BR9809409A - Método para a preparação de compostos tricarbonìlicos metálicos faciais e seu uso na rotulação de substratos biologicamente ativos - Google Patents
Método para a preparação de compostos tricarbonìlicos metálicos faciais e seu uso na rotulação de substratos biologicamente ativosInfo
- Publication number
- BR9809409A BR9809409A BR9809409-2A BR9809409A BR9809409A BR 9809409 A BR9809409 A BR 9809409A BR 9809409 A BR9809409 A BR 9809409A BR 9809409 A BR9809409 A BR 9809409A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- labeling
- compound
- compounds
- general formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 6
- 238000002360 preparation method Methods 0.000 title abstract 5
- 238000002372 labelling Methods 0.000 title abstract 4
- 239000000758 substrate Substances 0.000 title abstract 3
- 230000001815 facial effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G45/00—Compounds of manganese
- C01G45/04—Carbonyls
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G99/00—Subject matter not provided for in other groups of this subclass
- C01G99/006—Compounds containing a metal not provided for elsewhere in this subclass, with or without oxygen or hydrogen, and containing two or more other elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/88—Isotope composition differing from the natural occurrence
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Patente de Invenção:<B>"MéTODO PARA A PREPARAçãO DE COMPOSTOS TRICARBONìLICOS METáLICOS FACIAIS E SEU USO NA ROTULAçãO DE SUBSTRATOS BIOLOGICAMENTE ATIVOS"<D>. A invenção refere-se a um método de preparação de um composto de fórmula geral (I): fac-[M(CO)~ 3~(OH~ 2~)~ 3~]^ +^ onde M é Mn, ^ 99m^Tc, ^ 186^Re ou ^ 188^Re, por reação de um metal na forma de permetalato com monóxido de carbono e um agente redutor, caracterizado pelo fato de uma mistura de uma base, um agente redutor solúvel em água mas não substancialmente decomposto por água, e opcionalmente um agente estabilizante é dissolvido em um sistema de solvente contendo água contendo uma solução de metal na forma de permaganato, pertecnetato na presença de monóxido de carbono e opcionalmente na presença de um haleto. A invenção refere-se ainda a um método de preparação de um composto marcado com o auxílio do composto de fórmula geral (I), para um método de preparação direta de compostos marcados, para um método de rotulação de substratos tais como aminoácidos, peptídios, proteínas, açúcares, moléculas pequenas de ligação a receptor e células do corpo, com o auxílio do composto de fórmula geral (I) e para um kit para a preparação de uma composição de rotulação e um kit para a preparação de uma composição farmacêutica ou terapêutica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201232A EP0879606A1 (en) | 1997-04-25 | 1997-04-25 | Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates |
| PCT/US1998/007979 WO1998048848A1 (en) | 1997-04-25 | 1998-04-21 | Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9809409A true BR9809409A (pt) | 2000-06-13 |
| BR9809409B1 BR9809409B1 (pt) | 2008-11-18 |
Family
ID=8228251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9809409-2A BR9809409B1 (pt) | 1997-04-25 | 1998-04-21 | mÉtodo para a preparaÇço de compostos tricarbonÍlicos metÁlicos faciais e a kits para preparaÇço de uma composiÇço de marcaÇço ou de uma composiÇço farmacÊutica diagnàstica ou terapÊutica. |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0879606A1 (pt) |
| JP (1) | JP4357597B2 (pt) |
| KR (1) | KR100579168B1 (pt) |
| AT (1) | ATE211924T1 (pt) |
| AU (1) | AU748213B2 (pt) |
| BR (1) | BR9809409B1 (pt) |
| CA (1) | CA2282563C (pt) |
| CZ (1) | CZ295214B6 (pt) |
| DE (1) | DE69803205T2 (pt) |
| DK (1) | DK1019095T3 (pt) |
| ES (1) | ES2168751T3 (pt) |
| HU (1) | HU225487B1 (pt) |
| IL (1) | IL131658A (pt) |
| NO (1) | NO995160L (pt) |
| NZ (1) | NZ337303A (pt) |
| PL (1) | PL189514B1 (pt) |
| PT (1) | PT1019095E (pt) |
| WO (1) | WO1998048848A1 (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19860289C2 (de) * | 1998-12-21 | 2003-11-13 | Schering Ag | Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium |
| EP1021074B1 (en) | 1999-01-15 | 2012-06-20 | The Boeing Company | Solid state flight deck panels and components thereof |
| DK1154798T3 (da) * | 1999-02-24 | 2006-08-28 | Univ Zuerich | Molekyler til behandling og diagnose af tumorer |
| US6844425B1 (en) | 1999-02-24 | 2005-01-18 | Mallinckrodt Inc. | Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy |
| CZ20014603A3 (cs) * | 1999-06-29 | 2002-11-13 | Mallinckrodt Inc. | Pouľití aminopolykarboxylátových ligandů při značení biologicky aktivních substrátů Tc-99m-trikarbonylovými prekurzory |
| US6926883B1 (en) * | 1999-06-29 | 2005-08-09 | Mallinckrodt Inc | Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them |
| AUPQ262499A0 (en) | 1999-09-02 | 1999-09-23 | University Of Queensland, The | Novel iron chelators |
| US7053242B1 (en) | 1999-10-05 | 2006-05-30 | Mallinckrodt Inc. | Carbon monoxide source for preparation of transition-metal-carbonyl-complexes |
| US6359119B1 (en) * | 2000-05-24 | 2002-03-19 | Mallinckrodt Inc. | Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate |
| ES2518926T3 (es) * | 2000-06-02 | 2014-11-05 | Board Of Regents, The University Of Texas System | Conjugados de etilendicisteína y un análogo de glucosa |
| CN1136921C (zh) * | 2001-04-27 | 2004-02-04 | 北京师范大学 | 一种心肌显像剂及其制备方法 |
| GB0111872D0 (en) | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| US7011854B2 (en) | 2002-02-04 | 2006-03-14 | Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
| KR100445971B1 (ko) * | 2002-04-15 | 2004-08-25 | 한국원자력연구소 | 수소화붕소 교환수지를 이용한 테크네튬 또는 레늄의표지방법 |
| PL375530A1 (en) * | 2002-09-03 | 2005-11-28 | University Of Zurich | Preparation of m(co)3-complexes by solid phase techniques via metal assisted cleavage from the solid support |
| GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
| US7682601B2 (en) | 2003-04-15 | 2010-03-23 | Mallinckrodt Inc. | Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes |
| JP2007525452A (ja) | 2003-04-15 | 2007-09-06 | マリンクロッド・インコーポレイテッド | Ｒｅおよびｔｃトリカルボニル錯体のための配位子を含有する二官能性三座ピラゾリル |
| EP1618380B1 (en) * | 2003-04-29 | 2009-12-30 | Universität Zürich | N epsilon AND/OR N alpha DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH (M(OH2)3(CO)3)+ BY FAC COORDINATION |
| EP1797106A1 (en) * | 2004-09-07 | 2007-06-20 | Triumf, operating as a joint venture by the Governors of the Universities of Alberta, | Synthesis of radiolabeled sugar metal complexes |
| JP2008037752A (ja) * | 2004-11-19 | 2008-02-21 | Nihon Medi Physics Co Ltd | 新規放射性テクネチウム−ビスホスフィノアミン錯体および該錯体を含む放射性画像診断剤 |
| KR100650506B1 (ko) * | 2005-12-16 | 2006-11-30 | 한국원자력연구소 | 방사성 의약품용 레늄-트리카보닐 착물 및 그 전구체의제조방법 |
| US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
| GB0623482D0 (en) | 2006-11-24 | 2007-01-03 | Mallinckrodt Inc | Technetium-99m (l) tricarbonyl complexes with tridentate chelators for myocardium imaging |
| DE102010014412A1 (de) | 2010-04-08 | 2012-04-19 | Friedrich-Schiller-Universität Jena | Verwendung von zweikernigen Eisenkomplexen mit schwefelhaltigen Liganden als pharmakologische Wirkstoffe |
| DE102010014411A1 (de) | 2010-04-08 | 2011-10-13 | Friedrich-Schiller-Universität Jena | Kohlenmonoxid und Eisen freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung |
| US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
| ES2628634T3 (es) | 2011-07-21 | 2017-08-03 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas |
| DE102012004132A1 (de) | 2012-02-29 | 2013-08-29 | Friedrich-Schiller-Universität Jena | Kohlenstoffmonoxid freisetzende Materialien und deren Verwendung |
| KR101200049B1 (ko) * | 2012-05-14 | 2012-11-13 | 한국원자력연구원 | 테크네튬-99엠 트리카보닐 표지 글리신 단량체 또는 올리고머 활용 생리활성분자를 이용한 프로브의 제조방법 및 이를 포함하는 영상제 조성물 |
| DE102014008537A1 (de) | 2014-06-04 | 2015-12-17 | Friedrich-Schiller-Universität Jena | Wasserlösliche manganbasierte Kohlenstoffmonoxid freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung |
| RU2708076C1 (ru) * | 2019-09-10 | 2019-12-04 | федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский Томский политехнический университет» | Способ получения комплекса технеция-99м с производным октреотида для диагностики нейроэндокринных опухолей |
| KR102269315B1 (ko) | 2019-10-24 | 2021-06-24 | 서울대학교산학협력단 | 전립선 암의 영상 또는 치료를 위한 동위원소 표지 화합물 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2533570B1 (fr) * | 1982-09-23 | 1985-07-12 | Centre Nat Rech Scient | Complexes organometalliques d'oestrogenes et leur application au dosage des recepteurs hormonaux |
-
1997
- 1997-04-25 EP EP97201232A patent/EP0879606A1/en not_active Withdrawn
-
1998
- 1998-04-21 DK DK98918501T patent/DK1019095T3/da active
- 1998-04-21 EP EP98918501A patent/EP1019095B1/en not_active Expired - Lifetime
- 1998-04-21 DE DE69803205T patent/DE69803205T2/de not_active Expired - Lifetime
- 1998-04-21 HU HU0003255A patent/HU225487B1/hu unknown
- 1998-04-21 AU AU71413/98A patent/AU748213B2/en not_active Expired
- 1998-04-21 ES ES98918501T patent/ES2168751T3/es not_active Expired - Lifetime
- 1998-04-21 NZ NZ337303A patent/NZ337303A/xx not_active IP Right Cessation
- 1998-04-21 WO PCT/US1998/007979 patent/WO1998048848A1/en not_active Ceased
- 1998-04-21 CZ CZ19993751A patent/CZ295214B6/cs not_active IP Right Cessation
- 1998-04-21 JP JP54639198A patent/JP4357597B2/ja not_active Expired - Lifetime
- 1998-04-21 PL PL98336382A patent/PL189514B1/pl unknown
- 1998-04-21 IL IL13165898A patent/IL131658A/en not_active IP Right Cessation
- 1998-04-21 KR KR1019997009902A patent/KR100579168B1/ko not_active Expired - Lifetime
- 1998-04-21 AT AT98918501T patent/ATE211924T1/de active
- 1998-04-21 PT PT98918501T patent/PT1019095E/pt unknown
- 1998-04-21 BR BRPI9809409-2A patent/BR9809409B1/pt not_active IP Right Cessation
- 1998-04-21 CA CA002282563A patent/CA2282563C/en not_active Expired - Lifetime
-
1999
- 1999-10-22 NO NO995160A patent/NO995160L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995160D0 (no) | 1999-10-22 |
| IL131658A (en) | 2004-12-15 |
| CZ9903751A3 (en) | 2001-05-16 |
| JP4357597B2 (ja) | 2009-11-04 |
| DE69803205D1 (de) | 2002-02-21 |
| DK1019095T3 (da) | 2002-05-06 |
| BR9809409B1 (pt) | 2008-11-18 |
| ES2168751T3 (es) | 2002-06-16 |
| CZ295214B6 (cs) | 2005-06-15 |
| NO995160L (no) | 1999-12-13 |
| KR100579168B1 (ko) | 2006-05-12 |
| JP2002512616A (ja) | 2002-04-23 |
| ATE211924T1 (de) | 2002-02-15 |
| WO1998048848A1 (en) | 1998-11-05 |
| HU225487B1 (en) | 2006-12-28 |
| EP1019095B1 (en) | 2002-01-16 |
| PL336382A1 (en) | 2000-06-19 |
| EP0879606A1 (en) | 1998-11-25 |
| CA2282563A1 (en) | 1998-11-05 |
| PT1019095E (pt) | 2002-07-31 |
| AU7141398A (en) | 1998-11-24 |
| HUP0003255A3 (en) | 2003-06-30 |
| AU748213B2 (en) | 2002-05-30 |
| IL131658A0 (en) | 2001-01-28 |
| DE69803205T2 (de) | 2002-09-19 |
| KR20010020298A (ko) | 2001-03-15 |
| HUP0003255A2 (hu) | 2001-02-28 |
| NZ337303A (en) | 2000-12-22 |
| PL189514B1 (pl) | 2005-08-31 |
| CA2282563C (en) | 2007-12-04 |
| EP1019095A1 (en) | 2000-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
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