BR9907908A - Microgrânulos de liberação imediata, processo de preparação dos mesmos, e, preparações farmacêuticas - Google Patents

Microgrânulos de liberação imediata, processo de preparação dos mesmos, e, preparações farmacêuticas

Info

Publication number
BR9907908A
BR9907908A BR9907908-9A BR9907908A BR9907908A BR 9907908 A BR9907908 A BR 9907908A BR 9907908 A BR9907908 A BR 9907908A BR 9907908 A BR9907908 A BR 9907908A
Authority
BR
Brazil
Prior art keywords
microgranules
pharmaceutical preparations
preparing
immediate
relates
Prior art date
Application number
BR9907908-9A
Other languages
English (en)
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Original Assignee
Ethypharm Lab Prod Ethiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Lab Prod Ethiques filed Critical Ethypharm Lab Prod Ethiques
Publication of BR9907908A publication Critical patent/BR9907908A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"MICROGRâNULOS DE LIBERAçãO IMEDIATA, PROCESSO DE PREPARAçãO DOS MESMOS, E, PREPARAçõES FARMACêUTICAS". A presente invenção refere-se a uma nova formulação oral de liberação imediata de sulfato de morfina sob forma de microgrânulos. Cada microgrânulo compreende um grão de suporte neutro revestido com uma mistura de sulfato de morfina e um ligante como hidroxipropilmetilcelulose, que representa 10 a 50% em peso da mistura sulfato de morfina /ligante. A presente invenção refere-se igualmente a um processo de preparação destes microgrânulos completamente feitos em meio aquoso sobre os grãos de suporte neutros. A presente invenção refere-se, por fim, às preparações farmacêuticas contendo os microgrânulos de acordo com a invenção.
BR9907908-9A 1998-02-16 1999-02-15 Microgrânulos de liberação imediata, processo de preparação dos mesmos, e, preparações farmacêuticas BR9907908A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9801816A FR2774910B1 (fr) 1998-02-16 1998-02-16 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques
PCT/FR1999/000326 WO1999040918A1 (fr) 1998-02-16 1999-02-15 Microgranules de sulfate de morphine, procede de fabrication et preparations pharmaceutiques

Publications (1)

Publication Number Publication Date
BR9907908A true BR9907908A (pt) 2002-04-30

Family

ID=9522990

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907908-9A BR9907908A (pt) 1998-02-16 1999-02-15 Microgrânulos de liberação imediata, processo de preparação dos mesmos, e, preparações farmacêuticas

Country Status (15)

Country Link
US (2) US6482437B2 (pt)
EP (1) EP1054672B1 (pt)
JP (1) JP4447166B2 (pt)
CN (1) CN1135981C (pt)
AU (1) AU2429899A (pt)
BR (1) BR9907908A (pt)
CA (1) CA2320878C (pt)
CY (1) CY1107559T1 (pt)
DE (1) DE69934781T2 (pt)
DK (1) DK1054672T3 (pt)
ES (1) ES2277427T3 (pt)
FR (1) FR2774910B1 (pt)
NZ (1) NZ506307A (pt)
PT (1) PT1054672E (pt)
WO (1) WO1999040918A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
EP1429739A1 (en) 2001-09-21 2004-06-23 Egalet A/S Polymer release system
WO2003024430A1 (en) 2001-09-21 2003-03-27 Egalet A/S Morphine polymer release system
EP1610767B1 (en) 2003-03-26 2011-01-19 Egalet A/S Morphine controlled release system
JP5171038B2 (ja) * 2003-10-10 2013-03-27 エティファルム イチョウ・エキスを含む放出持続性の微小顆粒およびそのような顆粒の製造方法
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
US20100233257A1 (en) * 2006-06-09 2010-09-16 Ethypharm Low dose sublingual tablets of opioid analgesics and preparation process
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
AU2008258596B2 (en) 2007-06-04 2013-02-14 Egalet Ltd Controlled release pharmaceutical compositions for prolonged effect
ES2572157T3 (es) * 2007-09-03 2016-05-30 Nanotherapeutics Inc Composiciones en forma de partículas para la administración de fármacos poco solubles
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
WO2010149169A2 (en) 2009-06-24 2010-12-29 Egalet A/S Controlled release formulations
US9549899B2 (en) 2012-07-06 2017-01-24 Egalet Ltd. Abuse deterrent pharmaceutical compositions for controlled release
US9683448B2 (en) 2013-03-18 2017-06-20 Honeywell International Inc. Low conductivity thermal barrier coating
US11479846B2 (en) 2014-01-07 2022-10-25 Honeywell International Inc. Thermal barrier coatings for turbine engine components

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4093708A (en) * 1974-12-23 1978-06-06 Alza Corporation Osmotic releasing device having a plurality of release rate patterns
US4309996A (en) * 1980-04-28 1982-01-12 Alza Corporation System with microporous releasing diffusor
US4673405A (en) * 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US5026560A (en) * 1987-01-29 1991-06-25 Takeda Chemical Industries, Ltd. Spherical granules having core and their production
DE3708856A1 (de) 1987-03-18 1988-09-29 Kajetan Leitner Mit zaehnen versehene einpressmutter
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US5582838A (en) * 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation

Also Published As

Publication number Publication date
FR2774910B1 (fr) 2001-09-07
JP2002502877A (ja) 2002-01-29
US20020028246A1 (en) 2002-03-07
CN1291097A (zh) 2001-04-11
US20030129244A1 (en) 2003-07-10
DE69934781T2 (de) 2007-10-11
WO1999040918A1 (fr) 1999-08-19
JP4447166B2 (ja) 2010-04-07
DE69934781D1 (de) 2007-02-22
EP1054672A1 (fr) 2000-11-29
CA2320878A1 (fr) 1999-08-19
NZ506307A (en) 2003-11-28
PT1054672E (pt) 2007-04-30
EP1054672B1 (fr) 2007-01-10
ES2277427T3 (es) 2007-07-01
US6482437B2 (en) 2002-11-19
HK1036402A1 (en) 2002-01-04
AU2429899A (en) 1999-08-30
FR2774910A1 (fr) 1999-08-20
CN1135981C (zh) 2004-01-28
CY1107559T1 (el) 2013-03-13
DK1054672T3 (da) 2007-04-10
CA2320878C (fr) 2009-04-21

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO ESTABELECIDO NOS ARTIGOS 8O E 13 DA LPI - LEI 9729/96

B12B Appeal against refusal [chapter 12.2 patent gazette]