BR9810177A - Composto, formulação farmacêutica, uso de um composto, e, processos para tratamento de uma condição onde a inibição da trombina é requerida e para a preparação de compostos - Google Patents

Composto, formulação farmacêutica, uso de um composto, e, processos para tratamento de uma condição onde a inibição da trombina é requerida e para a preparação de compostos

Info

Publication number
BR9810177A
BR9810177A BR9810177-3A BR9810177A BR9810177A BR 9810177 A BR9810177 A BR 9810177A BR 9810177 A BR9810177 A BR 9810177A BR 9810177 A BR9810177 A BR 9810177A
Authority
BR
Brazil
Prior art keywords
compound
treating
processes
condition
pharmaceutical formulation
Prior art date
Application number
BR9810177-3A
Other languages
English (en)
Inventor
Olle Karlsson
Marcel Linschoten
Nystr M Jan-Erik
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9702378A external-priority patent/SE9702378D0/xx
Priority claimed from SE9801099A external-priority patent/SE9801099D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of BR9810177A publication Critical patent/BR9810177A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"COMPOSTO, FORMULAçãO FARMACêUTICA, USO DE UM COMPOSTO, E, PROCESSOS PARA TRATAMENTO DE UMA CONDIçãO ONDE A INIBIçãO DA TROMBINA é REQUERIDA E PARA A PREPARAçãO DE COMPOSTOS" Forneceu-se compostos da fórmula (I), em que R^ 1^, R~ x~, Y, R^ y^, n e B têm os significados dados na descrição, os quais são utilizáveis como inibidores competitivos das proteases semelhantes à tripsina, tais como a trombina, e em particular no tratamento de condições onde a inibição da trombina é requerida (por exemplo, na trombose) ou como anticoagulantes.
BR9810177-3A 1997-06-19 1998-06-09 Composto, formulação farmacêutica, uso de um composto, e, processos para tratamento de uma condição onde a inibição da trombina é requerida e para a preparação de compostos BR9810177A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702378A SE9702378D0 (sv) 1997-06-19 1997-06-19 New compounds
SE9801099A SE9801099D0 (sv) 1998-03-30 1998-03-30 New compounds
PCT/SE1998/001103 WO1998057932A1 (en) 1997-06-19 1998-06-09 New amidino derivatives and their use as thrombin inhibitors

Publications (1)

Publication Number Publication Date
BR9810177A true BR9810177A (pt) 2000-08-08

Family

ID=26663014

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810177-3A BR9810177A (pt) 1997-06-19 1998-06-09 Composto, formulação farmacêutica, uso de um composto, e, processos para tratamento de uma condição onde a inibição da trombina é requerida e para a preparação de compostos

Country Status (20)

Country Link
US (2) US6265397B1 (pt)
EP (1) EP1012140B1 (pt)
JP (2) JP3919236B2 (pt)
KR (1) KR100540413B1 (pt)
CN (1) CN1205187C (pt)
AR (1) AR013084A1 (pt)
AT (1) ATE277902T1 (pt)
AU (1) AU737645C (pt)
BR (1) BR9810177A (pt)
CA (1) CA2294059C (pt)
DE (1) DE69826693T2 (pt)
EE (1) EE9900600A (pt)
IL (1) IL133490A0 (pt)
IS (1) IS5302A (pt)
NO (1) NO315156B1 (pt)
NZ (1) NZ501635A (pt)
PL (1) PL337645A1 (pt)
SK (1) SK167099A3 (pt)
TR (1) TR199903134T2 (pt)
WO (1) WO1998057932A1 (pt)

Families Citing this family (26)

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AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
EE200100371A (et) 1999-01-13 2002-02-15 Astrazeneca Ab Amidinobensüülamiini derivaadid ja nende kasutamine trombiini inhibiitoritena
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
EP1059302A1 (en) * 1999-06-08 2000-12-13 Aventis Pharma Deutschland GmbH Factor VIIa inhibitors
SE0000382D0 (sv) 2000-02-07 2000-02-07 Astrazeneca Ab New process
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
SE0001803D0 (sv) * 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
WO2002088298A1 (en) 2001-04-27 2002-11-07 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
AU2004233863B2 (en) 2003-04-24 2010-06-17 Incyte Holdings Corporation Aza spiro alkane derivatives as inhibitors of metalloproteases
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
DE602004008959T2 (de) * 2003-11-07 2008-06-19 F. Hoffmann-La Roche Ag Benzoäbüä1,4üdioxepinderivate
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
UA95788C2 (en) 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
DE102008007440A1 (de) * 2008-02-01 2009-08-13 Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg Aminosäurederivate als Arzneistoffe
AR072278A1 (es) * 2008-06-23 2010-08-18 Astrazeneca Ab Compuestos inhibidores de trombina
CN104327029A (zh) * 2014-09-21 2015-02-04 湖南华腾制药有限公司 一种含氧杂环化合物的制备方法

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HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
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US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
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TW201303B (pt) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
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JPH1095898A (ja) 1996-09-25 1998-04-14 Sumitomo Bakelite Co Ltd 難燃性樹脂組成物およびこれを用いた積層板
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AR013084A1 (es) * 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados

Also Published As

Publication number Publication date
NZ501635A (en) 2001-09-28
DE69826693D1 (de) 2004-11-04
NO996313D0 (no) 1999-12-17
NO996313L (no) 2000-02-21
EP1012140A1 (en) 2000-06-28
US20020022612A1 (en) 2002-02-21
SK167099A3 (en) 2000-06-12
PL337645A1 (en) 2000-08-28
CN1266427A (zh) 2000-09-13
DE69826693T2 (de) 2006-02-16
EP1012140B1 (en) 2004-09-29
AU737645C (en) 2002-03-21
US6576657B2 (en) 2003-06-10
US6265397B1 (en) 2001-07-24
NO315156B1 (no) 2003-07-21
IS5302A (is) 1999-12-15
KR100540413B1 (ko) 2006-01-12
JP3919236B2 (ja) 2007-05-23
AU737645B2 (en) 2001-08-23
AU7946198A (en) 1999-01-04
CA2294059C (en) 2008-12-09
TR199903134T2 (xx) 2000-07-21
CN1205187C (zh) 2005-06-08
EE9900600A (et) 2000-08-15
ATE277902T1 (de) 2004-10-15
AR013084A1 (es) 2000-12-13
KR20010013982A (ko) 2001-02-26
IL133490A0 (en) 2001-04-30
JP2006321807A (ja) 2006-11-30
JP2002503256A (ja) 2002-01-29
CA2294059A1 (en) 1998-12-23
WO1998057932A1 (en) 1998-12-23

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL: A61K 31/401, A61K 31/4025, A61K 31/435, A61K 31/397, A61P 7/02

Ipc: C07D 207/16 (2008.04), A61K 31/40 (2008.04)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements