BRPI0113837B8 - compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreende - Google Patents

compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreende

Info

Publication number
BRPI0113837B8
BRPI0113837B8 BRPI0113837A BRPI0113837B8 BR PI0113837 B8 BRPI0113837 B8 BR PI0113837B8 BR PI0113837 A BRPI0113837 A BR PI0113837A BR PI0113837 B8 BRPI0113837 B8 BR PI0113837B8
Authority
BR
Brazil
Prior art keywords
mutilin
compounds
pharmaceutical composition
hydrogen
antimicrobial activity
Prior art date
Application number
Other languages
English (en)
Inventor
Ascher Gerd
Berner Heinz
Hildebrandt Johannes
Original Assignee
Biochemie Gmbh
Nabriva Therapeutics Ag
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0022439A external-priority patent/GB0022439D0/en
Priority claimed from GB0022440A external-priority patent/GB0022440D0/en
Priority claimed from GB0024674A external-priority patent/GB0024674D0/en
Application filed by Biochemie Gmbh, Nabriva Therapeutics Ag, Sandoz Ag filed Critical Biochemie Gmbh
Publication of BR0113837A publication Critical patent/BR0113837A/pt
Publication of BRPI0113837B1 publication Critical patent/BRPI0113837B1/pt
Publication of BRPI0113837B8 publication Critical patent/BRPI0113837B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

mutilinas antibacterianas. um composto de fórmula (i) em que r e r2 junto com o átomo de nitrogênio ao qual estão ligados formam pirrolidinila ou piperidinila, r1, é um grupo de fórmula (ii) r3 e r'3 são hidrogênio, deutério ou halogênio, r4, r5 e r10 são de modo independente um do outro hidrogênio ou alquila, r6, r7 e r8 são hidrogênio ou deutério; r9 é amino, alquila, arila, heterociclila ou mercapto; e, se x for oxigênio, r9 é adicionalmente hidrogênio; r'10 é alquila, x é enxofre, oxigênio, nr10, ou n+(r'10)2; y é enxofre ou oxigênio, e m é 0, 1 ou 2; com a condição de que, quando r e r2 junto com o átomo de nitrogênio ao qual estão ligados formam piperidinila, m é o, y é s e y está ligado na posição 3 do anel piperidina referido, o grupo de fórmula i o qual está ligado ao anel piperidina através do resíduo y está ou na configuração (s) ou na configuração (r), preferencialmente na configuração (s) o qual é, por exemplo, útil como antimicrobiano, antibacteriano.
BRPI0113837 2000-09-13 2001-09-11 compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreende BRPI0113837B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0022439A GB0022439D0 (en) 2000-09-13 2000-09-13 Organic compounds
GB0022440A GB0022440D0 (en) 2000-09-13 2000-09-13 Organic Compounds
GB0024674A GB0024674D0 (en) 2000-10-09 2000-10-09 Organic compounds
PCT/EP2001/010502 WO2002022580A1 (en) 2000-09-13 2001-09-11 Antibacterials mutilins

Publications (3)

Publication Number Publication Date
BR0113837A BR0113837A (pt) 2003-06-03
BRPI0113837B1 BRPI0113837B1 (pt) 2019-01-29
BRPI0113837B8 true BRPI0113837B8 (pt) 2021-05-25

Family

ID=27255885

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0113837 BRPI0113837B8 (pt) 2000-09-13 2001-09-11 compostos mutilinas com atividade antimicrobiana e composição farmacêutica que os compreende

Country Status (16)

Country Link
US (3) US7169804B2 (pt)
EP (1) EP1320525B1 (pt)
JP (1) JP5134181B2 (pt)
CN (1) CN1288134C (pt)
AR (1) AR030651A1 (pt)
AT (1) ATE264843T1 (pt)
AU (1) AU2001291854A1 (pt)
BR (1) BRPI0113837B8 (pt)
CA (1) CA2418538C (pt)
DE (1) DE60102936T2 (pt)
ES (1) ES2220809T3 (pt)
MY (1) MY133930A (pt)
PE (1) PE20020676A1 (pt)
PT (1) PT1320525E (pt)
TW (1) TWI306852B (pt)
WO (1) WO2002022580A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0209262D0 (en) * 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
DE60317208T2 (de) * 2002-07-24 2008-08-07 Nabriva Therapeutics Forschungs Gmbh Pleuromutilinderivate als antimikrobielle mittel
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
US7544963B2 (en) * 2005-04-29 2009-06-09 Cree, Inc. Binary group III-nitride based high electron mobility transistors
GB0513058D0 (en) * 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
WO2007037518A1 (ja) * 2005-09-29 2007-04-05 Dainippon Sumitomo Pharma Co., Ltd. ムチリン誘導体及びそれを含有する医薬組成物
EP1808431A1 (en) * 2006-01-16 2007-07-18 Nabriva Therapeutics Forschungs GmbH Mutilin derivatives and their use as pharmaceutical
WO2007143507A2 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted erythromycin analogs
EP1908750A1 (en) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
JP5322927B2 (ja) 2007-05-24 2013-10-23 杏林製薬株式会社 １４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
US20100184987A1 (en) * 2008-11-13 2010-07-22 Teva Pharmaceutical Industries Ltd. Preparation of Retapamulin via its Pleuromutilin-thiol precursor
CN103709115A (zh) * 2012-10-09 2014-04-09 山东亨利医药科技有限责任公司 截短侧耳素类抗生素衍生物
TWI762573B (zh) 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789629A (fr) * 1971-10-05 1973-04-03 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leurapplication en therapeutique
DE2811314A1 (de) * 1978-03-16 1979-09-27 Sandoz Ag Kokzidiostatisches kombinationspraeparat
EP0013768B1 (en) 1979-01-12 1984-02-01 Sandoz Ag New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
JPS5594359A (en) * 1979-01-12 1980-07-17 Sandoz Ag Novel pleuromutilin derivatives*their manufacture and use
EP0153277B1 (de) * 1984-02-17 1987-08-26 Sandoz Ag Neue Pleuromutilinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
JP3054875B2 (ja) * 1995-02-13 2000-06-19 株式会社小松製作所 プラズマトーチ
US6020368A (en) * 1996-01-03 2000-02-01 Hinks; Jeremy David Carbamoyloxy derivatives of mutiline and their use as antibacterials
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
WO2000027790A1 (en) 1998-11-11 2000-05-18 Smithkline Beecham P.L.C. Mutilin compounds
WO2000037074A1 (en) 1998-12-18 2000-06-29 Smithkline Beecham Plc Mutilin 14-ester derivatives having antibacterial activity
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0207495D0 (en) * 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
DE60317208T2 (de) * 2002-07-24 2008-08-07 Nabriva Therapeutics Forschungs Gmbh Pleuromutilinderivate als antimikrobielle mittel

Also Published As

Publication number Publication date
TWI306852B (en) 2009-03-01
CA2418538C (en) 2009-12-22
DE60102936T2 (de) 2005-03-24
US20090209584A1 (en) 2009-08-20
AU2001291854A1 (en) 2002-03-26
EP1320525B1 (en) 2004-04-21
CN1288134C (zh) 2006-12-06
CA2418538A1 (en) 2002-03-21
ATE264843T1 (de) 2004-05-15
JP5134181B2 (ja) 2013-01-30
DE60102936D1 (de) 2004-05-27
US20070135483A1 (en) 2007-06-14
AR030651A1 (es) 2003-08-27
US7569587B2 (en) 2009-08-04
ES2220809T3 (es) 2004-12-16
MY133930A (en) 2007-11-30
US7169804B2 (en) 2007-01-30
HK1079506A1 (en) 2006-04-07
WO2002022580A1 (en) 2002-03-21
US20040102482A1 (en) 2004-05-27
EP1320525A1 (en) 2003-06-25
CN1633415A (zh) 2005-06-29
BR0113837A (pt) 2003-06-03
JP2004509107A (ja) 2004-03-25
BRPI0113837B1 (pt) 2019-01-29
PT1320525E (pt) 2004-09-30
PE20020676A1 (es) 2002-08-27

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: BIOCHEMIE GMBH (AT)

Free format text: NOME ALTERADO DE: BIOCHEMIE GESSELLSCHAFT M.B.H.

B25D Requested change of name of applicant approved

Owner name: SANDOZ GMBH (AT)

Free format text: NOME ALTERADO DE: BIOCHEMIE GMBH

B25A Requested transfer of rights approved

Owner name: NABRIVA THERAPEUTICS AG (AT)

Free format text: TRANSFERIDO DE: SANDOZ GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/01/2019, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 11/09/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2687 DE 05-07-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.