BRPI0211665B8 - "composto de pirrol substituído" - Google Patents

"composto de pirrol substituído"

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Publication number
BRPI0211665B8
BRPI0211665B8 BRPI0211665A BR0211665A BRPI0211665B8 BR PI0211665 B8 BRPI0211665 B8 BR PI0211665B8 BR PI0211665 A BRPI0211665 A BR PI0211665A BR 0211665 A BR0211665 A BR 0211665A BR PI0211665 B8 BRPI0211665 B8 BR PI0211665B8
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutically acceptable
drug
substituted pyrrole
relates
Prior art date
Application number
BRPI0211665A
Other languages
English (en)
Other versions
BR0211665A (pt
BR0211665B1 (pt
Inventor
Bhushan Lohray Braj
Saurin Raval Preeti
Khimshankar Raval Saurin
Basu Sujay
Brushan Lohray Vidya
Kumar Barot Vijay
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of BR0211665A publication Critical patent/BR0211665A/pt
Publication of BR0211665B1 publication Critical patent/BR0211665B1/pt
Publication of BRPI0211665B8 publication Critical patent/BRPI0211665B8/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

"composto, composição farmacêutica, método para a redução de glicose, método para a prevenção ou para o tratamento de doenças, medicamento para a redução de glicose, medicamento para a prevenção ou para o tratamento de doenças, uso do composto, da composição farmacêuticas e do medicamento e processo para a preparação do composto". a presente invenção refere-se a novos compostos de pirrol substituídos, seus derivados, seus análogos, suas formas tautoméricas, seus estereoisômeros, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis e às composições farmaceuticamente aceitáveis contendo os mesmos. mais particularmente, a presente invenção refere-se a novos compostos de pirrol substituídos tendo a fórmula geral (i) seus derivados, seus análogos, suas formas tautoméricas, seus estereoisômeros, seus polimorfos, seus sais farmaceuticamente aceitáveis, seus solvatos farmaceuticamente aceitáveis e às composições farmaceuticamente aceitáveis contendo os mesmos. a presente invenção também refere-se ao processo para o preparo de tal composto, a uma composição contendo o composto e ao uso deste composto e composição na medicina. os compostos reduzem os níveis de triglicérides no sangue e podem ser úteis no tratamento de obesidade, hiperlipidêmia, hipercolesterêmia, síndrome x e diabete.
BRPI0211665A 2001-07-26 2002-07-25 "composto de pirrol substituído" BRPI0211665B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN711MU2001 2001-07-26
PCT/IN2002/000155 WO2003009841A1 (en) 2001-07-26 2002-07-25 Novel pyrroles having hypolipidemic hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them and their use in medicine

Publications (3)

Publication Number Publication Date
BR0211665A BR0211665A (pt) 2005-01-11
BR0211665B1 BR0211665B1 (pt) 2017-10-31
BRPI0211665B8 true BRPI0211665B8 (pt) 2021-05-25

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BRPI0211665A BRPI0211665B8 (pt) 2001-07-26 2002-07-25 "composto de pirrol substituído"

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US (6) US6987123B2 (pt)
EP (1) EP1414439B1 (pt)
JP (2) JP4313194B2 (pt)
KR (2) KR20060094545A (pt)
CN (1) CN100450477C (pt)
AP (1) AP1808A (pt)
AR (1) AR036347A1 (pt)
AT (1) ATE507828T1 (pt)
AU (1) AU2002355205B2 (pt)
BR (1) BRPI0211665B8 (pt)
CA (1) CA2454863C (pt)
CO (1) CO5390079A1 (pt)
CY (1) CY1111876T1 (pt)
DE (1) DE60239939D1 (pt)
DK (1) DK1414439T3 (pt)
EA (1) EA006858B1 (pt)
ES (1) ES2366279T3 (pt)
HR (1) HRP20040138B1 (pt)
IL (1) IL160042A (pt)
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MY (1) MY140057A (pt)
NO (1) NO326698B1 (pt)
NZ (2) NZ550375A (pt)
OA (1) OA12702A (pt)
PL (1) PL224397B1 (pt)
PT (1) PT1414439E (pt)
RS (1) RS51837B (pt)
SI (1) SI1414439T1 (pt)
UA (1) UA76992C2 (pt)
WO (1) WO2003009841A1 (pt)
ZA (1) ZA200400563B (pt)

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WO2003105864A1 (en) * 2002-06-13 2003-12-24 Board Of Regents, The University Of Texas System Methods and compositions involving aldose reductase inhibitors
US20050288373A1 (en) * 2002-10-24 2005-12-29 Ron Eyal S Methods of treating various conditions by administration of sustained release L-arginine
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
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