BR9810097A - Derivados de macrolìdeos c-4-substituìdos - Google Patents

Derivados de macrolìdeos c-4-substituìdos

Info

Publication number
BR9810097A
BR9810097A BR9810097-1A BR9810097A BR9810097A BR 9810097 A BR9810097 A BR 9810097A BR 9810097 A BR9810097 A BR 9810097A BR 9810097 A BR9810097 A BR 9810097A
Authority
BR
Brazil
Prior art keywords
formula
compounds
derivatives
relates
substituted
Prior art date
Application number
BR9810097-1A
Other languages
English (en)
Inventor
Brian Scott Bronk
Takushi Kaneko
Michael Anthony Letavic
Hengmiao Cheng
Edward Alan Glazer
Bingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR9810097A publication Critical patent/BR9810097A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Patente de Invenção: <D>"DERIVADOS DE MACROLìDEOS C-4"-SUBSTITUìDOS"<D>. Esta invenção refere-se a compostos da fórmula (1) ou seus sais farmaceuticamente aceitáveis. Os compostos de fórmula (1) são agentes antibacterianos potentes que podem ser utilizados para tratar várias infecções bacterianas e distúrbios relacionadas com tais infecções. A invenção refere-se também composições farmacêuticas contendo os compostos de fórmula (1) e os métodos para tratar infecções bacterianas através da administração de compostos de fórmula (1). A invenção refere-se ainda com métodos de preparação dos compostos de fórmula (1) e intermediários úteis em tal preparação.
BR9810097-1A 1997-06-11 1998-05-25 Derivados de macrolìdeos c-4-substituìdos BR9810097A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11
PCT/IB1998/000799 WO1998056801A1 (en) 1997-06-11 1998-05-25 C-4''-substituted macrolide derivatives

Publications (1)

Publication Number Publication Date
BR9810097A true BR9810097A (pt) 2000-08-08

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810097-1A BR9810097A (pt) 1997-06-11 1998-05-25 Derivados de macrolìdeos c-4-substituìdos

Country Status (39)

Country Link
EP (1) EP0988309B1 (pt)
JP (1) JP3262806B2 (pt)
KR (1) KR100369959B1 (pt)
CN (1) CN1145636C (pt)
AP (1) AP1189A (pt)
AR (1) AR013085A1 (pt)
AT (1) ATE310742T1 (pt)
AU (1) AU745006C (pt)
BG (1) BG64357B1 (pt)
BR (1) BR9810097A (pt)
CA (1) CA2293397C (pt)
CO (1) CO4950584A1 (pt)
DE (1) DE69832486T2 (pt)
DZ (1) DZ2515A1 (pt)
EA (1) EA002440B1 (pt)
ES (1) ES2251081T3 (pt)
GT (1) GT199800075A (pt)
HN (1) HN1998000074A (pt)
HR (1) HRP980315A2 (pt)
HU (1) HUP0004076A3 (pt)
ID (1) ID24530A (pt)
IL (1) IL132808A (pt)
IS (1) IS1979B (pt)
MA (1) MA24563A1 (pt)
MY (1) MY133027A (pt)
NO (1) NO315560B1 (pt)
NZ (1) NZ500652A (pt)
OA (1) OA11226A (pt)
PA (1) PA8452001A1 (pt)
PE (1) PE79999A1 (pt)
PL (1) PL337497A1 (pt)
SK (1) SK168299A3 (pt)
TN (1) TNSN98084A1 (pt)
TW (2) TW200418871A (pt)
UA (1) UA70298A (pt)
UY (1) UY25041A1 (pt)
WO (1) WO1998056801A1 (pt)
YU (1) YU62999A (pt)
ZA (1) ZA985016B (pt)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE353014T1 (de) * 1997-09-10 2007-02-15 Merial Ltd Verwendung von 9a-azaliden als antimikrobielle mittel für tiere
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
TR200200436T2 (tr) 1998-11-03 2002-06-21 Pfizer Inc. Yeni makrolit antibiyotikler
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
ATE315042T1 (de) * 1999-08-24 2006-02-15 Abbott Lab 9a-azalide mit antibakterieller wirkung
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
BRPI0017013B1 (pt) 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
WO2002088158A1 (en) * 2001-04-27 2002-11-07 Pfizer Products Inc. Process for preparing 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
AU2003255851B2 (en) 2002-07-08 2009-07-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
EP1551865B1 (en) 2002-07-08 2009-04-22 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Hybrid molecules of macrolides with steroidal/non-steroidal anti-inflammatory molecules
NZ537716A (en) * 2002-07-08 2007-05-31 Glaxosmithkline Zagreb Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
EP1638549A4 (en) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
WO2009019868A1 (ja) 2007-08-06 2009-02-12 Taisho Pharmaceutical Co., Ltd. １０ａ、１２位架橋型１０ａ－アザライド化合物
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
US8796232B2 (en) 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2532455T3 (es) * 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
JP6437523B2 (ja) 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
EP4118092B1 (en) * 2020-03-12 2025-07-16 Zoetis Services LLC Immunomodulating o-het-aryl azalides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
MA24563A1 (fr) 1998-12-31
DZ2515A1 (fr) 2003-02-01
BG64357B1 (bg) 2004-11-30
ES2251081T3 (es) 2006-04-16
ID24530A (id) 2000-07-20
NO996107L (no) 2000-02-10
MY133027A (en) 2007-10-31
TWI224106B (en) 2004-11-21
NO315560B1 (no) 2003-09-22
CN1259955A (zh) 2000-07-12
OA11226A (en) 2003-07-16
EP0988309B1 (en) 2005-11-23
AR013085A1 (es) 2000-12-13
DE69832486D1 (de) 2005-12-29
CA2293397C (en) 2004-08-31
SK168299A3 (en) 2000-09-12
AP1189A (en) 2003-07-16
KR100369959B1 (ko) 2003-02-12
UA70298C2 (uk) 2004-10-15
AU7228198A (en) 1998-12-30
EA002440B1 (ru) 2002-04-25
UY25041A1 (es) 2000-09-29
EA199901014A1 (ru) 2000-06-26
PE79999A1 (es) 1999-08-25
CO4950584A1 (es) 2000-09-01
YU62999A (sh) 2002-10-18
WO1998056801A1 (en) 1998-12-17
AP9801254A0 (en) 1998-06-30
EP0988309A1 (en) 2000-03-29
PA8452001A1 (es) 2000-05-24
HUP0004076A2 (hu) 2001-04-28
HN1998000074A (es) 1999-01-08
CA2293397A1 (en) 1998-12-17
NO996107D0 (no) 1999-12-10
UA70298A (uk) 2004-10-15
IL132808A0 (en) 2001-03-19
TW200418871A (en) 2004-10-01
KR20010013633A (ko) 2001-02-26
HUP0004076A3 (en) 2003-05-28
CN1145636C (zh) 2004-04-14
AU745006B2 (en) 2002-03-07
DE69832486T2 (de) 2006-07-27
ATE310742T1 (de) 2005-12-15
GT199800075A (es) 1999-11-30
ZA985016B (en) 1999-12-10
IL132808A (en) 2004-08-31
HRP980315A2 (en) 1999-04-30
IS5250A (is) 1999-11-16
NZ500652A (en) 2001-10-26
JP3262806B2 (ja) 2002-03-04
TNSN98084A1 (fr) 2005-03-15
HK1025974A1 (en) 2000-12-01
BG103969A (en) 2000-07-31
PL337497A1 (en) 2000-08-28
JP2000514097A (ja) 2000-10-24
IS1979B (is) 2005-01-14
AU745006C (en) 2006-02-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A,9A E 10A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 1986 DE 27/03/2009.