DK1668985T3 - Nukleofil-substituerede ecteinascidiner og N-oxid-ecteinascidiner - Google Patents

Nukleofil-substituerede ecteinascidiner og N-oxid-ecteinascidiner

Info

Publication number
DK1668985T3
DK1668985T3 DK06004129T DK06004129T DK1668985T3 DK 1668985 T3 DK1668985 T3 DK 1668985T3 DK 06004129 T DK06004129 T DK 06004129T DK 06004129 T DK06004129 T DK 06004129T DK 1668985 T3 DK1668985 T3 DK 1668985T3
Authority
DK
Denmark
Prior art keywords
ecteinascidins
nucleophil
substituted
oxide
designated
Prior art date
Application number
DK06004129T
Other languages
English (en)
Inventor
Kenneth Lloyd Rinehart
Tong Zhou
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Application granted granted Critical
Publication of DK1668985T3 publication Critical patent/DK1668985T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
DK06004129T 1997-04-15 1998-04-14 Nukleofil-substituerede ecteinascidiner og N-oxid-ecteinascidiner DK1668985T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4359697P 1997-04-15 1997-04-15
PCT/US1998/007340 WO1998046080A1 (en) 1997-04-15 1998-04-14 Nucleophile substituted ecteinascidins and n-oxide ecteinascidins

Publications (1)

Publication Number Publication Date
DK1668985T3 true DK1668985T3 (da) 2009-05-04

Family

ID=21927969

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06004129T DK1668985T3 (da) 1997-04-15 1998-04-14 Nukleofil-substituerede ecteinascidiner og N-oxid-ecteinascidiner

Country Status (20)

Country Link
US (1) US5985876A (da)
EP (2) EP1668985B1 (da)
JP (1) JP4382164B2 (da)
KR (1) KR100513668B1 (da)
CN (1) CN100343235C (da)
AT (1) ATE420092T1 (da)
AU (1) AU747303B2 (da)
BR (1) BR9808588A (da)
CA (1) CA2286796C (da)
CY (1) CY1108958T1 (da)
CZ (1) CZ298842B6 (da)
DE (1) DE69840458D1 (da)
DK (1) DK1668985T3 (da)
ES (1) ES2321019T3 (da)
HU (1) HUP0103590A3 (da)
IL (1) IL132403A (da)
NO (1) NO327455B1 (da)
PL (2) PL338508A1 (da)
PT (1) PT1668985E (da)
WO (1) WO1998046080A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
KR100643092B1 (ko) * 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
JP5219323B2 (ja) * 2000-04-12 2013-06-26 ファルマ・マール・ソシエダード・アノニマ 抗腫瘍性エクチナサイジン誘導体
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
EA005564B1 (ru) * 2000-11-06 2005-04-28 Фарма Мар, С.А. Эффективные противоопухолевые лекарственные средства
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0119243D0 (en) * 2001-08-07 2001-10-03 Pharma Mar Sa Antitumoral analogs of ET-743
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
SI1689404T1 (sl) * 2003-11-13 2009-02-28 Pharma Mar Sau Kombinacija et-743 s 5-fluorouracil pro zdravili za zdravljenje raka
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CN1897949A (zh) * 2003-11-14 2007-01-17 马尔药品公司 包含使用et－743和紫杉醇来治疗癌症的联合疗法
AU2005261860A1 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of BRCA1
AU2005288696A1 (en) * 2004-09-28 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
RU2359700C2 (ru) * 2004-10-26 2009-06-27 Фарма Мар С.А., Сосьедад Униперсональ Пегилированный липосомальный доксорубицин в комбинации с эктеинасцидином 743 (ecteinescidin 743)
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
GB0522082D0 (en) 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CA2703026A1 (en) * 2007-10-19 2009-04-23 Rafael Rosell Costa Prognostic molecular markers for et-743 treatment
DK2786753T3 (da) 2010-11-12 2019-04-15 Pharma Mar Sa Kombinationsterapi med et antitumorantibiotikum
US11332480B2 (en) 2017-04-27 2022-05-17 Pharma Mar, S.A. Antitumoral compounds
WO2021098992A1 (en) 2019-11-21 2021-05-27 Pharma Mar, S.A. Methods of treating small cell lung cancer with lurbinectedin formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4273773A (en) * 1979-09-24 1981-06-16 American Home Products Corporation Antihypertensive tricyclic isoindole derivatives
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
DK0574857T3 (da) * 1992-06-19 1998-05-04 Hoechst Ag Polycycliske 31668P- og 31668U-forbindelser, fremgangsmåder til deres fremstilling samt deres anvendelse som antibiotiske eller antitumorale lægemidler
US5426108A (en) * 1993-11-10 1995-06-20 American Cyanamid Company Antibiotic 31F508 ALPHA1, ALPHA2, BETA1 and BETA2
CZ301083B6 (cs) * 1998-04-06 2009-11-04 The Board Of Trustees Of The University Of Illinois Ekteinascidinová sloucenina, farmaceutický prostredek ji obsahující a její použití

Also Published As

Publication number Publication date
ATE420092T1 (de) 2009-01-15
EP1668985A3 (en) 2006-11-22
CN100343235C (zh) 2007-10-17
ES2321019T3 (es) 2009-06-01
KR20010006402A (ko) 2001-01-26
PL197708B1 (pl) 2008-04-30
EP1668985B1 (en) 2009-01-07
IL132403A (en) 2004-09-27
DE69840458D1 (de) 2009-02-26
CA2286796C (en) 2008-08-05
AU7111498A (en) 1998-11-11
CZ367999A3 (cs) 2000-07-12
PL338508A1 (en) 2000-11-06
NO995016D0 (no) 1999-10-14
IL132403A0 (en) 2001-03-19
NO327455B1 (no) 2009-07-06
NO995016L (no) 1999-12-10
CA2286796A1 (en) 1998-10-22
EP0975218A4 (en) 2001-08-08
HUP0103590A2 (hu) 2002-01-28
CZ298842B6 (cs) 2008-02-20
PT1668985E (pt) 2009-04-09
WO1998046080A1 (en) 1998-10-22
KR100513668B1 (ko) 2005-09-08
HUP0103590A3 (en) 2002-07-29
BR9808588A (pt) 2000-05-23
CN1261254A (zh) 2000-07-26
JP4382164B2 (ja) 2009-12-09
JP2001523228A (ja) 2001-11-20
AU747303B2 (en) 2002-05-16
CY1108958T1 (el) 2012-05-23
EP0975218A1 (en) 2000-02-02
US5985876A (en) 1999-11-16
EP1668985A2 (en) 2006-06-14

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