BRPI0315740B8 - formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolímeros de metacrilato e monômeros de metacrilato - Google Patents
formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolímeros de metacrilato e monômeros de metacrilatoInfo
- Publication number
- BRPI0315740B8 BRPI0315740B8 BRPI0315740A BR0315740A BRPI0315740B8 BR PI0315740 B8 BRPI0315740 B8 BR PI0315740B8 BR PI0315740 A BRPI0315740 A BR PI0315740A BR 0315740 A BR0315740 A BR 0315740A BR PI0315740 B8 BRPI0315740 B8 BR PI0315740B8
- Authority
- BR
- Brazil
- Prior art keywords
- methacrylate
- outer coating
- copolymers
- dosage forms
- active substances
- Prior art date
Links
- 239000011248 coating agent Substances 0.000 title abstract 4
- 238000000576 coating method Methods 0.000 title abstract 4
- 229920001577 copolymer Polymers 0.000 title abstract 4
- 239000000178 monomer Substances 0.000 title abstract 3
- 230000007935 neutral effect Effects 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 title abstract 2
- 239000002552 dosage form Substances 0.000 title abstract 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 title 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolímeros de metacrilato e monômeros de metacrilato". a presente invenção refere-se a uma forma de dosagem multicamadas compreendida por: a) um núcleo neutro; b) um revestimento interno consistindo em um copolímero de metacrilato; c) um revestimento externo consistindo em um copolímero do qual 40 a 95% em peso são compostos por c~ 1-4~ alquil éster radicalmente polimerizados de ácido acrílico ou de ácido metacrílico e dos quais 5 a 60% em peso são compostos por monômeros (met)acrilato tendo um grupo aniônico no radical alquila. a invenção é caracterizada em que o revestimento interno é essencialmente compreendido por um copolímero de metacrilato, do qual pelo menos até 90% em peso consistem em monômeros (met)acrilato com radicais neutros, que, de acordo com din 53 787, tem uma temperatura de formação de filme mínima não maior que 30<39>c, e que contém a substância farmacêutica ativa em forma ligada.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10250543A DE10250543A1 (de) | 2002-10-29 | 2002-10-29 | Mehrschichtige Arzneiform |
| DE10250543.8 | 2002-10-29 | ||
| PCT/EP2003/009800 WO2004039357A1 (de) | 2002-10-29 | 2003-09-04 | Mehrschichtige wirkstoffhaltige arzneiformen, die einen neutralen kern sowie einen inneren und äusseren überzug aus methacrylat-copolymeren und -monomeren umfassen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0315740A BR0315740A (pt) | 2005-09-06 |
| BRPI0315740B1 BRPI0315740B1 (pt) | 2018-06-19 |
| BRPI0315740B8 true BRPI0315740B8 (pt) | 2021-05-25 |
Family
ID=32114959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0315740A BRPI0315740B8 (pt) | 2002-10-29 | 2003-09-04 | formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolímeros de metacrilato e monômeros de metacrilato |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20060204576A1 (pt) |
| EP (1) | EP1556016B1 (pt) |
| JP (1) | JP4819362B2 (pt) |
| KR (1) | KR20050083847A (pt) |
| CN (1) | CN1688295B (pt) |
| AT (1) | ATE406876T1 (pt) |
| AU (1) | AU2003266351A1 (pt) |
| BR (1) | BRPI0315740B8 (pt) |
| CA (1) | CA2502371C (pt) |
| DE (2) | DE10250543A1 (pt) |
| ES (1) | ES2312853T3 (pt) |
| IL (1) | IL167334A (pt) |
| MX (1) | MXPA05004573A (pt) |
| PL (1) | PL206707B1 (pt) |
| SI (1) | SI1556016T1 (pt) |
| WO (1) | WO2004039357A1 (pt) |
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| CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| BRPI0415242B8 (pt) * | 2003-10-10 | 2021-05-25 | Ethypharm Sa | microgrânulos de liberação gradual contendo extrato de gingko biloba e o processo para fabricar estes |
| DE10353196A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix |
| DE10353186A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz |
| DE102004035936A1 (de) * | 2004-07-23 | 2006-03-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
| DE102005007059A1 (de) * | 2005-02-15 | 2006-08-24 | Röhm GmbH & Co. KG | Teilneutralisiertes anionisches (Meth)acrylat-Copolymer |
| CA2607272A1 (en) * | 2005-05-09 | 2006-11-16 | Azur Pharma Limited | Formulations of mast cell stabilizing agents for delivery to the colon |
| EP1883396B1 (en) | 2005-05-18 | 2013-07-03 | DA Volterra | Colonic delivery of adsorbents |
| US8048413B2 (en) | 2006-05-17 | 2011-11-01 | Helene Huguet | Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules |
| DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| CL2008001970A1 (es) * | 2007-07-03 | 2009-03-27 | Synthon Bv | Perla con un nucleo de celulosa microcristalina, un recubrimiento soluble en agua con un polimero vinil pirrolidina, una capa con tolterodina y un aglutinante, y una capa de liberacion controlada con un poliacrilato; proceso para prepararla; forma de dosificacion, util en trastornos urinarios como vejiga hiperactiva. |
| WO2009023672A2 (en) * | 2007-08-13 | 2009-02-19 | Abuse Deterrent Pharmaceutical Llc | Abuse resistant drugs, method of use and method of making |
| HUE043474T2 (hu) * | 2008-01-10 | 2019-08-28 | Evonik Roehm Gmbh | Bevont gyógyszerészeti vagy gyógyhatású étrend-kiegészítõ készítmény javított pulzáló hatóanyag-felszabadulással |
| CN101877971A (zh) | 2008-01-10 | 2010-11-03 | 赢创罗姆有限公司 | 具有活性物质在结肠中增强的释放的包衣药物或营养制剂 |
| CN101683323B (zh) * | 2008-09-24 | 2011-12-28 | 浙江医药股份有限公司新昌制药厂 | 含有万古霉素的结肠靶向微丸及其制备方法 |
| WO2010034342A1 (en) * | 2008-09-24 | 2010-04-01 | Evonik Röhm Gmbh | Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
| KR101535701B1 (ko) * | 2008-09-24 | 2015-07-09 | 에보니크 룀 게엠베하 | 에탄올의 영향에 대하여 내성을 갖는 비-오피오이드용 ｐｈ-의존성 조절 방출 제약 조성물 |
| US8945616B2 (en) * | 2009-02-17 | 2015-02-03 | Mylan Pharmaceuticals Inc. | Controlled release budesonide minitablets |
| US8945615B2 (en) * | 2009-02-17 | 2015-02-03 | Mylan Pharmaceuticals Inc. | Controlled release budesonide minitablets |
| JP2012519498A (ja) | 2009-03-09 | 2012-08-30 | ダウ コーニング コーポレーション | 乳酸発酵ブロスからビシナルジオールを除去する方法 |
| CN105287434A (zh) * | 2009-03-18 | 2016-02-03 | 赢创罗姆有限公司 | 采用含有中性乙烯基聚合物和赋形剂的包衣的具有耐乙醇影响的控释药物组合物 |
| CA2755808C (en) | 2009-03-18 | 2016-01-19 | Evonik Operations Gmbh | Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising neutral vinyl polymers and excipients |
| WO2010105673A1 (en) * | 2009-03-18 | 2010-09-23 | Evonik Röhm Gmbh | Controlled release pharmaceutical composition with resistance against the influence of ethanol employing a coating comprising a polymer mixture and excipients |
| EP2371356B1 (en) * | 2010-03-12 | 2012-12-19 | Phoeme GmbH | Multi-particle pharmaceutical formulation for colon absorption |
| HUE030548T2 (en) * | 2011-06-17 | 2017-05-29 | Evonik Roehm Gmbh | A stomach-resistant medical or nutritional preparation that is resistant to ethanol |
| US11229600B2 (en) * | 2014-09-24 | 2022-01-25 | Vital Beverages Global Inc. | Compositions and methods for selective GI tract delivery |
| CA2936746C (en) | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| SI3302444T1 (sl) | 2015-06-05 | 2021-01-29 | Evonik Operations Gmbh | Farmacevtski ali nutracevtski sestavek z odpornostjo na vpliv etanola |
| WO2016205701A1 (en) | 2015-06-19 | 2016-12-22 | University Of Southern California | Enteral fast access tract platform system |
| WO2016205754A1 (en) | 2015-06-19 | 2016-12-22 | University Of Southern California | Compositions and methods for modified nutrient delivery |
| US12472149B2 (en) | 2015-07-17 | 2025-11-18 | BE Pharbel Manufacturing | Multilayered pharmaceutically active compound-releasing microparticles in a liquid dosage form |
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| CN119236191A (zh) | 2018-05-24 | 2025-01-03 | 塞拉尼斯伊娃高性能聚合物公司 | 用于持续释放大分子药物化合物的可植入器件 |
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| US11689849B2 (en) | 2018-05-24 | 2023-06-27 | Nureva, Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| EP3613414A1 (de) | 2018-08-24 | 2020-02-26 | Dr. Falk Pharma Gmbh | Pellets mit mehrschichtiger struktur zur verzögerten freisetzung des wirkstoffs im distalen kolon |
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| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
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| WO2024206402A1 (en) * | 2023-03-27 | 2024-10-03 | The Cleveland Clinic Foundation | Topical pala therapy for cancer |
| WO2024224407A1 (en) * | 2023-04-28 | 2024-10-31 | Akums Drugs & Pharmaceuticals Limited | Multi-layer pellet formulation and process of preparation thereof |
| CN116650444B (zh) * | 2023-07-31 | 2023-10-31 | 国药集团川抗制药有限公司 | 一种他克莫司缓释药物及其制备方法 |
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| DE10353186A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz |
-
2002
- 2002-10-29 DE DE10250543A patent/DE10250543A1/de not_active Withdrawn
-
2003
- 2003-09-04 JP JP2004547485A patent/JP4819362B2/ja not_active Expired - Lifetime
- 2003-09-04 PL PL374907A patent/PL206707B1/pl unknown
- 2003-09-04 MX MXPA05004573A patent/MXPA05004573A/es active IP Right Grant
- 2003-09-04 ES ES03809716T patent/ES2312853T3/es not_active Expired - Lifetime
- 2003-09-04 CA CA2502371A patent/CA2502371C/en not_active Expired - Lifetime
- 2003-09-04 EP EP03809716A patent/EP1556016B1/de not_active Expired - Lifetime
- 2003-09-04 DE DE50310448T patent/DE50310448D1/de not_active Expired - Lifetime
- 2003-09-04 CN CN038240130A patent/CN1688295B/zh not_active Expired - Lifetime
- 2003-09-04 US US10/532,831 patent/US20060204576A1/en not_active Abandoned
- 2003-09-04 KR KR1020057007384A patent/KR20050083847A/ko not_active Ceased
- 2003-09-04 WO PCT/EP2003/009800 patent/WO2004039357A1/de not_active Ceased
- 2003-09-04 BR BRPI0315740A patent/BRPI0315740B8/pt active IP Right Grant
- 2003-09-04 AT AT03809716T patent/ATE406876T1/de active
- 2003-09-04 AU AU2003266351A patent/AU2003266351A1/en not_active Abandoned
- 2003-09-04 SI SI200331452T patent/SI1556016T1/sl unknown
-
2005
- 2005-03-09 IL IL167334A patent/IL167334A/en unknown
-
2018
- 2018-05-09 US US15/975,090 patent/US20180256606A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1688295B (zh) | 2011-08-24 |
| KR20050083847A (ko) | 2005-08-26 |
| WO2004039357A1 (de) | 2004-05-13 |
| MXPA05004573A (es) | 2005-11-23 |
| DE50310448D1 (de) | 2008-10-16 |
| AU2003266351A1 (en) | 2004-05-25 |
| CA2502371C (en) | 2011-04-12 |
| US20060204576A1 (en) | 2006-09-14 |
| CA2502371A1 (en) | 2004-05-13 |
| BR0315740A (pt) | 2005-09-06 |
| JP4819362B2 (ja) | 2011-11-24 |
| US20180256606A1 (en) | 2018-09-13 |
| JP2006508087A (ja) | 2006-03-09 |
| PL206707B1 (pl) | 2010-09-30 |
| PL374907A1 (en) | 2005-11-14 |
| ES2312853T3 (es) | 2009-03-01 |
| EP1556016B1 (de) | 2008-09-03 |
| EP1556016A1 (de) | 2005-07-27 |
| BRPI0315740B1 (pt) | 2018-06-19 |
| CN1688295A (zh) | 2005-10-26 |
| ATE406876T1 (de) | 2008-09-15 |
| DE10250543A1 (de) | 2004-05-19 |
| IL167334A (en) | 2010-11-30 |
| SI1556016T1 (sl) | 2009-02-28 |
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