068299A2 (en) * 2010-11-16 2012-05-24 University Of Southern California Cbp/catenin antagonists for enhancing asymmetric division of somatic stem cells
US10874669B2 (en) 2012-11-29 2020-12-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases
US10125127B2 (en) * 2012-11-29 2018-11-13 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases
US11285147B2 (en) 2018-09-07 2022-03-29 Wayne State University Neuroprotective agents for treatment of neurodegenerative diseases

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DK131775A (es) * 1974-03-28 1975-09-29 Wellcome Found
DE3263531D1 (en) * 1981-08-05 1985-06-20 Fisons Plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
EP0375668A3 (en) * 1983-10-25 1990-10-17 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
IT1224405B (it) * 1987-12-23 1990-10-04 Simes Composti attivi sul sistema cardiovascolare
US5358971A (en) * 1989-07-05 1994-10-25 Whitby Research, Inc. Substituted 2-aminotetralins
IT1254521B (it) * 1992-03-17 1995-09-25 Zambon Spa Derivati della 2-ammino-tetralina attivi sul sistema cardiovascolare
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

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DE69524610D1 (de) 2002-01-24
ATE210433T1 (de) 2001-12-15
IT1271007B (it) 1997-05-26
NO971134D0 (no) 1997-03-12
US5674909A (en) 1997-10-07
HUT76837A (en) 1997-11-28
EP0781126B1 (en) 2001-12-12
AU3565395A (en) 1996-03-29
KR970705989A (ko) 1997-11-03
NZ293258A (en) 1998-06-26
EP0781126A2 (en) 1997-07-02
AU694563B2 (en) 1998-07-23
JPH11501006A (ja) 1999-01-26
FI971039A7 (fi) 1997-03-12
ITMI941868A0 (it) 1994-09-13
PT781126E (pt) 2002-06-28
WO1996008228A2 (en) 1996-03-21
RU2149158C1 (ru) 2000-05-20
FI971039A0 (fi) 1997-03-12
WO1996008228A3 (en) 1996-07-25
DK0781126T3 (da) 2002-04-08
CA2199484A1 (en) 1996-03-21
ITMI941868A1 (it) 1996-03-13
DE69524610T2 (de) 2002-07-18
NO971134L (no) 1997-05-12
FI971039L (fi) 1997-03-12
CZ76597A3 (en) 1997-10-15

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