AR014687A1 - VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR. - Google Patents

VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR.

Info

Publication number
AR014687A1
AR014687A1 ARP990100978A ARP990100978A AR014687A1 AR 014687 A1 AR014687 A1 AR 014687A1 AR P990100978 A ARP990100978 A AR P990100978A AR P990100978 A ARP990100978 A AR P990100978A AR 014687 A1 AR014687 A1 AR 014687A1
Authority
AR
Argentina
Prior art keywords
espinosine
produce
vector
spinosine
composite
Prior art date
Application number
ARP990100978A
Other languages
English (en)
Inventor
Richard H Baltz
M Christine Broughton
Kathryn P Crawford
Krishnamurthy Woodlawn Madduri
Donald J Merlo
Patti J Treadway
Jan R Turner
Clive Waldron
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of AR014687A1 publication Critical patent/AR014687A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ARP990100978A 1998-03-09 1999-03-08 VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR. AR014687A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/036,987 US6143526A (en) 1998-03-09 1998-03-09 Biosynthetic genes for spinosyn insecticide production

Publications (1)

Publication Number Publication Date
AR014687A1 true AR014687A1 (es) 2001-03-28

Family

ID=21891822

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100978A AR014687A1 (es) 1998-03-09 1999-03-08 VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR.

Country Status (18)

Country Link
US (4) US6143526A (es)
EP (1) EP1062345B1 (es)
JP (1) JP2002505881A (es)
KR (1) KR100588436B1 (es)
CN (1) CN1227362C (es)
AR (1) AR014687A1 (es)
AT (1) ATE380872T1 (es)
AU (1) AU764737B2 (es)
BR (1) BR9909257B1 (es)
CA (1) CA2322449C (es)
DE (1) DE69937732T2 (es)
ES (1) ES2299240T3 (es)
ID (1) ID26862A (es)
IL (2) IL138241A0 (es)
NZ (1) NZ506624A (es)
TW (1) TWI237058B (es)
WO (1) WO1999046387A1 (es)
ZA (1) ZA991837B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
JP2003508050A (ja) * 1999-08-27 2003-03-04 バイエル アクチェンゲゼルシャフト スピノシン生合成の酵素活性をコードする核酸
AR033022A1 (es) 2001-03-30 2003-12-03 Dow Agrosciences Llc Genes biosinteticos para la produccion de insecticida de butenilespinosina
AU2002324580A1 (en) * 2001-08-06 2003-02-24 Cubist Pharmaceuticals, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
WO2003070908A2 (en) * 2002-02-19 2003-08-28 Dow Agrosciences Llc Novel spinosyn-producing polyketide synthases
EP1477563A3 (en) * 2003-05-16 2004-11-24 Wyeth Cloning genes from streptomyces cyaneogriseus subsp.noncyanogenus for biosynthesis of antibiotics and methods of use
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
ES2392142T3 (es) * 2008-09-22 2012-12-05 Entarco Sa Composiciones antiincrustantes de espinosina, procedimientos de uso de las mismas y artículos protegidos de la adhesión de organismos bioincrustantes
TW201041509A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041510A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041508A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041507A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity and methods for preparing same
US8697661B2 (en) 2009-06-24 2014-04-15 Christine Kritikou Use of spinosyns and spinosyn compositions against herpesviridae viral infections
CN102191208A (zh) * 2010-03-17 2011-09-21 上海医药工业研究院 高产多杀菌素的基因工程菌及其制备方法
BR112012028860A2 (pt) 2010-05-11 2020-09-01 Dow Agrosciences Llc cepas spnk.
EP2654757A1 (en) 2010-12-22 2013-10-30 Entarco SA The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents
CN103459610A (zh) 2011-01-28 2013-12-18 阿迈瑞斯公司 凝胶包裹的微集落筛选
US8741603B2 (en) * 2011-05-03 2014-06-03 Agrigenetics Inc. Enhancing spinosyn production with oxygen binding proteins
US9404107B2 (en) * 2011-05-03 2016-08-02 Dow Agrosciences Llc Integration of genes into the chromosome of Saccharopolyspora spinosa
EP2520653B1 (en) 2011-05-03 2017-03-29 Dow AgroSciences LLC Integration of genes into the chromosome of saccharopolyspora spinosa
EP2707722A1 (en) 2011-05-13 2014-03-19 Amyris, Inc. Methods and compositions for detecting microbial production of water-immiscible compounds
WO2013009690A2 (en) * 2011-07-09 2013-01-17 The Regents Of The University Of California Leukemia stem cell targeting ligands and methods of use
US9631195B2 (en) * 2011-12-28 2017-04-25 Dow Agrosciences Llc Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa
BR112015002724B1 (pt) 2012-08-07 2022-02-01 Total Marketing Services Método para produzir um composto não catabólico heterólogo, e, composição de fermentação
AU2014227811C1 (en) 2013-03-15 2018-09-27 Amyris, Inc. Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
WO2015020649A1 (en) 2013-08-07 2015-02-12 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
CN103740631B (zh) * 2013-12-31 2015-09-30 天津大学 能提高多杀菌素产量的基因工程菌及构建方法及应用
EP3219788A4 (en) * 2014-11-14 2018-05-23 Zhejiang Hisun Pharmaceutical Co., Ltd Spinosad heterologous expression strain and construction method thereof and use
EP3313996A1 (en) 2015-06-25 2018-05-02 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
BR112018004310A2 (pt) 2015-09-03 2018-10-09 Agrimetis Llc derivados de espinosina e método de preparação
JP2020506891A (ja) 2017-01-13 2020-03-05 アグリメティス，エルエルシー アジリジンスピノシン誘導体および製造方法
WO2018226810A1 (en) * 2017-06-06 2018-12-13 Zymergen Inc. High throughput transposon mutagenesis
CN109096366B (zh) * 2017-06-21 2021-09-10 中南大学 Rgd环肽偶联亲脂性阳离子多杀菌素衍生物及其制备方法和应用
CN116334021B (zh) * 2023-03-30 2026-02-03 上海交通大学 一种多杀菌素酰基转移酶突变体及其应用
WO2025003522A1 (en) * 2023-06-30 2025-01-02 Acies Bio D.O.O Genetically modified organism and method for spinosyn production
CN118420725A (zh) * 2024-05-07 2024-08-02 武汉大学 Orf-l16基因在调控多杀菌素合成中的应用

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US4935340A (en) * 1985-06-07 1990-06-19 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
WO1987003907A1 (en) * 1985-12-17 1987-07-02 Lubrizol Genetics, Inc. Isolation of genes for biosynthesis of polyketide antibiotics
US5672497A (en) * 1986-03-21 1997-09-30 Eli Lilly And Company Method for increasing the antibiotic-producing ability of antibiotic-producing microorganisms
US4874748A (en) * 1986-03-24 1989-10-17 Abbott Laboratories Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
US5149638A (en) * 1988-09-29 1992-09-22 Eli Lilly And Company Tylosin biosynthetic genes tylA, tylB and tylI
US5362634A (en) * 1989-10-30 1994-11-08 Dowelanco Process for producing A83543 compounds
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5614619A (en) * 1991-09-18 1997-03-25 Hoechst Aktiengesellschaft Secondary-metabolite biosynthesis genes from actinomycetes, method of isolating them and their use
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
EP0725778B1 (en) * 1993-09-20 2001-09-26 The Leland Stanford Junior University Recombinant production of novel polyketides
CA2197524A1 (en) * 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
JP2003508050A (ja) * 1999-08-27 2003-03-04 バイエル アクチェンゲゼルシャフト スピノシン生合成の酵素活性をコードする核酸
DE19957268A1 (de) * 1999-08-27 2001-03-08 Bayer Ag Nucleinsäuren, die für Enzymaktivitäten der Spinosyn-Biosynthese kodieren
AR033022A1 (es) * 2001-03-30 2003-12-03 Dow Agrosciences Llc Genes biosinteticos para la produccion de insecticida de butenilespinosina

Also Published As

Publication number Publication date
JP2002505881A (ja) 2002-02-26
IL138241A0 (en) 2001-10-31
US7015001B2 (en) 2006-03-21
DE69937732D1 (de) 2008-01-24
KR100588436B1 (ko) 2006-06-13
EP1062345A1 (en) 2000-12-27
BR9909257B1 (pt) 2014-01-14
ATE380872T1 (de) 2007-12-15
AU2680099A (en) 1999-09-27
IL138241A (en) 2007-09-20
NZ506624A (en) 2003-08-29
ZA991837B (en) 2000-09-08
WO1999046387A1 (en) 1999-09-16
US20040023343A1 (en) 2004-02-05
US6521406B1 (en) 2003-02-18
CN1227362C (zh) 2005-11-16
TWI237058B (en) 2005-08-01
ES2299240T3 (es) 2008-05-16
ID26862A (id) 2001-02-15
WO1999046387A9 (en) 2001-10-04
CA2322449A1 (en) 1999-09-16
CA2322449C (en) 2013-01-15
US6143526A (en) 2000-11-07
KR20010041750A (ko) 2001-05-25
AU764737B2 (en) 2003-08-28
CN1298447A (zh) 2001-06-06
BR9909257A (pt) 2000-11-28
EP1062345B1 (en) 2007-12-12
US6274350B1 (en) 2001-08-14
DE69937732T2 (de) 2008-12-04

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