BRPI0401908A - Compostos inibidores de serina protease, processo de obtenção e uso para tratamento de flaviviroses - Google Patents
Compostos inibidores de serina protease, processo de obtenção e uso para tratamento de flavivirosesInfo
- Publication number
- BRPI0401908A BRPI0401908A BRPI0401908A BRPI0401908A BR PI0401908 A BRPI0401908 A BR PI0401908A BR PI0401908 A BRPI0401908 A BR PI0401908A BR PI0401908 A BRPI0401908 A BR PI0401908A
- Authority
- BR
- Brazil
- Prior art keywords
- flaviviroses
- serine protease
- obtaining
- treatment
- protease inhibitor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229940122055 Serine protease inhibitor Drugs 0.000 title abstract 2
- 101710102218 Serine protease inhibitor Proteins 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000003001 serine protease inhibitor Substances 0.000 title abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
- 208000001490 Dengue Diseases 0.000 abstract 1
- 206010012310 Dengue fever Diseases 0.000 abstract 1
- 208000005176 Hepatitis C Diseases 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 208000025729 dengue disease Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
"COMPOSTOS INIBIDORES DE SERINA PROTEASE, PROCESSO DE OBTENçãO E USO PARA TRATAMENTO DE FLAVIVIROSES". Refere-se a presente invenção a compostos inibidores de serina protease sintéticos tendo um eixo de simetrica C~ 2~, possuindo na porção central uma estrutura do tipo 1,4:3,6-dianidromanitol e, nas porções laterais, ligações peptidomiméticas com aminoácidos, como por exemplo, lisina (Lis), fenilalanina (Phe), dentre outros, utilizados como base para a preparação de formulações antivirais capazes de cessar a proliferação dos vírus responsáveis pela maioria das flaviviroses, como por exemplo, hepatite C, Dengue e febre do oeste do Nilo.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0401908 BRPI0401908A (pt) | 2004-06-04 | 2004-06-04 | Compostos inibidores de serina protease, processo de obtenção e uso para tratamento de flaviviroses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0401908 BRPI0401908A (pt) | 2004-06-04 | 2004-06-04 | Compostos inibidores de serina protease, processo de obtenção e uso para tratamento de flaviviroses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0401908A true BRPI0401908A (pt) | 2006-01-17 |
Family
ID=35551003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0401908 BRPI0401908A (pt) | 2004-06-04 | 2004-06-04 | Compostos inibidores de serina protease, processo de obtenção e uso para tratamento de flaviviroses |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BRPI0401908A (pt) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8541424B2 (en) | 2008-12-23 | 2013-09-24 | Abbott Laboratories | Anti-viral compounds |
| US8686026B2 (en) | 2010-06-10 | 2014-04-01 | Abbvie Inc. | Solid compositions |
| US8691938B2 (en) | 2009-06-11 | 2014-04-08 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US9187496B2 (en) | 2009-12-18 | 2015-11-17 | Idenix Pharmaceuticals Llc | 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors |
| US9278922B2 (en) | 2009-04-15 | 2016-03-08 | Abbvie Inc. | Anti-viral compounds |
| US9333204B2 (en) | 2014-01-03 | 2016-05-10 | Abbvie Inc. | Solid antiviral dosage forms |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US10201541B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
-
2004
- 2004-06-04 BR BRPI0401908 patent/BRPI0401908A/pt not_active Application Discontinuation
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8541424B2 (en) | 2008-12-23 | 2013-09-24 | Abbott Laboratories | Anti-viral compounds |
| US9278922B2 (en) | 2009-04-15 | 2016-03-08 | Abbvie Inc. | Anti-viral compounds |
| US8921514B2 (en) | 2009-06-11 | 2014-12-30 | Abbvie Inc. | Anti-viral compounds |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8691938B2 (en) | 2009-06-11 | 2014-04-08 | Abbvie Inc. | Anti-viral compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| US10039754B2 (en) | 2009-06-11 | 2018-08-07 | Abbvie Inc. | Anti-viral compounds |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US10028937B2 (en) | 2009-06-11 | 2018-07-24 | Abbvie Inc. | Anti-viral compounds |
| US9586978B2 (en) | 2009-06-11 | 2017-03-07 | Abbvie Inc. | Anti-viral compounds |
| US9187496B2 (en) | 2009-12-18 | 2015-11-17 | Idenix Pharmaceuticals Llc | 5,5-fused arylene or heteroarylene hepatitis C virus inhibitors |
| US8686026B2 (en) | 2010-06-10 | 2014-04-01 | Abbvie Inc. | Solid compositions |
| US10201541B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| US9333204B2 (en) | 2014-01-03 | 2016-05-10 | Abbvie Inc. | Solid antiviral dosage forms |
| US9744170B2 (en) | 2014-01-03 | 2017-08-29 | Abbvie Inc. | Solid antiviral dosage forms |
| US10105365B2 (en) | 2014-01-03 | 2018-10-23 | Abbvie Inc. | Solid antiviral dosage forms |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B03A | Publication of an application: publication of a patent application or of a certificate of addition of invention | ||
| B06F | Objections, documents and/or translations needed after an examination request according art. 34 industrial property law | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law | ||
| B07E | Notice of approval relating to section 229 industrial property law |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B07A | Technical examination (opinion): publication of technical examination (opinion) | ||
| B09B | Decision: refusal | ||
| B09B | Decision: refusal |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |