ES2168751T3 - Metodo para la preparacion de compuestos metalicos tricarbonilicos faciales y su uso en el marcado de sustratos biologicamente activos. - Google Patents

Metodo para la preparacion de compuestos metalicos tricarbonilicos faciales y su uso en el marcado de sustratos biologicamente activos.

Info

Publication number
ES2168751T3
ES2168751T3 ES98918501T ES98918501T ES2168751T3 ES 2168751 T3 ES2168751 T3 ES 2168751T3 ES 98918501 T ES98918501 T ES 98918501T ES 98918501 T ES98918501 T ES 98918501T ES 2168751 T3 ES2168751 T3 ES 2168751T3
Authority
ES
Spain
Prior art keywords
tricarbonilic
facial
marking
preparation
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98918501T
Other languages
English (en)
Inventor
Roger Alberto
Roger Schibli
Andre Egli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ES2168751T3 publication Critical patent/ES2168751T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G45/00—Compounds of manganese
    • C01G45/04—Carbonyls
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G99/00—Subject matter not provided for in other groups of this subclass
    • C01G99/006—Compounds containing a metal not provided for elsewhere in this subclass, with or without oxygen or hydrogen, and containing two or more other elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/88—Isotope composition differing from the natural occurrence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Método para preparar un compuesto de la fórmula general fac-[M(CO)3(H2O)3]+ (I) donde M es Mn, 99mTc, 186Re o 188Re, haciendo reaccionar un metal en forma de permetalato con monóxido de carbono y un agente reductor, caracterizado porque una mezcla de una base, un agente reductor soluble en agua pero no descomponible sustancialmente por el agua, y opcionalmente un agente estabilizante, se disuelve en un agua que contiene el sistema disolvente que contiene una disolución del metal en forma de permanganato, pertecnetato o perrenato en presencia de monóxido de carbono.
ES98918501T 1997-04-25 1998-04-21 Metodo para la preparacion de compuestos metalicos tricarbonilicos faciales y su uso en el marcado de sustratos biologicamente activos. Expired - Lifetime ES2168751T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201232A EP0879606A1 (en) 1997-04-25 1997-04-25 Method for the preparation of facial metal tricarbonyl compounds and their use in the labelling of biologically active substrates

Publications (1)

Publication Number Publication Date
ES2168751T3 true ES2168751T3 (es) 2002-06-16

Family

ID=8228251

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98918501T Expired - Lifetime ES2168751T3 (es) 1997-04-25 1998-04-21 Metodo para la preparacion de compuestos metalicos tricarbonilicos faciales y su uso en el marcado de sustratos biologicamente activos.

Country Status (18)

Country Link
EP (2) EP0879606A1 (es)
JP (1) JP4357597B2 (es)
KR (1) KR100579168B1 (es)
AT (1) ATE211924T1 (es)
AU (1) AU748213B2 (es)
BR (1) BR9809409B1 (es)
CA (1) CA2282563C (es)
CZ (1) CZ295214B6 (es)
DE (1) DE69803205T2 (es)
DK (1) DK1019095T3 (es)
ES (1) ES2168751T3 (es)
HU (1) HU225487B1 (es)
IL (1) IL131658A (es)
NO (1) NO995160L (es)
NZ (1) NZ337303A (es)
PL (1) PL189514B1 (es)
PT (1) PT1019095E (es)
WO (1) WO1998048848A1 (es)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
DE19860289C2 (de) * 1998-12-21 2003-11-13 Schering Ag Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium
EP1021074B1 (en) 1999-01-15 2012-06-20 The Boeing Company Solid state flight deck panels and components thereof
WO2000050086A1 (en) * 1999-02-24 2000-08-31 Mallinckrodt Inc. Molecules for the treatment and diagnosis of tumors
US6844425B1 (en) 1999-02-24 2005-01-18 Mallinckrodt Inc. Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
US6926883B1 (en) * 1999-06-29 2005-08-09 Mallinckrodt Inc Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
EP1192166B1 (en) * 1999-06-29 2004-09-29 Mallinckrodt Inc. Group(vii) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
AUPQ262499A0 (en) * 1999-09-02 1999-09-23 University Of Queensland, The Novel iron chelators
WO2001025243A1 (en) * 1999-10-05 2001-04-12 Mallinckrodt Inc. Carbon monoxide source for preparation of transition-metal-carbonyl-complexes
US6359119B1 (en) * 2000-05-24 2002-03-19 Mallinckrodt Inc. Formulation of Tc and Re carbonyl complexes using stannous ion as the reductant for pertechnetate and perrhenate
IL153218A0 (en) * 2000-06-02 2003-07-06 Univ Texas Ethylenedicysteine (ec) -drug conjugates
CN1136921C (zh) * 2001-04-27 2004-02-04 北京师范大学 一种心肌显像剂及其制备方法
GB0111872D0 (en) 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
NZ534912A (en) 2002-02-04 2007-08-31 Alfama Investigacao E Desenvol supramolecule aggregate comprising CO containing organometallic or transition metal complex and anti-inflammatory agent or biphosphonate phosphonate derivative
KR100445971B1 (ko) * 2002-04-15 2004-08-25 한국원자력연구소 수소화붕소 교환수지를 이용한 테크네튬 또는 레늄의표지방법
DE60326465D1 (de) * 2002-09-03 2009-04-16 Univ Zuerich Herstellung von m(co)3-komplexen durch festphasentechniken durch metal-unterstützte trennung vom festen träger
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US7682601B2 (en) 2003-04-15 2010-03-23 Mallinckrodt Inc. Bifunctional tridentate pyrazolyl containing ligands for re and tc tricarbonyl complexes
AU2004229568A1 (en) 2003-04-15 2004-10-28 Mallinckrodt Inc. Bifunctional tridentate pyrazolyl containing ligands for Re and Tc tricarbonyl complexes
EP1618380B1 (en) * 2003-04-29 2009-12-30 Universität Zürich N epsilon AND/OR N alpha DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH (M(OH2)3(CO)3)+ BY FAC COORDINATION
EP1797106A1 (en) * 2004-09-07 2007-06-20 Triumf, operating as a joint venture by the Governors of the Universities of Alberta, Synthesis of radiolabeled sugar metal complexes
JP2008037752A (ja) * 2004-11-19 2008-02-21 Nihon Medi Physics Co Ltd 新規放射性テクネチウム−ビスホスフィノアミン錯体および該錯体を含む放射性画像診断剤
KR100650506B1 (ko) * 2005-12-16 2006-11-30 한국원자력연구소 방사성 의약품용 레늄-트리카보닐 착물 및 그 전구체의제조방법
US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
GB0623482D0 (en) 2006-11-24 2007-01-03 Mallinckrodt Inc Technetium-99m (l) tricarbonyl complexes with tridentate chelators for myocardium imaging
DE102010014411A1 (de) 2010-04-08 2011-10-13 Friedrich-Schiller-Universität Jena Kohlenmonoxid und Eisen freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung
DE102010014412A1 (de) 2010-04-08 2012-04-19 Friedrich-Schiller-Universität Jena Verwendung von zweikernigen Eisenkomplexen mit schwefelhaltigen Liganden als pharmakologische Wirkstoffe
EP2699242B1 (en) 2011-04-19 2017-11-01 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
JP6134710B2 (ja) 2011-07-21 2017-05-24 アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． 一酸化ルテニウム放出分子およびその使用
DE102012004132A1 (de) 2012-02-29 2013-08-29 Friedrich-Schiller-Universität Jena Kohlenstoffmonoxid freisetzende Materialien und deren Verwendung
KR101200049B1 (ko) * 2012-05-14 2012-11-13 한국원자력연구원 테크네튬-99엠 트리카보닐 표지 글리신 단량체 또는 올리고머 활용 생리활성분자를 이용한 프로브의 제조방법 및 이를 포함하는 영상제 조성물
DE102014008537A1 (de) 2014-06-04 2015-12-17 Friedrich-Schiller-Universität Jena Wasserlösliche manganbasierte Kohlenstoffmonoxid freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung
RU2708076C1 (ru) * 2019-09-10 2019-12-04 федеральное государственное автономное образовательное учреждение высшего образования «Национальный исследовательский Томский политехнический университет» Способ получения комплекса технеция-99м с производным октреотида для диагностики нейроэндокринных опухолей
KR102269315B1 (ko) 2019-10-24 2021-06-24 서울대학교산학협력단 전립선 암의 영상 또는 치료를 위한 동위원소 표지 화합물

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FR2533570B1 (fr) * 1982-09-23 1985-07-12 Centre Nat Rech Scient Complexes organometalliques d'oestrogenes et leur application au dosage des recepteurs hormonaux

Also Published As

Publication number Publication date
AU7141398A (en) 1998-11-24
BR9809409A (pt) 2000-06-13
JP4357597B2 (ja) 2009-11-04
CZ9903751A3 (en) 2001-05-16
ATE211924T1 (de) 2002-02-15
DE69803205T2 (de) 2002-09-19
EP1019095A1 (en) 2000-07-19
PT1019095E (pt) 2002-07-31
HU225487B1 (en) 2006-12-28
PL189514B1 (pl) 2005-08-31
CA2282563C (en) 2007-12-04
EP1019095B1 (en) 2002-01-16
WO1998048848A1 (en) 1998-11-05
DK1019095T3 (da) 2002-05-06
AU748213B2 (en) 2002-05-30
JP2002512616A (ja) 2002-04-23
NO995160L (no) 1999-12-13
PL336382A1 (en) 2000-06-19
EP0879606A1 (en) 1998-11-25
NZ337303A (en) 2000-12-22
IL131658A0 (en) 2001-01-28
HUP0003255A2 (hu) 2001-02-28
NO995160D0 (no) 1999-10-22
KR100579168B1 (ko) 2006-05-12
KR20010020298A (ko) 2001-03-15
BR9809409B1 (pt) 2008-11-18
CZ295214B6 (cs) 2005-06-15
IL131658A (en) 2004-12-15
DE69803205D1 (de) 2002-02-21
CA2282563A1 (en) 1998-11-05
HUP0003255A3 (en) 2003-06-30

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