DK1309593T3 - Substituerede pyrazoler - Google Patents

Substituerede pyrazoler

Info

Publication number: DK1309593T3
Authority: DK; Denmark
Prior art keywords: substituted pyrazoles; methods; pyrazoles; substituted; cathepsin
Prior art date: 2000-08-14

Application number

DK01965898T

Other languages

English (en)

Inventor

Christopher R Butler

Darin J Gustin

Hui Cai

James P Edwards

Cheryl A Grice

Haripada Khatuya

Steven P Meduna

Barbara A Pio

Kevin L Tays

Jianmei Wei

Clark A Sehon

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-14

Filing date

2001-08-10

Publication date

2006-07-17

2001-08-10 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2006-07-17 Application granted granted Critical

2006-07-17 Publication of DK1309593T3 publication Critical patent/DK1309593T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

DK01965898T 2000-08-14 2001-08-10 Substituerede pyrazoler DK1309593T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22517800P	2000-08-14	2000-08-14
US09/927,324 US6953793B2 (en)	2000-08-14	2001-08-10	Substituted pyrazoles

Publications (1)

Publication Number	Publication Date
DK1309593T3 true DK1309593T3 (da)	2006-07-17

Family

ID=26919364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01965898T DK1309593T3 (da)	2000-08-14	2001-08-10	Substituerede pyrazoler

Country Status (19)

Country	Link
US (2)	US6953793B2 (da)
EP (1)	EP1309593B1 (da)
JP (1)	JP5049447B2 (da)
KR (1)	KR100837193B1 (da)
AT (1)	ATE320427T1 (da)
AU (2)	AU8645401A (da)
BR (1)	BRPI0113286B8 (da)
CA (1)	CA2419552C (da)
CZ (1)	CZ307185B6 (da)
DE (1)	DE60118004T2 (da)
DK (1)	DK1309593T3 (da)
ES (1)	ES2261463T3 (da)
HU (1)	HU230538B1 (da)
MX (1)	MXPA03001422A (da)
NZ (1)	NZ524191A (da)
PL (1)	PL213103B1 (da)
PT (1)	PT1309593E (da)
RU (1)	RU2317988C2 (da)
WO (1)	WO2002014315A2 (da)

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US11628162B2 (en)	2019-03-08	2023-04-18	Incyte Corporation	Methods of treating cancer with an FGFR inhibitor
CN113597532B (zh)	2019-03-14	2023-02-17	泰尔茂比司特生物技术有限公司	冻干容器填充固定装置、系统及使用方法
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en)	2019-10-01	2021-04-08	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
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JP7832891B2 (ja)	2019-12-04	2026-03-18	インサイト・コーポレイション	Ｆｇｆｒ阻害剤の誘導体
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2001
- 2001-08-10 EP EP01965898A patent/EP1309593B1/en not_active Expired - Lifetime
- 2001-08-10 CZ CZ2003-429A patent/CZ307185B6/cs not_active IP Right Cessation
- 2001-08-10 AT AT01965898T patent/ATE320427T1/de active
- 2001-08-10 HU HU0303108A patent/HU230538B1/hu not_active IP Right Cessation
- 2001-08-10 MX MXPA03001422A patent/MXPA03001422A/es active IP Right Grant
- 2001-08-10 WO PCT/US2001/025290 patent/WO2002014315A2/en not_active Ceased
- 2001-08-10 NZ NZ524191A patent/NZ524191A/en not_active IP Right Cessation
- 2001-08-10 ES ES01965898T patent/ES2261463T3/es not_active Expired - Lifetime
- 2001-08-10 US US09/927,324 patent/US6953793B2/en not_active Expired - Lifetime
- 2001-08-10 CA CA2419552A patent/CA2419552C/en not_active Expired - Lifetime
- 2001-08-10 KR KR1020037002163A patent/KR100837193B1/ko not_active Expired - Lifetime
- 2001-08-10 AU AU8645401A patent/AU8645401A/xx active Pending
- 2001-08-10 DE DE60118004T patent/DE60118004T2/de not_active Expired - Lifetime
- 2001-08-10 PL PL360696A patent/PL213103B1/pl unknown
- 2001-08-10 JP JP2002519455A patent/JP5049447B2/ja not_active Expired - Lifetime
- 2001-08-10 PT PT01965898T patent/PT1309593E/pt unknown
- 2001-08-10 DK DK01965898T patent/DK1309593T3/da active
- 2001-08-10 AU AU2001286454A patent/AU2001286454B2/en not_active Expired
- 2001-08-10 BR BRPI0113286A patent/BRPI0113286B8/pt not_active IP Right Cessation
- 2001-08-10 RU RU2003107016/04A patent/RU2317988C2/ru not_active Application Discontinuation
2005
- 2005-06-30 US US11/174,077 patent/US20050245576A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2001286454B2 (en)	2006-09-14
PL213103B1 (pl)	2013-01-31
JP2004511440A (ja)	2004-04-15
HU230538B1 (hu)	2016-11-28
RU2317988C2 (ru)	2008-02-27
NZ524191A (en)	2004-11-26
BR0113286B1 (pt)	2013-04-16
EP1309593A2 (en)	2003-05-14
DE60118004T2 (de)	2006-11-16
RU2003107016A (ru)	2004-11-27
KR20030060876A (ko)	2003-07-16
DE60118004D1 (de)	2006-05-11
HK1055422A1 (en)	2004-01-09
PL360696A1 (en)	2004-09-20
CZ307185B6 (cs)	2018-03-07
CA2419552A1 (en)	2002-02-21
CA2419552C (en)	2010-10-12
EP1309593B1 (en)	2006-03-15
US20030078419A1 (en)	2003-04-24
WO2002014315A2 (en)	2002-02-21
HUP0303108A2 (hu)	2004-01-28
ATE320427T1 (de)	2006-04-15
MXPA03001422A (es)	2004-01-26
KR100837193B1 (ko)	2008-06-13
JP5049447B2 (ja)	2012-10-17
CZ2003429A3 (cs)	2003-12-17
ES2261463T3 (es)	2006-11-16
BR0113286A (pt)	2003-09-09
PT1309593E (pt)	2006-08-31
US20050245576A1 (en)	2005-11-03
AU8645401A (en)	2002-02-25
HUP0303108A3 (en)	2012-10-29
BRPI0113286B8 (pt)	2021-05-25
WO2002014315A3 (en)	2002-06-13
US6953793B2 (en)	2005-10-11

Publication	Publication Date	Title
DK1309593T3 (da)	2006-07-17	Substituerede pyrazoler
DK1309592T3 (da)	2006-08-21	Substituerede pyrazoler
WO2002014314A3 (en)	2002-06-06	Substituted pyrazoles
NO20030845D0 (no)	2003-02-24	Utvalgte fusjonerte pyrrolokarbazoler
BG66084B1 (bg)	2011-03-31	Циклопентаноиндоли, състави,съдържащи такива съединения и използването им
BG66080B1 (bg)	2011-03-31	Заместени тиоацетамиди
NO991732L (no)	1999-06-04	Nye heterocyklylmetylsubstituerte pyrazolderivater
SG149045A1 (en)	2009-01-29	Novel fused pyrrolocarbazoles
MY149041A (en)	2013-07-15	Novel fused pyrrolocarbazoles
TR200402030T4 (tr)	2004-09-21	İkame edilen I-aminobutan-3-ol-türevleri
DK1438034T3 (da)	2008-12-01	Anvendelse af -phenyl-3-dimethylaminiopropanforbindelser til behandling af urininkontinens
ATE247130T1 (de)	2003-08-15	Inhibitoren für den urokinaserezeptor
UA87829C2 (en)	2009-08-25	Fused pyrrolocarbazoles
CY1111290T1 (el)	2015-08-05	Παραγωγα 9-αλκυλαμινo-1-νιτρoακριδινης
ATE423780T1 (de)	2009-03-15	Makrozyclen zur behandlung von krebserkrankungen
SE0001631D0 (sv)	2000-05-04	New use
BR0111221A (pt)	2003-03-18	Condensados glioxal-fenólicos com fluorescência intensificada