IS1979B - "C-4'' - setnar makrólít afleiður og aðferð til framleiðslu þeirra, ásamt lyfjasamsetningu" - Google Patents

"C-4'' - setnar makrólít afleiður og aðferð til framleiðslu þeirra, ásamt lyfjasamsetningu"

Info

Publication number
IS1979B
IS1979B IS5250A IS5250A IS1979B IS 1979 B IS1979 B IS 1979B IS 5250 A IS5250 A IS 5250A IS 5250 A IS5250 A IS 5250A IS 1979 B IS1979 B IS 1979B
Authority
IS
Iceland
Prior art keywords
macrolite
derivatives
substituted
production
pharmaceutical composition
Prior art date
Application number
IS5250A
Other languages
English (en)
Other versions
IS5250A (is
Inventor
Scott Bronk Brian
Kaneko Takushi
Anthony Letavic Michael
Cheng Hengmiao
Alan Glazer Edward
Vera Yang Bingwei
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of IS5250A publication Critical patent/IS5250A/is
Publication of IS1979B publication Critical patent/IS1979B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IS5250A 1997-06-11 1999-11-16 "C-4'' - setnar makrólít afleiður og aðferð til framleiðslu þeirra, ásamt lyfjasamsetningu" IS1979B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11
PCT/IB1998/000799 WO1998056801A1 (en) 1997-06-11 1998-05-25 C-4''-substituted macrolide derivatives

Publications (2)

Publication Number Publication Date
IS5250A IS5250A (is) 1999-11-16
IS1979B true IS1979B (is) 2005-01-14

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5250A IS1979B (is) 1997-06-11 1999-11-16 "C-4'' - setnar makrólít afleiður og aðferð til framleiðslu þeirra, ásamt lyfjasamsetningu"

Country Status (39)

Country Link
EP (1) EP0988309B1 (is)
JP (1) JP3262806B2 (is)
KR (1) KR100369959B1 (is)
CN (1) CN1145636C (is)
AP (1) AP1189A (is)
AR (1) AR013085A1 (is)
AT (1) ATE310742T1 (is)
AU (1) AU745006C (is)
BG (1) BG64357B1 (is)
BR (1) BR9810097A (is)
CA (1) CA2293397C (is)
CO (1) CO4950584A1 (is)
DE (1) DE69832486T2 (is)
DZ (1) DZ2515A1 (is)
EA (1) EA002440B1 (is)
ES (1) ES2251081T3 (is)
GT (1) GT199800075A (is)
HN (1) HN1998000074A (is)
HR (1) HRP980315A2 (is)
HU (1) HUP0004076A3 (is)
ID (1) ID24530A (is)
IL (1) IL132808A (is)
IS (1) IS1979B (is)
MA (1) MA24563A1 (is)
MY (1) MY133027A (is)
NO (1) NO315560B1 (is)
NZ (1) NZ500652A (is)
OA (1) OA11226A (is)
PA (1) PA8452001A1 (is)
PE (1) PE79999A1 (is)
PL (1) PL337497A1 (is)
SK (1) SK168299A3 (is)
TN (1) TNSN98084A1 (is)
TW (2) TWI224106B (is)
UA (1) UA70298C2 (is)
UY (1) UY25041A1 (is)
WO (1) WO1998056801A1 (is)
YU (1) YU62999A (is)
ZA (1) ZA985016B (is)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
EE200100245A (et) 1998-11-03 2002-10-15 Pfizer Products Inc. Uued makroliidsed antibiootikumid
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
CA2380455C (en) * 1999-08-24 2009-06-02 Abbott Laboratories 9a-azalides with antibacterial activity
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
ATE243703T1 (de) * 2000-01-27 2003-07-15 Pfizer Prod Inc Antibiotische azalid-zusammensetzungen
CA2445306C (en) * 2001-04-27 2008-02-12 Pfizer Products Inc. Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
CN100577681C (zh) 2002-07-08 2010-01-06 葛兰素伊斯特拉齐瓦基森塔萨格勒布公司 用于治疗炎性疾病和病症的新化合物、组合物和方法
WO2004005309A2 (en) * 2002-07-08 2004-01-15 Pliva - Istrazivacki Institut D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
ES2325495T3 (es) 2002-07-08 2009-09-07 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Moleculas hibridas de macrolidos con moleculas anti-inflamatorias esteroideas y no esteroideas.
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
US7601695B2 (en) * 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
JPWO2009019868A1 (ja) 2007-08-06 2010-10-28 大正製薬株式会社 １０ａ、１２位架橋型１０ａ−アザライド化合物
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
EP4095146A1 (en) 2013-04-04 2022-11-30 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
US12390440B2 (en) * 2020-03-12 2025-08-19 Zoetis Services Llc Immunomodulating trifluoromethyl-aminal azalides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
BR9810097A (pt) 2000-08-08
EA002440B1 (ru) 2002-04-25
AU7228198A (en) 1998-12-30
CA2293397C (en) 2004-08-31
HUP0004076A3 (en) 2003-05-28
AP1189A (en) 2003-07-16
BG103969A (en) 2000-07-31
CO4950584A1 (es) 2000-09-01
DE69832486T2 (de) 2006-07-27
UY25041A1 (es) 2000-09-29
EP0988309B1 (en) 2005-11-23
CN1259955A (zh) 2000-07-12
EP0988309A1 (en) 2000-03-29
UA70298A (uk) 2004-10-15
SK168299A3 (en) 2000-09-12
ATE310742T1 (de) 2005-12-15
YU62999A (sh) 2002-10-18
HK1025974A1 (en) 2000-12-01
PE79999A1 (es) 1999-08-25
CA2293397A1 (en) 1998-12-17
AR013085A1 (es) 2000-12-13
TNSN98084A1 (fr) 2005-03-15
PL337497A1 (en) 2000-08-28
WO1998056801A1 (en) 1998-12-17
ZA985016B (en) 1999-12-10
EA199901014A1 (ru) 2000-06-26
HN1998000074A (es) 1999-01-08
MA24563A1 (fr) 1998-12-31
KR100369959B1 (ko) 2003-02-12
JP3262806B2 (ja) 2002-03-04
PA8452001A1 (es) 2000-05-24
AP9801254A0 (en) 1998-06-30
KR20010013633A (ko) 2001-02-26
TW200418871A (en) 2004-10-01
BG64357B1 (bg) 2004-11-30
NO996107D0 (no) 1999-12-10
MY133027A (en) 2007-10-31
HRP980315A2 (en) 1999-04-30
ES2251081T3 (es) 2006-04-16
TWI224106B (en) 2004-11-21
IL132808A0 (en) 2001-03-19
JP2000514097A (ja) 2000-10-24
CN1145636C (zh) 2004-04-14
IL132808A (en) 2004-08-31
ID24530A (id) 2000-07-20
OA11226A (en) 2003-07-16
UA70298C2 (uk) 2004-10-15
NO996107L (no) 2000-02-10
DE69832486D1 (de) 2005-12-29
NO315560B1 (no) 2003-09-22
DZ2515A1 (fr) 2003-02-01
AU745006B2 (en) 2002-03-07
HUP0004076A2 (hu) 2001-04-28
AU745006C (en) 2006-02-23
GT199800075A (es) 1999-11-30
NZ500652A (en) 2001-10-26
IS5250A (is) 1999-11-16

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