BR9808588A - Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo - Google Patents

Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo

Info

Publication number
BR9808588A
BR9808588A BR9808588-3A BR9808588A BR9808588A BR 9808588 A BR9808588 A BR 9808588A BR 9808588 A BR9808588 A BR 9808588A BR 9808588 A BR9808588 A BR 9808588A
Authority
BR
Brazil
Prior art keywords
ecteinascidins
compounds
oxide
nucleophile
substituted
Prior art date
Application number
BR9808588-3A
Other languages
English (en)
Inventor
Kenneth L Rinehart
Tong Zhou
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of BR9808588A publication Critical patent/BR9808588A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: <B>"ECTEINASCIDINAS E ECTEINASCIDINAS DE N-óXIDO SUBSTITUìDAS POR NUCLEóFILO"<D>. Cinco novos compostos de ecteinascidina (Et) substituída por nucleófilo foram isolados de Ecteinascidia turbinata. Estes compostos foram purificados por técnicas cromatográficas e foram determinadas suas estruturas e bioatividades. Os cinco compostos de Et substituída por nucleófilo foram designados neste caso como Et 802 (1), Et 788 (2), Et 760 (3), Et 858 (4) e Et 815 (5). Também foram obtidos três novos compostos de ecteinascidinas de N-óxido, que foram designados neste caso como Et 717 (6), Et 775 (7) e Et 789 (8). Alguns destes compostos de Et recentemente verificados apresentam citotoxicidez excessivamente potente contra L1210.
BR9808588-3A 1997-04-15 1998-04-14 Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo BR9808588A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4359697P 1997-04-15 1997-04-15
PCT/US1998/007340 WO1998046080A1 (en) 1997-04-15 1998-04-14 Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

Publications (1)

Publication Number Publication Date
BR9808588A true BR9808588A (pt) 2000-05-23

Family

ID=21927969

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9808588-3A BR9808588A (pt) 1997-04-15 1998-04-14 Ecteinascidinas e ecteinascidinas de n-óxido substituìdas por nucleófilo

Country Status (20)

Country Link
US (1) US5985876A (pt)
EP (2) EP0975218A4 (pt)
JP (1) JP4382164B2 (pt)
KR (1) KR100513668B1 (pt)
CN (1) CN100343235C (pt)
AT (1) ATE420092T1 (pt)
AU (1) AU747303B2 (pt)
BR (1) BR9808588A (pt)
CA (1) CA2286796C (pt)
CY (1) CY1108958T1 (pt)
CZ (1) CZ298842B6 (pt)
DE (1) DE69840458D1 (pt)
DK (1) DK1668985T3 (pt)
ES (1) ES2321019T3 (pt)
HU (1) HUP0103590A3 (pt)
IL (1) IL132403A (pt)
NO (1) NO327455B1 (pt)
PL (2) PL197708B1 (pt)
PT (1) PT1668985E (pt)
WO (1) WO1998046080A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
CA2331593C (en) * 1998-05-11 2008-08-05 Pharma Mar, S.A. Metabolites of ecteinascidin 743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
WO2001077115A1 (en) * 2000-04-12 2001-10-18 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
BR0115162A (pt) * 2000-11-06 2003-10-21 Pharma Mar Sa Tratamentos antitumorais eficazes
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
HRP20080598T3 (en) * 2003-11-13 2009-01-31 Pharma Mar Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
AU2004291037A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2006005602A2 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
EP1827500B1 (en) * 2004-10-26 2009-05-06 Pharma Mar S.A., Sociedad Unipersonal Pegylated liposomal doxorubicin in combination with ecteinescidin 743
ATE368461T1 (de) 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
RS54648B1 (sr) 2010-11-12 2016-08-31 Pharma Mar S.A. Kombinovana terapija sa antitumorskim alkaloidom
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
PE20252386A1 (es) 2019-11-21 2025-10-10 Pharma Mar Sa Metodo de tratamiento del cancer de pulmon de celulas pequenas con formulaciones de lurbinectedina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) * 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
EP0574857B1 (en) * 1992-06-19 1997-09-17 Hoechst Aktiengesellschaft Polycyclic compounds 31668P and 31668U, a process for their production and their use as antibiotic or antitumor agents
US5426108A (en) * 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
BR9909488B1 (pt) * 1998-04-06 2011-02-08 ecteinascidinas semi-sintéticas e composição farmacêutica.

Also Published As

Publication number Publication date
WO1998046080A1 (en) 1998-10-22
NO995016D0 (no) 1999-10-14
CN1261254A (zh) 2000-07-26
DE69840458D1 (de) 2009-02-26
CN100343235C (zh) 2007-10-17
CZ367999A3 (cs) 2000-07-12
EP0975218A4 (en) 2001-08-08
CA2286796C (en) 2008-08-05
JP2001523228A (ja) 2001-11-20
EP1668985B1 (en) 2009-01-07
AU7111498A (en) 1998-11-11
EP1668985A3 (en) 2006-11-22
KR100513668B1 (ko) 2005-09-08
IL132403A0 (en) 2001-03-19
PL197708B1 (pl) 2008-04-30
NO327455B1 (no) 2009-07-06
NO995016L (no) 1999-12-10
KR20010006402A (ko) 2001-01-26
CY1108958T1 (el) 2012-05-23
ES2321019T3 (es) 2009-06-01
EP0975218A1 (en) 2000-02-02
IL132403A (en) 2004-09-27
DK1668985T3 (da) 2009-05-04
AU747303B2 (en) 2002-05-16
US5985876A (en) 1999-11-16
EP1668985A2 (en) 2006-06-14
JP4382164B2 (ja) 2009-12-09
PT1668985E (pt) 2009-04-09
CA2286796A1 (en) 1998-10-22
CZ298842B6 (cs) 2008-02-20
HUP0103590A3 (en) 2002-07-29
PL338508A1 (en) 2000-11-06
ATE420092T1 (de) 2009-01-15
HUP0103590A2 (hu) 2002-01-28

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CI: A61K 35/56; A61P 35/00; C07D 519/00

Ipc: A61K 35/56 (2008.04), A61P 35/00 (2008.04), C07D 5

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 37, INDEFIRO O PRESENTE PEDIDO, TENDO POR BASE OS ARTIGOS 8O E 13 DA LEI 9279 DE 14/05/1996.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 14A, 15A E 16A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2256 DE 01/04/2014 POR TER SIDO INDEVIDA.