BR9901403A - Biologia molecular para fabricação de isoprenóides - Google Patents

Biologia molecular para fabricação de isoprenóides

Info

Publication number
BR9901403A
BR9901403A BR9901403-3A BR9901403A BR9901403A BR 9901403 A BR9901403 A BR 9901403A BR 9901403 A BR9901403 A BR 9901403A BR 9901403 A BR9901403 A BR 9901403A
Authority
BR
Brazil
Prior art keywords
molecular biology
isoprenoid
manufacturing
isoprenoids
plasmids
Prior art date
Application number
BR9901403-3A
Other languages
English (en)
Inventor
Tatsuo Hoshino
Kazuyuki Ojima
Yutaka Setogushi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9901403A publication Critical patent/BR9901403A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"BIOLOGIA MOLECULAR PARA FABRICAçãO DE ISOPRENóIDES"<D>. A presente invenção é dirigida a uma codificação de seq³ência DNA isolada para uma enzima envolvida na etapa mevalonato ou a etapa de pirofosfato isopentenila para pirofosfato farnesila, vetores ou plasmídeos compreendendo tal DNA, hospedeiros transformados por quer tais DNAs ou vetores ou plasmídeos e um processo para a produção de isoprenoides e carotenóides através do uso de tais células hospedeiras transformadas.
BR9901403-3A 1998-05-06 1999-05-05 Biologia molecular para fabricação de isoprenóides BR9901403A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98108210 1998-05-06

Publications (1)

Publication Number Publication Date
BR9901403A true BR9901403A (pt) 2000-10-17

Family

ID=8231884

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9901403-3A BR9901403A (pt) 1998-05-06 1999-05-05 Biologia molecular para fabricação de isoprenóides

Country Status (11)

Country Link
US (3) US6284506B1 (pt)
JP (2) JP2000050884A (pt)
KR (1) KR100626511B1 (pt)
CN (2) CN1262648C (pt)
AU (1) AU762939B2 (pt)
BR (1) BR9901403A (pt)
CA (1) CA2270711A1 (pt)
CL (1) CL2009002108A1 (pt)
ID (1) ID23300A (pt)
NO (1) NO992165L (pt)
TW (1) TWI250210B (pt)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002010398A2 (en) 2000-07-31 2002-02-07 Hahn Frederick M Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
US6933374B2 (en) * 2000-10-06 2005-08-23 Sapporo Breweries Limited Farnesyl pyrophosphate synthase protein, nucleic acid and promoter region thereof
US6413758B1 (en) * 2000-10-20 2002-07-02 New England Biolabs, Inc. Method for cloning and expression of Bpml restriction endonuclease in E. coli
US6335190B1 (en) * 2000-10-20 2002-01-01 New England Biolabs, Inc. Method for cloning and producing the BsmI restriction endonuclease in E. coli
US7172886B2 (en) * 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
JPWO2003095651A1 (ja) * 2002-05-10 2005-09-15 協和醗酵工業株式会社 メバロン酸の製造方法
US8524397B1 (en) 2004-11-08 2013-09-03 Quallion Llc Battery having high rate and high capacity capabilities
AU2003273888A1 (en) * 2002-09-27 2004-04-19 Dsm Ip Assets B.V. Astaxanthin production using fed-batch fermentation process byphaffia rhodozyma
US7632317B2 (en) * 2002-11-04 2009-12-15 Quallion Llc Method for making a battery
US7422884B2 (en) * 2003-06-12 2008-09-09 Dsm Ip Assetts B.V. Feedback-resistant mevalonate kinases
US8338155B2 (en) * 2004-12-14 2012-12-25 Dsm Ip Assets B.V. Modified mevalonate kinase with reduced feedback inhibition
EP1866428A2 (en) 2005-03-18 2007-12-19 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
EP2078092A2 (en) 2006-09-28 2009-07-15 Microbia, Inc. Production of carotenoids in oleaginous yeast and fungi
KR100845582B1 (ko) * 2006-11-09 2008-07-11 부경대학교 산학협력단 이소프레노이드와 카로티노이드 생합성 유전자로 형질전환된 대장균 및 이를 이용한 아스타잔틴의 대량 생산방법
JP2009000046A (ja) * 2007-06-21 2009-01-08 Hitachi Zosen Corp トチュウのメバロン酸経路の酵素をコードする遺伝子
MX318543B (es) 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
BRPI0919349A2 (pt) 2008-09-22 2015-12-29 Procter & Gamble aldeídos ramificados específicos alcoóis, tensoativos e produtos á base dos mesmos destinados ao consumidor.
US8232431B2 (en) * 2008-09-22 2012-07-31 The Procter & Gamble Company Specific branched surfactants and consumer products
US8569562B2 (en) 2009-12-18 2013-10-29 Danisco Us Inc. Purification of isoprene from renewable resources
EP2575432B1 (en) 2010-06-02 2019-08-14 Evolva, Inc. Recombinant production of steviol glycosides
CA3128532A1 (en) 2011-08-08 2013-02-14 Evolva Sa Recombinant production of steviol glycosides
JP2015226469A (ja) * 2012-09-24 2015-12-17 株式会社カネカ 新規ｄｎａ、およびそれを利用したカロテノイドの製造方法
MY199452A (en) 2013-02-06 2023-10-30 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
BR112015019160A2 (pt) 2013-02-11 2017-08-22 Dalgaard Mikkelsen Michael Produção de glicosídeos de esteviol em hospedeiros recombinantes
EP2969020B1 (en) 2013-03-15 2017-11-29 The Procter and Gamble Company Specific unsaturated and branched functional materials for use in consumer products
JP6282813B2 (ja) * 2013-07-16 2018-02-21 住友ゴム工業株式会社 ヒドロキシメチルグルタリルＣｏＡレダクターゼの発現をｂＺＩＰ型転写因子により調整する方法、ｂＺＩＰ型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法
CN106414736B (zh) 2014-04-09 2019-09-06 株式会社Adeka 突变酶及使用所述突变酶的类萜的制备方法
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2960693A1 (en) 2014-09-09 2016-03-17 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3250686A1 (en) 2015-01-30 2017-12-06 Evolva SA Production of steviol glycosides in recombinant hosts
WO2016146711A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
MX2018001620A (es) 2015-08-07 2018-06-11 Evolva Sa Produccion de glucosidos de esteviol en hospedadores recombinantes.
US10982249B2 (en) 2016-04-13 2021-04-20 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (en) 2016-05-16 2019-03-27 Evolva SA Production of steviol glycosides in recombinant hosts
WO2018083338A1 (en) 2016-11-07 2018-05-11 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
JP2021506316A (ja) 2017-12-21 2021-02-22 ザイマージェン インコーポレイテッド ネペタラクトールオキシドレダクターゼ、ネペタラクトールシンターゼ、及びネペタラクトンを産生する能力がある微生物
CN109777815B (zh) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
CA3148418A1 (en) * 2019-07-26 2021-02-04 Nextferm Technologies Ltd. Astaxanthin over-producing strains of phaffia rhodozyma
CA3215316A1 (en) * 2021-04-16 2022-10-20 Andrew P. MAGYAR Methods of isoprenoid synthesis using a genetically engineered hydrocarbonoclastic organism in a biofilm bioreactor
CN113621631A (zh) * 2021-08-11 2021-11-09 昆明理工大学 一种甲羟戊酸激酶基因rkmk及其应用
WO2026015601A1 (en) 2024-07-12 2026-01-15 International N&H Denmark Aps Method for enhancing the nutritional value of plant-based beverages employing a combination of phytase and xylanase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
JP2754975B2 (ja) 1991-10-01 1998-05-20 トヨタ自動車株式会社 ファルネシル二リン酸合成酵素およびそれをコードするｄｎａ配列
FR2687284B1 (fr) 1992-02-14 1995-06-23 Verneuil Rech Plante portant des genes codant pour des enzymes de la voie de biosynthese des phytosterols, et procede d'obtention.
NZ248628A (en) 1992-09-11 1996-02-27 Gist Brocades Nv Transformed phaffia (yeast) strains and methods and vectors used
CA2241267C (en) 1995-12-22 2012-12-04 Gist-Brocades B.V. Improved methods for transforming phaffia strains, transformed phaffia strains so obtained and recombinant dna in said methods
JPH10248575A (ja) 1997-03-12 1998-09-22 Kirin Brewery Co Ltd カロチノイド生産の増量に有用な遺伝子、およびカロチノイドの製造法

Also Published As

Publication number Publication date
ID23300A (id) 2000-04-05
US20030190734A1 (en) 2003-10-09
CN100487120C (zh) 2009-05-13
US20030054523A1 (en) 2003-03-20
AU762939B2 (en) 2003-07-10
US6586202B2 (en) 2003-07-01
US6284506B1 (en) 2001-09-04
JP2010104378A (ja) 2010-05-13
KR100626511B1 (ko) 2006-09-20
CL2009002108A1 (es) 2010-04-09
TWI250210B (en) 2006-03-01
CN1970770A (zh) 2007-05-30
CA2270711A1 (en) 1999-11-06
NO992165L (no) 1999-11-08
AU2696299A (en) 1999-11-18
US6872556B2 (en) 2005-03-29
JP2000050884A (ja) 2000-02-22
CN1262648C (zh) 2006-07-05
CN1234445A (zh) 1999-11-10
KR19990088053A (ko) 1999-12-27
NO992165D0 (no) 1999-05-04

Similar Documents

Publication Publication Date Title
BR9901403A (pt) Biologia molecular para fabricação de isoprenóides
Dodson et al. Specialized nucleoprotein structures at the origin of replication of bacteriophage lambda: localized unwinding of duplex DNA by a six-protein reaction.
BR9813968A (pt) Moléculas de ácido nucléico que codificam proteìnas tendo atividade frutosil transferase e processos para produzir inulina de cadeia longa
BR9811870A (pt) Processos melhorados para preparar tensoativos via separação adsortiva e produtos dos mesmos
BR0114199A (pt) Sequências de nucleotìdeos que medeiam a fertilidade masculina e métodos de uso das mesmas
ES2172092T3 (es) Asociacion de un retinoide con un polimero poliaminado.
BR9803955A (pt) Fabricação de carotenóides.
HN1999000083A (es) Compuestos de pirrolo(2,3-d) pirimidina
GT199700091A (es) Celdillas de alta resistencia para el desarrollo de virus.
WO1999054459A8 (en) Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
BR9902232A (pt) Organossilanopolissulfanos oligoméricos, seus usos em misturas de borracha e para preparação de artigos moldados
DE60221004D1 (de) Immunostimulierende oligodeoxyribonuklein moleküle
BR9909218A (pt) Picolé moldado
DE69939982D1 (de) B7l-1 moleküle
AU2489197A (en) Carbocyclic intermediates and process of manufacture thereof
BR0004493A (pt) Composto, uso do mesmo, sistema de catalisador, uso do mesmo, e, processo para preparar poliolefinas
BR0203785A (pt) ácido silìcico precipitante com elevada proporção bet/ctab
BR9909696A (pt) Isomerização de xileno
BR9807618A (pt) Análogo de fator xdelta, dna recombinante codificante para um análogo de fator xdelta, células transformadas, preparação, uso da mesma, e, processos para produzir uma preparação contendo análogo de fator xdelta recombinante purificado e análogo de fator xa.
BRPI9814894A (pt) processo para a preparação de ácidos 8-metóxi-quinolonocarboxílicos.
BR9910031A (pt) Processo para hidrogenação de fenil acetileno em um meio contento estireno com auxìlio de um catalisador
BRPI0410518A (pt) composição que compreende pelo menos uma matriz termoplástica, processo de fabricação de uma composição, processo de fabricação de um artigo e artigo
PT83255B (pt) Polipeptidos e anticorpos, caracteristicos do polilomavirus e suas aplicacoes no diagnostico &#34;in vitro&#34; na pervencao e ou na luta contra as infeccoes por papilomavirus
ES2077324T3 (es) Procedimiento para fabricar pinturas de varias capas, mas particularmente para los vehiculos automoviles, que proporcionan una buena adherencia de capas intermedias.
ES2169779T3 (es) Procedimiento para la preparacion de poli(diorganosiloxanos), composiciones que contienen los mismos y su uso.

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Free format text: DSM IP ASSETS B.V. (NL)

B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: PORTANTO, INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ARTS. 8O, 10 (IX), 11, 18(III) E 25.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.