BR9909257A - Genes biossintéticos para produção de inseticida de espinosina - Google Patents

Genes biossintéticos para produção de inseticida de espinosina

Info

Publication number
BR9909257A
BR9909257A BR9909257-3A BR9909257A BR9909257A BR 9909257 A BR9909257 A BR 9909257A BR 9909257 A BR9909257 A BR 9909257A BR 9909257 A BR9909257 A BR 9909257A
Authority
BR
Brazil
Prior art keywords
biosynthetic genes
production
spinosyn
genes
insecticide
Prior art date
Application number
BR9909257-3A
Other languages
English (en)
Other versions
BR9909257B1 (pt
Inventor
Richard H Baltz
Christine M Broughton
Kathryn P Crawford
Krishnamurthy Madduri
Donald J Merlo
Patty J Treadway
Jan R Turner
Clive Waldron
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of BR9909257A publication Critical patent/BR9909257A/pt
Publication of BR9909257B1 publication Critical patent/BR9909257B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Patente de Invenção: <B>"GENES BIOSSINTéTICOS PARA PRODUçãO DE INSETICIDA DE ESPINOSINA"<D>. Genes biossintéticos da espinosina, microorganismos produtores de espinosina transformados com os genes biossintéticos, processos para utilização dos genes biossintéticos para aumentar a produção de macrolídeos inseticidas de espinosina e processos de utilização dos genes ou fragmentos dos mesmos para modificar os produtos obtidos pelos microorganismos produtores de espinosina.
BRPI9909257-3A 1998-03-09 1999-02-16 Molécula de DNA para produção de inseticida de espinosina, vetor recombinante, célula hospedeira e microorganismo procariótico bem como processos para produção de espinosina BR9909257B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/036,987 1998-03-09
US09/036,987 US6143526A (en) 1998-03-09 1998-03-09 Biosynthetic genes for spinosyn insecticide production
PCT/US1999/003212 WO1999046387A1 (en) 1998-03-09 1999-02-16 Biosynthetic genes for spinosyn insecticide production

Publications (2)

Publication Number Publication Date
BR9909257A true BR9909257A (pt) 2000-11-28
BR9909257B1 BR9909257B1 (pt) 2014-01-14

Family

ID=21891822

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9909257-3A BR9909257B1 (pt) 1998-03-09 1999-02-16 Molécula de DNA para produção de inseticida de espinosina, vetor recombinante, célula hospedeira e microorganismo procariótico bem como processos para produção de espinosina

Country Status (18)

Country Link
US (4) US6143526A (pt)
EP (1) EP1062345B1 (pt)
JP (1) JP2002505881A (pt)
KR (1) KR100588436B1 (pt)
CN (1) CN1227362C (pt)
AR (1) AR014687A1 (pt)
AT (1) ATE380872T1 (pt)
AU (1) AU764737B2 (pt)
BR (1) BR9909257B1 (pt)
CA (1) CA2322449C (pt)
DE (1) DE69937732T2 (pt)
ES (1) ES2299240T3 (pt)
ID (1) ID26862A (pt)
IL (2) IL138241A0 (pt)
NZ (1) NZ506624A (pt)
TW (1) TWI237058B (pt)
WO (1) WO1999046387A1 (pt)
ZA (1) ZA991837B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
WO2001016303A2 (de) * 1999-08-27 2001-03-08 Bayer Aktiengesellschaft Nucleinsäuren, die für enzymaktivitäten der spinosyn-biosynthese codieren
AR033022A1 (es) 2001-03-30 2003-12-03 Dow Agrosciences Llc Genes biosinteticos para la produccion de insecticida de butenilespinosina
IL160169A0 (en) * 2001-08-06 2004-07-25 Cubist Pharm Inc Nucleic acid molecules that encode a daptomycin non-ribosomal peptide synthetase and methods for the production thereof
MXPA04008071A (es) * 2002-02-19 2004-11-26 Dow Agrosciences Llc Nuevas sintasas de poliquetida que producen espinosina.
EP1477563A3 (en) * 2003-05-16 2004-11-24 Wyeth Cloning genes from streptomyces cyaneogriseus subsp.noncyanogenus for biosynthesis of antibiotics and methods of use
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
DK2343975T3 (da) * 2008-09-22 2012-12-03 Entarco Sa Spinosyn-antibegroningssammensætninger, fremgangsmåder til deres anvendelse samt genstande beskyttet mod vedhæftning af biobegroningsorganismer
TW201041509A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041510A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041508A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041507A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity and methods for preparing same
CA2764526A1 (en) 2009-06-24 2010-12-29 Christine Kritikou The use of spinosyns and spinosyn compositions against diseases caused by protozoans, viral infections and cancer
CN102191208A (zh) * 2010-03-17 2011-09-21 上海医药工业研究院 高产多杀菌素的基因工程菌及其制备方法
KR20130080007A (ko) * 2010-05-11 2013-07-11 다우 아그로사이언시즈 엘엘씨 Ｓｐｎｋ 균주
EP2654757A1 (en) 2010-12-22 2013-10-30 Entarco SA The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents
CN103459610A (zh) 2011-01-28 2013-12-18 阿迈瑞斯公司 凝胶包裹的微集落筛选
EP2520653B1 (en) 2011-05-03 2017-03-29 Dow AgroSciences LLC Integration of genes into the chromosome of saccharopolyspora spinosa
US9404107B2 (en) 2011-05-03 2016-08-02 Dow Agrosciences Llc Integration of genes into the chromosome of Saccharopolyspora spinosa
US8741603B2 (en) * 2011-05-03 2014-06-03 Agrigenetics Inc. Enhancing spinosyn production with oxygen binding proteins
US20140057314A1 (en) 2011-05-13 2014-02-27 Amyris, Inc. Methods and compositions for detecting microbial production of water-immiscible compounds
CN103764668B (zh) * 2011-07-09 2016-08-17 加利福尼亚大学董事会 白血病干细胞靶向配体及应用方法
US9631195B2 (en) * 2011-12-28 2017-04-25 Dow Agrosciences Llc Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa
AU2013299608B2 (en) 2012-08-07 2019-02-21 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
MX364748B (es) 2013-03-15 2019-05-06 Amyris Inc Uso de fosfoquetolasa y fosfotransacetilasa para la produccion de compuestos derivados de acetil-coenzima a.
CA2918891C (en) 2013-08-07 2023-03-14 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
CN103740631B (zh) * 2013-12-31 2015-09-30 天津大学 能提高多杀菌素产量的基因工程菌及构建方法及应用
US10844415B2 (en) 2014-11-14 2020-11-24 Zhejiang Hisun Pharmaceutical Co., Ltd. Spinosad heterologous expression strain and construction method thereof and use
EP3313996A1 (en) 2015-06-25 2018-05-02 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
CN108137529A (zh) 2015-09-03 2018-06-08 阿格里麦蒂斯有限责任公司 作为杀虫剂的多杀菌素衍生物
EP3568399B1 (en) 2017-01-13 2026-04-22 Agrimetis, LLC Aziridine spinosyn derivatives and methods of making
EP3635111A1 (en) * 2017-06-06 2020-04-15 Zymergen, Inc. High throughput transposon mutagenesis
CN109096366B (zh) * 2017-06-21 2021-09-10 中南大学 Rgd环肽偶联亲脂性阳离子多杀菌素衍生物及其制备方法和应用
CN116334021B (zh) * 2023-03-30 2026-02-03 上海交通大学 一种多杀菌素酰基转移酶突变体及其应用
WO2025003522A1 (en) * 2023-06-30 2025-01-02 Acies Bio D.O.O Genetically modified organism and method for spinosyn production
CN118420725A (zh) * 2024-05-07 2024-08-02 武汉大学 Orf-l16基因在调控多杀菌素合成中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4935340A (en) * 1985-06-07 1990-06-19 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
JPS63502636A (ja) * 1985-12-17 1988-10-06 ルブリゾル　ジエネテイクス，インコ−ポレイテツド ポリケチド抗生物質生合成用遺伝子の単離
US5672497A (en) * 1986-03-21 1997-09-30 Eli Lilly And Company Method for increasing the antibiotic-producing ability of antibiotic-producing microorganisms
US4874748A (en) * 1986-03-24 1989-10-17 Abbott Laboratories Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
US5149638A (en) * 1988-09-29 1992-09-22 Eli Lilly And Company Tylosin biosynthetic genes tylA, tylB and tylI
US5362634A (en) * 1989-10-30 1994-11-08 Dowelanco Process for producing A83543 compounds
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
CA2119379A1 (en) * 1991-09-18 1993-04-01 Wolfgang Piepersberg Secondary-metabolite biosynthesis genes from actinomycetes, method of isolating them and their use
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
ES2164713T3 (es) * 1993-09-20 2002-03-01 Univ Leland Stanford Junior Produccion recombinante de nuevos poliquetidos.
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
CA2197524A1 (en) * 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
WO2001016303A2 (de) * 1999-08-27 2001-03-08 Bayer Aktiengesellschaft Nucleinsäuren, die für enzymaktivitäten der spinosyn-biosynthese codieren
DE19957268A1 (de) * 1999-08-27 2001-03-08 Bayer Ag Nucleinsäuren, die für Enzymaktivitäten der Spinosyn-Biosynthese kodieren
AR033022A1 (es) * 2001-03-30 2003-12-03 Dow Agrosciences Llc Genes biosinteticos para la produccion de insecticida de butenilespinosina

Also Published As

Publication number Publication date
ATE380872T1 (de) 2007-12-15
US7015001B2 (en) 2006-03-21
US6521406B1 (en) 2003-02-18
CN1298447A (zh) 2001-06-06
AR014687A1 (es) 2001-03-28
IL138241A0 (en) 2001-10-31
US6143526A (en) 2000-11-07
ES2299240T3 (es) 2008-05-16
BR9909257B1 (pt) 2014-01-14
ID26862A (id) 2001-02-15
WO1999046387A1 (en) 1999-09-16
TWI237058B (en) 2005-08-01
CN1227362C (zh) 2005-11-16
NZ506624A (en) 2003-08-29
AU764737B2 (en) 2003-08-28
JP2002505881A (ja) 2002-02-26
US20040023343A1 (en) 2004-02-05
DE69937732D1 (de) 2008-01-24
KR100588436B1 (ko) 2006-06-13
CA2322449A1 (en) 1999-09-16
EP1062345A1 (en) 2000-12-27
EP1062345B1 (en) 2007-12-12
DE69937732T2 (de) 2008-12-04
AU2680099A (en) 1999-09-27
IL138241A (en) 2007-09-20
CA2322449C (en) 2013-01-15
WO1999046387A9 (en) 2001-10-04
KR20010041750A (ko) 2001-05-25
US6274350B1 (en) 2001-08-14
ZA991837B (en) 2000-09-08

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)