BR9915612A - Benzilglicosilamidas como inibidores de proliferação de células do músculo liso - Google Patents
Benzilglicosilamidas como inibidores de proliferação de células do músculo lisoInfo
- Publication number
- BR9915612A BR9915612A BR9915612-1A BR9915612A BR9915612A BR 9915612 A BR9915612 A BR 9915612A BR 9915612 A BR9915612 A BR 9915612A BR 9915612 A BR9915612 A BR 9915612A
- Authority
- BR
- Brazil
- Prior art keywords
- carbon atoms
- substituted
- smooth muscle
- inhibitors
- hydrogen
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 210000000329 smooth muscle myocyte Anatomy 0.000 title abstract 3
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- -1 cyclic acetal Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000006201 3-phenylpropyl group Chemical class [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000003071 maltose group Chemical group 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Patente de Invenção: <B>"BENZILGLICOSILAMIDAS COMO INIBIDORES DE PROLIFERAçãO DE CéLULAS DO MúSCULO LISO"<D>. A invenção proporciona inibidores de proliferação de células do músculo liso de fórmula (I) que apresentam uma estrutura onde Y é C ou N; onde n é 0 - 3; X é (A) onde R¹ e R² são cada um, independentemente, hidrogênio, alquila de 1 a 6 átomos de carbono, halo, acetila, fenila, CF~ 3~, CN, OH, NO~ 2~, NH~ 2~, alcóxi de 1 a 6 átomos de carbono, ou alcoxinitrila de 1 a 6 átomos de carbono; R^ 3^ é hidrogênio, acilamida de 2 a 6 átomos de carbono ou alcóxi de 1 a 6 átomos de carbono; R^ 4^, R^ 5^, R^ 6^, R^ 7^ e R^ 8^ são cada um, independentemente, hidrogênio, acila de 1 a 6 átomos de carbono, benzila substituída com R¹ e R², ou benzoíla substituída com R¹ e R²; R^ 9^ e R^ 10^ são cada um, independentemente, acila de 1 a 6 átomos de carbono, ou os grupos R^ 9^ e R^ 10^ nas posições 4' e 6' da maltose poderão ser tomados juntamente para formar um acetal cíclico que poderá ser substituído com alquila de 1 a 6 átomos de carbono, dois grupos alquila cada um apresentando 1 a 6 átomos de carbono, piridina substituída com R¹, fenila substituída com R¹, benzila substituída com R¹, 2-feniletila substiutuída com R¹, ou 3-fenilpropila substituída com R¹; ou um sal farmaceuticamente aceitável dos mesmos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19843298A | 1998-11-24 | 1998-11-24 | |
| PCT/US1999/027780 WO2000031093A2 (en) | 1998-11-24 | 1999-11-23 | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9915612A true BR9915612A (pt) | 2001-08-14 |
Family
ID=22733358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9915612-1A BR9915612A (pt) | 1998-11-24 | 1999-11-23 | Benzilglicosilamidas como inibidores de proliferação de células do músculo liso |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1133508A2 (pt) |
| JP (1) | JP2002530418A (pt) |
| CN (1) | CN1333781A (pt) |
| AU (1) | AU1743700A (pt) |
| BR (1) | BR9915612A (pt) |
| CA (1) | CA2350758A1 (pt) |
| WO (1) | WO2000031093A2 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1829300A (en) * | 1998-11-24 | 2000-06-13 | American Home Products Corporation | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3655327B2 (ja) * | 1994-05-09 | 2005-06-02 | 三井化学株式会社 | オリゴ糖鎖を有するスチレン誘導体およびその製造方法 |
| DE4436164A1 (de) * | 1994-10-10 | 1996-04-11 | Hoechst Ag | Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion |
| AU1829300A (en) * | 1998-11-24 | 2000-06-13 | American Home Products Corporation | Benzylglycosylamides as inhibitors of smooth muscle cell proliferation |
-
1999
- 1999-11-23 BR BR9915612-1A patent/BR9915612A/pt not_active Application Discontinuation
- 1999-11-23 WO PCT/US1999/027780 patent/WO2000031093A2/en not_active Ceased
- 1999-11-23 CN CN99815709A patent/CN1333781A/zh active Pending
- 1999-11-23 EP EP99960570A patent/EP1133508A2/en not_active Withdrawn
- 1999-11-23 CA CA002350758A patent/CA2350758A1/en not_active Abandoned
- 1999-11-23 AU AU17437/00A patent/AU1743700A/en not_active Abandoned
- 1999-11-23 JP JP2000583921A patent/JP2002530418A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000031093A2 (en) | 2000-06-02 |
| EP1133508A2 (en) | 2001-09-19 |
| CN1333781A (zh) | 2002-01-30 |
| JP2002530418A (ja) | 2002-09-17 |
| WO2000031093A3 (en) | 2000-12-28 |
| CA2350758A1 (en) | 2000-06-02 |
| AU1743700A (en) | 2000-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |