BRPI0301159B8 - solução protetora para prevenção de danos isquêmicos, e seu processo de preparação - Google Patents

solução protetora para prevenção de danos isquêmicos, e seu processo de preparação

Info

Publication number
BRPI0301159B8
BRPI0301159B8 BRPI0301159A BR0301159A BRPI0301159B8 BR PI0301159 B8 BRPI0301159 B8 BR PI0301159B8 BR PI0301159 A BRPI0301159 A BR PI0301159A BR 0301159 A BR0301159 A BR 0301159A BR PI0301159 B8 BRPI0301159 B8 BR PI0301159B8
Authority
BR
Brazil
Prior art keywords
ischemic damage
protective solution
preparation process
preventing ischemic
mosm
Prior art date
Application number
BRPI0301159A
Other languages
English (en)
Other versions
BR0301159A (pt
BRPI0301159B1 (pt
Inventor
Koehler Gernot
De Groot Herbert
Rauen Ursula
Bruns Wilfried
Original Assignee
Dr Franz Koehler Chemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Franz Koehler Chemie Gmbh filed Critical Dr Franz Koehler Chemie Gmbh
Publication of BR0301159A publication Critical patent/BR0301159A/pt
Publication of BRPI0301159B1 publication Critical patent/BRPI0301159B1/pt
Publication of BRPI0301159B8 publication Critical patent/BRPI0301159B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)

Abstract

"solução protetora para prevenção de danos isquêmicos". a presente invenção refere-se a uma solução protetora para evitar danos isquêmicos em órgãos, ou em sistemas celulares isolados, ou partes de tecidos após perfusão, operação, transplante, ou crioconservação e em seguida reperfusão, que contém como eletrólitos íons alcalinos, opcionalmente também íons alcalino-terrosos, uma solução tampão, assim como poliol e/ou um açúcar, que apresenta uma osmolaridade de cerca de 290 mosm/l até cerca de 250 mosm/l, assim como um valor de ph de cerca de 6,8 até cerca de 7,4, e são adicionados o ácido hidroxâmico, e/ou um ou mais derivados de ácido hidroxâmico.
BRPI0301159A 2002-05-17 2003-05-16 solução protetora para prevenção de danos isquêmicos, e seu processo de preparação BRPI0301159B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10222561A DE10222561B4 (de) 2002-05-17 2002-05-17 Protektive Lösung zur Verhinderung von Ischämieschäden
DE10222561.3 2002-05-17

Publications (3)

Publication Number Publication Date
BR0301159A BR0301159A (pt) 2004-08-17
BRPI0301159B1 BRPI0301159B1 (pt) 2018-05-15
BRPI0301159B8 true BRPI0301159B8 (pt) 2021-05-25

Family

ID=29265373

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0301159A BRPI0301159B8 (pt) 2002-05-17 2003-05-16 solução protetora para prevenção de danos isquêmicos, e seu processo de preparação

Country Status (13)

Country Link
US (2) US7977383B2 (pt)
EP (2) EP1859679B1 (pt)
JP (1) JP4603246B2 (pt)
KR (2) KR101014990B1 (pt)
CN (1) CN100448440C (pt)
AR (2) AR039819A1 (pt)
AT (2) ATE446676T1 (pt)
BR (1) BRPI0301159B8 (pt)
CA (1) CA2429097C (pt)
DE (4) DE10222561B4 (pt)
DK (1) DK1859679T3 (pt)
ES (2) ES2335145T3 (pt)
MX (1) MXPA03004315A (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10222561B4 (de) 2002-05-17 2009-12-10 Dr. Franz Köhler Chemie GmbH Protektive Lösung zur Verhinderung von Ischämieschäden
US8029815B2 (en) 2004-04-28 2011-10-04 Elford Howard L Methods for treating or preventing restenosis and other vascular proliferative disorders
EP1759582B1 (en) * 2004-05-26 2016-11-23 National University Corporation Kagawa University Preservative solution for cells, tissues and organs comprising rare sugar and preservation method with the use of the same
DE102007026392A1 (de) * 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
EP2030615A3 (en) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
AU2011295629B2 (en) * 2010-09-01 2014-05-01 Organ Transport Pty Ltd Perfusion composition
US9402866B2 (en) 2011-04-07 2016-08-02 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
BRPI1101935B1 (pt) * 2011-04-15 2017-12-12 Universidade Federal De Minas Gerais Antioxidant composition for preservation of organs and fabrics
DE102012005177A1 (de) 2012-03-16 2013-09-19 Bitop Ag Organlagerlösung
NL2010010C2 (en) * 2012-12-19 2014-06-23 Sulfateq B V Compounds for protection of cells.
CN103238586B (zh) * 2013-03-28 2014-03-26 辽宁亿灵科创生物医药科技有限公司 一种心肌脏器保存液制备方法
EP2821081A1 (en) * 2013-07-05 2015-01-07 ResuSciTec GmbH Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
PL3639828T3 (pl) 2013-12-24 2022-05-02 Virginia Commonwealth University Zastosowanie utlenowanych siarczanów cholesterolu (ocs) w leczeniu ostrej niewydolności wątroby
ES3048139T3 (en) 2016-05-01 2025-12-09 Univ California Glutarate compounds for treating ischemia-reperfusion injuries
DE102016125414A1 (de) 2016-12-22 2018-06-28 Bitop Ag Zusammensetzung enthaltend N-Acetyldiaminobuttersäure
CN110536687B (zh) * 2018-03-27 2022-12-16 华东理工大学 N-羟基吡啶酮类化合物及其用途
KR20200069995A (ko) 2018-12-08 2020-06-17 이은지 접이식 빗자루
WO2021041836A1 (en) * 2019-08-28 2021-03-04 The Regents Of The University Of Michigan Preservation of organs for transplant and non-transplant surgeries
US20230241076A1 (en) * 2020-06-29 2023-08-03 The Regents Of The University Of Michigan Histone-acetylation-modulating agents for the treatment and prevention of organ injury
EP4248959A1 (en) * 2022-03-22 2023-09-27 Dr. Franz Köhler Chemie GmbH Preparation for reduction of pathological iron overload

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH639270A5 (de) 1978-12-14 1983-11-15 Koehler Franz Dr Chemie Kg Protektive loesung fuer herz und niere.
DE3168925D1 (en) * 1980-12-23 1985-03-28 Koehler Chemie Dr Franz Protective solution for heart and kidney, and manufacturing process
US4419365A (en) 1981-12-21 1983-12-06 Ciba-Geigy Corporation Method of treating Alzheimer's disease
US4562006A (en) * 1984-01-11 1985-12-31 Warner-Lambert Company Cycloheptadiene derivatives
US4607053A (en) * 1984-05-17 1986-08-19 E. R. Squibb & Sons, Inc. Arylhydroxamates useful as antiallergy agents
US4604407A (en) * 1985-04-04 1986-08-05 E. R. Squibb & Sons, Inc. Hydroxamates
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
DK36389A (da) 1988-02-05 1989-08-06 Eastman Kodak Co Praeparat og fremgangsmaade til at forebygge vaevskader ved reperfusion
EP0523037A4 (en) 1990-03-30 1993-07-28 Biomedical Frontiers, Inc. Fluid resuscitation
JPH11514326A (ja) 1990-03-30 1999-12-07 バイオメディカル フロンティアーズ インコーポレイテッド 液体蘇生用医薬物
JP2768799B2 (ja) 1990-04-12 1998-06-25 株式会社大塚製薬工場 心筋保護液
WO1992004023A1 (en) * 1990-09-10 1992-03-19 Shug Austin L Composition and method for protecting the heart during reperfusion
JP2860301B2 (ja) * 1990-09-19 1999-02-24 ヘキスト・マリオン・ルセル株式会社 臓器保存用溶液
GB9024820D0 (en) * 1990-11-15 1991-01-02 Davies Michael J Pharmaceutical compositions
US5498427A (en) * 1990-11-20 1996-03-12 Pasteur Merieux Serums Et Vaccines Solutions for the perfusion, preservation and reperfusion of organs
US5290766A (en) * 1991-02-18 1994-03-01 The National Heart Foundation Of New Zealand Cardioplegic compositions
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
WO1995005076A1 (en) * 1993-08-12 1995-02-23 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
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DE10222561B4 (de) 2002-05-17 2009-12-10 Dr. Franz Köhler Chemie GmbH Protektive Lösung zur Verhinderung von Ischämieschäden

Also Published As

Publication number Publication date
ES2335145T3 (es) 2010-03-22
ATE446676T1 (de) 2009-11-15
DE10222561A1 (de) 2003-12-04
ATE503383T1 (de) 2011-04-15
CA2429097C (en) 2013-06-18
DE10262084B4 (de) 2009-12-24
EP1859679A1 (de) 2007-11-28
BR0301159A (pt) 2004-08-17
US7977383B2 (en) 2011-07-12
JP4603246B2 (ja) 2010-12-22
EP1362511A1 (de) 2003-11-19
DE10222561B4 (de) 2009-12-10
KR101061293B1 (ko) 2011-08-31
KR20030089495A (ko) 2003-11-21
EP1859679B1 (de) 2009-10-28
KR20100093023A (ko) 2010-08-24
BRPI0301159B1 (pt) 2018-05-15
AR098880A2 (es) 2016-06-22
CA2429097A1 (en) 2003-11-17
CN1480132A (zh) 2004-03-10
EP1362511B1 (de) 2011-03-30
DE50312079D1 (de) 2009-12-10
JP2004002418A (ja) 2004-01-08
DK1859679T3 (da) 2010-03-15
MXPA03004315A (es) 2005-02-14
KR101014990B1 (ko) 2011-02-16
ES2362867T3 (es) 2011-07-14
AR039819A1 (es) 2005-03-02
US9603354B2 (en) 2017-03-28
CN100448440C (zh) 2009-01-07
DE50313573D1 (de) 2011-05-12
US20030215781A1 (en) 2003-11-20
US20110300237A1 (en) 2011-12-08

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B03H Publication of an application: rectification [chapter 3.8 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

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Ipc: A01N 1/02 (2006.01), A61K 31/16 (2006.01), A61K 31

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B06A Patent application procedure suspended [chapter 6.1 patent gazette]
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