BR9917005A - Combinação de inibidores de fbpase e sensibilizadores de insulina para o tratamento de diabete - Google Patents

Combinação de inibidores de fbpase e sensibilizadores de insulina para o tratamento de diabete

Info

Publication number
BR9917005A
BR9917005A BR9917005-1A BR9917005A BR9917005A BR 9917005 A BR9917005 A BR 9917005A BR 9917005 A BR9917005 A BR 9917005A BR 9917005 A BR9917005 A BR 9917005A
Authority
BR
Brazil
Prior art keywords
insulin
diabetes
treatment
combination
insulin sensitizers
Prior art date
Application number
BR9917005-1A
Other languages
English (en)
Inventor
Mark D Erion
Paul Van Poelje
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of BR9917005A publication Critical patent/BR9917005A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Patente de Invenção: "COMBINAçãO DE INIBIDORES DE FBPase E SENSIBILIZADORES DE INSULINA PARA O TRATAMENTO DE DIABETE". São fornecidas composições farmacêuticas contendo um inibidor de FBPase e um sensibilizador de insulina, bem como métodos para tratamento de diabetes e doenças responsivas a controle glicêmico melhorado, uma melhora na sensibilidade de insulina, uma redução nos níveis de insulina, ou um melhora na secreção de insulina.
BR9917005-1A 1998-12-24 1999-12-22 Combinação de inibidores de fbpase e sensibilizadores de insulina para o tratamento de diabete BR9917005A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11471898P 1998-12-24 1998-12-24
PCT/US1999/030713 WO2000038666A2 (en) 1998-12-24 1999-12-22 A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES

Publications (1)

Publication Number Publication Date
BR9917005A true BR9917005A (pt) 2002-04-02

Family

ID=22357016

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9917005-1A BR9917005A (pt) 1998-12-24 1999-12-22 Combinação de inibidores de fbpase e sensibilizadores de insulina para o tratamento de diabete

Country Status (25)

Country Link
EP (1) EP1143955B1 (pt)
JP (1) JP2003515523A (pt)
KR (3) KR20060114724A (pt)
CN (3) CN1714866A (pt)
AT (1) ATE300288T1 (pt)
AU (1) AU771039B2 (pt)
BR (1) BR9917005A (pt)
CA (1) CA2354053A1 (pt)
CZ (1) CZ20012353A3 (pt)
DE (1) DE69926400T2 (pt)
DK (1) DK1143955T3 (pt)
ES (1) ES2246586T3 (pt)
HK (1) HK1046863B (pt)
HU (1) HUP0402506A3 (pt)
ID (1) ID30237A (pt)
IL (2) IL143569A0 (pt)
MX (1) MXPA01006511A (pt)
NO (1) NO20013115L (pt)
NZ (1) NZ512219A (pt)
PL (1) PL352756A1 (pt)
PT (1) PT1143955E (pt)
RU (2) RU2227749C2 (pt)
SK (1) SK9172001A3 (pt)
WO (1) WO2000038666A2 (pt)
ZA (1) ZA200105016B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039344A1 (en) 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
US6312662B1 (en) 1998-03-06 2001-11-06 Metabasis Therapeutics, Inc. Prodrugs phosphorus-containing compounds
WO2000014095A1 (en) 1998-09-09 2000-03-16 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
EP1240174A2 (en) * 1999-12-22 2002-09-18 Metabasis Therapeutics, Inc. Novel bisamidate phosphonate prodrugs
KR20020079988A (ko) * 2000-03-08 2002-10-21 메타베이시스 테라퓨틱스, 인크. 신규한 아릴 프럭토스-1,6-비스포스파타제 억제제
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
HUP0301830A3 (en) * 2000-07-06 2007-10-29 Metabasis Therapeutics Inc Pharmaceutical composition containing a combination of fbpase inhibitors and antidiabetic agents useful for the treatment of diabetes
US7022725B2 (en) 2000-11-17 2006-04-04 Takeda Pharmaceutical Company Limited Isoxazole derivatives
NZ536328A (en) 2002-05-13 2007-11-30 Metabasis Therapeutics Inc Novel phosphonic acid based prodrugs of PMEA and its analogues
AU2003235501A1 (en) 2002-05-13 2003-11-11 Metabasis Therapeutics, Inc. PMEA and PMPA cyclic producing synthesis
US7648957B2 (en) * 2002-09-04 2010-01-19 Dsm Ip Assets B.V. Nutritional and therapeutic composition of an insulin sensitizer and a peptide fraction
UA80991C2 (en) 2002-10-07 2007-11-26 Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
SI1611112T1 (sl) * 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
JP4638355B2 (ja) 2003-12-26 2011-02-23 協和発酵キリン株式会社 チアゾール誘導体
WO2006023515A2 (en) * 2004-08-18 2006-03-02 Metabasis Therapeutics, Inc. Novel thiazole inhibitors of fructose 1,6-bisphosphatase
CA2590883A1 (en) * 2004-12-13 2006-06-22 Daiichi Sankyo Company, Limited Medicinal composition for treating diabetes
BRPI0519015A2 (pt) * 2004-12-15 2008-12-23 Daiichi Sankyo Co Ltd composiÇço farmacÊutica, agente profilÁtico ou agente terapÊutico, agentes para melhorar a funÇço das cÉlulas b no pÂncreas, e para a reduÇço da razço da hemoglobina glicosilada, e, usos da 5-[4-(6-metàxi-1-metil-1h-benzimidazol-2-ilmetàxi)benzi l] tiazolidina-2,4-diona ou de um sal farmacologicamente aceitÁvel da mesma e de um inibidor de fbpase, e do 2-amino-5-isobutil-4-[2-[5-(n,n'-bis((s)-1etoxicarbonil)eti l) fosfonamido] furanil} tiazol ou de um sal farmacologicamente aceitÁvel do mesmo
EP1889618A4 (en) * 2005-05-27 2010-11-24 Daiichi Sankyo Co Ltd Combined drug for treating diabetes
US20100280023A1 (en) 2005-06-23 2010-11-04 Kyowa Hakko Kogyo Co., Ltd. Thiazole derivatives
EP2089023A2 (en) 2006-11-02 2009-08-19 Aestus Therapeutics, Inc. Methods of treating neuropathic pain with agonists of ppar-gamma
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
US9631825B2 (en) 2012-12-18 2017-04-25 Nortek Air Solutions, Llc Air filter assembly
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN105481896A (zh) * 2015-12-03 2016-04-13 浙江大学 一种地马格列的制备方法
CN113416739B (zh) * 2021-06-24 2022-04-19 黑龙江八一农垦大学 鲁氏酵母菌基因在提高微生物产hdmf的产量中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968790A (en) * 1988-08-12 1990-11-06 American Cyanamid Company Antidiabetic phosphates
JPH03157377A (ja) * 1988-11-18 1991-07-05 Takeda Chem Ind Ltd チオ尿素誘導体及びａｇｅ生成阻害剤
EP0427799B1 (en) * 1989-01-24 1994-11-30 Gensia, Inc. Method and compounds for aica riboside delivery and for lowering blood glucose
TW438587B (en) * 1995-06-20 2001-06-07 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5859037A (en) * 1997-02-19 1999-01-12 Warner-Lambert Company Sulfonylurea-glitazone combinations for diabetes
ZA981936B (en) * 1997-03-07 1999-09-06 Metabasis Therapeutics Inc Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
WO1998039344A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel purine inhibitors of fructose-1,6-bisphosphatase
WO1998039342A1 (en) * 1997-03-07 1998-09-11 Metabasis Therapeutics, Inc. Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase

Also Published As

Publication number Publication date
KR100689943B1 (ko) 2007-03-08
AU771039B2 (en) 2004-03-11
CN1350466A (zh) 2002-05-22
ID30237A (id) 2001-11-15
NO20013115L (no) 2001-08-24
HK1046863A1 (zh) 2003-01-30
CN100352505C (zh) 2007-12-05
WO2000038666A2 (en) 2000-07-06
ZA200105016B (en) 2002-09-19
DE69926400T2 (de) 2006-05-24
AU2058300A (en) 2000-07-31
CN101164618A (zh) 2008-04-23
JP2003515523A (ja) 2003-05-07
CN1714866A (zh) 2006-01-04
MXPA01006511A (es) 2004-03-19
KR20070046210A (ko) 2007-05-02
ATE300288T1 (de) 2005-08-15
PL352756A1 (en) 2003-09-08
EP1143955B1 (en) 2005-07-27
PT1143955E (pt) 2005-11-30
WO2000038666A3 (en) 2001-11-29
RU2227749C2 (ru) 2004-04-27
HK1046863B (zh) 2008-07-25
IL143569A (en) 2006-06-11
SK9172001A3 (en) 2002-04-04
CA2354053A1 (en) 2000-07-06
DE69926400D1 (de) 2005-09-01
NO20013115D0 (no) 2001-06-21
CZ20012353A3 (cs) 2001-12-12
DK1143955T3 (da) 2005-11-14
RU2003132054A (ru) 2005-04-20
KR20010099942A (ko) 2001-11-09
IL143569A0 (en) 2002-04-21
ES2246586T3 (es) 2006-02-16
EP1143955A3 (en) 2002-08-28
KR20060114724A (ko) 2006-11-07
NZ512219A (en) 2004-12-24
HUP0402506A2 (hu) 2005-04-28
HUP0402506A3 (en) 2007-05-29
EP1143955A2 (en) 2001-10-17

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: A61K 31/185, A61K 31/192, A61K 31/203, A61K 31/421, A61K 31/426, A61K 31/427, A61K 31/4439, A61K 31/665, A61K 31/662, A61K 31/664, A61K 31/665, A61K 31/675, A61K 31/7056, A61K 31/7042, A61K 33/00, A61K 45/06, A61P 3/00, A61P 3/04, A61P 3/08, A61P 3/10, A61P 9/12, A61P 15/00

Ipc: A61K 31/00 (2009.01)

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE ACORDO COM OS ARTIGOS 8O, 10 (VIII), 13 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.