AR014687A1 - VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR. - Google Patents

VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR.

Info

Publication number
AR014687A1
AR014687A1 ARP990100978A ARP990100978A AR014687A1 AR 014687 A1 AR014687 A1 AR 014687A1 AR P990100978 A ARP990100978 A AR P990100978A AR P990100978 A ARP990100978 A AR P990100978A AR 014687 A1 AR014687 A1 AR 014687A1
Authority
AR
Argentina
Prior art keywords
espinosine
produce
vector
spinosine
composite
Prior art date
Application number
ARP990100978A
Other languages
English (en)
Inventor
Richard H Baltz
M Christine Broughton
Kathryn P Crawford
Krishnamurthy Woodlawn Madduri
Donald J Merlo
Patti J Treadway
Jan R Turner
Clive Waldron
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of AR014687A1 publication Critical patent/AR014687A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
ARP990100978A 1998-03-09 1999-03-08 VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR. AR014687A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/036,987 US6143526A (en) 1998-03-09 1998-03-09 Biosynthetic genes for spinosyn insecticide production

Publications (1)

Publication Number Publication Date
AR014687A1 true AR014687A1 (es) 2001-03-28

Family

ID=21891822

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100978A AR014687A1 (es) 1998-03-09 1999-03-08 VECTOR DE ADN RECOMBINANTE QUE CODIFICA UNA ENZIMA DE BIOSíNTESIS DE ESPINOSINA, MÉTODO PARA PRODUCIR ESPINOSINA EN CANTIDADES INCREMENTADAS Y PROCESO PARA PRODUCIR UN COMPUESTO DE ESPINOSINA USANDO DICHO VECTOR.

Country Status (18)

Country Link
US (4) US6143526A (es)
EP (1) EP1062345B1 (es)
JP (1) JP2002505881A (es)
KR (1) KR100588436B1 (es)
CN (1) CN1227362C (es)
AR (1) AR014687A1 (es)
AT (1) ATE380872T1 (es)
AU (1) AU764737B2 (es)
BR (1) BR9909257B1 (es)
CA (1) CA2322449C (es)
DE (1) DE69937732T2 (es)
ES (1) ES2299240T3 (es)
ID (1) ID26862A (es)
IL (2) IL138241A0 (es)
NZ (1) NZ506624A (es)
TW (1) TWI237058B (es)
WO (1) WO1999046387A1 (es)
ZA (1) ZA991837B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
US7285653B1 (en) 1999-08-27 2007-10-23 Bayer Aktiengesellschaft Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis
AR033022A1 (es) 2001-03-30 2003-12-03 Dow Agrosciences Llc Genes biosinteticos para la produccion de insecticida de butenilespinosina
US20050027113A1 (en) * 2001-08-06 2005-02-03 Miao Vivian Pak Woon Compositions and methods relating to the daptomycin biosynthetic gene cluster
KR101016561B1 (ko) * 2002-02-19 2011-02-22 다우 아그로사이언시즈 엘엘씨 신규한 스피노신 생산 폴리케타이드 신타제
EP1477563A3 (en) * 2003-05-16 2004-11-24 Wyeth Cloning genes from streptomyces cyaneogriseus subsp.noncyanogenus for biosynthesis of antibiotics and methods of use
GB0327721D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Polyketides and their synthesis
EP2343975B8 (en) * 2008-09-22 2012-10-24 Entarco SA Spinosyn antifouling compositions, methods of use thereof and articles protected from attachment of biofouling organisms
TW201041508A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041509A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041510A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041507A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity and methods for preparing same
WO2010150100A1 (en) 2009-06-24 2010-12-29 Entarco Sa The use of spinosyns and spinosyn compositions against diseases caused by protozoans, viral infections and cancer
CN102191208A (zh) * 2010-03-17 2011-09-21 上海医药工业研究院 高产多杀菌素的基因工程菌及其制备方法
KR20130080007A (ko) * 2010-05-11 2013-07-11 다우 아그로사이언시즈 엘엘씨 Ｓｐｎｋ 균주
EP2654757A1 (en) 2010-12-22 2013-10-30 Entarco SA The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents
MX2013008062A (es) 2011-01-28 2013-08-09 Amyris Inc Seleccion de microcolonias encapsuladas en gel.
US9404107B2 (en) * 2011-05-03 2016-08-02 Dow Agrosciences Llc Integration of genes into the chromosome of Saccharopolyspora spinosa
EP2998399A1 (en) 2011-05-03 2016-03-23 Dow AgroSciences LLC Enhancing spinosyn production with oxygen binding proteins
US8741603B2 (en) 2011-05-03 2014-06-03 Agrigenetics Inc. Enhancing spinosyn production with oxygen binding proteins
BR112013027954A2 (pt) 2011-05-13 2017-01-17 Amyris Inc métodos e composições para detectar a produção microbiana de compostos imiscíveis em água
WO2013009690A2 (en) * 2011-07-09 2013-01-17 The Regents Of The University Of California Leukemia stem cell targeting ligands and methods of use
US9631195B2 (en) * 2011-12-28 2017-04-25 Dow Agrosciences Llc Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa
AU2013299608B2 (en) 2012-08-07 2019-02-21 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
BR112015023089A2 (pt) 2013-03-15 2017-11-21 Amyris Inc célula hospedeira, método para produzir um isoprenoide, e método para aumentar a produção de acetil-coa ou um composto derivado de acetil-coa
BR112016002526B1 (pt) 2013-08-07 2021-11-23 Total Marketing Services Método para produção de um composto heterólogo não catabólico, e, composição de fermentação
CN103740631B (zh) * 2013-12-31 2015-09-30 天津大学 能提高多杀菌素产量的基因工程菌及构建方法及应用
BR112017010073A2 (pt) * 2014-11-14 2018-05-15 Zhejiang Hisun Pharmaceutical Co., Ltd. cepa de expressão heteróloga de espinosade e método de construção e uso da mesma
WO2016210350A1 (en) 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
WO2017040763A1 (en) 2015-09-03 2017-03-09 Agrimetis, Llc Spinosyn derivatives as insecticides
CA3049576A1 (en) 2017-01-13 2018-07-19 Agrimetis, Llc Aziridine spinosyn derivatives and methods of making
KR20200014836A (ko) * 2017-06-06 2020-02-11 지머젠 인코포레이티드 고 처리량 트랜스포존 돌연변이유발
CN109096366B (zh) * 2017-06-21 2021-09-10 中南大学 Rgd环肽偶联亲脂性阳离子多杀菌素衍生物及其制备方法和应用
CN116334021B (zh) * 2023-03-30 2026-02-03 上海交通大学 一种多杀菌素酰基转移酶突变体及其应用
WO2025003522A1 (en) * 2023-06-30 2025-01-02 Acies Bio D.O.O Genetically modified organism and method for spinosyn production
CN117946934A (zh) * 2024-02-08 2024-04-30 武汉合生科技有限公司 刺糖多孢菌菌株及其突变株
CN118420725A (zh) * 2024-05-07 2024-08-02 武汉大学 Orf-l16基因在调控多杀菌素合成中的应用

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US4935340A (en) * 1985-06-07 1990-06-19 Eli Lilly And Company Method of isolating antibiotic biosynthetic genes
EP0262154A1 (en) * 1985-12-17 1988-04-06 Lubrizol Genetics Inc. Isolation of genes for biosynthesis of polyketide antibiotics
US5672497A (en) * 1986-03-21 1997-09-30 Eli Lilly And Company Method for increasing the antibiotic-producing ability of antibiotic-producing microorganisms
US4874748A (en) * 1986-03-24 1989-10-17 Abbott Laboratories Cloning vectors for streptomyces and use thereof in macrolide antibiotic production
US5149638A (en) * 1988-09-29 1992-09-22 Eli Lilly And Company Tylosin biosynthetic genes tylA, tylB and tylI
US5362634A (en) * 1989-10-30 1994-11-08 Dowelanco Process for producing A83543 compounds
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
WO1993006219A1 (de) 1991-09-18 1993-04-01 Hoechst Aktiengesellschaft Sekundärmetabolit-biosynthesegene aus aktinomyceten, verfahren zu ihrer isolierung sowie ihre verwendung
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
WO1995008548A1 (en) * 1993-09-20 1995-03-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
US5712146A (en) * 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
CA2197524A1 (en) * 1996-02-22 1997-08-22 Bradley Stuart Dehoff Polyketide synthase genes
US6143526A (en) * 1998-03-09 2000-11-07 Baltz; Richard H. Biosynthetic genes for spinosyn insecticide production
DE19957268A1 (de) * 1999-08-27 2001-03-08 Bayer Ag Nucleinsäuren, die für Enzymaktivitäten der Spinosyn-Biosynthese kodieren
US7285653B1 (en) * 1999-08-27 2007-10-23 Bayer Aktiengesellschaft Nucleic acids which code for the enzyme activities of the spinosyn biosynthesis
AR033022A1 (es) * 2001-03-30 2003-12-03 Dow Agrosciences Llc Genes biosinteticos para la produccion de insecticida de butenilespinosina

Also Published As

Publication number Publication date
DE69937732D1 (de) 2008-01-24
US20040023343A1 (en) 2004-02-05
ATE380872T1 (de) 2007-12-15
DE69937732T2 (de) 2008-12-04
WO1999046387A1 (en) 1999-09-16
NZ506624A (en) 2003-08-29
CN1227362C (zh) 2005-11-16
KR100588436B1 (ko) 2006-06-13
BR9909257B1 (pt) 2014-01-14
KR20010041750A (ko) 2001-05-25
AU764737B2 (en) 2003-08-28
CN1298447A (zh) 2001-06-06
CA2322449C (en) 2013-01-15
AU2680099A (en) 1999-09-27
WO1999046387A9 (en) 2001-10-04
US6274350B1 (en) 2001-08-14
CA2322449A1 (en) 1999-09-16
ZA991837B (en) 2000-09-08
US7015001B2 (en) 2006-03-21
ID26862A (id) 2001-02-15
EP1062345B1 (en) 2007-12-12
IL138241A (en) 2007-09-20
US6143526A (en) 2000-11-07
JP2002505881A (ja) 2002-02-26
TWI237058B (en) 2005-08-01
IL138241A0 (en) 2001-10-31
BR9909257A (pt) 2000-11-28
EP1062345A1 (en) 2000-12-27
US6521406B1 (en) 2003-02-18
ES2299240T3 (es) 2008-05-16

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