ES2120499T3 - Derivado de eritromicina. - Google Patents

Derivado de eritromicina.

Info

Publication number
ES2120499T3
ES2120499T3 ES93910399T ES93910399T ES2120499T3 ES 2120499 T3 ES2120499 T3 ES 2120499T3 ES 93910399 T ES93910399 T ES 93910399T ES 93910399 T ES93910399 T ES 93910399T ES 2120499 T3 ES2120499 T3 ES 2120499T3
Authority
ES
Spain
Prior art keywords
represents hydrogen
lower alkyl
pair
same
erythromycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93910399T
Other languages
English (en)
Inventor
Hiroshi Koga
Tsutomu Sato
Hisanori Takanashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2120499T3 publication Critical patent/ES2120499T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN COMPUESTO REPRESENTADO POR LA FORMULA GENERAL [1] O UNA SAL DEL MISMO, ESTANDO EXTREMADAMENTE REDUCIDA EN LA DESCOMPOSABILIDAD POR EL ACIDO GASTRICO SI SE COMPARA CON OTROS DERIVADOS DE ERITROMICIN CONOCIDOS Y QUE TIENE UNA ACTIVIDAD EXCELENTE PARA PROMOVER EL MOVIMIENTO DE TRACTOS DIGESTIVOS, EN DONDE R1 REPRESENTA HIDROGENO, HIDROXI, ACILOXI O AMINO O ALTERNATIVAMENTE R2 Y R3 SE COMBINAN JUNTOS PARA REPRESENTAN =0 O =NOR10, EN DONDE R10 REPRESENTA HIDROGENO O UN ALQUILO INFERIOR; R4 REPRESENTA HIDROGENO O UN ALQUILO INFERIOR; E Y REPRESENTA -NR5R6 O -N+R7R8R9X-, EN DONDE R5, R6, R7, R8 Y R9 PUEDEN SER EL MISMO O DIFERENTE UNO DE OTRO Y CADA UNO REPRESENTA HIDROGENO, ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO, ALQUENILO INFERIOR, ALQUINILO INFERIOR O CICLOALQUILO, O UN GRUPO HETEROCICLICO DE 3 A 7 MIEMBROS QUE CONTIENE OXIGENO, NITROGENO O AZUFRE COMO HETEROATOMO, Y X REPRESENTA UN ANION, SIEMPRE QUE UN PAR DE R5 Y R6 Y UN PAR DE R7 Y R8 PUEDAN SER COMBINADOS CON EL ATOMO DE NITROGENO ADYACENTE PARA REPRESENTAR AZACICLOALQUILO.
ES93910399T 1992-05-26 1993-05-26 Derivado de eritromicina. Expired - Lifetime ES2120499T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13382892 1992-05-26

Publications (1)

Publication Number Publication Date
ES2120499T3 true ES2120499T3 (es) 1998-11-01

Family

ID=15113997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93910399T Expired - Lifetime ES2120499T3 (es) 1992-05-26 1993-05-26 Derivado de eritromicina.

Country Status (20)

Country Link
US (1) US5658888A (es)
EP (1) EP0643068B1 (es)
JP (1) JP3068367B2 (es)
KR (1) KR100226311B1 (es)
CN (1) CN1036199C (es)
AT (1) ATE169927T1 (es)
AU (1) AU659740B2 (es)
CA (1) CA2117883C (es)
DE (1) DE69320476T2 (es)
DK (1) DK0643068T3 (es)
ES (1) ES2120499T3 (es)
HR (1) HRP930926B1 (es)
IL (1) IL105810A (es)
MY (1) MY113693A (es)
SG (1) SG52785A1 (es)
SI (1) SI9300281B (es)
TW (1) TW240230B (es)
WO (1) WO1993024509A1 (es)
YU (1) YU48771B (es)
ZA (1) ZA933679B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007204490A (ja) * 1995-08-03 2007-08-16 Chugai Pharmaceut Co Ltd エリスロマイシン誘導体の製造方法
ZA966601B (en) * 1995-08-03 1997-02-19 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivatives.
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
WO1998003531A1 (fr) * 1996-07-24 1998-01-29 Chugai Seiyaku Kabushiki Kaisha Derives d'erythromycine
AU4968997A (en) * 1996-11-26 1998-06-22 Chugai Seiyaku Kabushiki Kaisha 13-membered ring macrolide compounds, medicine containing the same, and process for producing the same
US5780605A (en) * 1997-09-08 1998-07-14 Abbott Laboratories 6,9-bridged erythromycin derivatives
US6562795B2 (en) 2000-02-18 2003-05-13 Kosan Biosciences, Inc. Motilide compounds
AU8257701A (en) 2000-09-01 2002-03-13 Chugai Pharmaceutical Co Ltd Process for producing erythromycin derivative
WO2002030943A1 (fr) * 2000-10-12 2002-04-18 Chugai Seiyaku Kabushiki Kaisha Derive d'erythromycine possedant des nouvelles structures cristallines et procedes associes de production
ES2249588T3 (es) * 2001-06-13 2006-04-01 Ube Industries, Ltd. Procedimiento para preparar un compuesto de eritromicina.
TW200302830A (en) * 2002-01-11 2003-08-16 Chugai Pharmaceutical Co Ltd Anhydrate/hydrate of an erythromycin derivative and processes for preparing said anhydrate/hydrate
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20040010035A1 (en) * 2002-07-15 2004-01-15 Ciociola Arthur A. Gastrointestinal compositions
CA2491797A1 (en) * 2002-07-10 2004-01-22 Warner-Lambert Company Llc Gastrointestinal compositions
US6986901B2 (en) * 2002-07-15 2006-01-17 Warner-Lambert Company Llc Gastrointestinal compositions
WO2004019879A2 (en) * 2002-08-29 2004-03-11 Kosan Biosciences, Inc. Motilide compounds
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
BRPI0408117A (pt) * 2003-03-05 2006-03-01 Rib X Pharmaceuticals Inc compostos heterocìclicos bifuncionais e métodos de produção e uso dos mesmos
CA2528375C (en) 2003-06-18 2013-11-19 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
EP2716647A3 (en) * 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
TW200633714A (en) * 2004-12-28 2006-10-01 Chugai Pharmaceutical Co Ltd Drugs for the treatment and/or prophylaxis of gastroparesis symptom
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
US8470985B2 (en) 2005-08-24 2013-06-25 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
JP2009506066A (ja) 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
NZ568763A (en) * 2005-12-08 2010-04-30 Pfizer Method for demethylating the 3'-dimethylamino group of erythromycin compounds
EP2431380A3 (en) 2006-09-11 2013-07-03 Tranzyme Pharma, Inc. Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders
ES2401467T3 (es) 2006-12-05 2013-04-19 Bristol-Myers Squibb Company Polimorfos de motilida
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60218321A (ja) * 1984-04-13 1985-11-01 Satoshi Omura 消化管収縮運動促進剤
JPS6187625A (ja) * 1984-10-05 1986-05-06 Satoshi Omura 消化管収縮運動促進剤
JPH0759513B2 (ja) * 1985-08-31 1995-06-28 北里研究所（社団法人） 消化管収縮運動促進剤
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
EP0215355B1 (en) * 1985-08-31 1994-04-06 Kitasato Kenkyusho Erythromycin derivative and process for preparing the same
DE69317877T2 (de) * 1992-01-21 1998-10-29 Abbott Lab 4''-deoxyerythromycinderivate

Also Published As

Publication number Publication date
TW240230B (es) 1995-02-11
CN1081184A (zh) 1994-01-26
CA2117883C (en) 2003-10-21
SI9300281A (sl) 1993-12-31
EP0643068B1 (en) 1998-08-19
US5658888A (en) 1997-08-19
AU659740B2 (en) 1995-05-25
HK1009969A1 (en) 1999-09-10
HRP930926A2 (en) 1995-02-28
CN1036199C (zh) 1997-10-22
CA2117883A1 (en) 1993-12-09
SG52785A1 (en) 1998-09-28
IL105810A0 (en) 1993-09-22
SI9300281B (en) 2001-02-28
EP0643068A1 (en) 1995-03-15
DK0643068T3 (da) 1999-02-08
ATE169927T1 (de) 1998-09-15
KR100226311B1 (ko) 1999-10-15
YU48771B (sh) 1999-12-27
DE69320476D1 (en) 1998-09-24
DE69320476T2 (de) 1999-03-25
YU36693A (sh) 1996-07-24
JP3068367B2 (ja) 2000-07-24
WO1993024509A1 (fr) 1993-12-09
HRP930926B1 (en) 2000-10-31
ZA933679B (en) 1993-12-21
JPH0656873A (ja) 1994-03-01
AU4089793A (en) 1993-12-30
MY113693A (en) 2002-05-31
IL105810A (en) 1998-12-27
KR950701640A (ko) 1995-04-28
EP0643068A4 (en) 1995-08-02

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