BRPI0318250B8 - emplastro tópico com matriz de polissiloxano e método para a produção de preparação de um emplastro tópico - Google Patents

emplastro tópico com matriz de polissiloxano e método para a produção de preparação de um emplastro tópico

Info

Publication number
BRPI0318250B8
BRPI0318250B8 BRPI0318250A BR0318250A BRPI0318250B8 BR PI0318250 B8 BRPI0318250 B8 BR PI0318250B8 BR PI0318250 A BRPI0318250 A BR PI0318250A BR 0318250 A BR0318250 A BR 0318250A BR PI0318250 B8 BRPI0318250 B8 BR PI0318250B8
Authority
BR
Brazil
Prior art keywords
capsaicin
therapeutic compound
topical plaster
topical
preparation
Prior art date
Application number
BRPI0318250A
Other languages
English (en)
Other versions
BR0318250A (pt
BRPI0318250B1 (pt
Inventor
Müller Walter
Original Assignee
Lts Lohmann Therapie Systeme Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie Systeme Ag filed Critical Lts Lohmann Therapie Systeme Ag
Publication of BR0318250A publication Critical patent/BR0318250A/pt
Publication of BRPI0318250B1 publication Critical patent/BRPI0318250B1/pt
Publication of BRPI0318250B8 publication Critical patent/BRPI0318250B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"emplastro terapêutico com matriz de polissiloxano compreendendo capsaicina". a presente invenção refere-se a emplastro tópico contendo capsaicina ou análogo de capsaicina, processo para a sua preparação e seu uso. a invenção relaciona-se a um emplastro tópico compreendendo uma camada de apoio impermeável ao composto terapêutico, uma matriz auto-adesiva baseada em polissiloxanos e contendo capsaicina, ou um composto terapêutico análogo à capsaicina, e um filme protetor a ser removido antes do uso, em que a matriz contém microrreservatórios líquidos baseados em um solvente anfifílico, no qual o composto terapêutico está presente na forma completamente dissolvida e a concentração do composto terapêutico nas gotículas de microrreservatórios está abaixo da concentração de saturação. a invenção, além disso, relaciona-se a um processo para a sua produção e ao seu uso no tratamento de dor neuropática.
BRPI0318250A 2003-04-14 2003-11-19 emplastro tópico com matriz de polissiloxano e método para a produção de preparação de um emplastro tópico BRPI0318250B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46263003P 2003-04-14 2003-04-14
PCT/EP2003/012929 WO2004089361A1 (en) 2003-04-14 2003-11-19 Therapeutic patch with polysiloxane matrix comprising capsaicin

Publications (3)

Publication Number Publication Date
BR0318250A BR0318250A (pt) 2006-05-23
BRPI0318250B1 BRPI0318250B1 (pt) 2015-08-11
BRPI0318250B8 true BRPI0318250B8 (pt) 2021-05-25

Family

ID=33159857

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0318250A BRPI0318250B8 (pt) 2003-04-14 2003-11-19 emplastro tópico com matriz de polissiloxano e método para a produção de preparação de um emplastro tópico

Country Status (23)

Country Link
US (2) US8821920B2 (pt)
EP (1) EP1613297B1 (pt)
JP (1) JP4943657B2 (pt)
KR (1) KR101050672B1 (pt)
CN (2) CN100512806C (pt)
AT (1) ATE363900T1 (pt)
AU (1) AU2003289710B2 (pt)
BR (1) BRPI0318250B8 (pt)
CA (1) CA2517493C (pt)
CY (1) CY1106744T1 (pt)
DE (1) DE60314298T2 (pt)
DK (1) DK1613297T3 (pt)
ES (1) ES2288222T3 (pt)
IL (1) IL171249A (pt)
MX (1) MXPA05011012A (pt)
NO (1) NO337896B1 (pt)
NZ (1) NZ541956A (pt)
PL (1) PL219512B1 (pt)
PT (1) PT1613297E (pt)
RU (1) RU2349315C9 (pt)
UA (1) UA81665C2 (pt)
WO (1) WO2004089361A1 (pt)
ZA (1) ZA200506462B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7943166B2 (en) 2003-04-10 2011-05-17 Neurogesx, Inc. Methods and compositions for administration of TRPV1 agonists
DE102004044578A1 (de) * 2004-09-13 2006-03-30 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit einer Haftschicht, Verfahren zum Silikonisieren einer Rückschicht des Systems und Verwendung der Rückschicht
JP2006206471A (ja) * 2005-01-26 2006-08-10 Nitto Denko Corp テープ製剤
ZA200707492B (en) * 2005-02-14 2009-02-25 Neurogesx Inc Device for delivery of TRPV1 agonists
CA2602832A1 (en) * 2005-03-30 2006-10-05 Keith R. Bley Low-concentration capsaicin patch and methods for treating neuropathic pain
JP4505645B2 (ja) * 2006-02-17 2010-07-21 フジコピアン株式会社 固定シートの貼付方法
JP4505644B2 (ja) * 2006-02-17 2010-07-21 フジコピアン株式会社 固定シート
JP4505646B2 (ja) * 2006-02-20 2010-07-21 フジコピアン株式会社 固定シート
JP4505649B2 (ja) * 2006-03-23 2010-07-21 フジコピアン株式会社 固定シート
JP2007284370A (ja) * 2006-04-14 2007-11-01 Alcare Co Ltd 体表面用貼付材
US7943666B2 (en) * 2006-07-24 2011-05-17 Trinity Laboratories, Inc. Esters of capsaicin for treating pain
CN101677969B (zh) * 2007-06-08 2011-12-28 株式会社三养社 骨架型透皮给药系统及其制备方法
KR101857827B1 (ko) * 2010-06-09 2018-05-14 카오카부시키가이샤 수증기 발생 온열구
TW201431570A (zh) 2012-11-22 2014-08-16 Ucb Pharma Gmbh 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
CN105263469B (zh) * 2013-03-14 2018-11-02 阿勒根公司 包含比马前列素的局部组合物和利用其刺激毛发生长的方法
AP2015008920A0 (en) * 2013-06-04 2015-12-31 Lohmann Therapie Syst Lts Transdermal delivery system
US10046151B2 (en) 2013-07-03 2018-08-14 Lts Lohmann Therapie-Systeme, Ag Transdermal therapeutic system with electronic component
CN104586818A (zh) * 2013-11-01 2015-05-06 北京中卫神农慢性病医学研究院有限公司 辣椒碱微孔久释器材
KR101574760B1 (ko) * 2013-11-13 2015-12-04 주식회사 엘지생활건강 흡수속도를 개선한 마이크로니들 시스템
US11633367B2 (en) 2014-05-20 2023-04-25 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system containing rotigotine
WO2015177212A1 (en) 2014-05-20 2015-11-26 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an interface mediator
WO2015177209A1 (en) 2014-05-20 2015-11-26 Lts Lohmann Therapie-Systeme Ag Method for adjusting the release of active agent in a transdermal delivery system
MA40998A (fr) 2014-11-21 2017-09-26 Ophirex Inc Thérapies contre une envenimation, ainsi que compositions, systèmes et kits pharmaceutiques associés
CN104546805A (zh) * 2014-12-15 2015-04-29 刘闯 一种治疗皮肤色斑的药膏贴
EP3266472A1 (en) * 2016-07-08 2018-01-10 Mölnlycke Health Care AB A medical dressing comprising a carrier and a composite material
KR101880442B1 (ko) * 2017-02-02 2018-07-23 대구한의대학교산학협력단 혈압 강하용 패치 조성물
CN111093638B (zh) * 2017-09-04 2024-03-26 罗曼治疗系统股份公司 包含乳化剂的透皮递送系统
MX2022011400A (es) 2020-03-17 2022-10-13 Gruenenthal Gmbh Aplicacion topica repetida de parche de capsaicina para usarse para tratar pacientes que no responden inicialmente al tratamiento.
EP4125841A1 (en) * 2020-04-03 2023-02-08 Grünenthal GmbH Regimen for repeated topical application of capsaicin patch
TWI807338B (zh) * 2020-06-26 2023-07-01 美商美國禮來大藥廠 結合ＴＧＦ-α及表皮調節素（ＥＰＩＲＥＧＵＬＩＮ）之抗體於治療疼痛之用途
US11234947B2 (en) * 2020-06-30 2022-02-01 Imperial College Innovations Limited Treatment of peripheral neuropathy induced by cancer chemotherapy
CN116782890A (zh) * 2020-12-30 2023-09-19 埃肯有机硅（上海）有限公司 涂有含辣椒素的硅凝胶的贴剂
EP4046630A1 (en) * 2021-02-18 2022-08-24 LTS Lohmann Therapie-Systeme AG Tts-formulation with thc
EP4680209A1 (en) * 2023-03-15 2026-01-21 LTS Lohmann Therapie-Systeme AG Medical patch comprising capsaicin
JP2026508602A (ja) * 2023-03-15 2026-03-11 エルテーエス ローマン テラピー－ジステーメ アーゲー 皮膚刺激活性薬剤を含む医療用パッチ
WO2025087915A1 (en) * 2023-10-23 2025-05-01 Lts Lohmann Therapie-Systeme Ag Medical patch comprising capsaicin or a capsaicin analog

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3946106A (en) * 1974-10-24 1976-03-23 G. D. Searle & Co. Microsealed pharmaceutical delivery device
US4053580A (en) * 1975-01-01 1977-10-11 G. D. Searle & Co. Microsealed pharmaceutical delivery device
DE3333240A1 (de) * 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
US5145682A (en) * 1986-05-30 1992-09-08 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration
GB8704755D0 (en) * 1987-02-28 1987-04-01 Dow Corning Ltd Pharmaceutical delivery device
US5788983A (en) * 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5494680A (en) * 1993-12-08 1996-02-27 Minnesota Mining And Manufacturing Company Transdermal delivery device
CN1037242C (zh) * 1994-04-22 1998-02-04 天津轻工业学院 以干红辣椒为原料制备辣椒碱的方法
US5714162A (en) * 1994-09-16 1998-02-03 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Scopolamine patch
US5762963A (en) * 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
US6248788B1 (en) * 1996-11-06 2001-06-19 The Regents Of The University Of California Therapeutic method with capsaicin and capasicin analogs
US6239180B1 (en) 1995-11-08 2001-05-29 The Regents Of The University Of California Transdermal therapeutic device and method with capsaicin and capsaicin analogs
RU2097057C1 (ru) * 1995-11-15 1997-11-27 Акционерное общество открытого типа "Нижегородский химико-фармацевтический завод" Состав мази болеутоляющего и местнораздражающего действия с тепловым эффектом
GB2340751B (en) * 1998-08-12 2003-11-05 Edko Trading Representation Pharmaceutical compositions
CA2267049A1 (en) 1999-02-05 2000-08-05 Bioglan Laboratories Ltd. Pharmaceutical compositions
DE19923427A1 (de) * 1999-05-21 2000-11-23 Lohmann Therapie Syst Lts Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen
MXPA02000118A (es) 1999-07-02 2003-02-27 Lohmann Therapie Syst Lts Sistema de microdepositos a base de polisiloxanos y solventes ambifilos.
DE19958554C2 (de) * 1999-07-02 2002-06-13 Lohmann Therapie Syst Lts Mikroreservoirsystem auf Basis von Polysiloxanen und ambiphilen Lösemitteln und ihre Herstellung
US6348501B1 (en) * 1999-09-29 2002-02-19 Medical Merchandising, Inc. Lotion compositions utilizing capsaicin
DE10025971B4 (de) * 2000-05-25 2004-09-02 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System in Plasterform mit verminderter Tendenz zur Wirkstoffkristallisation und seine Verwendung
DE10114382A1 (de) * 2001-03-23 2002-09-26 Beiersdorf Ag Feuchtigkeitsaufnehmende Matrix auf Silikonbasis insbesondere zur Wundversorgung und/oder pharmazeutisch/kosmetischen Hautbehandlung
JP3989188B2 (ja) 2001-04-27 2007-10-10 クリストファー・エム・キム 蜂針を用いない蜂毒療法
EP1390084B1 (en) * 2001-05-01 2011-03-23 A.V. Topchiev Institute of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
DE10141651B4 (de) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System (TTS) mit dem Wirkstoff Fentanyl und Verfahren zu seiner Herstellung
WO2003015698A2 (en) * 2001-08-13 2003-02-27 University Of Pittsburgh Application of lipid vehicles and use for drug delivery
WO2003015678A1 (en) * 2001-08-17 2003-02-27 Lavipharm Laboratories Inc. Composition and transdermal drug delivery device
US8246979B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system for the administration of rotigotine

Also Published As

Publication number Publication date
ZA200506462B (en) 2006-05-31
JP4943657B2 (ja) 2012-05-30
PL378806A1 (pl) 2006-05-15
WO2004089361A1 (en) 2004-10-21
BR0318250A (pt) 2006-05-23
US20140335150A1 (en) 2014-11-13
RU2005134984A (ru) 2007-05-27
JP2006514977A (ja) 2006-05-18
NO20055310L (no) 2005-11-10
KR101050672B1 (ko) 2011-07-19
ES2288222T3 (es) 2008-01-01
PT1613297E (pt) 2007-08-23
PL219512B1 (pl) 2015-05-29
AU2003289710B2 (en) 2009-07-30
KR20060002997A (ko) 2006-01-09
IL171249A (en) 2010-06-16
CY1106744T1 (el) 2012-05-23
UA81665C2 (ru) 2008-01-25
CN100512806C (zh) 2009-07-15
US20040202707A1 (en) 2004-10-14
AU2003289710A1 (en) 2004-11-01
EP1613297A1 (en) 2006-01-11
CN101601664B (zh) 2012-05-23
HK1090844A1 (zh) 2007-01-05
CN101601664A (zh) 2009-12-16
HK1136957A1 (en) 2010-07-16
US8821920B2 (en) 2014-09-02
DE60314298T2 (de) 2008-01-31
CA2517493A1 (en) 2004-10-21
NZ541956A (en) 2008-09-26
BRPI0318250B1 (pt) 2015-08-11
CA2517493C (en) 2011-05-31
RU2349315C2 (ru) 2009-03-20
DK1613297T3 (da) 2007-09-24
NO337896B1 (no) 2016-07-04
CN1784222A (zh) 2006-06-07
EP1613297B1 (en) 2007-06-06
DE60314298D1 (de) 2007-07-19
ATE363900T1 (de) 2007-06-15
RU2349315C9 (ru) 2010-02-27
MXPA05011012A (es) 2005-12-12

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