BRPI0115483B8 - preparação de pantoprazol seco por congelação e injeção de pantoprazol - Google Patents

preparação de pantoprazol seco por congelação e injeção de pantoprazol

Info

Publication number
BRPI0115483B8
BRPI0115483B8 BRPI0115483A BR0115483A BRPI0115483B8 BR PI0115483 B8 BRPI0115483 B8 BR PI0115483B8 BR PI0115483 A BRPI0115483 A BR PI0115483A BR 0115483 A BR0115483 A BR 0115483A BR PI0115483 B8 BRPI0115483 B8 BR PI0115483B8
Authority
BR
Brazil
Prior art keywords
pantoprazole
injection
freeze
dried
preparation
Prior art date
Application number
BRPI0115483A
Other languages
English (en)
Other versions
BR0115483A (pt
BRPI0115483B1 (pt
Inventor
Dietrich Rango
Linder Rudolf
Original Assignee
Altana Pharma Ag
Nycomed Asset Man Gmbh
Nycomed Germany Holding Gmbh
Nycomed Gmbh
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8170452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0115483(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Altana Pharma Ag, Nycomed Asset Man Gmbh, Nycomed Germany Holding Gmbh, Nycomed Gmbh, Takeda Gmbh filed Critical Altana Pharma Ag
Publication of BR0115483A publication Critical patent/BR0115483A/pt
Publication of BRPI0115483B1 publication Critical patent/BRPI0115483B1/pt
Publication of BRPI0115483B8 publication Critical patent/BRPI0115483B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"preparação de pantoprazol seco por congelação e injeção de pantoprazol". a presente invenção refere-se a preparações de pantoprazol liofilizado que são obteníveis através de secagem por congelação de uma solução aquosa de pantoprazol, ácido etilenodiamina tetracético e/ou um sal adequado do mesmo, e hidróxido de sódio e/ou carbonato de sódio. as preparações apresentam propriedades vantajosas quando reconstituídas para injeção.
BRPI0115483A 2000-11-22 2001-11-17 preparação de pantoprazol seco por congelação e injeção de pantoprazol BRPI0115483B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00125569 2000-11-22
PCT/EP2001/013296 WO2002041919A1 (en) 2000-11-22 2001-11-17 Freeze-dried pantoprazole preparation and pantoprazole injection

Publications (3)

Publication Number Publication Date
BR0115483A BR0115483A (pt) 2003-10-21
BRPI0115483B1 BRPI0115483B1 (pt) 2017-05-09
BRPI0115483B8 true BRPI0115483B8 (pt) 2021-05-25

Family

ID=8170452

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0115483A BRPI0115483B8 (pt) 2000-11-22 2001-11-17 preparação de pantoprazol seco por congelação e injeção de pantoprazol

Country Status (39)

Country Link
US (3) US6780881B2 (pt)
EP (2) EP1762249A3 (pt)
JP (1) JP4886158B2 (pt)
KR (2) KR100910606B1 (pt)
CN (1) CN1250292C (pt)
AR (2) AR034277A1 (pt)
AT (1) ATE381946T1 (pt)
AU (2) AU1604202A (pt)
BG (1) BG66329B1 (pt)
BR (1) BRPI0115483B8 (pt)
CA (2) CA2428870C (pt)
CY (1) CY1107896T1 (pt)
CZ (1) CZ304348B6 (pt)
DE (1) DE60132108T2 (pt)
DK (1) DK1339430T3 (pt)
EA (1) EA007602B1 (pt)
EC (1) ECSP034613A (pt)
EE (1) EE05236B1 (pt)
ES (1) ES2298295T3 (pt)
GE (1) GEP20053461B (pt)
HR (1) HRP20030410B1 (pt)
HU (1) HUP0303278A3 (pt)
IL (2) IL155601A0 (pt)
IS (1) IS2971B (pt)
ME (1) ME00556A (pt)
MX (1) MXPA03004548A (pt)
MY (1) MY137726A (pt)
NO (1) NO332937B1 (pt)
NZ (1) NZ525911A (pt)
PE (1) PE20020582A1 (pt)
PL (1) PL201188B1 (pt)
PT (1) PT1339430E (pt)
RS (1) RS52024B (pt)
SI (1) SI1339430T1 (pt)
SK (1) SK287993B6 (pt)
TW (1) TWI284041B (pt)
UA (1) UA80961C2 (pt)
WO (1) WO2002041919A1 (pt)
ZA (1) ZA200303593B (pt)

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CL2004000983A1 (es) * 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
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AR045258A1 (es) * 2003-08-21 2005-10-19 Altana Pharma Ag Un producto farmaceutico para inyeccion
WO2005070426A1 (en) * 2004-01-27 2005-08-04 Altana Pharma Ag Freeze-dried (-)-pantoprazole preparation and (-)-pantoprazole injection
DE102004007854A1 (de) * 2004-02-17 2005-09-01 Hexal Ag Stabile, wässrige Formulierung für Benzimidazole
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CN1293879C (zh) * 2005-01-20 2007-01-10 杭州华东医药集团生物工程研究所有限公司 泮托拉唑钠冻干粉针剂及其制备方法
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EP2106788A1 (en) * 2008-04-04 2009-10-07 Ipsen Pharma Liquid and freeze dried formulations
CN101744777B (zh) * 2009-12-30 2012-09-26 北京四环科宝制药有限公司 奥美拉唑钠冻干粉针剂及制备方法和检测方法
CN101961309B (zh) * 2010-09-15 2012-06-27 河南辅仁怀庆堂制药有限公司 注射用泮托拉唑钠配制工艺
CN102000034B (zh) * 2010-10-13 2011-12-21 江苏奥赛康药业股份有限公司 一种供注射用的s-泮托拉唑钠组合物及其制备方法
CN102225063B (zh) * 2011-05-10 2012-10-10 江苏奥赛康药业股份有限公司 一种供注射用的泮托拉唑钠组合物
TR201108946A2 (tr) * 2011-09-12 2012-04-24 World Medicine İlaç Sanayi̇ Ve Ti̇caret Li̇mi̇ted Şi̇rketi̇ Dondurularak kurutulmuş atp, vitamin b kompleksi preparatı ve enjeksiyonu.
SG11201408511QA (en) * 2012-06-27 2015-01-29 Takeda Pharmaceutical Liquid preparations of amines and organic acids stabilized by salts
CN104000786A (zh) * 2013-02-25 2014-08-27 杭州赛利药物研究所有限公司 泮托拉唑钠冻干制剂及其制备方法
CN104414979A (zh) * 2013-08-21 2015-03-18 哈药集团三精制药股份有限公司 一种泮托拉唑钠冻干粉针剂及其制备方法
CN104019635B (zh) * 2014-06-19 2015-05-27 上海慈瑞医药科技有限公司 一种兰索拉唑原料药化合物及其干燥工艺
CN104055791A (zh) * 2014-07-10 2014-09-24 北京人福军威医药技术开发有限公司 西地碘治疗眼角结膜炎的用途
CN104055792A (zh) * 2014-07-10 2014-09-24 北京人福军威医药技术开发有限公司 西地碘治疗中耳炎的用途
BE1021311B1 (nl) * 2014-07-31 2015-10-28 Neogen N.V. Werkwijze voor het maken van een poedervormige protonpompremmer samenstelling, genoemde samenstelling en gebruik
US20170042806A1 (en) 2015-04-29 2017-02-16 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN111643460A (zh) * 2020-06-30 2020-09-11 武汉九州钰民医药科技有限公司 泮托拉唑钠冻干制剂及其制备方法、由其制得的注射制剂
US12102624B2 (en) 2020-08-26 2024-10-01 Nivagen Pharmaceuticals, Inc. Pantoprazole compositions and methods
CN112274481A (zh) * 2020-10-27 2021-01-29 海南卫康制药(潜山)有限公司 一种注射用泮托拉唑钠组合物及其制备方法
KR20250036905A (ko) * 2022-08-04 2025-03-14 쟝쑤 케어파르 파마슈티컬 컴퍼니 리미티드 피롤류 위산분비 억제제를 함유하는 약물 조성물 및 그 제조 방법
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Also Published As

Publication number Publication date
AU2002216042B2 (en) 2006-08-03
EA200300501A1 (ru) 2003-12-25
IL155601A0 (en) 2003-11-23
AR034277A1 (es) 2004-02-18
JP4886158B2 (ja) 2012-02-29
EP1339430B1 (en) 2007-12-26
BR0115483A (pt) 2003-10-21
HRP20030410A2 (en) 2005-04-30
PL201188B1 (pl) 2009-03-31
PE20020582A1 (es) 2002-07-06
CZ304348B6 (cs) 2014-03-19
KR20030055308A (ko) 2003-07-02
SK6062003A3 (en) 2003-10-07
ME00556B (me) 2011-12-20
NO332937B1 (no) 2013-02-04
NO20032303L (no) 2003-05-21
CZ20031416A3 (cs) 2003-09-17
HUP0303278A2 (hu) 2004-01-28
CA2428870A1 (en) 2002-05-30
SI1339430T1 (sl) 2008-06-30
CA2541946A1 (en) 2002-05-30
NZ525911A (en) 2004-11-26
BG66329B1 (bg) 2013-06-28
PT1339430E (pt) 2008-03-27
PL361118A1 (en) 2004-09-20
WO2002041919A1 (en) 2002-05-30
CN1250292C (zh) 2006-04-12
ZA200303593B (en) 2004-04-23
HUP0303278A3 (en) 2007-08-28
EE200300182A (et) 2003-06-16
CY1107896T1 (el) 2013-09-04
SK287993B6 (sk) 2012-09-03
US20030003058A1 (en) 2003-01-02
ATE381946T1 (de) 2008-01-15
MY137726A (en) 2009-03-31
ECSP034613A (es) 2003-08-29
US7351723B2 (en) 2008-04-01
EP1339430A1 (en) 2003-09-03
GEP20053461B (en) 2005-02-25
KR100910606B1 (ko) 2009-08-04
AR092374A2 (es) 2015-04-15
BRPI0115483B1 (pt) 2017-05-09
HK1060848A1 (en) 2004-08-27
DK1339430T3 (da) 2008-05-13
US20090093522A1 (en) 2009-04-09
HRP20030410B1 (en) 2011-02-28
TWI284041B (en) 2007-07-21
IS6820A (is) 2003-05-19
EP1762249A3 (en) 2014-05-14
IS2971B (is) 2017-05-15
IL155601A (en) 2008-12-29
ES2298295T3 (es) 2008-05-16
US6780881B2 (en) 2004-08-24
YU37703A (sh) 2006-05-25
NO20032303D0 (no) 2003-05-21
EP1762249A2 (en) 2007-03-14
EA007602B1 (ru) 2006-12-29
CN1476335A (zh) 2004-02-18
JP2004513970A (ja) 2004-05-13
BG107828A (bg) 2004-07-30
DE60132108D1 (de) 2008-02-07
AU1604202A (en) 2002-06-03
CA2428870C (en) 2006-05-23
KR100910607B1 (ko) 2009-08-04
ME00556A (en) 2011-12-20
EE05236B1 (et) 2009-12-15
US20040220228A1 (en) 2004-11-04
US8754108B2 (en) 2014-06-17
KR20080003010A (ko) 2008-01-04
MXPA03004548A (es) 2003-09-10
UA80961C2 (en) 2007-11-26
DE60132108T2 (de) 2008-12-11
RS52024B (sr) 2012-04-30

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