BRPI0212028B1 - sistema terapêutico transdérmico (tts) e seu processo de produção - Google Patents

sistema terapêutico transdérmico (tts) e seu processo de produção

Info

Publication number
BRPI0212028B1
BRPI0212028B1 BRPI0212028A BRPI0212028A BRPI0212028B1 BR PI0212028 B1 BRPI0212028 B1 BR PI0212028B1 BR PI0212028 A BRPI0212028 A BR PI0212028A BR PI0212028 A BRPI0212028 A BR PI0212028A BR PI0212028 B1 BRPI0212028 B1 BR PI0212028B1
Authority
BR
Brazil
Prior art keywords
active substance
transdermal therapeutic
tts
therapeutic system
fentanyl
Prior art date
Application number
BRPI0212028A
Other languages
English (en)
Inventor
Mueller Walter
Original Assignee
Lts Lohmann Therapie Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie Systeme Ag filed Critical Lts Lohmann Therapie Systeme Ag
Publication of BR0212028A publication Critical patent/BR0212028A/pt
Publication of BRPI0212028B1 publication Critical patent/BRPI0212028B1/pt
Publication of BRPI0212028B8 publication Critical patent/BRPI0212028B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

sistema terapêutico transdérmico (tts) com a substância ativa fentanila. a presente invenção refere-se a sistemas terapêuticos transdérmicos com fentanila ou com um derivado análogo à fentanila como substância ativa. para excluir superdosagens inadvertidas pela liberação descontrolada da substância ativa como conseqüência de um dano, a substância ativa está contida em microrreservatórios enchidos com líquido da camada contendo substância ativa. eventualmente, a camada contendo substância ativa pode ser provida de uma membrana.
BRPI0212028 2001-08-24 2002-07-10 sistema terapêutico transdérmico (tts) e seu processo de produção BRPI0212028B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10141651A DE10141651B4 (de) 2001-08-24 2001-08-24 Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
PCT/EP2002/007663 WO2003018071A1 (de) 2001-08-24 2002-07-10 Transdermales therapeutisches system (tts) mit dem wirkstoff fentanyl

Publications (3)

Publication Number Publication Date
BR0212028A BR0212028A (pt) 2004-08-03
BRPI0212028B1 true BRPI0212028B1 (pt) 2020-11-24
BRPI0212028B8 BRPI0212028B8 (pt) 2021-05-25

Family

ID=7696569

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0212028 BRPI0212028B8 (pt) 2001-08-24 2002-07-10 sistema terapêutico transdérmico (tts) e seu processo de produção

Country Status (23)

Country Link
US (2) US7390500B2 (pt)
EP (1) EP1418951B1 (pt)
JP (1) JP4628673B2 (pt)
KR (1) KR100895188B1 (pt)
CN (1) CN100438859C (pt)
AT (1) ATE455541T1 (pt)
AU (1) AU2002321199B2 (pt)
BR (1) BRPI0212028B8 (pt)
CA (1) CA2457245C (pt)
CY (1) CY1109954T1 (pt)
DE (2) DE10141651B4 (pt)
DK (1) DK1418951T3 (pt)
ES (1) ES2339640T3 (pt)
HU (1) HU229942B1 (pt)
IL (2) IL160515A0 (pt)
MX (1) MXPA04001679A (pt)
NZ (1) NZ530795A (pt)
PL (1) PL204348B1 (pt)
PT (1) PT1418951E (pt)
RU (1) RU2311908C2 (pt)
TW (1) TW570815B (pt)
WO (1) WO2003018071A1 (pt)
ZA (1) ZA200400473B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20040086551A1 (en) 2002-10-30 2004-05-06 Miller Kenneth J. Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl
NZ541576A (en) * 2003-02-07 2008-03-28 Lohmann Therapie Syst Lts Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof
PT1613297E (pt) * 2003-04-14 2007-08-23 Lohmann Therapie Syst Lts Emplastro terapêutico com matriz de polissiloxano compreendendo capsaicina
US20110086086A1 (en) * 2005-07-26 2011-04-14 Pfizer Inc Transdermal system for varenicline
DE102006019293A1 (de) * 2006-04-21 2007-10-25 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH Pflaster, enthaltend ein Fentanyl Analogum
GB0615429D0 (en) * 2006-08-03 2006-09-13 Chowdhury Dewan F H Transdermal drug delivery with temporal control
DE102006054732B4 (de) 2006-11-21 2010-12-30 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren
DE102006054731B4 (de) 2006-11-21 2013-02-28 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie
DE102008016804B4 (de) * 2008-04-02 2012-01-05 Lts Lohmann Therapie-Systeme Ag Selbstzerstörendes transdermales therapeutisches System mit verbesserter Funktionalität und Wirksamkeit sowie seine Verwendung
US20100221313A1 (en) * 2008-12-01 2010-09-02 Innovative Pharmaceuticals, Llc Transdermal reservoir patch
EP2456839A1 (en) * 2009-07-21 2012-05-30 Mylan Inc. Process for the continuous manufacture of a polyisobutylene based transdermal patch
US9822088B2 (en) 2011-03-30 2017-11-21 The United States Of America As Represented By The Administrator Of Nasa Anisotropic copoly(imide oxetane) coatings and articles of manufacture, copoly(imide oxetane)s containing pendant fluorocarbon moieties, oligomers and processes therefor
DE102011080390B3 (de) * 2011-08-03 2012-07-12 Acino Ag Applikationshilfe
TW201338813A (zh) 2011-12-12 2013-10-01 洛曼治療系統股份有限公司 經皮遞送系統
TW201431570A (zh) * 2012-11-22 2014-08-16 Ucb Pharma Gmbh 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
BR112015029920A2 (pt) * 2013-06-04 2017-07-25 Lts Lohmann Therapie Systeme Ag sistema de administração transdérmica
CA2916183C (en) 2013-07-03 2022-03-29 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system with electronic component
JP6573913B2 (ja) 2014-05-20 2019-09-11 エルテーエス ローマン テラピー−ジステーメ アーゲー ロチゴチンを含む経皮送達システム
JP6895755B2 (ja) 2014-05-20 2021-06-30 エルテーエス ローマン テラピー−ジステーメ アーゲー 経皮送達システムにおける活性薬剤の放出を調節するための方法
EP4238580A3 (en) 2014-05-20 2023-10-25 LTS Lohmann Therapie-Systeme AG Transdermal delivery system including an interface mediator
US9962340B2 (en) 2015-06-09 2018-05-08 Life Tech Global, Llc Device and method for the transdermal delivery of cannabidiol
US10272125B2 (en) * 2015-09-14 2019-04-30 Life Tech Global, Llc Transdermal delivery of cannabidiol with other active moieties including cannabinoids
US9650338B1 (en) 2016-07-29 2017-05-16 VDM Biochemicals, Inc. Opioid antagonist compounds and methods of making and using
DE102017107468B4 (de) 2017-04-06 2019-02-21 Lts Lohmann Therapie-Systeme Ag Verfahren zur herstellung eines, insbesondere oralen, wirkstofflaminats und wirkstofflaminat, insbesondere orales wirkstofflaminat
IL269957B (en) 2017-04-18 2022-08-01 Breakthrough Tech Llc Sulfur production
CA3074636C (en) 2017-09-04 2024-04-30 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an emulsifier
JP6912122B2 (ja) * 2019-02-28 2021-07-28 日本臓器製薬株式会社 経皮投与製剤

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310559A (en) * 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US6110488A (en) * 1986-08-28 2000-08-29 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
US4822802A (en) * 1987-02-24 1989-04-18 Alza Corporation Method of fentanly administration for postoperative pain relief
US4849224A (en) * 1987-11-12 1989-07-18 Theratech Inc. Device for administering an active agent to the skin or mucosa
FR2623718B1 (fr) * 1987-11-27 1994-04-15 Fabre Medicament Pierre Dispositif therapeutique transdermique et son procede de preparation
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
DE3905051A1 (de) * 1989-02-18 1990-08-30 Lohmann Therapie Syst Lts Therapeutisches system zur verzoegerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (i)
DE3910543A1 (de) * 1989-04-01 1990-10-11 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit erhoehtem wirkstofffluss und verfahren zu seiner herstellung
US5788983A (en) * 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
SE8904296D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system
JP3202777B2 (ja) * 1992-01-24 2001-08-27 リンテック株式会社 経皮吸収促進剤及びテープ製剤
DE59409873D1 (de) * 1993-04-20 2001-10-25 Hexal Ag Wirkstoffpflaster
CN1094972A (zh) * 1993-05-21 1994-11-16 深圳广信生物工程公司 控释透皮治疗系统及其制备与应用
JP3240496B2 (ja) * 1993-09-30 2001-12-17 タキロン株式会社 経皮吸収製剤
US5665378A (en) * 1994-09-30 1997-09-09 Davis; Roosevelt Transdermal therapeutic formulation
FR2728463A1 (fr) * 1994-12-21 1996-06-28 Lhd Lab Hygiene Dietetique Systeme transdermique d'administration simultanee de plusieurs principes actifs
JP4346696B2 (ja) * 1996-05-28 2009-10-21 久光製薬株式会社 経皮治療用装置
DE19728517C2 (de) * 1997-07-04 1999-11-11 Sanol Arznei Schwarz Gmbh TTS zur Verabreichung von Sexualsteroidhormonen und Verfahren zu seiner Herstellung
KR19980025307A (ko) * 1998-04-11 1998-07-06 조태임 진통효과를 갖는 약물의 경피흡수제제
US6312715B1 (en) * 1998-05-01 2001-11-06 3M Innovative Properties Company Adhesive microsphere drug delivery composition
CA2374930C (en) * 1999-07-02 2008-08-05 Lts Lohmann Therapie-Systeme Ag Microreservoir system based on polysiloxanes and ambiphilic solvents
DE19958554C2 (de) * 1999-07-02 2002-06-13 Lohmann Therapie Syst Lts Mikroreservoirsystem auf Basis von Polysiloxanen und ambiphilen Lösemitteln und ihre Herstellung
US6893655B2 (en) * 2001-10-09 2005-05-17 3M Innovative Properties Co. Transdermal delivery devices

Also Published As

Publication number Publication date
EP1418951A1 (de) 2004-05-19
CN100438859C (zh) 2008-12-03
MXPA04001679A (es) 2004-05-31
CN1545407A (zh) 2004-11-10
PL366857A1 (en) 2005-02-07
CA2457245C (en) 2010-09-07
HUP0401512A3 (en) 2012-08-28
DE10141651A1 (de) 2003-03-13
DK1418951T3 (da) 2010-05-10
ZA200400473B (en) 2004-10-14
ES2339640T3 (es) 2010-05-24
JP2005501865A (ja) 2005-01-20
KR100895188B1 (ko) 2009-04-24
CY1109954T1 (el) 2012-05-23
RU2004108849A (ru) 2005-05-10
US20040234583A1 (en) 2004-11-25
AU2002321199B2 (en) 2007-08-16
BR0212028A (pt) 2004-08-03
NZ530795A (en) 2005-08-26
RU2311908C2 (ru) 2007-12-10
IL160515A (en) 2009-09-22
EP1418951B1 (de) 2010-01-20
US20080274167A1 (en) 2008-11-06
PT1418951E (pt) 2010-04-07
IL160515A0 (en) 2004-07-25
HU229942B1 (en) 2015-01-28
HK1069534A1 (en) 2005-05-27
PL204348B1 (pl) 2010-01-29
CA2457245A1 (en) 2003-03-06
TW570815B (en) 2004-01-11
ATE455541T1 (de) 2010-02-15
DE10141651B4 (de) 2007-02-15
US7390500B2 (en) 2008-06-24
JP4628673B2 (ja) 2011-02-09
DE50214184D1 (de) 2010-03-11
WO2003018071A1 (de) 2003-03-06
KR20040029021A (ko) 2004-04-03
BRPI0212028B8 (pt) 2021-05-25
HUP0401512A2 (hu) 2004-12-28

Similar Documents

Publication Publication Date Title
BRPI0212028B8 (pt) sistema terapêutico transdérmico (tts) e seu processo de produção
BRPI0416044A (pt) sistema e método para distribuição transdérmica
AR019262A1 (es) Proceso para la preparacion de una formulacion que comprende una sustancia activa o sustancias activas asociadas con un portador, y formulacion preparadapor dicho proceso.
BRPI0113477B8 (pt) proteína de fusão para distribuição de um peptídeo, proteína, glicoproteína ou oligonucleotídeo em uma célula
ECSP034869A (es) Una composicion para la piel, permeable selectiva inhibidora de ciclooxigenasa-2
BR112012027651A2 (pt) método, e, sistema
BR0318373A (pt) formas de dosagem de liberação sustentada de anestésicos para controle de dor
BRPI0714399B8 (pt) composição farmacêutica líquida oral
CL2003002043A1 (es) Compuestos derivados de tetrahidropiridina sustituidos en posicion 3 y 4; composicion farmaceutica, y sus usos en el tratamiento de enfermedades que estan asociadas con el sistema renina-angiotensina (ras), tales como hipertension, insuficiencia card
AR073499A1 (es) Derivados de 2-heteroaril-pirrolo[3,4-c]pirrolo, procesos para su preparacion, medicamentos que comprenden dichos compuestos y su uso como inhibidor de scd"
UY30587A1 (es) Benzoxazoles y oxazolopiridinas que son utiles como inhibidores de las cinasa s janus
AR039037A1 (es) Un sistema de liberacion de una droga vaginal con un ph esencialmente neutro y un metodo para tratar una enfermedad vaginal que comprende dicho sistema
RU2009123368A (ru) Трансдермальная терапевтическая система для введения активного вещества бупренорфина
BR0317743A (pt) Dispositivo de liberação de agente ativo tendo membros de compósito
ATE363900T1 (de) Therapeutisches pflaster mit capsaicin-haltiger polysiloxan-matrix
BR0012152A (pt) Sistema de microrreservatórios na base de polissiloxanos e solventes ambifìlicos
MY183873A (en) Transdermal therapeutic system for application of an agent
BR112015013660A2 (pt) sistema de entrega transdérmica
DE50311778D1 (de) Mischsystem zur löslichkeitsvermittlung von pharmazeutischen wirkstoffen in polymermatrizes
BR112019024566A2 (pt) inibidores de pirazol magl
BR112012008348A2 (pt) métodos e aparelhos para controle de sessão em um sistema de localização de rede
AR034493A1 (es) Combinacion de principios activos para el tratamiento medico de toxicomanias.
UY25192A1 (es) Formulación medicamentosa con liberación controlada de sustancia activa
BR0309625A (pt) Sistema de cristalização que utiliza atomização
BR112012014107A2 (pt) sistema terapêutico transdérmico para administração de peptídeos

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: A61K 9/70

Ipc: A61K 31/4468 (2011.01), A61K 9/70 (2011.01), A61P

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 24/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/07/2002 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2678 DE 03-05-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.